From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?

作     者：Rita Caridade Silva Helena Sofia Domingues António J.Salgado Fábio G.Teixeira Rita Caridade Silva;Helena Sofia Domingues;António J.Salgado;Fábio G.Teixeira

作者机构：Life and Health Sciences Research Institute(ICVS)School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate LabPT Government Associated LabBraga/GuimarãesPortugal 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第5期

页      面：933-936页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：the financial support from Prémios Santa Casa Neurociências Prize Mantero Belard for Neurodegenerative Diseases Research(MB-28-2019) supported by the European Regional Development Fund(FEDER) through the Competitiveness Internationalization Operational Programme(POCI) by National funds through the Foundation for Science and Technology(FCT) under the scope of projects UIDB/50026/2020 UIDP/50026/2020 and POCI-01-0145-FEDER-029751 developed under the scope of the project NORTE-01-0145-FEDER-000023 supported by the Northern Portugal Regional Operational Programme(NORTE 2020) under the Portugal 2020 Partnership Agreement,through the European Regional Development Fund(FEDER) funded by ICVS Scientific Microscopy Platform,member of the national infrastructure PPBI-Portuguese Platform of Bioimaging(PPBI-POCI-01-0145-FEDER-022122)(to FGT) 

主　　题：disease-modifying strategies mesenchymal stem cells N-acetylcysteine neuroprotection Parkinson's disease stem cells secretome 

摘      要：Parkinson s disease is the second most prevalent neurodegenerative disorder ***,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic *** treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal ***,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson s *** instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell *** the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative ***,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based *** cells secretome has been proposed as a promising therapeutic approach for Parkinson s disease,given its ability to modulate cell viability/preservation of dopaminergic *** approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson s ***,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson s disease.