Rebuilding trust in proton pump inhibitor therapy

作     者：Alla Turshudzhyan Sonia Samuel Angela Tawfik Micheal Tadros 

作者机构：Department of MedicineUniversity of ConnecticutFarmingtonCT 06030United States Department of MedicineAlbany Medical CollegeAlbanyNY 12208United States Guilderland High SchoolGuilderland CenterAlbanyNY 12085United States Department of Gastroenterology and HepatologyAlbany Medical CollegeAlbanyNY 12208United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第24期

页      面：2667-2679页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 10[医学] 

主　　题：Proton pump inhibitor Side-effects Gastro-esophageal reflux disease Therapy 

摘      要：Introduction of proton pump inhibitor(PPI)therapy into clinical practice has revolutionized treatment approach to acid-related *** its clinical success came a widespread use of PPI ***,several studies found that PPIs were oftentimes overprescribed in primary care and emergency setting,likely attributed to seemingly low side-effect profile and physicians having low threshold to initiate ***,now there is a growing concern over PPI side-effect profile among both patients and *** would like to bring more awareness to the currently available guidelines on PPI use,discuss clinical indications for PPIs and the evidence behind the reported *** hope that increased awareness of proper PPI use will make the initiation or continuation of therapy a well informed and an evidence-based decision between patient and *** also hope that discussing evidence behind the reported side-effect profile will help clarify the growing concerns over PPI therapy.