New era of personalized medicine:Advanced therapy medicinal products in Europe
作者机构：Strategy and Market AccessPharmaceutical IndustryMadrid 28012Spain Clinical ResearchInternational CROMadrid 28003Spain Department of PhysiologyFaculty of Medicine and DentistryUniversity of ValenciaValencia 46010Spain Center for Biomedical Research in Rare Diseases Network(CIBERER)Carlos III Health InstituteValencia 46010Spain INCLIVA Institute of Sanitary ResearchValencia 46010Spain
出 版 物：《World Journal of Immunology》 (世界免疫学杂志)
年 卷 期：2021年第11卷第1期
页 面：1-10页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Advanced therapy Advanced therapy medicinal products Cell therapy Gene therapy Tissue therapy Chimeric antigen receptor T cell
摘 要：Advanced therapy medicinal products are human medical therapies based on genes,cells,or tissues,and due to their characteristics,they offer new innovative opportunities for the treatment of diseases and injuries,especially for diseases beyond the reach of traditional *** therapies are at the forefront of innovation and have historically been very controversial,although in the last decade they have gained prominence while the number of new advanced therapies has increased every *** this regard,despite the controversy they may generate,they are expected to dominate the market in the coming *** based on advanced therapies are the present and future of medicine and bring us closer to the long-awaited precision *** we review the field as it stands today,with a focus on the molecular mechanisms that guided the different advanced therapies approved by the European Medicines Agency,their current status,and their legal approval.
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