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Effect of silver in thermal treatments of Fe-Mn-C degradable metals:Implications for stent processing

Bioactive Materials 2022年第6期7卷 30-41页

作者： Sergio Loffredo sofia Gambaro Francesco Copes Carlo Paternoster Nicolas Giguere Maurizio Vedani Diego Mantovani Laboratory for Biomaterials and Bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityQC G1V 0A6Canada Department of Mechanical Engineering Politecnico di MilanoMilan20156Italy National Research Council Institute of Condensed Matter Chemistry and Technologies for Energy CNR-ICMATEGenoa16149Italy Quebec Metallurgy Center CMQ Trois-RivieresQCG9A 5E1Canada

Twinning-induced plasticity(TWIP)steels are considered excellent materials for manufacturing products requiring extremely high mechanical properties for various applications including thin medical devices,such as biodegradable intravascular *** is also proven that the addition of Ag can guarantee an appropriate degradation while implanted in human body without affecting its bioactive *** order to develop an optimized manufacturing process for thin stents,the effect of Ag on the recrystallization behavior of TWIP steels needs to be *** is of major importance since manufacturing stents involves several intermediate recrystallization annealing *** this work,the recrystallization mechanism of two Fe-Mn-C steels with and without Ag was thoroughly investigated by microstructural and mechanical *** was observed that Ag promoted a finer microstructure with a different texture evolution,while the recrystallization kinetics resulted *** presence of Ag also reduced the effectiveness of the recrystallization *** behavior was attributed to the presence of Ag-rich second phase particles,precipitation of carbides and to the preferential development of grains possessing a{111}orientation upon thermal *** prominence of{111}grains can also give rise to premature twinning,explaining the role of Ag in reducing the ductility of TWIP steels already observed in other ***,in vitro biological performances were unaffected by *** findings could allow the design of efficient treatments for supporting the transformation of Fe-Mn-C steels alloyed with Ag into commercial products.

关键词： Twinning Recrystallization Biomaterials Silver Steels

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Children in Disaster Risk Reduction in Portugal: Policies,Education,and (Non) Participation

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International Journal of Disaster Risk Science 2017年第3期8卷 246-257页

作者： Ana Delicado ussara Rowland Susana Fonseca Ana Nunes de Almeida Luísa Schmidt Ana sofia Ribeiro Instituto de Ciências Sociais Universidade de Lisboa1600-189 LisbonPortugal

International agencies and scientific research have been calling for the inclusion of children in disaster preparedness and risk reduction, to hear their voices in order to address their specific needs and vulnerabilities and harness their capabilities in terms of building community resilience. This article assesses the roles ascribed to children in policy and education for disaster risk reduction in Portugal. The approach is based on a scoping methodology that encompasses document analysis and interviews with national and local stakeholders and policymakers in the disaster risk reduction field. The research is carried out within the scope of a European funded project, CUIDAR Cultures of Disaster Resilience among Children and Young People. More specifically, the article provides an overview of the discourses on the roles ascribed to children in urban disaster risk reduction(DRR). The authors maintain that although children are often taken as a target group in urban disaster prevention and management, they are seldom considered in terms of active participation in disaster risk reduction programs in the Portuguese context. Nevertheless, our analysis shows that there is a growing awareness of the relevance of active participation by children in order to create successful DRR.

关键词： Children’s nonparticipation Disaster risk reduction Emergency planning Portugal Risk education

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Imaging of the chemotherapy-induced hepatic damage:Yellow liver,blue liver,and pseudocirrhosis

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World Journal of Gastroenterology 2021年第46期27卷 7866-7893页

作者： Linda Calistri Vieri Rastrelli Cosimo Nardi Davide Maraghelli sofia Vidali Michele Pietragalla Stefano Colagrande Department of Experimental and Clinical Biomedical Sciences Mario Serio University of FlorenceAzienda Ospedaliera Universitaria CareggiFlorence 50134Italy

The liver is the major drug-metabolizing and drug-detoxifying *** drugs can cause liver damage through various mechanisms;however,the liver response to injury includes a relatively narrow spectrum of alterations that,regardless of the cause,are represented by phlogosis,oxidative stress and *** combination of these alterations mainly results in three radiological findings:vascular alterations,structural changes and metabolic function *** has changed in recent decades in terms of the drugs,protocols and duration,allowing patients a longer life *** a consequence,we are currently observing an increase in chemotherapy-associated liver injury patterns once considered *** this form of damage in an early stage is crucial for reconsidering the therapy regimen and thus avoiding severe *** this frontier article,we analyze the role of imaging in detecting some of these pathological patterns,such as pseudocirrhosis,“yellow liver”due to chemotherapy-associated steatosis-steatohepatitis,and“blue liver”,including sinusoidal obstruction syndrome,veno-occlusive disease and peliosis.

关键词： Hepatic damage Yellow liver Chemotherapy-associated steatohepatitis Blue liver Sinusoidal obstruction syndrome Veno-occlusive disease Peliosis Pseudocirrhosis

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From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?

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Neural Regeneration Research 2022年第5期17卷 933-936页

作者： Rita Caridade Silva Helena sofia Domingues António J.Salgado Fábio G.Teixeira Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimarãesPortugal

Parkinson's disease is the second most prevalent neurodegenerative disorder ***,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic *** treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal ***,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's *** instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell *** the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative ***,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based *** cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic *** approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's ***,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease.

关键词： disease-modifying strategies mesenchymal stem cells N-acetylcysteine neuroprotection Parkinson's disease stem cells secretome

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Which Proof We Have against Continuous Trajectories for Particles?

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Journal of Modern Physics 2017年第1期8卷 68-81页

作者： sofia Wechsler Kyriat Motzkin Israel

It is in general accepted that the concept of continuous trajectories for particles is at odds with the relativistic quantum mechanics. Namely, when examining the evolution of entangled quantum objects according to frames of coordinates in relative move-ment, one gets contradictory trajectories. Such a situation is typically derived from the famous “Hardy’s paradox”. However, it is argued here that if the rationale ignores the principle of quantum contextuality, as happens typically when using Hardy’s thought-experiment, the conclusion—rejection of the assumption of trajectories—is questionable. The issue is exemplified by an additional example: the 101 property of spin 1 bosons implies conflicting trajectories when the singlet state of two such bosons is examined according to frames in relative movement. It is concluded here that in the absence of a rationale which doesn’t violate the quantum contextuality, there are no sufficient arguments for refuting the possibility of a substructure of the quantum mechanics, consisting in particles following continuous trajectories.

关键词： 101 Property Bosonic Singlet Continuous Trajectories Nonlocality Relativity Theory

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History and evolution of the use of oral mucosa for urethral reconstruction

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Asian Journal of Urology 2017年第2期4卷 96-101页

作者： Guido Barbagli sofia Balo Francesco Montorsi Salvatore Sansalone Massimo Lazzeri Centro Chirurgico Toscano ArezzoItaly Division of Oncology/Unit of Urology IRCCS Ospedale San RaffaeleMilanItaly Department of Experimental Medicine and Surgery University of Tor VergataRomeItaly Department of Urology Istituto Clinico Humanitas IRCCSClinical and Research HospitalRozzanoItaly

We report here the history and evolution of the use of oral mucosa in reconstructive urethral surgery since it was first used for urethroplasty in *** that time,many authors have contributed to develop,improve and popularize the use of oral mucosa as a substitute *** urologists should be considered pioneers on the use of oral mucosa as they used it to repair primary and failed *** use of oral mucosa to repair penile and bulbar urethral strictures was described,for the first time,in *** evolutions in the technique for harvesting oral mucosa from the cheek were reported in ***,oral mucosa is considered the gold standard material for any type of anterior urethroplasty in a one-or two-stage repair due to its biological and structural characteristics that make it a highly versatile that is adaptable to any environment required by the reconstructive urethral *** the future approaches,tissue engineering techniques will provide patients with new materials originating from the oral epithelial mucosal cells,which are cultured and expanded into a ***,the path to reach this ambitious objective is still long and many difficulties must be overcome along the way.

关键词： Oral mucosa Cheek Urethra Urethroplasty Tissue engineering Reconstructive urology

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A case of primary isolated non-Hodgkin’s lymphoma of the esophagus in an immunocompetent patient

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World Journal of Gastroenterology 2009年第15期15卷 1901-1903页

作者： Ioannis V Kalogeropoulos Athanasios N Chalazonitis sofia Tsolaki Fotios Laspas Nikolaos Ptohis Ioannis Neofytou Dimitra Rontogianni Department of Radiology "Evagelismos" General Hospital Department of Radiology "Hippocratio" General Hospital

Primary non-Hodgkin’s lymphoma of the esophagus is a rare disease.A case of primary isolated nonHodgkin’s lymphoma of the esophagus in a 77-yearold man without acquired immunodeficiency syndrome is *** describe the clinical features and the imaging findings(barium swallow,endoscopic ultrasonography and CT)of a biopsy proven B-cell lymphoma with diffuse transmural involvement of the esophagus wall,which was discovered *** also briefly review the literature.

关键词： Endoscopic ultrasonography Esophagus Lymphoma Non-Hodgkin's lymphoma

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How Travels a Bohmian Particle?

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Journal of Modern Physics 2012年第12期3卷 1842-1848页

作者： sofia Wechsler Israel Institute of Technology Haifa Israel

Bohm’s mechanics was built for explaining individual results in measurements, and mainly for getting rid of the enigmatic reduction postulate. Its main idea is that particles have at any time definite positions and velocities. An additional axiom is that particles follow continuous trajectories that admit the first derivative in time, the velocity. In the quantum theory, if the position of a quantum object is well-defined at some time, a Δt time later the object may be found anywhere in space, so, the velocity defined as Δx/Δt is completely undefined. This incompatibility is regarded in standard quantum theory as nature’s property. The disagreement between quantum and Bohm’s mechanics is particularly strong in wave-like phenomena, e.g. interference. For a particle traveling through an interference fringe, Bohm’s velocity formula shows a dependence of the time-of-flight on the fringe length. Such a dependence is not supported by the quantum theory. Thus, for deciding which prediction is correct one has to measure times-of-flight. But this is a problem. If one detects a particle at two positions and records the detection times, the time difference is meaningless, because the first position measurement disturbs the particle’s Bohm velocity (if exists). This text suggests a way around: instead of measuring positions and times, the particles are raised to an excited, unstable level, by passing them through a laser beam. The unstable level will decay in time, s.t. the density of probability of the excited atoms will indicate the time elapsed since excitation. For comparing the Bohmian and quantum predictions, this text proposes in continuation to send the beam of excited particle upon a mirror. Bohm’s velocity leads to anomalies in the reflected wave.

关键词： Bohmian Particle Bohmian Velocity Bohmian Trajectory Group Velocity Interference Time-of-Flight

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Pylephlebitis—a rare complication of a fish bone migration mimicking metastatic pancreatic cancer:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6768-6774页

作者： sofia Bezerra Nuno J França Firmo Mineiro Germano Capela Cristina Duarte António Ribeiro Mendes Department of Surgery Centro Hospitalar do Médio TejoTomar 2304-909Portugal

BACKGROUND Pylephlebitis is a rare condition,poorly recognized by clinicians and with few *** this case,the clinical appearance resembled the clinical course of a pancreatic cancer and was originated by the ingestion of a fish bone,making the case more interesting and *** SUMMARY A 79-year-old female presented to the emergency department with fever,loss of appetite and *** in the right upper quadrant was *** marker were high.A computed tomography(CT)scan revealed gallstones and aspects compatible with acute *** patient was admitted to surgery ward and has her condition aggravated.A magnetic resonance revealed multifocal liver ***,a cholangiopancreatography and an endoscopic ultrasound(US)were able to diagnose the *** treatment was implemented and the patient made a complete *** In conclusion,this case report demonstrates for the first time the diagnosis of an unusual case of pylephlebitis complicated by the migration of a fish bone,mimicking metastatic pancreatic *** presentation and traditional imaging studies,such as transabdominal US and CT,remain the standard for diagnosing this condition.

关键词： Pylephlebitis Portal vein thrombosis Abdominal infection Fish bone Pancreatic cancer Case report

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Validation of the Portuguese version of the social isolation scale with a sample of community-dwelling older adults

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International Journal of Nursing Sciences 2023年第2期10卷 151-157页

作者： João Tavares Ana Faria Delphine Gonçalves Diana Mendes sofia Silva Liliana Sousa Health School University of AveiroAveiroPortugal Center for Health Technology and Services Research(CINTESIS@RISE) Portugal Health Sciences Research Unit:Nursing(UICISA:E) Portugal Department of Education and Psychology University of AveiroAveiroPortugal The Polytechnic Institute of Coimbra Coimbra Education SchoolCoimbraPortugal

Objectives The aim of this study was to analyze the psychometric properties(reliability and validity)of the Social Isolation Scale(SIS)in a sample of Portuguese community-dwelling older *** A transversal descriptive study was carried out with a convenience sample of 250 community-dwelling older adults(≥65 years).The survey comprised a sociodemographic questionnaire,SIS,Geriatric Depression Scale-4(GDS-4),6-item Lubben Social Network Scale(LSNS-6),a loneliness self-assessment question,and Satisfaction with Life Scale(SWLS).Construct validity(confirmatory factor analysis)and convergent validity were analyzed,and ISI internal reliability(composite reliability),external reliability(test-retest,intraclass correlation coefficient)and inter-rater reliability(Cohen’s kappa coefficient)were *** Confirmatory factor analysis showed a two-factor model with an excellent index of *** SIS showed significant correlations with LSNS-6(rs=0.47),SWLS(rs=0.26),the loneliness self-assessment question(rs=0.35),and GDS-4(rs=−0.16).SIS composite reliability was good(0.708).The inter-class correlation coefficient varied from 0.84 to *** Cohen’s kappa coefficient ranged from 0.936 to *** SIS has been shown to be a valid and reliable instrument for assessing social isolation among Portuguese community-dwelling older *** professionals,particularly nurses working in community settings,can use SIS to assess social isolation in older adults to design,implement,and evaluate interventions.

关键词： Aged Loneliness Portugal Psychometrics Social isolation

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