检索结果-南通市图书馆

Corrosion in Mg-alloy biomedical implants-the strategies to reduce the impact of the corrosion inflammatory reaction and microbial activity

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2022年第12期10卷 3306-3326页

作者： soumya saha Widya Lestari Caroline Dini Murni Nazira Sarian Hendra Hermawan Valentim A.R.Barão Cortino Sukotjo Christos Takoudis Department of Biomedical Engineering University of Illinois at ChicagoChicagoUnited States Fundamental Dental and Medical Sciences Department Kulliyyah of DentistryInternational Islamic University MalaysiaKuantanMalaysia Department of Prosthodontics and Periodontology Piracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaBrazil Institute of Systems Biology(INBIOSIS) Universiti Kebangsaan MalaysiaBandar Baru BangiSelangor 43600Malaysia Department of Mining Metallurgical and Materials EngineeringLaval UniversityQuebec CityQC G1V 0A6Canada Department of Restorative Dentistry University of Illinois at Chicago College of DentistryChicagoUnited States Department of Chemical Engineering University of Illinois at ChicagoChicagoUnited States

The most common complication of orthopedic surgery is implant failure, which can result in catastrophic injury and a significant financial burden for patients. Implant failure can be caused by a variety of factors, the most common of which are peri–implant infection(or implantrelated infection), excessive inflammatory response which caused pain and aseptic loosening. Orthopedic surgeons now have a variety of options for treating these issues, including revision surgery, which has demonstrated to be effective. If excessive inflammatory reaction caused by the corrosion and peri–implant infection can be avoided, it will be of enormous social benefits. This review will provide a summary of corrosion and the inflammation reactions due to the corrosion and antimicrobial properties of Mg alloy-based implants covering both in vitro and in vivo studies. The strategies on hindering/overcoming the excessive inflammatory response and enhancing the antimicrobial activity are discussed in this review.

关键词： Mg-alloy implants review Corrosion and inflammation Microbial infection

Collagen membrane functionalized with magnesium oxide via room-temperature atomic layer deposition promotes osteopromotive and antimicrobial properties

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第12期30卷 46-61页

作者： soumya saha Raphael Cavalcante Costa Mirela Caroline Silva Joao Matheus Fonseca-Santos Lin Chen Abhijit H.Phakatkar Harshdeep Bhatia Leonardo P.Faverani Valentim A.R.Barao Tolou Shokuhfar Cortino Sukotjo Christos Takoudis Department of Biomedical Engineering University of Illinois ChicagoChicagoUSA Department of Prosthodontics and Periodontology Piracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaSao PauloBrazil Department of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and ImplantologySao Paulo State University(UNESP)School of DentistryAraçatubaSao PauloBrazil Department of Periodontics Center for Wound Healing and Tissue RegenerationCollege of DentistryUniversity of Illinois ChicagoChicagoUSA Department of Chemical Engineering University of Illinois ChicagoChicagoUSA Department of Restorative Dentistry University of Illinois Chicago College of DentistryChicagoUSA

Artificial bone grafting materials such as collagen are gaining interest due to the ease of production and ***,collagen must be supplemented with additional coating materials for improved ***,we report room-temperature atomic layer deposition(ALD)of MgO,a novel method to coat collagen membranes with *** techniques such as X-ray photoelectron spectroscopy,Raman spectroscopy,and electron beam dispersion mapping confirm the chemical nature of the *** electron and atomic force microscopies show the surface topography and morphology of the collagen fibers were not altered during the ALD of *** release of magnesium ions promotes bone growth,and we show the deposited MgO film leaches trace amounts of Mg when incubated in phosphate-buffered saline at 37◦*** coated collagen membrane had a superhydrophilic surface immediately after the deposition of *** film was not toxic to human cells and demonstrated antibacterial properties against bacterial ***,in vivo studies performed on calvaria rats showed MgO-coated membranes(200 and 500 ALD)elicit a higher inflammatory response,leading to an increase in angiogenesis and a greater bone formation,mainly for Col-MgO500,compared to uncoated *** on the characterization of the MgO film and in vitro and in vivo data,the MgO-coated collagen membranes are excellent candidates for guided bone regeneration.

关键词： coating magnesium atomic

Hemostatic radiotherapy for bleeding gastrointestinal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2261-2263页

作者： Vrushab Rao soumya Singh Bhooshan Zade Department of Cyberknife Radiosurgery and Radiation Oncology Ruby Hall ClinicPune 411001MaharashtraIndia

Hemostatic radiotherapy is a non-invasive treatment for bleeding gastrointestinal(GI)tumors,promoting tumor shrinkage,blood supply reduction,and fibrotic tissue *** is effective in cases where traditional interventions are insufficient or contraindicated and can prevent recurrent bleeding in patients with GI bleeding *** schedules are also effective for tumor control and patient compliance.

关键词： Gastrointestinal tumors Hemostatic radiotherapy Palliative radiotherapy Acute bleeding Hypofractionation

SARS-CoV2 Nsp3 protein triggers cell death and exacerbates amyloid β42-mediated neurodegeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1385-1392页

作者： Aditi Singh Anuradha Venkatakrishnan Chimata Prajakta Deshpande soumya Bajpai Anjali Sangeeth Mrigendra Rajput Amit Singh Department of Biology University of Dayton Premedical Program University of Dayton Center for Tissue Regeneration and Engineering at Dayton (TREND) University of Dayton The Integrative Science and Engineering Center University of Dayton Center for Genomic Advocacy (TCGA) Indiana State University

Infection caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV2) virus, responsible for the coronavirus disease 2019(COVID-19) pandemic, induces symptoms including increased inflammatory response, severe acute respiratory syndrome(SARS), cognitive dysfunction like brain fog, and cardiovascular defects. Long-term effects of SARS-CoV2 COVID-19 syndrome referred to as post-COVID-19 syndrome on age-related progressive neurodegenerative disorders such as Alzheimer’s disease remain understudied. Using the targeted misexpression of individual SARS-CoV2 proteins in the retinal neurons of the Drosophila melanogaster eye, we found that misexpression of nonstructural protein 3(Nsp3), a papain-like protease, ablates the eye and generates dark necrotic spots. Targeted misexpression of Nsp3 in the eye triggers reactive oxygen species production and leads to apoptosis as shown by cell death reporters, terminal deoxynucleotidyl transferase(TdT) dUTP Nick-end labeling(TUNEL) assay, and dihydroethidium staining. Furthermore, Nsp3 misexpression activates both apoptosis and autophagy mechanism(s) to regulate tissue homeostasis. Transient expression of SARS-CoV2 Nsp3 in murine neuroblastoma, Neuro-2a cells, significantly reduced the metabolic activity of these cells and triggers cell death. Misexpression of SARS-CoV2 Nsp3 in an Alzheimer’s disease transgenic fly eye model(glass multiple repeats [GMR]>amyloid β42) further enhances the neurodegenerative rough eye phenotype due to increased cell death. These findings suggest that SARS-CoV2 utilizes Nsp3 protein to potentiate cell death response in a neurodegenerative disease background that has high pre-existing levels of neuroinflammation and cell death.

关键词： Alzheimer's disease apoptosis autophagy COVID-19 Drosophila necrosis Neuro-2a cells neurodegeneration post COVID-19 syndrome SARS-CoV2

Dietary supplementation of zinc oxide modulates intestinal functionality during the post-weaning period in clinically healthy piglets

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第1期15卷 313-328页

作者： Dirkjan Schokker soumya K.Kar Els Willems Alex Bossers Ruud A.Dekker Alfons J.M.Jansman Wageningen Bioveterinary Research LelystadThe Netherlands Wageningen Livestock Research Wageningen University&ResearchWageningenThe Netherlands Royal Agrifirm Group ApeldoornThe Netherlands Institute for Risk Assessment Sciences Utrecht UniversityUtrechtThe Netherlands

Background To improve our understanding of host and intestinal microbiome interaction,this research investigated the effects of a high-level zinc oxide in the diet as model intervention on the intestinal microbiome and small intestinal functionality in clinically healthy post-weaning *** study 1,piglets received either a high concentration of zinc(Zn)as zinc oxide(Zn O,Zn,2,690 mg/kg)or a low Zn concentration(100 mg/kg)in the diet during the post weaning period(d 14–23).The effects on the piglet's small intestinal microbiome and functionality of intestinal tissue were *** study 2,the impact of timing of the dietary zinc intervention was investigated,i.e.,between d 0–14 and/or d 14–23 post weaning,and the consecutive effects on the piglet's intestinal functionality,here referring to microbiota composition and diversity and gene expression *** Differences in the small intestinal functionality were observed during the post weaning period between piglets receiving a diet with a low or high concentration Zn O content.A shift in the microbiota composition in the small intestine was observed that could be characterized as a non-pathological change,where mainly the commensals *** the immediate post weaning period,i.e.,d 0–14,the highest number of differentially expressed genes(DEGs)in intestinal tissue were observed between animals receiving a diet with a low or high concentration Zn O content,i.e.,23 DEGs in jejunal tissue and 11 DEGs in ileal *** genes are involved in biological processes related to immunity and inflammatory *** example,genes CD59 and REG3G were downregulated in the animals receiving a diet with a high concentration Zn O content compared to low Zn O content in both jejunum and ileum *** the second study,a similar result was obtained regarding the expression of genes in intestinal tissue related to immune pathways when comparing piglets receiving a diet with a high concentration Zn O con

关键词： Immune system Intestinal functionality Microbiota Piglets Zinc oxide

Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第2期15卷 645-658页

作者： Christina Larsen Simone Margaard Offersen Anders Brunse Mattia Pirolo soumya Kanti Kar Luca Guadabassi Thomas Thymann Department of Veterinary and Animal Science University of CopenhagenDyrlagevej 681870 Frederiksberg CDenmark Animal Nutrition Wageningen Livestock ResearchWageningen University&Research1 De Elst6708 WageningenThe Netherlands

Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig *** and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the *** secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning *** objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and *** Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single ***,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all P<0.05).CcFT also showed a lower ETEC prevalence on d 27(P<0.05).CMT showed a higher alpha diversity and a difference in beta diversity compared to CON(P<0.05).Growth and other paraclinical endpoints were similar across *** In conclusion,only CcFT reduced ETEC-related post-weaning ***,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration

关键词： Colonic content filtrate transplantation Colonic microbiota transplantation Gastric microbiota transplantation Gut microbiota Mucosa Neonatal Post-weaning diarrhea

Liver injury induced by COVID 19 treatment–what do we know?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第45期28卷 6314-6327页

作者： Lekha saha soumya Vij Kajal Rawat Department of Pharmacology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

The severity of coronavirus disease 2019(COVID-19)may be correlated with the risk of liver injury *** increasing number of studies indicate that degrees of hepatotoxicity have been associated with using some medications in the management of COVID-19 ***,limited studies have systematically investigated the evidence of drug-induced liver injury(DILI)in COVID-19 *** increasing number of studies indicate that degrees of hepatotoxicity have been associated with using some of these medications in the management of COVID-19 ***,it was relieved after the cessation of these ***,to our knowledge,no studies have systematically investigated the evidence of DILI in COVID-19 *** this review,we discussed the association between hepatotoxicity in COVID-19 patients and the drugs used in these patients and possible mechanisms of *** currently available evidence on the association of different therapeutic agents with hepatotoxicity in COVID-19 patient was systematically reviewed.

关键词： Liver injury COVID-19 Anti-COVID drugs Mechanisms Clinical evidences

Two-Stent Strategy for Bifurcation Lesions in Percutaneous Transluminal Coronary Angioplasty: Real-World Evidence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Diseases 2024年第3期14卷 140-156页

作者： Dilip Kumar Amit Malviya Animesh Mishra Rabin Chakraborty Sanjeev S. Mukherjee soumya Patra Arindam Pande Rana Rathor Roy Debopriyo Mondal Ashesh Halder Sumit Shanker Medica Superspecialty Hospital 127 Eastern Metropolitan Bypass Nitai Nagar Mukundapur Kolkata West Bengal India North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS) Mawdiangdiang Shillong Meghalaya India

Background: Bifurcation lesions pose a high risk for adverse events after percutaneous coronary intervention (PCI). Evidence supporting the benefits of the two-stent strategy (2SS) for treating coronary bifurcation lesions in India is limited. This study aimed to evaluate the clinical outcomes of various 2SSs for percutaneous transluminal coronary angioplasty for bifurcation lesions in India. Materials and Methods: This retrospective, observational, multicentric, real-world study included 64 patients over 8 years. Data on demographics, medical history, PCI procedures, and outcomes were recorded. Descriptive statistics were computed using the SPSS software. Results: Patients (n = 64) had an average age of 65.3 ± 11.1 years, with 78.1% males. Acute coronary syndrome was reported in 18.8%, chronic stable angina in 40.6%, and unstable angina in 34.4% of participants. Two-vessel disease was observed in 98.4% of patients, and 99.4% had true bifurcation lesions. The commonly involved vessels were the left anterior descending artery (50%), left circumflex coronary artery (34.4%), and first diagonal artery (43.8%). Mean percent diameter stenosis was 87.2% ± 10.1%. The mean number of stents used was 2.00 ± 0.34. The 2SS techniques included the T and small protrusion (TAP) (39.1%), double kissing (DK) crush (18.8%), and the culotte techniques (14.1%). Procedural and angiographic success rate was 92.18%. Major adverse cardiovascular events at 1-year follow-up occurred in 7.8% of cases. Conclusion: The 2SS for bifurcation lesions showed favorable in-hospital and follow-up outcomes. Findings can serve as a resource for bifurcation angioplasty in India. Larger real-world studies with robust methodology are needed to validate these results.

关键词： Bifurcation Stenting Coronary Bifurcation Lesions Percutaneous

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

极端质量比旋近数据分析方法研究综述

北京大学学报(自然科学版) 2024年

作者：邹晓博 soumya Mohanty 谢群英陈弦罗洪刚刘玉孝韩文标矫佳庚张学昊赵少东郭意扬王瀚之金书竹北京大学物理学院兰州大学理论物理中心甘肃省理论物理重点实验室中国科学院大学国际理论物理中心(亚太地区) 中国科学院上海天文台中国科学院数学与系统科学研究院科学与工程计算国家重点实验室兰州大学物理与科学技术学院中国科学院晨兴数学中心 University of Texas Rio Grande Valley

极端质量比旋近(Extrem Mass-Ratio Inspiral， EMRI)是指质量比在104～107之间的双星系统，其中小质量天体被捕获后绕大质量黑洞旋近，期间损失的能量以引力波的形式向外辐射。旋近结束前的最后一年估计能产生105个旋近周期，因此可提... 详细信息

极端质量比旋近(Extrem Mass-Ratio Inspiral， EMRI)是指质量比在104～107之间的双星系统，其中小质量天体被捕获后绕大质量黑洞旋近，期间损失的能量以引力波的形式向外辐射。旋近结束前的最后一年估计能产生105个旋近周期，因此可提供丰富的引力波相位演化信息。小质量天体处在大质量黑洞的强引力环境中，运动轨迹能反映大质量黑洞周围的时空结构，其波形可用来限制引力理论、无毛定理等；大质量黑洞一般处在星系中心，星系所处的天文学环境会在波形中留下痕迹；多个波源能给出大黑洞的质量、自旋分布，可用于限制宇宙演化和星系演化等。基于上述科学意义，EMRI成为空间引力波计划LISA、太极和天琴的重要观测目标，EMRI的数据分析就成为一个重要任务。EMRI波形的高维度和复杂性对数据分析方法较要求高，目前还没有公认的满意答案。首先回顾了LISA模拟数据挑战赛中提出的方法和最近的讨论，然后基于自身研究总结了难点、提出了改进方法，最后讨论了之后的发展可能用到的几个线索。

关键词：极端质量比旋近信号探测参数估计频谱法匹配滤波