检索结果-南通市图书馆

Two new secoiridoid glucosides from Syringa velutina Kom

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2009年第6期20卷 702-705页

作者： xue song Feng Yang Qu Zhao Hua Wu Lei Xu Dong song Zhang Hui Yuan Gao Li Jun Wu School of Traditional Chinese Medicines Shenyang Pharmaceutical University Shenyang 110016 China School of Pharmaceutical Sciences China Medical University Shenyang 110001 China Pharmacy Department Mudanjiang Medical University Mudanjiang 157011 China

Chemical investigation of Syringa velutina Kom. led to the isolation of two new secoiridoid glucosides. Their structures were identified as 6＇-O-（6, 7-dihyrofoliamenthoyl）-8-epi-longisidic acid （syrveoside A, 1） and 6＇-O-menthiafoloyl-8-epi-ldngisidic acid （syrveoside B, 2） on the basis of chemical and physicochemical evidence.

关键词： Syringa velutina Kom. Secoiridoid glucosides Syrveoside A Syrveoside B

Combining of chemotherapy with targeted therapy for advanced biliary tract cancer:A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第10期14卷 2061-2076页

作者： xue-song Bai Sheng-Nan Zhou Yi-Qun Jin Xiao-Dong He Department of General Surgery Peking Union Medical College HospitalChina Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Affiliated Hangzhou First People’s Hospital Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Targeted therapy(TT)has resulted in controversial efficacy as first-line treatment for biliary tract cancer(BTC).More efficacy comparisons are required to clarify the overall effects of chemotherapy(CT)combined with TT and CT alone on advanced *** To conduct a meta-analysis of the available evidence on the efficacy of CT combined with TT for advanced *** The PubMed,EMBASE,ClinicalTrials,Scopus and Cochrane Library databases were systematically searched for relevant studies published from inception to August *** randomized clinical trials(RCTs)including comparisons between the combination of gemcitabine-based CT with TT and CT alone as firstline treatment for advanced BTC were eligible(PROSPERO-CRD42022313001).The odds ratios(ORs)for the objective response rate(ORR)and hazard ratios(HRs)for both progression-free survival(PFS)and overall survival(OS)were calculated and *** analyses based on different targeted agents,CT regimens and tumor locations were *** Nine RCTs with a total of 1361 individuals were included and *** overall analysis showed a significant improvement in ORR in patients treated with CT+TT compared to those treated with CT alone(OR=1.43,95%CI:1.11-1.86,P=0.007)but no difference in PFS or *** trends were observed in the subgroup treated with agents targeting epidermal growth factor receptor(OR=1.67,95%CI:1.17-2.37,P=0.004)but not in the subgroups treated with agents targeting vascular endothelial growth factor receptor or mesenchymal-epithelial transition ***,patients who received a CT regimen of gemcitabine+oxaliplatin in the CT+TT arm had both a higher ORR(OR=1.75,95%CI:1.20-2.56,P=0.004)and longer PFS(HR=0.83,95%CI:0.70-0.99,P=0.03)than those in the CT-only ***,patients with cholangiocarcinoma treated with CT+TT had significantly increased ORR and PFS(ORR,OR=2.06,95%CI:1.27-3.35,PFS,HR=0.79,95%CI:0.66-0.94).CONCLUSION CT+TT is a potential first-line treat

关键词： Advanced biliary tract cancer Targeted therapy Chemotherapy Meta-analysis Randomized controlled trial First-line treatment

Experimental research in leaching of copper-bearing tailings enhanced by ultrasonic treatment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of China University of Mining and Technology 2008年第1期18卷 98-102页

作者： ZHANG Jie WU Ai-xiang WANG Yi-ming CHEN xue-song School of Resources and Safety Engineering Central South University Changsha Hunan 410083 China School of Civil and Environment Engineering Beijing University of Science and Technology Beijing 100083 China

On the basis of an experiment in ultrasonic enhanced ammonia leaching of tailings, the effect of ultrasonic waves on copper dissolution was studied. The mechanism of ultrasonic enhanced tailing leaching was analyzed and a technique of ultrasonic enhanced pipe leaching of tailings was proposed. The results show that tailings with ultrasonic treatment can leach up to 89.5% of Cu, which is 13.5% more than those without the treatment. Ultrasonic technology is capable of improving leaching rates and the overall recovery of tailing leaching. Impact waves and micro jet streams can strip and erode affected surfaces of tailing particles to create new active surfaces and disturbances can intensify mass transfer processes in "dead zones". The technique of ultrasonic enhanced pipe leaching of tailings is a combination of existing agitation enhancement with ultrasonic enhancement and can improve mineral recovery.

关键词： ultrasonic treatment tailings leaching pipe active surfaces mass transfer

Lysobacter hymeniacidonis sp. nov., Isolated from a Crude Oil-Contaminated Marine Sponge

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2015年第6期14卷 1019-1024页

作者： XIN Yanjuan QU Junge XU Junyi WU Peichun CAO Xupeng xue song Marine Bioproducts Engineering Group Dalian Institute of Chemical PhysicsChinese Academy of Sciences Department of Biology and Pharmacy Zhejiang Pharmaceutical College Liaoning Entry-Exit Inspection and Quarantine Bureau

An aerobic, Gram-negative bacterium, strain 2-5~T, was isolated from a crude oil-contaminated marine sponge collected near Dalian Bay, China, and subjected to a polyphasic taxonomic investigation. Cells of strain 2-5~T were non-spore forming, non-motile, rods 0.2–0.3 μm wide and 1.1–1.2μm long. Strain 2-5~T grew well on nutrient agar, ~TSA, R2 A agar and LB agar. Colonies of strain 2-5~T on LB agar were circular, smooth with entire margins, non-transparent and pale yellow after 3 d of incubation at 30℃. Growth of strain 2-5~T occurred in LN medium with 0–6% Na Cl; no growth occurred in the presence of 8.0% NaCl. Strain 2-5~T grew at 15–42℃ and at pH 6.0–8.0. Comparative 16 S r RNA gene sequence analysis showed that strain 2-5~T clustered with the species of the genus Lysobacter. Its closet neighbors were the type strains of Lysobacter concretionis KC^TC 12205~T(97% similarity), Lysobacter arseniciresistens ZS79~T(96%), and Lysobacter defluii APB-9 ~T(96%). ~The value for DNA-DNA relatedness between strain 2-5~~T and L. concretionis KC^TC 12205 ~T was 23%. Branched fatty acids iso-C16: 0, iso-C15: 0, iso-C11: 0 3-OH, iso-C17: 1ω9c and iso-C11: 0 were found to be predominant. ~The major polar lipids were diphosphatidylglycerol, phosphatidylethanolamine and phosphatidylglycerol. Strain 2-5~T had a DNA G+C content of 63.8 mol%. On the basis of the phenotypic, chemotaxonomic, DNA-DNA hybridization and phylogenetic data, strain 2-5~T represents a novel species of the genus Lysobacter, for which the name Lysobacter hymeniacidonis sp. nov. is proposed. ~The type strain is 2-5~T(=CGMCC 1.12190 ~T = JCM 18137~T).

关键词： Lysobacter hymeniacidonis sp.nov. taxonomy phylogenetic analysis

Guanosine-5'-triphosphate cyclohydrolase 1 regulated long noncoding RNAs are potential targets for microglial activation in neuropathic pain

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第3期16卷 596-600页

作者： Yan-Hu Liang Guo-Wu Chen xue-song Li Shu Jia Chun-Yang Meng Department of Clinical Medical College Jining Medical UniversityJiningShandong ProvinceChina Neuropathic Pain Institute for Spinal Nerve of Jining Medical University JiningShandong ProvinceChina Department of Spine Surgery Affiliated Hospital of Jining Medical UniversityJiningShandong ProvinceChina Department of Joint Surgery Yanzhou CampusAffiliated Hospital of Jining Medical UniversityJiningShandong ProvinceChina

Several studies have confirmed that microglia are involved in neuropathic *** of guanosine-5′-triphosphate cyclohydrolase 1(GTPCH1)can reduce the inflammation of ***,the precise mechanism by which GTPCH1 regulates neuropathic pain remains *** this study,BV2 microglia were transfected with adenovirus to knockdown GTPCH1 *** throughput sequencing analysis revealed that the mitogen-activated protein kinase(MAPK)related pathways and proteins were the most significantly downregulated molecular ***-expression network analysis of Mapk14 mRNA and five long noncoding RNAs(lnc RNAs)revealed their *** reverse transcription-polymerase chain reaction revealed that among five lnc RNAs,ENSMUST00000205634,ENSMUST00000218450 and ENSMUST00000156079 were related to the downregulation of Mapk14 mRNA *** provide some new potential targets for the involvement of GTPCH1 in neuropathic *** study is the first to note the differential expression of lnc RNAs and mRNA in GTPCH1 knockdown BV2 *** from this study reveal the mechanism by which GTPCH1 activates microglia and provide new potential targets for microglial activation in neuropathic pain.

关键词： cells factors inflammation microglia pain pathway protein RNA

Computational insights into the effects of reagent structure and bases on nucleophilic monofluoromethylation of aldehydes

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第5期33卷 2387-2390页

作者： Meng-Meng Zheng Hao-Dong Tan Yueqian Sang Xiao-song xue Jin-Pei Cheng State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin 300071China Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China Center of Basic Molecular Science Department of ChemistryTsinghua UniversityBeijing 100084China

Although fluorobis(phenylsulfonyl)methane(FBSM)and its cyclic analog 2-fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide(FBDT)possess similar physicochemical properties,Shibata et *** that FBSM failed to undergo nucleophilic monofluoromethylation of aldehydes regardless of the reaction conditions at-tempted(using various organic and inorganic bases).However,it was later discovered by Hu et *** the nucleophilic monofluoromethylation could be accomplished by employing lithium hexamethyldisi-lazide(LiHMDS)as a ***,we present an in-depth computational investigation into the intrigu-ing effects of reagent structure and bases on the nucleophilic monofluoromethylation of *** computations reveal the 1,4-diazabicyclo[2.2.2]octane(DABCO)catalyzed nucleophilic monofluoromethy-lation of benzaldehyde with acyclic FBSM is a thermodynamically unfavorable process mainly due to the destabilizing O···O lone pair repulsions in FBSM product,whereas such repulsion could be largely avoided in FBDT product because of its constrained five-membered ring *** LiHMDS as a base can not only facilitate the nucleophilic monofluoromethylation via Li–O interactions but also render the monofluoromethylation of benzaldehyde with FBSM thermodynamically favored.

关键词： Nucleophilic monofluoromethylation Fluoroalkylation reagent DFT calculations Thermodynamic effect Lone pair repulsion

PRLs Promote Spreading, Adhesion, and Proliferation of Human SW480 and SW620 Cells

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2006年第1期22卷 68-72页

作者： LI Zhao-fa XU xue-song SHEN Xing-gui LI Qing-shan ZHAO Zhi-zhuang FU xue-qi LI Yu-lin LI Yi-lei Edmond H. Fischer Signal Transduction Laboratory College of Life Sciences Jilin University Changchun 130021 P. R. China China-Japan Union Hospital Jilin University Changchun 130031 P. R. China The Key Laboratory of Pathobiology Ministry of Education Jilin University Changchun 130023 P. R. China

Recent studies suggest that PRL-3 is involved in the metastasis of colorectal cancer, but the mechanism concerning that has not been well defined. This article expresses PRL-1, PRL-2, and PRL-3 and the catalytically inactive mutant forms of those enzymes in SW620 and SW480 cells, two human cell lines derived from non-metastatic cancer and metastatic colorectal cancer, respectively. While the expression of the native forms of PRLs promotes the spreading, adhesion, and proliferation of these cells, the expression of their mutant forms inhibits the earlier-mentioned processes. These data thus provide a cellular mechanism for the role of PRL-3 in tumor metastasis and suggest that all the three PRLs have similar functions.

关键词： PRL Metastasis Proliferation Expression SW480 cell SW620 cell

Experimental research on heat transfer to liquid sodium and its incipient boiling wall superheat in an annulus

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2006年第3期17卷 177-184页

作者： XIAO Ze-Jun ZHANG Gui-Qin SHAN Jian-Qiang BAI xue-song JIA Dou-Nan National Key Laboratory of Bubble Physics ＆ Natural Circulation Nuclear Power Institute of China Chengdu 610041 China School of Energy and Power Engineering Xi＇an Jiaotong University Xi＇an 710049 China

Liquid sodium is mainly used as a cooling fluid in the liquid metal fast breeder reactor (LMFBR), whose heat transfer, whether convective heat transfer or boiling heat transfer, is different from that of water. So it is important for both normal and accidental operations of LMFBR to perform experimental research on heat transfer to liquid sodium and its boiling heat transfer. This study deals with heat transfer with high temperature (300-700℃) and low Pe number (20～70) and heat transfer with low temperature (250～270℃) and high Pe number (125～860), and its incipient boiling wall superheat in an annulus. Research on heat transfer involves theoretical research and experiments on heat transfer to liquid sodium. It also focuses on the theoretical analysis and experimental research on its incipient boiling wall superheat at positive pressure in an annulus. Semiempirical correlations were obtained and they were well coincident with the experimental data.

关键词：流体钠热传递初始沸腾墙体过热环面反应堆工程

Microcalorimetric Study on the Antibiotic Activity of Clarithromycin and Erythromycin

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2000年第2期5卷 215-218页

作者： Shen xue-song Liu Yi Zhou Chuan-pei Zhao Ru-ming Qu song-sheng College of Chemistry and Environment Science Wuhan University Wuhan 430072 China

By using LKB-2277 Bioactivity Monitoring System, the heat effect changes in the process of inhibitory action of clarithromycin and erythromycin onEscherichia coli at 37°C were determined. Quantitative analysis showed that relationship between antibiotic concentrationc and rate contantk ofEscherichia coli growth, and half inhibitory ratio concentration IC50: clarithromycin:k=0. 030 03–1. 1736×10?3 c, 8. 45 mg ·L?1; erythromycin:k=0.031 08–8.4657×10?4 c, 14. 45 mg·L?1. As a result of the microcalorimetry experiments, it not only indicated that antibacterial activity of clarithromycin was stronger than that of erythromycin, but also reported the changeable features of thermodynamics of the bacterial cell in biological, biochemical and metabolic process under different drug action.

关键词： clarithromycin erythromycin escherichia coli microcalorimetry