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燃烧科学与技术 1999年第1期5卷 96-99页

作者：卞晓明孙志远普拉布sk 德雷克塞尔大学天津大学

火花点火发动机缸内一小部分ＨＣ燃料未经燃烧即与已燃气体一起排出缸外。为了研究燃料结构对ＨＣ排放的影响，在一台单缸发动机上燃用单一燃料及燃料混合物，对排放的循环平均值进行了研究。结果表明，燃料结构对ＨＣ排放有重要影响。

关键词： HC排放燃料结构单一燃料燃料混合物内燃机

Attenuation of mitochondrial,but not cytosolic,Ca2+ overload reduces myocardial injury induced by ischemia and reperfusion

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Acta Pharmacologica Sinica 2006年第7期27卷 911-918页

作者： Kenneth WL KAM James sk SHAM Tlak-ming WONG Department of Physiology the University of Hong KongHong Kong SARChina Division of Pulmonary Critical Care Medicine Johns Hopkins School of MedicineBaltimoreMaryland 21224USA

Aim:Attenuation of mitochondrial Ca2+([Ca2+]m),but not cytosolic Ca2+([Ca2+]c),overload improves contractile *** hypothesized that attenuation of[Ca2+]m,but not[Ca2+]c,overload confers cardioprotection against ischemia/reperfusion-induced ***:Infarct size from isolated perfused rat heart,cell viability,and electrically-induced Ca2+transient in isolated rat ventricularmyocytes were *** determined the effects of BAPTA-AM,a Ca2+chelator,at concentrations that abolish the overload of both[Ca2+]cand[Ca2+]m,and ruthenium red,an inhibitor of mitochondrial uniporter of Ca2+transport,atconcentrations that abolish the overload of[Ca2+]m,but not[Ca2+]c,on cardiacinjury induced by ischemia/***:Attenuation of both[Ca2+]mand[Ca2+]cby BAPTA-AM,and attenuation of[Ca2+]m,but not[Ca2+]c,overloadby ruthenium red,reduced the cardiac injury observations,indicating the impor-tance of[Ca2+]min cardioprotection and contractile recovery in response to is-chemia/***:The study has provided unequivocal evidenceusing a cause-effect approach that attenuation of[Ca2+]m,but not[Ca2+]c,over-load is responsible for cardioprotection against ischemia/*** also confirmed the previous observation that attenuation of[Ca2+]m,but not[Ca2+]c,by ruthenium red improves contractile recovery following ischemia/reperfusion.

关键词： ruthenium red BAPTA-AM infarct size electrically-induced Ca2+transient isolated perfused rat heart cardiac myocytes

Genome-wide gene expression analysis for target genes to differentiate patients with intestinal tuberculosis and Crohn’s disease and discriminative value of FOXP3 mRNA expression

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Gastroenterology Report 2016年第1期4卷 59-67,I0003页

作者： Vineet Ahuja Swati Subodh Amit Tuteja Veena Mishra Sushil Kumar Garg Neha Gupta Govind Makharia sk Acharya Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew DelhiIndia The Centre for Genomic Application(An IGIB–IMM collaboration) New DelhiIndia

Background and aims:Crohn’s disease(CD)and intestinal tuberculosis(ITB)are both chronic granulomatous conditions with similar phenotypic ***,there is need for a biomarker to differentiate between both these two *** study aimed at genome-wide gene expression analysis of colonic biopsies from confirmed cases of ITB and CD in comparison with *** evaluate the role of T regulatory cells,forkhead box P3(FOXP3)mRNA expression was quantified in serum as well as in colonic biopsies from patients with ITB and with the ***:Paired samples,including serum and colonic biopsies,were taken from 33 study subjects(CD,ITB and controls),and total RNA was *** whole genome gene expression microarray analysis was performed using the Illumina HumanWG-6 BeadChip Kit with six total RNA samples of the three groups in ***-time PCR for FOXP3 mRNA expression was analyzed in serum samples and colonic biopsy samples(4-CD,5-ITB,4-controls).Results:In CD and ITB there was 1.5-fold upregulation of 92 and 382 genes and 1.5-fold downregulation of 91 and 256 genes,*** proliferators via the PPARc pathway were most significantly downregulated(P2-fold *** ITB,the complement activation pathway,specifically the classical pathway,was the most significantly ***3 mRNA expression was significantly elevated in colonic biopsies obtained from ITB patients as compared with CD cases(4.7062.21 vs 1.4860.31,P=0.016).Conclusions:FOXP3 mRNA expression in colonic mucosa could be a discriminatory marker between ITB and *** of the complement activation pathway in ITB suggests that pathogenetic mechanisms for ITB are similar to those of pulmonary *** CD,downregulation of PPARc was seen in colonic tissue,suggesting that restoratio

关键词： Crohn’s disease intestinal tuberculosis microarray gene expression profiling signaling pathway FOXP3 mRNA

Revealing Genetic Relationship and Prospecting of Novel Donors Among Upland Rice Genotypes Using qDTY-Linked SSR Markers

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Rice science 2018年第6期25卷 308-319页

作者： Mitadru MUKHERJEE Barada PADHY Bharathkumar SRINIVASAN Pradosh MAHADANI sk Yasin BAKSH Ravindra DONDE Onkar Nath SINGH Lambodar BEHERA Padmini SWAIN Sushanta Kumar DASH Crop Improvement Division ICAR-National Rice Research Institute Departement of Botany Kandaswamy Kandar’s College Crop Physiology and Biochemistry Division National Rice Research Institute

A total of 17 simple sequence repeat(SSR) markers linked to QTLs(qDTYs) governing grain yield under reproductive stage(RS) drought stress were used to assess the genetic relationship and prospecting new donors for q DTYs among 32 popular upland rice genotypes. These SSR markers generated a total of 36 alleles with an average allele count of 2.1 per locus. Polymorphic information content value of the markers ranged from 0.376 to 0.662 with an average value of 0.484. The expected heterozyogosity ranged from 0.381 to 0.632. STRUCTURE analysis divided the 32 genotypes into three sub-populations. Subsequent phenotyping revealed that all the tolerant genotypes were grouped into one sub-population, whereas the moderately tolerant and susceptible genotypes were grouped into separate sub-populations. Phylogenetic tree constructed by the unweighted neighbour-joining method also divided the genotypes into three clusters. The grouping pattern of genotypes into the clusters was similar to that into the STRUCTURE analysis, on the basis of drought tolerance level. The average value of genetic dissimilarity coefficient among the genotypes was observed to be 0.486. Furthermore, by combining genotyping data with phenotyping data, 16 new donors for 6 qDTYs were identified.

关键词： drought screening genetic relationship population structure qDTY donor upland rice grain yield

Variability of platelet aggregation in patients with clopidogrel treatment and hip fracture: A retrospective case-control study on 112 patients

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World Journal of Orthopedics 2015年第5期6卷 439-445页

作者： Anna Clareus Inga Fredriksson Hkan Wallén Max Gordon André Stark Olof skldenberg Division of Orthopaedics Department of Clinical Sciences at Danderyd Hospital Karolinska Institutet Division of Anesthesiology Department of Clinical Sciences at Danderyd Hospital Karolinska Institutet Division of Cardiology Department of Clinical Sciences at Danderyd Hospital Karolinska Institute

AIM: To identify the rate of non-responders to clopidogrel treatment in hip fracture patients and study how non-responders differ from ***: In a retrospective case-control study we included 28 cases of acute proximal femoral fracture with clopidogrel treatment 2011 to 2013. Eighty-four controls from the same time period were included. Data collected included response to clopidogrel measured with multiple electrode aggregometry(MEA), intraoperative bleeding, erythrocyte transfusion, time to surgery and the incidence of adverse events up to 3 mo after surgery. RESULTS: Eight(29%) of the 28 cases were nonresponders. The median intraoperative bleeding was 300 mL(range, 0-1500), and was lower for non-responders(50 m L) but did not reach statistical significance. Erythrocyte transfusions did not differ between responders, non-responders and controls. Forty-five(40%) of 112 patients had adverse events postoperatively but the rate did not differ between patients with and without clopidogrel ***: Almost one-third of patients withclopidogrel treatment and an acute proximal femoral fracture are non-responders to antiplatelet therapy and can be operated without delay.

关键词： Proximal femoral fracture Clopidogrel Variability Bleeding Adverse events

COMPUTER-AIDED DESIGN OF ADAPTIVE PULSED ARC WELDING OF ROOT WELDS BY MELTING ELECTRODE

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Acta Metallurgica Sinica(English Letters) 2000年第1期13卷 63-68页

作者： Yu. N. Sarave O. I.Shpigunova(Institute of Shength Physics and Materials Science, Siberian Branch, Russian Academy Of Sciences,Tom-sk, Russia)

The purpose of computer-aided design of new adaptive pulsed arc technologies of welding is: to de- sign optimum algorithms of pulsed control over main energy parameters of *** permits:to in- crease welding productivity, to stabilize the welding regime, to control weld formation,taking into ac- count its spatial position, to proveal specie strength of the welded and coatings. Computer- aided design reduces the time of development of new pulsed arc technology:provides the optimization of technological referes according to the operating conditions of welded joints,the prediction of the ser- vice life of the *** developed methodology of computer-aided design of advanced technologies, models, original software, adaptive algorithms of pulsed control, and spend equipment permits to regulate penetration,the weld shape, the sizes of heat - affected zone; to predict sired properties and quality of welded joints.

关键词： pulse welding,algorithm of control,computer- aided design

Abundance and biomass of assorted small indigenous fish species:Observations from rural fish markets of West Bengal,India

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Aquaculture and Fisheries 2018年第3期3卷 129-134页

作者： Dibyendu Saha Santanu Pal Supratim Mukherjee Gargi Nandy Anupam Chakraborty sk Habibur Rahaman Gautam Aditya Department of Zoology The University of BurdwanGolapbagBurdwan713104India Department of Zoology Government General Degree CollegeSingurHooghly712409India Department of Zoology University of Calcutta35 Ballygunge Circular RoadKolkata700019India

The small indigenous fish species(SIS)are harvested as ensemble of different fish species of varying size and *** appraisal of the abundance and biomass of fish species constituting such ensemble was carried out with samples collected from fish markets ofWest Bengal,*** data revealed that at least 22 different fish species were present varying in numbers and species *** abundance and biomass of the individual fish species was negatively correlated,indicating numerical dominance of small sized *** regression showed a good fit of the relative abundance(y)with the species richness(x)in the samples of SIS(y=55.72ln(x)e 77.27;r^(2)=0.940),while power regression was best fit for the relative biomass of individual fish(y)with the species richness(x)in the samples of SIS(y=24.58x^(-1.54);R^(2)=0.831).In overall both species specific and individual based biomass and abundance relationships were negatively *** order to ascertain the harvest and marketability of the SIS in a judicious manner,monitoring of the fish assemblages in natural habitats is recommended.

关键词： Small indigenous fish species Abundance-biomass relation Species diversity Rice fields Fish market

GIS-based landslide susceptibility modeling:A comparison between fuzzy multi-criteria and machine learning algorithms

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Geoscience Frontiers 2021年第2期12卷 857-876页

作者： sk Ajim Ali Farhana Parvin Jana Vojteková Romulus Costache Nguyen Thi Thuy Linh Quoc Bao Pham Matej Vojtek Ljubomir Gigović Ateeque Ahmad Mohammad Ali Ghorbani Department of Geography Faculty of ScienceAligarh Muslim University(AMU)AligarhUP 202002India Department of Geography and Regional Development Faculty of Natural SciencesConstantine the Philosopher University in NitraTrieda A.Hlinku 194901 NitraSlovakia Research Institute of the University of Bucharest 90-92 Sos.Panduri5th DistrictBucharest 050663Romania National Institute of Hydrology and Water Management București-Ploiești Road97E1st DistrictBucharest 013686Romania Thuyloi University 175 Tay SonDong DaHanoiViet Nam Institute of Research and Development Duy Tan UniversityDanang 550000Viet Nam Faculty of Environmental and Chemical Engineering Duy Tan UniversityDanang 550000Viet Nam Department of Geography University of Defence11000 BelgradeSerbia Sustainable Management of Natural Resources and Environment Research Group Faculty of Environment and Labour SafetyTon Duc Thang UniversityHo Chi Minh CityViet Nam

Hazards and disasters have always negative impacts on the way of *** is an overwhelming natural as well as man-made disaster that causes loss of natural resources and human properties throughout *** present study aimed to assess and compare the prediction efficiency of different models in landslide susceptibility in the Kysuca river basin,*** this regard,the fuzzy decision-making trial and evaluation laboratory combining with the analytic network process(FDEMATEL-ANP),Naïve Bayes(NB)classifier,and random forest(RF)classifier were ***,a landslide inventory map was produced with 2000 landslide and nonlandslide points by randomly dividedwith a ratio of 70%:30%for training and testing,*** geospatial database for assessing the landslide susceptibility was generated with the help of 16 landslide conditioning factors by allowing for topographical,hydrological,lithological,and land cover *** ReliefF methodwas considered for determining the significance of selected conditioning factors and inclusion in the model ***,the landslide susceptibility maps(LSMs)were generated using the FDEMATEL-ANP,Naïve Bayes(NB)classifier,and random forest(RF)classifier ***,the area under curve(AUC)and different arithmetic evaluation were used for validating and comparing the results and *** results revealed that random forest(RF)classifier is a promising and optimum model for landslide susceptibility in the study area with a very high value of area under curve(AUC=0.954),lower value of mean absolute error(MAE=0.1238)and root mean square error(RMSE=0.2555),and higher value of Kappa index(K=0.8435)and overall accuracy(OAC=92.2%).

关键词： Landslide susceptibility modeling Geographic information system Fuzzy DEMATEL Analytic network process Naïve Bayes classifier Random forest classifier

Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action

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World Journal of Gastroenterology 2007年第27期13卷 3705-3713页

作者： S Bhattacharya D Banerjee AK Bauri S Chattopadhyay sk Bandyopadhyay Department of Biochemistry Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences IPGME&R 244B Acharya Jagadish Chandra Bose Road Kolkata-700020 India Bio-Organic Division Bhabha Atomic Research Centre Mumbai-400085 India

AIM：To evaluate the protective activity of allylpyrocatechol （APC）, the major antioxidant constituent of Piper betel, against the indomethacin-induced stomach ulceration in the rat model and correlates with its antioxidative and mucin protecting properties.METHODS： Male Sprague-Dawley rats were divided into five groups. Normal control rats （group Ⅰ ） were given the vehicle oral dose of gum acacia in distilled water （1 mL per rat）; ulcerated control and treated rats （groups Ⅱ-V） were given a single dose of indomethacin （30 mg/kg body wt.）; group Ⅱ rats were sacrificed 4 h after indomethacin administration; groups Ⅲ-Ⅴ rats were given the vehicle （1 mL per rat） or APC （2 mg/kg body wt.） or misoprostol （1.43 μg/kg body wt.） once daily by oral intubation for 7 d starting from 4 h after the indomethacin administration. After 7 d, the stomach tissues were excised for histological examination and biochemical analysis. RESULTS： Treatment with APC （2 mg/kg body wt per day） and misoprostol （1.43 μg/kg body wt per day） for 7 d could effectively heal the stomach ulceration as revealed from the ulcer index and histopathological studies. Compared to the zero day ulcerated group, treatment with APC and misoprostol reduced the ulcer index by 93.4% and 85.4% respectively （P 〈 0.05）. Both APC and misoprostol accelerated ulcer healing observed in natural recovery （P 〈 0.05）, their respective healing capacities not being significantly different. The healing capacities of APC and misoprostol could be attributed to their antioxidant activity as well as the ability to enhance the rnucin content of the gastric tissues. Compared to the ulcerated untreated rats, those treated with APC and rnisoprostol showed near normal MDA levels, while the protein levels were 86% and 78% of the normal value respectively （P 〈 0.05）. Likewise, both APC and rnisoprostol increased the SOD, catalase, and rnucin levels significantly （P 〈 0.05）, the effect of APC being better. CONCLUSION： APC can protect ind

关键词： Allylpyrocatechol Antioxidant Histopathology Indornethacin Mucin Piper betel Stomach ulcer

表观遗传学：生物医学研究和眼科研究的新时代

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中华实验眼科杂志 2016年第10期34卷 865-873页

作者： He sk,Ouyang S Ouyang S 南加州大学Keck医学院眼科及病理系 USCRoski眼科研究所洛杉矶CA90033美国中南大学湘雅医院眼科长沙410000

表观遗传学研究已成为生物医学领域的研究热点.越来越多的关于人类疾病发生机制的研究表明,疾病的发生不仅受到遗传因素的影响,也受环境因素的影响,因此表观遗传学因素在各种疾病的发生和发展中发挥很大的作用,眼科疾病的发生也与表观... 详细信息

表观遗传学研究已成为生物医学领域的研究热点.越来越多的关于人类疾病发生机制的研究表明,疾病的发生不仅受到遗传因素的影响,也受环境因素的影响,因此表观遗传学因素在各种疾病的发生和发展中发挥很大的作用,眼科疾病的发生也与表观遗传因素有关.迄今为止在表观基因组研究上所取得的进展进一步明确了表观遗传因子在生物发育、炎症、衰老、免疫、新生血管形成、肿瘤以及干细胞生物学等许多复杂的病理生理过程中所扮演的角色.眼科医师应该深入研究表观遗传学三大机制的研究进展及其在各类疾病,尤其是眼科疾病中起到的作用,跟踪近年来应用表观遗传学方法和手段在眼病治疗中取得的进展,明确目前表观遗传学研究发展中面临的主要挑战,关注表观遗传学在眼科研究领域的研究前景.

关键词：表观遗传学眼科疾病 DNA甲基化组蛋白修饰非编码RNA