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β-Estradiol 17-acetate enhances the in vitro vitality of endothelial cells isolated from the brain of patients subjected to neurosurgery

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Neural Regeneration Research 2023年第2期18卷 389-395页

作者： sonia Guzzo Pasquale De Bonis Barbara Pavan Luciano Fadiga Department of Neuroscience and Rehabilitation Section of PhysiologyUniversity of FerraraFerraraItaly Center for Translational Neurophysiology of Speech and Communication(CTNSC) Italian Institute of Technology(IIT)FerraraItaly Department of Translational Medicine and for Romagna University of FerraraFerraraItaly

In the current landscape of endothelial cell isolation for building in vitro models of the blood-brain barrier,our work moves towards reproducing the features of the neurovascular unit to achieve glial compliance through an innovative biomimetic coating technology for brain chronic *** hypothesized that the autologous origin of human brain mic rovascular endothelial cells(hBMECs)is the first requirement for the suitable coating to prevent the glial inflammato ry response trigge red by foreign *** re,this study established a new procedure to preserve the in vitro viability of hBMECs isolated from gray and white matter specimens taken from neurosurge ry *** adult hBMECs is generally considered a challenging task due to the difficult survival ex vivo and progressive reduction in proliferation of these *** addition of 10 nMβ-estradiol 17-acetate to the hBMEC culture medium was found to be an essential and discriminating factor promoting adhesion and proliferation both after isolation and thawing,suppo rting the well-known protective role played by estrogens on *** particular,β-estradiol 17-acetate was critical for both freshly isolated and thawed female-derived hBMECs,while it was not necessary for freshly isolated male-derived hBMECs;however,it did countera ct the decay in the viability of the latter after *** tumo r-free hBMECs were thus cultured for up to 2 months and their growth efficiency was assessed befo re and after two periods of *** pite the thermal stress,the hBMECs remained viable and suitable for re-freezing and storage for several *** approach increasing in vitro viability of hBMECs opens new perspectives for the use of cryopreserved autologous hBMECs as biomimetic therapeutic tools,offering the potential to avoid additional surgical sampling for each patient.

关键词： β-estradiol 17-acetate 17β-estradiol cryopreservation gender-specific gray matter human brain microvascular endothelial cells surgical resections vascular protection white matter

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Bill Morphology Does Not Influence Vocal Performance in Darwin’s Small Tree Finch on Floreana Island

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Zoological Research 2009年第4期30卷 423-428页

作者： Rebekah Christensen sonia Kleindorfer School of Biological Sciences Flinders University

Bird song is used for mate attraction and is important for establishing reproductive isolation. Current research highlights performance constraints on song production that may be influenced by variation in bill morphology. Darwin＇s finches are a model system for studying the relationship between morphology and song performance, with previous studies suggesting that lower vocal performance is correlated with larger bill size. Here, we tested for a relationship between bill morphology and vocal performance in Darwin＇s Small Tree Finch （Camarhynchus parvulus） on Floreana Island. We found no evidence of a correlation between bill morphology and vocal performance. This finding is in agreement with prior study of the Small Tree Finch, but contrasts a greater body of work addressing song in Darwin＇s Finches. We discussed our findings in the context of ecological divergence, and ecological variation across species.

关键词： Darwin's finches Bill morphology Small Tree Finch Song Vocal performance

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Long term immunological perturbations post DAA therapy in chronic HCV/HIV co-infected patients

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BIOCELL 2022年第12期46卷 2695-2699页

作者： sonia MORETTI FLAVIA MANCINI ALESSANDRA BORSETTI National HIV/AIDS Research Center Istituto Superiore di SanitàRome00161Italy

Direct-acting antiviral(DAA)therapies are efficacious for the achievement of sustained virologic response(SVR)in almost all treated hepatitis C virus(HCV)-infected ***,the impacts of HCV eradication on immune function and chronic immune activation in the long-term remain controversial and limited,especially in patients co-infected with human immunodeficiency virus(HIV).Indeed,although restoration of many immune responses clearly can be observed,several features of immune perturbations persist over time after HCV *** the degree and reasons of the partial recovery of the immune system in chronic HCV/HIV coinfection after HCV elimination is pivotal to avoid disease progression and possible long-term clinical outcomes in cured patients,as well as contributing to the development of immunotherapy drug design.

关键词： HCV infection HCV/HIV co-infection DAA therapy Immune activation Inflammation Immune system

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One-Pot Green Synthesis of 1,4-Dihydropyridine Derivatives Using Polyindole TiO2 Nanocatalyst by Solvent Free Method

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Open Journal of Composite Materials（复合材料期刊） 2024年第3期 109页

作者： Deepak Babasaheb Phasage Sanjay K. Sharma Balram Tripathi sonia Chahar Srivastava

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Experimental evaluation of eco-friendly flocculants prepared from date palm rachis

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Journal of Environmental Sciences 2010年第10期22卷 1539-1543页

作者： Ramzi Khiari sonia Dridi-Dhaouadi Chadlia Aguir Mohamed Farouk Mhenni Research Unity of Applied Chemistry & Environment Department of Chemistry

Sodium carboxymethylcellulose （CMCNa） is an anionic water soluble polyelectrolyte widely used in many industrial sectors including food, textiles, papers, adhesives, paints, pharmaceuticals, cosmetics and mineral processing. CMCNa was produced by chemical modification of cellulose, and represents many advantages： natural, renewable, non-toxic and biodegradable. In this study, different kinds of CMCNa, prepared from an agricultural waste date palm rachis, were tested as eco-friendly flocculants for drinking water treatment and their performances as flocculants in turbidity removal enhancement were assessed. The prepared materials were characterized by the degree of substitution （DS） and polymerisation （DP）. The study of the effect of some experimental parameters on the coagulation-flocculation performance, using the prepared materials combined with aluminium sulphate （as coagulant）, showed that the best conditions for turbidity treatment were given for pH 8, coagulant dose 20 mg/L, flocculant concentration of 100 mg/L and stirring velocity （during the flocculation step） of 30 r/min. Under the optimum conditions, the turbidity removal using CMCNa, prepared from raw material, was about 95%. A comparison study between the flocculation performance of a commercial anionic flocculant （A100PWG： polyacrylamide） and that of the prepared CMCNa showed that the performance of the waste-based flocculant with a DS of 1.17 and a DP of 480 was 10% better than that achieved by the commercial one.

关键词： carboxymethylcellulose flocculants date palm rachis flocculation process

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Collaborative Efforts and Strategies for Cholera Outbreak Control in Garissa County, Kenya: Implementation of Water Quality Monitoring Interventions

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Journal of Water Resource and Protection 2024年第2期16卷 123-139页

作者： Michael Habtu Mark Nanyingi Ali A. Hassan Abdiwahid M. Noor Joel Mutyandia Muli Alan Mwika Julius Wekesa Ahmed Fidhow Diba Dulacha Landry Kabego Ishata Nannie Conteh Andre Arsene Bita Fouda sonia Chene Aden H. Ibrahim Ahmed Nadhir Omar Martins C. Livinus Abdourahmane Diallo World Health Organization Nairobi Kenya Department of Health Garissa County Government Garissa Kenya Water Resources Authority Garissa Kenya World Health Organization Regional Office for Africa Brazzaville Congo Regional Agency for Health Dijon France

A multi-faceted Case Area Targeted Intervention (CATI) approach emphasizing the integration of Water, Sanitation and Hygiene (WASH) interventions and Oral Cholera Vaccine (OCV) campaign was employed to respond to the outbreak of cholera in Garissa County. Drinking water sources in areas heavily impacted by cholera were systematically mapped and tested for microbiological quality. The quality assessment was carried out in April 2023 during an ongoing cholera outbreak in the county. A total of 109 samples were collected and tested for thermotolerant coliforms and other in situ parameters. The finding revealed that more than 87% of the samples did not meet the World Health Organization (WHO) standard for thermotolerant coliforms;and 30% had turbidity values above the recommended threshold values. None of the 109 samples had any traceable residual chlorine. Following these findings, the county government implemented the targeted interventions which resulted in a positive impact in the fight against cholera. The WHO supported key interventions which included capacity building in water quality monitoring and prepositioning of critical WASH commodities to the cholera affected areas.

关键词： Cholera Drinking Water Household Water Treatment Kenya

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Effect of Electrolyte Nature on Micellar Soft-Template Electropolymerization in Organic Solvent to Form Nanoporous Polymer Films with a Bioinspired Strategy

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Journal of Bionic Engineering 2022年第2期19卷 547-553页

作者： Caroline Fradin Francois Orange sonia Amigoni Frédéric Guittard Thierry Darmanin NICE Lab UniversitéCote d’Azur06100 NiceFrance Centre Commun de Microscopie Appliquée(CCMA) UniversitéCote d’Azur06100 NiceFrance

Here,using a bioinspired approach,the soft-template electropolymerization of naphtho[2,3-b]thieno[3,4-e][1,4]dioxine(NaphDOT)was conducted in dichloromethane with different water content,and using different supporting *** role of the electrolytes in the formation of reverse micelles that constitutes the soft template is *** reverse micelles stabilized by the electrolyte and the monomer were observed by TEM and related to the various porous nanostructures of the obtained polymer *** show that the nature of the electrolyte is not only fundamental for the formation of reverse micelles and thus porous nanostructures,but also plays a huge role in the good deposition of the oligomers upon the soft *** with nanostructures such as nanotubes,nanorings or nanomembranes were realized.

关键词： Electropolymerization Soft template Reverse micelles Porous nanostructures

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Rebuilding trust in proton pump inhibitor therapy

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World Journal of Gastroenterology 2022年第24期28卷 2667-2679页

作者： Alla Turshudzhyan sonia Samuel Angela Tawfik Micheal Tadros Department of Medicine University of ConnecticutFarmingtonCT 06030United States Department of Medicine Albany Medical CollegeAlbanyNY 12208United States Guilderland High School Guilderland CenterAlbanyNY 12085United States Department of Gastroenterology and Hepatology Albany Medical CollegeAlbanyNY 12208United States

Introduction of proton pump inhibitor(PPI)therapy into clinical practice has revolutionized treatment approach to acid-related *** its clinical success came a widespread use of PPI ***,several studies found that PPIs were oftentimes overprescribed in primary care and emergency setting,likely attributed to seemingly low side-effect profile and physicians having low threshold to initiate ***,now there is a growing concern over PPI side-effect profile among both patients and *** would like to bring more awareness to the currently available guidelines on PPI use,discuss clinical indications for PPIs and the evidence behind the reported *** hope that increased awareness of proper PPI use will make the initiation or continuation of therapy a well informed and an evidence-based decision between patient and *** also hope that discussing evidence behind the reported side-effect profile will help clarify the growing concerns over PPI therapy.

关键词： Proton pump inhibitor Side-effects Gastro-esophageal reflux disease Therapy

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Should gastroenterologists prescribe cannabis? The highs, the lows and the unknowns

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World Journal of Clinical Cases 2023年第18期11卷 4210-4230页

作者： sonia Samuel Mark Michael Micheal Tadros Department of Internal Medicine Albany Medical CenterAlbanyNY 12208United States Department of Gastroenterology and Hepatology Albany Medical CenterAlbanyNY 12208United States

Cannabis,commonly known as marijuana,is a drug extracted from the Cannabis plant known for its psychotropic and medicinal *** has been used for healing purposes during ancient times,although its psychoactive components led to its restricted use in ***,cannabis is found to have modulatory effects on the endocannabinoid system exhibiting its medicinal role in the gastrointestinal(GI)*** animal and human studies demonstrate the influential effects of cannabis on a variety of GI diseases including inflammatory bowel disease,motility disorders and GI *** also has a regulatory role in GI symptoms including nausea and vomiting,anorexia,weight gain,abdominal pain,among ***,both its acute and chronic use can lead to undesirable side effects such as dependency and addiction,cognitive impairment and cannabinoid hyperemesis *** will discuss the role of cannabis in the GI system as well as dosing strategies to help guide gastroenterologists to assess its efficacy and provide patient counseling before prescription of medical marijuana.

关键词： Marijuana cannabis Endocannabinoid system Side effects Gastrointestinal disorders

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Game-Oriented Security Strategy Against Hotspot Attacks for Internet of Vehicles

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Computers, Materials & Continua 2021年第8期68卷 2145-2157页

作者： Juan Guo Yanzhu Liu Shan Li Zhi Li sonia Kherbachi Guilin University of Electronic Technology Beihai536000GuangxiChina Great Wall Computer Software and Systems Inc. Beijing100083China Department of Electronics and Communication Engineering Beijing Electronic Science and Technology InstituteBeijing100070China State Grid Information&Telecommunication Group Co. Ltd.Beijing100031China Department of Management University of BejaiaBejaia06000Algeria

With the rapid development of mobile communication technology,the application of internet of vehicles(IoV)services,such as for information services,driving safety,and traffic efficiency,is growing *** businesses with low transmission delay,high data processing capacity and large storage capacity,by deploying edge computing in the IoV,data processing,encryption and decision-making can be completed at the local end,thus providing real-time and highly reliable communication *** roadside unit(RSU),as an important part of edge computing in the IoV,fulfils an important data forwarding function and provides an interactive communication channel for vehicles and server *** computing resources can be configured to accommodate the computing requirements of *** this study,a virtual traffic defense strategy based on a differential game is proposed to solve the security problem of user-sensitive information leakage when an RSU is *** incentive mechanism encourages service vehicles within the hot range to send virtual traffic to another *** attracting the attention of attackers,it covers the target RSU and protects the system from *** results show that the scheme provides the optimal strategy for intelligent vehicles to transmit virtual data,and ensures the maximization of users’interests.

关键词： Edge computing internet of vehicles differential games security defense

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