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Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain

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Neuroscience Bulletin 2022年第4期38卷 403-416页

作者： Fu-Jun Zhai song-ping han Tian-Jia song Ran Huo Xing-Yu Lan Rong Zhang Ji-Sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijing 100191China Key Laboratory for Neuroscience Ministry of EducationNational Health CommissionPeking UniversityBeijing 100191China Wuxi hanS Health Medical Technology Co. Ltd.Wuxi 214122China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China

Spinal cord stimulation(SCS)-induced analgesia was characterized,and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in *** analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20%and 80%motor *** frequencies(2,15,50,100,10000 Hz,and 2/100 Hz dense-dispersed)of SCS were similarly ***-induced analgesia was maintained without tolerance within 24 h of continuous *** at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal *** analgesic effect of 2 Hz was abolished byμorκopioid receptor *** effect of 100 Hz was prevented by aκantagonist,and that of 10 kHz was blocked by any of theμ,δ,orκreceptor antagonists,suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors.

关键词： SCS Analgesia Opioid receptors Methionine-Enkephalin Dynorphin Endorphins

Development of an Autism Subtyping Questionnaire Based on Social Behaviors

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Neuroscience Bulletin 2018年第5期34卷 789-800页

作者： Fan-Chao Meng Xin-Jie Xu Tian-Jia song Xiao-Jing Shou Xiao-Li Wang song-ping han Ji-Sheng han Rong Zhang Neuroscience Research Institute Peking University Key Laboratory for Neuroscience Ministry of Education of China Peking University Key Laboratory for Neuroscience National Committee of Health and Family Planning of China Peking University Department of Neurobiology School of Basic Medical Sciences Peking University Central Laboratory Research Center for Translational Medicine Department of Scientific Research Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Division of Maternal and Child Health School of Public Health Peking University Health Science Center Wuxi Shenpingxintai Medical Technology Co. Ltd.

Autism spectrum disorder can be differentiated into three subtypes （aloof, passive, and active-but-odd） based on social behaviors according to the Wing Subgroups Questionnaire （WSQ）. However, the correlations between the scores on some individual items and the total score are poor. In the present study, we translated the WSQ into Chinese, modified it, validated it in autistic and typically- developing Chinese children, and renamed it the Beijing Autism Subtyping Questionnaire （BASQ）. Our results demonstrated that the BASQ had improved validity and reliability, and differentiated autistic children into these three subtypes more precisely. We noted that the autistic symptoms tended to be severe in the aloof, moderate in the passive, and mild in the active-but-odd subtypes. The modified questionnaire may facilitate etiological studies and the selection of therapeutic regimes.

关键词： Autism spectrum disorder Subtypes Wing Subgroups Questionnaire Beijing Autism Subtyping Questionnaire

Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies:Characterization by Single-Unit Recording in Rats

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Neuroscience Bulletin 2020年第8期36卷 907-918页

作者： Ran Huo song-ping han Feng-Yu Liu Xiao-Jing Shou Ling-Yu Liu Tian-Jia song Fu-Jun Zhai Rong Zhang Guo-Gang Xing Ji-Sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology Peking University School of Basic Medical SciencesBeijing 100191China Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100191China Department of Radiology Peking University Third HospitalBeijing 100191China Department of Integration of Chinese and Western Medicine Peking University School of Basic Medical SciencesBeijing 100191China

The pain-relieving effect of acupuncture is known to involve primary afferent nerves(PANs) via their roles in signal transmission to the *** single-unit recording in rats,we characterized the generation and transmission of electrical signals in Aβ and Aδ fibers induced by acupuncture-like ***-like signals were elicited in PANs using three techniques:manual acupuncture(MAc),emulated acupuncture(EAc),and electro-acupuncture(EA)-like peripheral electrical stimulation(PES).The discharges evoked by MAc and EAc were mostly in a burst pattern with average intra-burst and inter-burst firing rates of 90 Hz and 2 Hz,*** frequency of discharges in PANs was correlated with the frequency of *** highest discharge frequency was 246 Hz in Aβ fibers and 180 Hz in Aδ ***,EA in a dense-disperse mode(at alternating frequency between 2 Hz and 15 Hz or between 2 Hz and 100 Hz) best mimics *** of EA output>250 Hz appear to be obsolete for pain relief.

关键词： Acupuncture Peripheral electrical stimulation Dorsal root Primary afferent fiber Electrophysiology Single unit recording

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

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Neuroscience Bulletin 2016年第5期32卷 423-432页

作者： Hong-Feng Zhang Yu-Chuan Dai Jing Wu Mei-Xiang Jia Ji-Shui Zhang Xiao-Jing Shou song-ping han Rong Zhang Ji-Sheng han Neuroscience Research Institute Peking University Department of Neurobiology School of Basic Medical Sciences Peking University Health Science Center Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning Commission Peking University Center of Medical and Health Analysis Peking University Mental Health Institute Peking University Department of Neurology and Center of Rehabilitation Beijing Children’s Hospital Capital University of Medical Sciences

Autism spectrum disorder（ASD） is defined by impairments of social interaction and the presence of obsessive behaviors. The ＇＇twin＇＇ nonapeptides oxytocin（OXT） and arginine-vasopressin（AVP） are known to play regulatory roles in social behaviors. However, the plasma levels and behavioral relevance of OXT and AVP in children with ASD have seldom been investigated. It is also unknown whether their mothers have abnormal plasma peptide levels. Here, using well-established methods of neuropeptide measurement and a relatively large sample size, we determined the plasma levels of the two neuropeptides in 85 normal children, 84 children with ASD, and 31 mothers from each group of *** expected, children with ASD had lower plasma OXT levels than gender-matched controls（P = 0.028）. No such difference was found for plasma AVP concentrations. Correlation analysis showed that ASD children with higher plasma OXT concentrations tended to have less impairment of verbal communication（Rho =-0.22,P = 0.076）, while those with higher plasma AVP levels tended to have lower levels of repetitive use of objects（Rho =-0.231, P = 0.079）. Unlike the findings in children, maternal plasma OXT levels showed no group difference. However, plasma AVP levels in the mothers of ASD children tended to be lower than in the mothers of normal children（P = 0.072）. In conclusion, our results suggest that the OXT system is dysregulated in children with ASD, and that OXT and AVP levels in plasma seem to be associated with specific autistic symptoms. The plasma levels of OXT or AVP in mothers and their ASD children did not seem to change in the same direction.

关键词： Autism spectrum disorder Oxytocin Vasopressin Behavioral relevance

A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children

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Neuroscience Bulletin 2017年第2期33卷 130-142页

作者： Xiao-Jing Shou Xin-Jie Xu Xiang-Zhu Zeng Ying Liu Hui-Shu Yuan Yan Xing Mei-Xiang Jia Qing-Yun Wei song-ping han Rong Zhang Ji-Sheng han Neuroscience Research Institute Peking UniversityBeijing 100191China Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijing 100191China Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijing 100191China Radiology Department Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China Mental Health Institute Peking UniversityBeijing 100191China Key Laboratory of Ministry of National Health and Family Planning Commission Beijing 100191China Sunshine Friendship Rehabilitation Centre Beijing 100085China

Dysfunction of brain-derived arginine-vasopressin（AVP） systems may be involved in the etiology of autism spectrum disorder（ASD）. Certain regions such as the hypothalamus, amygdala, and hippocampus are known to contain either AVP neurons or terminals and may play an important role in regulating complex social *** present study was designed to investigate the concomitant changes in autistic behaviors, circulating AVP levels, and the structure and functional connectivity（FC） of speci？c brain regions in autistic children compared with typically developing children（TDC） aged from 3 to5 years. The results showed：（1） children with ASD had a signi？cantly increased volume in the left amygdala and left hippocampus, and a signi？cantly decreased volume in the bilateral hypothalamus compared to TDC, and these were positively correlated with plasma AVP level.（2） Autistic children had a negative FC between the left amygdala and the bilateral supramarginal gyri compared to TDC. The degree of the negative FC between amygdala and supramarginal gyrus was associated with a higher score on the clinical autism behavior checklist.（3） The degree of negative FC between left amygdala and left supramarginal gyrus was associated with a lowering of the circulating AVP concentration in boys with ASD.（4） Autistic children showed a higher FC between left hippocampus and right subcortical area compared to TDC.（5） The circulating AVP was negatively correlated with the visual and listening response score of the childhood autism rating *** results strongly suggest that changes in structure and FC in brain regions containing AVP may be involved in the etiology of autism.

关键词： Autism Children Arginine-vasopressin MRI Structure Connectivity Behavior

A robust statistical prediction model for late-summer heavy precipitation days in North China

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Science China Earth Sciences 2025年第1期68卷 158-171页

作者： Shunli JIANG Tingting han Xin ZHOU Huijun WANG Zhicong YIN Xiaolei song Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education Nanjing University for Information Science and Technology Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)

Recently, heavy precipitation(HP) events have occurred frequently in North China(NC), causing devastating economic losses and human fatalities. However, the short-term climate prediction of HP is quite limited. Combining year-to-year increment(DY) method and sliding correlations, we developed a robust seasonal prediction model for late-summer HP days(HPDs) in NC during 1982–2022, utilizing three independent predictors—February sea surface temperature(SST) in the Indian Ocean(SST＿IO), February snow depth over North Asia(SDE＿NA), and May melted snow depth in NC(MSDE＿NC). The SST＿IO anomalies affect NC's precipitation through the Pacific-Japan pattern. The SDE＿NA anomalies are associated with East Asian anomalous anticyclone by southeastern propagation of Rossby wave at Eurasia. The MSDE＿NC anomalies are followed by vertical motion and moisture anomalies in situ and thereby cause precipitation anomalies. This prediction model can well simulate the variations of the HPDs, with a correlation coefficient(CC) of 0.81(0.65) between the observed and predicted HPDs＿DY(HPDs＿anomaly). The percentage with the same sign for 15 extreme HPDs＿anomaly years(PSSE) is 100%.Moreover, in the cross-validation test during 1982–2022, the PSSE for HPDs＿anomaly is as high as 100%, along with a low rootmean-square error of 1.14. For independent hindcasts during 2013–2022, the CC between the observed and predicted HPDs＿DY(HPDs＿anomaly) is 0.93(0.83), together with high Nash-Sutcliffe efficiency(0.82) and agreement index(0.89). Specifically, the predictions are broadly consistent with the observations for 2015, 2016, 2017, 2021, and 2022, reflecting excellent performance of this prediction model of HPDs in NC.

关键词： Heavy precipitation at North China Year-to-year increment approach Robust seasonal prediction Sea surface temperature Snow depth

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han Tang Jianian Hu Siying Kang song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

The response of primary afferent fibers to peripheral electrical stimulation of different frequencies: validation by in vivo single-fiber recording in rats

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The response of primary afferent fibers to peripheral electr...

A brain structural connectivity biomarker for autism spectrum disorder diagnosis in early childhood

中国神经科学学会第十二届全国学术会议

作者： HUO Ran Feng-Yu Liu song-ping han Ling-Yu Liu Xiao-Jing Shou Tian-Jia song Yu-Chuan Dai Rong Zhang Guo-Gang Xing Ji-Sheng han Neuroscience Research Institute Peking University Department of Neurobiology School of Basic Medical Sciences Peking University Key laboratory for Neuroscience Ministry of Education/National Health and Family Planning Commission Peking University

Background: As an important technique with a history of more than two thousand years in Traditional Chinese Medicine（TCM）, manual acupuncture, together with electroacupuncture（EA） and Transcutaneous Electric Acupoint Stimulation（TEAS） are known for its mobilization of anti-disease capability. Numerous studies have shown that the signal of EA is transmitted by afferent nerve fibers from periphery to the central nervous system where neurotransmitters and neuropeptides are released to produce an analgesic effect. Our previous studies have shown that the types of opioid peptides released and the analgesic effect produced by EA is frequency dependent. For example, low frequency（2 Hz） EA facilitates the release of enkephalin and high frequency（100 Hz） EA stimulates the release of dynorphin, alternating frequency（2/100 Hz, alternating between 2 and 100 Hz, 3 seconds each） produce a simultaneous activation of the enkephalin and dynorphin systems. However, direct evidence is lacking on which type of afferent fibers are involved and how the signal of peripheral electrical stimulation（PES） is processed in the nervous system. Theoretically, the afferent fibers should be able to transmit electrical signals up to 1000 Hz if the absolute refractory period of a neuron is one millisecond. However, the excitability of nerve fibers seems to be reduced when the frequency of electrical stimulus is higher than a certain level. Different level of ability to transmit PES into CNS was observed in different types of primary afferent fibers in response to higher frequencies（100-1000 Hz）. Objectives: Using single nerve fiber recording technique, the present study was designed to explore the capability of transmitting EA-like signals from periphery to CNS. Methods: Male SD rats weighing 250-350 g were used. The dorsal root（DR） of L4 or L5 spinal nerve on the left side was cut close to the entrance into the spinal cord following the laminectomy and teased from the DR using fine forceps and place

关键词： peripheral electrical stimulation single nerve fiber recording spinal dorsal root acupuncture

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Psychoradiology 2023年第1期3卷 171-181页

作者： Xi Jiang Xiao-Jing Shou Zhongbo Zhao Yuzhong Chen Fan-Chao Meng Jiao Le Tian-Jia song Xin-Jie Xu Weitong Guo Xiaoyan Ke Xiao-E Cai Weihua Zhao Juan Kou Ran Huo Ying Liu Hui-Shu Yuan Yan Xing Ji-Sheng han song-ping han Yun Li Hua Lai Lan Zhang Mei-Xiang Jia Jing Liu Xuan Liu Keith M.Kendrick Rong Zhang The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroinformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731China Neuroscience Research Institute Key Laboratory for NeuroscienceMinistry of Education of ChinaKey Laboratory for NeuroscienceNational Committee of Health and Family Planning of ChinaDepartment of NeurobiologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Cognitive Neuroscience and Leamning Beijing Key Laboratory of Brain Imaging and Connectomicsand IDG/McGovermn Institute for Brain ResearchBeijing Normal UniversityBeijng 100875China Chengdu Women's and Children's Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Child Mental Health Research Center Nanjing Brain Hospital Affliated of Nanjing Medical UniversityNanjing 210029China Radiology Department Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China Wuxi Shenpingxintai Medical Technology Co LtdWuxi 214091China Mental Health Institute Peking UniversityKey Laboratory of Ministry of HealthThe Ministry of Public HealthBeijing 100191China Shandong Ke Luo Ni Ke(CLINIC)Medical Technology Co LtdDezhou 253011China Autism Research Center of Peking University Health Science Center Beiing 100191China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking University100191BeijingChina

Background:Autism spectrum disorder(ASD)is associated with altered brain development,but it is unclear which specific structural changes may serve as potential diagnostic markers,particularly in young children at the age when symptoms become fully ***,such brain markers need to meet the requirements of precision medicine and be accurate in aiding diagnosis at an individual rather than only a group ***:This study aimed to identify and model brain-wide differences in structural connectivity using diffusion tensor imaging(DTI)in young ASD and typically developing(TD)***:A discovery cohort including 93 ASD and 26 TD children and two independent validation cohorts including 12 ASD and 9 TD children from three different cities in China were ***-wide(294 regions)structural connectivity was measured using DTI(fractional anisotropy,FA)together with symptom severity and cognitive development.A connection matrix was constructed for each child for comparisons between ASD and TD *** classification was performed on the discovery dataset and the resulting model was tested on the two independent validation ***:Thirty-three structural connections showed increased FA in ASD compared to TD children and associated with both autistic symptom severity and impaired general cognitive *** majority(29/33)involved the frontal lobe and comprised five different networks with functional relevance to default mode,motor control,social recognition,language and ***,clas-sification achieved very high accuracy of 96.77%in the discovery dataset,and 91.67%and 88.89%in the two independent validation ***:Identified structural connectivity differences primarily involving the frontal cortex can very accurately distinguish novel individual ASD from TD children and may therefore represent a robust early brain biomarker which can address the requirements of precision medicine.

关键词： autism spectrum disorder diffusion tensor imaging fractional anisotropy brain structural connectivity individual diag-nosis early childhood