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Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain

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Neuroscience Bulletin 2022年第4期38卷 403-416页

作者： Fu-Jun Zhai song-ping han Tian-Jia song Ran Huo Xing-Yu Lan Rong Zhang Ji-Sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijing 100191China Key Laboratory for Neuroscience Ministry of EducationNational Health CommissionPeking UniversityBeijing 100191China Wuxi hanS Health Medical Technology Co. Ltd.Wuxi 214122China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China

Spinal cord stimulation(SCS)-induced analgesia was characterized,and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in *** analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20%and 80%motor *** frequencies(2,15,50,100,10000 Hz,and 2/100 Hz dense-dispersed)of SCS were similarly ***-induced analgesia was maintained without tolerance within 24 h of continuous *** at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal *** analgesic effect of 2 Hz was abolished byμorκopioid receptor *** effect of 100 Hz was prevented by aκantagonist,and that of 10 kHz was blocked by any of theμ,δ,orκreceptor antagonists,suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors.

关键词： SCS Analgesia Opioid receptors Methionine-Enkephalin Dynorphin Endorphins

Development of an Autism Subtyping Questionnaire Based on Social Behaviors

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Neuroscience Bulletin 2018年第5期34卷 789-800页

作者： Fan-Chao Meng Xin-Jie Xu Tian-Jia song Xiao-Jing Shou Xiao-Li Wang song-ping han Ji-Sheng han Rong Zhang Neuroscience Research Institute Peking University Key Laboratory for Neuroscience Ministry of Education of China Peking University Key Laboratory for Neuroscience National Committee of Health and Family Planning of China Peking University Department of Neurobiology School of Basic Medical Sciences Peking University Central Laboratory Research Center for Translational Medicine Department of Scientific Research Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Division of Maternal and Child Health School of Public Health Peking University Health Science Center Wuxi Shenpingxintai Medical Technology Co. Ltd.

Autism spectrum disorder can be differentiated into three subtypes （aloof, passive, and active-but-odd） based on social behaviors according to the Wing Subgroups Questionnaire （WSQ）. However, the correlations between the scores on some individual items and the total score are poor. In the present study, we translated the WSQ into Chinese, modified it, validated it in autistic and typically- developing Chinese children, and renamed it the Beijing Autism Subtyping Questionnaire （BASQ）. Our results demonstrated that the BASQ had improved validity and reliability, and differentiated autistic children into these three subtypes more precisely. We noted that the autistic symptoms tended to be severe in the aloof, moderate in the passive, and mild in the active-but-odd subtypes. The modified questionnaire may facilitate etiological studies and the selection of therapeutic regimes.

关键词： Autism spectrum disorder Subtypes Wing Subgroups Questionnaire Beijing Autism Subtyping Questionnaire

Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies:Characterization by Single-Unit Recording in Rats

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Neuroscience Bulletin 2020年第8期36卷 907-918页

作者： Ran Huo song-ping han Feng-Yu Liu Xiao-Jing Shou Ling-Yu Liu Tian-Jia song Fu-Jun Zhai Rong Zhang Guo-Gang Xing Ji-Sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology Peking University School of Basic Medical SciencesBeijing 100191China Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100191China Department of Radiology Peking University Third HospitalBeijing 100191China Department of Integration of Chinese and Western Medicine Peking University School of Basic Medical SciencesBeijing 100191China

The pain-relieving effect of acupuncture is known to involve primary afferent nerves(PANs) via their roles in signal transmission to the *** single-unit recording in rats,we characterized the generation and transmission of electrical signals in Aβ and Aδ fibers induced by acupuncture-like ***-like signals were elicited in PANs using three techniques:manual acupuncture(MAc),emulated acupuncture(EAc),and electro-acupuncture(EA)-like peripheral electrical stimulation(PES).The discharges evoked by MAc and EAc were mostly in a burst pattern with average intra-burst and inter-burst firing rates of 90 Hz and 2 Hz,*** frequency of discharges in PANs was correlated with the frequency of *** highest discharge frequency was 246 Hz in Aβ fibers and 180 Hz in Aδ ***,EA in a dense-disperse mode(at alternating frequency between 2 Hz and 15 Hz or between 2 Hz and 100 Hz) best mimics *** of EA output>250 Hz appear to be obsolete for pain relief.

关键词： Acupuncture Peripheral electrical stimulation Dorsal root Primary afferent fiber Electrophysiology Single unit recording

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

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Neuroscience Bulletin 2016年第5期32卷 423-432页

作者： Hong-Feng Zhang Yu-Chuan Dai Jing Wu Mei-Xiang Jia Ji-Shui Zhang Xiao-Jing Shou song-ping han Rong Zhang Ji-Sheng han Neuroscience Research Institute Peking University Department of Neurobiology School of Basic Medical Sciences Peking University Health Science Center Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning Commission Peking University Center of Medical and Health Analysis Peking University Mental Health Institute Peking University Department of Neurology and Center of Rehabilitation Beijing Children’s Hospital Capital University of Medical Sciences

Autism spectrum disorder（ASD） is defined by impairments of social interaction and the presence of obsessive behaviors. The ＇＇twin＇＇ nonapeptides oxytocin（OXT） and arginine-vasopressin（AVP） are known to play regulatory roles in social behaviors. However, the plasma levels and behavioral relevance of OXT and AVP in children with ASD have seldom been investigated. It is also unknown whether their mothers have abnormal plasma peptide levels. Here, using well-established methods of neuropeptide measurement and a relatively large sample size, we determined the plasma levels of the two neuropeptides in 85 normal children, 84 children with ASD, and 31 mothers from each group of *** expected, children with ASD had lower plasma OXT levels than gender-matched controls（P = 0.028）. No such difference was found for plasma AVP concentrations. Correlation analysis showed that ASD children with higher plasma OXT concentrations tended to have less impairment of verbal communication（Rho =-0.22,P = 0.076）, while those with higher plasma AVP levels tended to have lower levels of repetitive use of objects（Rho =-0.231, P = 0.079）. Unlike the findings in children, maternal plasma OXT levels showed no group difference. However, plasma AVP levels in the mothers of ASD children tended to be lower than in the mothers of normal children（P = 0.072）. In conclusion, our results suggest that the OXT system is dysregulated in children with ASD, and that OXT and AVP levels in plasma seem to be associated with specific autistic symptoms. The plasma levels of OXT or AVP in mothers and their ASD children did not seem to change in the same direction.

关键词： Autism spectrum disorder Oxytocin Vasopressin Behavioral relevance

The First Ground-based White Light Lunar Polarization Imaging:A New Kind of FeO Observation on the Near Side of the Moon

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Research in Astronomy and Astrophysics 2024年第6期24卷 1-6页

作者： Wei-Nan Wang Jin-song ping Ming-Yuan Wang Wen-Zhao Zhang han-Lin Ye Xing-Wei han song-Feng Kou Changchun Observatory National Astronomical ObservatoriesChinese Academy of SciencesChangchun 130117China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Astronomy Department Beijing Normal UniversityBeijing 100875China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Nanjing Institute of Astronomical Optics and Technology Chinese Academy of SciencesNanjing 210042China

Lunar optical polarization is a fascinating phenomenon that occurs when sunlight reflects off the surface of the Moon and becomes *** study employs a novel split-focus plane polarimetric camera to conduct the initial white light polarimetric observations on the near side of the *** obtained the linear degree of polarization(DOP)parameters of white light by observation from the eastern and western hemispheres of the *** findings indicate that the white light polarization is lower in the lunar highland than in the lunar maria *** the analysis of lunar soil samples,we noticed and determined that the DOP parameters of white light demonstrate high consistency with iron oxide on the *** study may serve as a new diagnostic tool for the Moon.

关键词： techniques:photometric polarization methods:observational Moon

Heterostructured Pt-Ni_(3)Mo_(3)N formed via ammonia-containing polyoxometalates for highly efficient electrocatalytic hydrogen evolution in acid medium

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Journal of Energy Chemistry 2024年第5期92卷 698-704页

作者： Bianqing Ren Xue Gong Jing Cao Dezheng Zhang Zizhun Wang ping song Ce han Weilin Xu State Key Laboratory of Electroanalytical Chemistry Jilin Province Key Laboratory of Low Carbon Chemical PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026AnhuiChina Key Laboratory of Automobile Materials MOE School of Materials Science&EngineeringJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsElectron Microscopy Centerand International Center of Future ScienceJilin UniversityChangchun 130012JilinChina

Constructing heterostructured nanohybrid is considered as a prominent route to fabricate alternative electrocatalysts to commercial Pt/C for hydrogen evolution reaction(HER).In this work,(NH_(4))_(4)[NiH_(6)Mo_(6)O_(4)]·5H_(2)O polyoxometalates(NiMo_(6))are adopted as the cluster precursors for simple fabrication of heterostructured Pt-Ni_(3)Mo_(3)N nanohybrids supported by carbon black(Pt-Ni_(3)Mo_(3)N/C)without using additional N *** improved porosity and enhanced electronic interaction of Pt-Ni_(3)Mo_(3)N/C should be attributed to the integration of Pt with NiMo_(6),which favors the mass transport,promotes the formation of exposed catalytic sites,and benefits the regulation of intrinsic ***,the as-obtained Pt-Ni_(3)Mo_(3)N/C exhibits impressive and durable HER performance as indicated by the low overpotential of 13.7 mV at the current density of 10 mA cm^(-2) and the stable overpotential during continuous working at 100 mA cm^(-2) for 100 *** work provides significant insights for the synthesis of new highly active heterostructured electrocatalysts for renewable energy devices.

关键词： Polyoxometalates Cluster precursors Heterostructured nanohybrids Hydrogen evolution reaction Electrocatalysis

A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children

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Neuroscience Bulletin 2017年第2期33卷 130-142页

作者： Xiao-Jing Shou Xin-Jie Xu Xiang-Zhu Zeng Ying Liu Hui-Shu Yuan Yan Xing Mei-Xiang Jia Qing-Yun Wei song-ping han Rong Zhang Ji-Sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijing 100191China Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100191China Radiology Department Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China Mental Health Institute Peking UniversityBeijing 100191China Key Laboratory of Ministry of National Health and Family Planning Commission Beijing 100191China Sunshine Friendship Rehabilitation Centre Beijing 100085China

Dysfunction of brain-derived arginine-vasopressin（AVP） systems may be involved in the etiology of autism spectrum disorder（ASD）. Certain regions such as the hypothalamus, amygdala, and hippocampus are known to contain either AVP neurons or terminals and may play an important role in regulating complex social *** present study was designed to investigate the concomitant changes in autistic behaviors, circulating AVP levels, and the structure and functional connectivity（FC） of speci？c brain regions in autistic children compared with typically developing children（TDC） aged from 3 to5 years. The results showed：（1） children with ASD had a signi？cantly increased volume in the left amygdala and left hippocampus, and a signi？cantly decreased volume in the bilateral hypothalamus compared to TDC, and these were positively correlated with plasma AVP level.（2） Autistic children had a negative FC between the left amygdala and the bilateral supramarginal gyri compared to TDC. The degree of the negative FC between amygdala and supramarginal gyrus was associated with a higher score on the clinical autism behavior checklist.（3） The degree of negative FC between left amygdala and left supramarginal gyrus was associated with a lowering of the circulating AVP concentration in boys with ASD.（4） Autistic children showed a higher FC between left hippocampus and right subcortical area compared to TDC.（5） The circulating AVP was negatively correlated with the visual and listening response score of the childhood autism rating *** results strongly suggest that changes in structure and FC in brain regions containing AVP may be involved in the etiology of autism.

关键词： Autism Children Arginine-vasopressin MRI Structure Connectivity Behavior

Multi-physics multi-scale simulation of unique equiaxed-to-columnar-to-equiaxed transition during the whole solidification process of Al-Li alloy laser welding

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Journal of Materials Science & Technology 2024年第4期171卷 235-251页

作者： Chu han ping Jiang Shaoning Geng Liangyuan Ren School of Mechanical Science and Engineering Huazhong University of Science&Technology(HUST)Wuhan430074China

In this study,a novel multi-physics multi-scale model with the dilute multicomponent phase-field method in three-dimensional(3D)space was developed to investigate the complex microstructure evolu-tion in the molten pool during laser welding of Al-Li *** accurately compute mass data within both two and three-dimensional computational domains,three efficient computing methods,including central processing unit parallel computing,adaptive mesh refinement,and moving-frame algorithm,were *** was placed on the distinctive equiaxed-to-columnar-to-equiaxed transition phenomenon that occurs during the entire solidification process of Al-Li alloy laser *** results indi-cated that the growth distance of columnar grains that epitaxially grew from the base metal(BM)de-creased as the nucleation rate *** the nucleation rate increased,the morphology of the newly formed grains near the fusion boundary(FB)changed from columnar to equiaxed,and newly formed equiaxed grains changed from having high-order dendrites to no obvious dendrite *** the nucleation rate was sufficiently high,non-dendritic equiaxed grains could directly form near the FB,and there was nearly no epitaxial growth from the ***,simulation results illustrated the com-petition among multiple grains with varying orientations that grow in 3D space near the ***,how equiaxed grain bands develop was *** equiaxed band not only hindered the growth of early columnar grains but also some of its grains could grow epitaxially to form new columnar *** predicted results were in good agreement with experimental measurements and observations.

关键词： Laser welding Al-Li alloy Equiaxed-to-columnar-to-equiaxed transition Multi-physics multi-scale model Multicomponent alloys 3D phase-field model

Channel assignment and power allocation for throughput improvement with PPO in B5G heterogeneous edge networks

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Digital Communications and Networks 2024年第1期10卷 109-116页

作者： Xiaoming He Yingchi Mao Yinqiu Liu ping ping Yan Hong han Hu The College of Computer and Information Hohai UniversityNanjingChina The Key Laboratory of Water Big Data Technology of Ministry of Water Resources Hohai UniversityNanjing China The School of Computer Science and Engineering Nanyang Technological UniversitySingapore The College of Textile and Clothing Engineering Soochow UniversitySuzhouChina The College of Internet of Things Nanjing University of Posts and TelecomurunicationsNanjingChina

In Beyond the Fifth Generation(B5G)heterogeneous edge networks,numerous users are multiplexed on a channel or served on the same frequency resource block,in which case the transmitter applies coding and the receiver uses interference ***,uncoordinated radio resource allocation can reduce system throughput and lead to user inequity,for this reason,in this paper,channel allocation and power allocation problems are formulated to maximize the system sum rate and minimum user achievable *** the construction model is non-convex and the response variables are high-dimensional,a distributed Deep Reinforcement Learning(DRL)framework called distributed Proximal Policy Optimization(PPO)is proposed to allocate or assign ***,several simulated agents are trained in a heterogeneous environment to find robust behaviors that perform well in channel assignment and power ***,agents in the collection stage slow down,which hinders the learning of other ***,a preemption strategy is further proposed in this paper to optimize the distributed PPO,form DP-PPO and successfully mitigate the straggler *** experimental results show that our mechanism named DP-PPO improves the performance over other DRL methods.

关键词： B5G Heterogeneous edge networks PPO Channel assignment Power allocation Throughput