Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats作者机构：CIBER Digestive and Hepatic Deseases Service of SurgeryUniversity Hospital "Lozano Blesa" Service of PathologyUniversity Hospital "Lozano Blesa" Department of MedicineUniversity of Zaragoza Service of Clinical BiochemistryUniversity Hospital "Lozano Blesa" Aragon Health Science Institute Service of GastroenterologyUniversity Hospital "Lozano Blesa"
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2012年第18卷第35期
页 面：4866-4874页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by Instituto de Salud Carlos III (CIBERehd) MFtricyclic was supplied free of charge by Merck Frosst Canada Inc
主 题：COX-2抑制剂 吲哚美辛 食管 大鼠 PGE2 前列腺素E2 二氟苯基 实验模型
摘 要：AIM:To evaluate the effects of indomethacin [dual cyclooxygenase(COX)-1/COX-2 inhibitor] and 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl) phenyl)2-(5H)-furanone(MF-tricyclic)(COX-2 selective inhibitor) in a rat experimental model of Barrett s esophagus and esophageal ***:A total of 112 surviving post-surgery rats were randomly divided into three groups:the control group(n = 48),which did not receive any treatment;the indomethacin group(n = 32),which were given 2 mg/kg per day of the COX-1/COX-2 inhibitor;and the MF-tricyclic group(n = 32),which received 10 mg/kg per day of the selective COX-2 *** selected rats were killed either 8 wk or 16 wk after *** timing of the deaths was in accordance with a previous study performed in our *** rats that were killed at the times designated by the protocol were included in the *** then assessed the histology and prostaglandin E2(PGE2) expression levels in the rat *** additional group of eight animals that did not undergo esophagojejunostomy were included in order to obtain normal esophageal tissue as a ***:Compared to a control group with no treatment(vehicle-treated rats),indomethacin treatment was associated with decreases in ulcerated esophageal mucosa(16% vs 35% and 14% vs 17%,2 mo and 4 mo after surgery,respectively;P = 0.021),length of intestinal metaplasia in continuity with anastomosis(2 ± 1.17 mm vs 2.29 ± 0.75 mm and 1.25 ± 0.42 mm vs 3.5 ± 1.54 mm,2 mo and 4 mo after surgery,respectively;P = 0.007),presence of intestinal metaplasia beyond anastomosis(20% vs 71.4% and 0% vs 60%,2 mo and 4 mo after surgery,respectively;P = 0.009),severity of dysplasia(0% vs 71.4% and 20% vs 85.7% high-grade dysplasia,2 mo and 4 mo after surgery,respectively;P = 0.002),and adenocarcinoma incidence(0% vs 57.1% and 0% vs 60%,2 mo and 4 mo after surgery,respectively;P 0.0001).Treatment with the selective COX-2 inhibitor,MF-tricyclic,did not prevent development of in
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