Microcalorimetric Study on the Antibiotic Activity of Clarithromycin and Erythromycin

作     者：Shen Xue-song Liu Yi Zhou Chuan-pei Zhao Ru-ming Qu Song-sheng 

作者机构：College of Chemistry and Environment Science Wuhan University Wuhan 430072 China Guilin Medical College Guilin 54001 China College of Chemistry and Environment Science Wuhan University Wuhan 430072 China College of Chemistry and Environment Science Wuhan University Wuhan 430072 China 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：2000年第5卷第2期

页      面：215-218页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：Supported by Natinal Natural Science Fundation of China!(2 973030) Natural Science Fundation of Hubei Province!(98J052) Po 

主　　题：clarithromycin erythromycin escherichia coli microcalorimetry 

摘      要：By using LKB-2277 Bioactivity Monitoring System, the heat effect changes in the process of inhibitory action of clarithromycin and erythromycin onEscherichia coli at 37°C were determined. Quantitative analysis showed that relationship between antibiotic concentrationc and rate contantk ofEscherichia coli growth, and half inhibitory ratio concentration IC50: clarithromycin:k=0. 030 03–1. 1736×10?3 c, 8. 45 mg ·L?1; erythromycin:k=0.031 08–8.4657×10?4 c, 14. 45 mg·L?1. As a result of the microcalorimetry experiments, it not only indicated that antibacterial activity of clarithromycin was stronger than that of erythromycin, but also reported the changeable features of thermodynamics of the bacterial cell in biological, biochemical and metabolic process under different drug action.