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Hepatic osteodystrophy: An important matter for consideration in chronic liver disease

World Journal of Hepatology 2011年第12期3卷 300-307页

作者： Germán López-Larramona Alfredo J Lucendo sonia gonzález-castillo José M Tenias Department of Internal Medicine Hospital General de Tomelloso 13700 Ciudad Real Spain Department of Gastroenterology Hospital General de Tomelloso 13700 Ciudad Real Spain Research Support Unit Complejo Hospitalario Mancha Centro Alcázar de San Juan 13700 Ciudad Real Spain

Hepatic osteodystrophy (HO) is the generic term defining the group of alterations in bone mineral metabolism found in patients with chronic liver disease. This paper is a global review of HO and its main pathophysiological, epidemiological and therapeutic aspects. Studies examining the most relevant information concerning the prevalence, etiological factors, diagnostic and therapeutic aspects involved in HO were identified by a systematic literature search of the PubMed database. HO generically defines overall alterations in bone mineral density (BMD) (osteoporosis or osteopenia) which appear as a possible complication of chronic liver disease. The origin of HO is multifactorial and its etiology and severity vary in accordance with the underlying liver disease. Its exact prevalence is unknown, but different studies estimate that it could affect from 20% to 50% of patients. The reported mean prevalence of osteoporosis ranges from 13%-60% in chronic cholestasis to 20% in chronic viral hepatitis and 55% in viral cirrhosis. Alcoholic liver disease is not always related to osteo-penia. HO has been commonly studied in chronic cholestatic disease (primary biliary cirrhosis and primary sclerosing cholangitis). Several risk factors and pathogenic mechanisms have been associated with the loss of BMD in patients with chronic liver disease. However, little information has been discovered in relationship to most of these mechanisms. Screening for osteopenia and osteoporosis is recommended in advanced chronic liver disease. There is a lack of randomized studies assessing specific management for HO.

关键词： Hepatic osteodystrophy Liver disease Osteoporosis Osteopenia

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Resolution of metabolic syndrome after following a gluten free diet in an adult woman diagnosed with celiac disease

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World Journal of Gastrointestinal Pathophysiology 2011年第3期2卷 49-52页

作者： lvaro García-Manzanares Alfredo J Lucendo sonia gonzález-castillo Jesús Moreno-Fernández Department of Endocrinology Hospital General de Tomellosorea de Atención especializada La Mancha Centro13700 Tomelloso(Ciudad Real)Spain Department of Gastroenterology Hospital General de Tomelloso

Adult celiac disease(CD) presents with very diverse symptoms that are clearly different from those typically seen in pediatric patients,including ferropenic anemia,dyspepsia,endocrine alterations and elevated transaminase concentration. We present the case of a 51-year-old overweight woman with altered basal blood glucose,hypercholesterolemia,hypertriglyceridemia and persisting elevated transaminase levels,who showed all the symptoms for a diagnosis of metabolic syndrome. Because she presented iron deficiency anemia,she was referred to the gastroenterology department and subsequently diagnosed with celiac disease after duodenal biopsies and detection of a compatible HLA haplotype. Gluten-free diet(GFD) was prescribed and after 6 mo the patient showed resolution of laboratory abnormalities(including recovering anemia and iron reserves,normalization of altered lipid and liver function parameters and decrease of glucose blood levels) . No changes in weight or waist circumference were observedand no significant changes in diet were documented apart from the GFD. The present case study is the first reported description of an association between CD and metabolic syndrome,and invites investigation of the metabolic changes induced by gluten in celiac patients.

关键词： Celiac disease Metabolic syndrome Glutenfree diet

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Response of bioaerosol cells to photocatalytic inactivation with ZnO and TiO_(2)impregnated onto Perlite and Poraver carriers

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Frontiers of Environmental Science & Engineering 2021年第3期15卷 137-149页

作者： Mariana Valdez-castillo sonia Arriaga Environmental Science Department Institute for Scientific and Technological Research of San Luis PotosiIPICYT.Camino Presa San Jose 2055Lomas 4a SeccionCP 78216San Luis PotosiMexico

Bioaerosols are airborne microorganisms that cause infectious sickness,respiratory and chronic health *** have become a latent threat,particularly in indoor *** is a promising process to inactivate completely bioaerosols from ***,in systems treating a continuous air flow,catalysts can be partially lost in the gaseous *** avoid such phenomenon,supporting materials can be used to fix *** the present work,four photocatalytic systems using Perlite or Poraver glass beads impregnated with ZnO or TiO_(2)were *** inactivation mechanism of bioaerosols and the cytotoxic effect of the catalysts to^bioaeros^ls were *** plug flow photocatalytic reactor treated a bioaerosol flow of 460×10^(6)cells/m^(3)_(air)with a residence time of 5.7 *** Cytometry(FC)was used to quantify and characterize bioaerosols in terms of dead,injured and live *** most efficient system was ZnO/Perlite with 72%inactivation of bioaerosols,maintaining such inactivation during 7.5 h due to the higher water retention capacity of Perlite(2.8 mL/gpcriite)in comparison with Poraver(1.5 mL/gperiite).However,a global balance showed that Ti0_(2)/Poraver system triggered the highest level of cytotoxicity to bioaerosols retained on the support after 96 h with 95%of dead *** and FC analyses showed that the mechanism of inactivation with ZnO was based on membrane damage,morphological cell changes and cell lysis;whereas only membrane damage and cell lysis were involved with Ti0_(2).Overall,results highlighted that photocatalytic technologies can completely inactivate bioaerosols in indoor environments.

关键词： Immobilized catalysts Continuous flow Photocatalysis Bioaerosols Cytotoxicity Inactivation mechanism

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Ontogenetic transition in leaf traits: a new cost associated with the increase in leaf longevity

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Journal of Plant Ecology 2014年第6期7卷 567-575页

作者： sonia Mediavilla Maria Herranz Patricia gonzález-Zurdo Alfonso Escudero Departamento de Ecología Facultad de BiologíaUniversidad de SalamancaSalamanca 37071Spain

Aims Recent work has identified a worldwide‘economics’spectrum of correlated leaf traits that mainly reflects the compromises between maximizing leaf longevity and short-term ***,during the early stages of tree growth different species tend to exhibit a common strategy,because competition for soil water and nutrients forces the maximization of short-term productivity owing to the need for rapid growth during the most vulnerable part of the tree’s life ***,our aim here was to compare the variations that occur during ontogeny in the different leaf traits(morphology and leaf chemical composition)of several coexisting Mediterranean woody species differing in their leaf life spans and to test our hypothesis that tree species with a long leaf life span should exhibit larger shifts in leaf characteristics along *** Six Mediterranean tree species differing in leaf life span,selected from three plots located in central-western Spain,were studied during three growth stages:seedlings,juveniles and mature *** life span,leaf morphology(leaf area,dry weight,thickness and mass per unit area)and chemical composition(N and fibre con-centrations)were measured in all six *** magnitude of the ontogenetic changes in the different traits was estimated and related to the mean leaf longevity of the different *** Findings Along ontogeny,strong changes were observed in all variables *** early growth stages showed lower leaf thickness,leaf thickness and mass per unit area and N,cellulose and hemi-cellulose concentrations than mature trees,but a higher lignin ***,these changes were especially marked in species with a longer leaf life span at *** dif-ferences in leaf life span,leaf morphology and chemical com-position were stronger at the mature stage than at the seedling *** conclude that greater plasticity and more intense strat-egy shifts along ontogeny are necessarily associ

关键词： leaf morphology leaf N concentration fibre content Pinus Quercus tree age class

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Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation

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Neural Regeneration Research 2019年第10期14卷 1787-1795页

作者： Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto Alma Y. Gálvez-Contreras sonia Luquín Edith Oregon-Romero Oscar gonzález-Pérez Rocio E. gonzález-Castaneda Laboratorio de Microscopía de Alta Resolución Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Laboratorio de Neurociencias Facultad de PsicologíaUniversidad de ColimaColimaMéxico División de Inmunología Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico División de Neurociencias Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico Instituto de Investigación en Ciencias Biomédicas (IICB) Departamento de Biología Molecular y GenómicaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Unidad de Atención en Neurociencias Departamento de Neurociencias. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico

Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult ***,this effect has not been observed in long-term sleep *** precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this *** this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword *** results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate *** observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep *** addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated *** findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived *** procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval ***-16610)on January 2,2016.

关键词： sleep-deprivation melatonin microRNA neurogenesis Sirtuin 1 SIRT1 methyl-CpG-binding protein 2 MECP2 epigenetic text-mining mir-9 let-7b

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