PRLs Promote Spreading, Adhesion, and Proliferation of Human SW480 and SW620 Cells

作     者：LI Zhao-fa XU Xue-song SHEN Xing-gui LI Qing-shan ZHAO Zhi-zhuang FU Xue-qi LI Yu-lin LI Yi-lei 

作者机构：Edmond H. Fischer Signal Transduction Laboratory College of Life Sciences Jilin University Changchun 130021 P. R. China China-Japan Union Hospital Jilin University Changchun 130031 P. R. China The Key Laboratory of Pathobiology Ministry of Education Jilin University Changchun 130023 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2006年第22卷第1期

页      面：68-72页

核心收录：

学科分类：1002[医学-临床医学] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：SupportedbyOpenFoundationofStateKeyLaboratoryofBiomembraneandMembraneBiotechnology TsinghuaUniversity 

主　　题：PRL Metastasis Proliferation Expression SW480 cell SW620 cell 

摘      要：Recent studies suggest that PRL-3 is involved in the metastasis of colorectal cancer, but the mechanism concerning that has not been well defined. This article expresses PRL-1, PRL-2, and PRL-3 and the catalytically inactive mutant forms of those enzymes in SW620 and SW480 cells, two human cell lines derived from non-metastatic cancer and metastatic colorectal cancer, respectively. While the expression of the native forms of PRLs promotes the spreading, adhesion, and proliferation of these cells, the expression of their mutant forms inhibits the earlier-mentioned processes. These data thus provide a cellular mechanism for the role of PRL-3 in tumor metastasis and suggest that all the three PRLs have similar functions.