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Multimorbidity patterns and association with mortality in 0.5 million Chinese adults

Chinese Medical Journal 2022年第6期135卷 648-657页

作者： Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness and Response Peking UniversityBeijing 100191China National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China China Kadoorie Biobank National Coordination Centre Chinese Academy of Medical SciencesBeijing 100730China Nuffield Department of Population Health Medical Research Council Population Health Research UnitUniversity of OxfordOxford OX37LFUnited Kingdom Nuffield Department of Population Health University of OxfordClinical Trial Service Unit and Epidemiological Studies Unit(CTSU)Oxford OX37LFUnited Kingdom Suzhou Center for Disease Control and Prevention SuzhouJiangsu 215004China China National Center for Food Safety Risk Assessment Beijing 100022China Key Laboratory of Molecular Cardiovascular Sciences Peking UniversityMinistry of EducationBeijing 100191China 不详

Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and d

关键词： Multimorbidity Pattern Mortality Chinese

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非晶硅TFT强光稳定性的研究及改善

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现代信息科技 2022年第2期6卷 43-47页

作者：张亚军叶发科陆磊 simon Han gilbert Seo 深圳市华星光电半导体显示技术有限公司广东深圳518132 北京大学深圳研究生院广东深圳518071

随着显示产业的迅猛发展,大尺寸、宽色域、高动态范围(HDR)和高亮度给薄膜晶体管(TFT)面板带来了更大的挑战。经过测试,在40000 nit高亮度背光照明下,经过500小时照明,面板的充电能力衰减幅度高达13%。其机理与TFT结构密切相关,如栅极... 详细信息

随着显示产业的迅猛发展,大尺寸、宽色域、高动态范围(HDR)和高亮度给薄膜晶体管(TFT)面板带来了更大的挑战。经过测试,在40000 nit高亮度背光照明下,经过500小时照明,面板的充电能力衰减幅度高达13%。其机理与TFT结构密切相关,如栅极的功函数和栅极绝缘层(GI)的光学带隙(E_(g))。经研究,通过将GI层光学带隙从4.1 eV提升到4.7 eV,高亮度应力下衰减幅度从13%改善到了1%以下。

关键词： LCD a-Si TFT PECVD 高亮度

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Human seroreactivity against Bartonella species in the Democratic Republic of Congo

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Asian Pacific Journal of Tropical Medicine 2011年第4期4卷 320-322页

作者： Anne Laudisoit Jennifer Iverson simon Neerinckx Jean-Christophe Shako Jean-Marie Mafuko Nsabimana gilbert Kersh Michael Kosoy Nordin Zeidner University of Liverpool LiverpoolUnited Kingdom University of Antwerpen AntwerpenBelgium Centers for Disease Control and Prevention Fort CollinsColoradoUSA Katholieke Universiteit Leuven HeverleeBelgium Medical Reference Laboratory BuniaDemocratic Republic of Congo Urban Refugees Health Supervisor Handicap International France/ Burundi Centers for Disease Control and Prevention AtlantaUSA

Objective:To assess the presence and identity of Bartonella species in a pool of human blood samples from DRC Congo.Methods:Blood(±120μL) was collected anonymously from Congolese patients and placed on calibrated filter papers.Bartonella serology determination was performed using an indirect immun of luorescence assay(IFA) against six specific Bartonella antigens and Coxiella burnetii(C.burnetii) antigen.The end cut- of f value for Bartonella sp.was a titre greater than 1200.Results:None of the patients was positive for Bartonella elizabethae, Bartonella vinsonii subsp.vinsonii or Bartonella vinsonii subsp.arupensis nor for C.burnetti, but 4.5%of the 1SS samples were positive for either Bartonella henselae,Bartonella quintana, or Bartonella clarridgeiae.Conclusions:This preliminary study presents the first report of Bartonella species in the DR Congo and the first report of antibodies to Bartonella clarridgeiae in an African human population.Although few experimental trials have established the link between fleas and Bartonella transmission,the repeated detection of similar Bartonella species in fleas and humans in several countries suggests that Bartonellosis could be another flea-borne disease which specific reservoirs are still unknown.

关键词： Bartonella Democratic Republic of Congo Serology Human

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ROUND TWO Tommy Robredo returns to the Shenzhen Open

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城市漫步（GBA版） 2015年第9期 16-16页

作者： CHRISTINE gilbert 不详

The second year of the ATP Shenzhen Open will begin September 28,running until October 4 at the Longgang Sports Center.Top tennis talent like Gilles simon,Marin Cilic and Tommy Robredo will vie for the win at the ATP ... 详细信息

关键词： Open Tommy Rob

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Ore Texture,Mineralogy and Whole Rock Geochemistry of the Iron Mineralization from Edea North Area,Nyong Complex,Southern Cameroon:Implication for Origin and Enrichment Process

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International Journal of Geosciences 2017年第5期8卷 659-677页

作者： Bravo Martin Mbang Bonda Jacques Etame Arnaud Patrice Kouske Elie Constantin Bayiga gilbert Francois Ngon Ngon simon Joel Mbai Martine Gerard Department of Earth Sciences Faculty of ScienceUniversity of DoualaDoualaCameroon Department of Civil Engineering The University Institute of TechnologyUniversity of DoualaDoualaCameroon IRD UMR 161 CEREGEInstitut de mineralogie et physique des milieux condensesParisFrance

This study presents the ore texture, mineralogy and whole rock geochemistry of iron occurrence from the Edea North area located at the upper limit of the Nyong Unit, part of the Congo craton. This iron mineralization is of magnetite quartzite type enclosed by metamorphic rocks of the granulite facies. Two main facies have been identified over the study area including the banded and the massive facies. The mineralogical set of these facies is in majority represented by magnetite, quartz and pyroxene martite in addition to minor biotite, apatite, and amphibole. Magnetite presents as irregular and elongated minerals which can contain quartz inclusions of various shapes and sizes, as blasts clustering, around pyroxenes and isolated xenomorphic magnetite minerals in the silicate phases. Quartz varies from fine to coarse-grained and ribbon quartz. This indicates re-crystallization and deformation during metamorphism. Electron microprobe analysis on magnetite and martite show Fe2O3 contents that vary between 96.11 and 99.76. Whole rock chemical data showed that Fe-contents are as high as 62.9 wt%. The SiO2 content varies between 33.8 wt% and 51.2 wt%. Iron oxides and SiO2 are negatively correlated. Moreover, the low positive correlations between Al2O3 and HFSE, and LILE suggest a contribution of clastic materials in the protolith of studied materials. The samples show low contents of V, Cr, Ba, Zr with respect to igneous rocks. This may infer a sedimentary origin for the studied rocks;furthermore, these materials may have undergone hydrothermal alteration. The REE patterns reveal enrichment in LREE compared to HREE. Some samples show positive Eu (1.82) and other negative anomalies Eu (0.54 to 0.97). The lack of Ce anomalies suggests that the depositional environment of the Edea North iron occurrence was anoxic or suboxic. Overall, the Edea North iron occurrence may have undergone significant input from hydrothermal sources with imprints of the clastic during its deposition.

关键词： Magnetite Texture Edea North Nyong Complex Southern Cameroon

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Geological,Mineralogical and Geochemical Studies of Pyrite Deposits in the Eastern Part of Douala Sub-Basin(Cameroon,Central Africa)

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International Journal of Geosciences 2015年第8期6卷 882-893页

作者： gilbert Francois Ngon Ngon Pierre Steve Abomo Michel Bertrand Mbog Andre Mbabi Bitchong Joel simon Mbai Therese Valerie Ngonlep Minyemeck Rose Yongue Fouateu Laboratory of Geosciences and Environment Department of Earth SciencesFaculty of ScienceUniversity of DoualaDoualaCameroon Laboratory of Applied Geology-Metallogeny Department of Earth SciencesFaculty of ScienceUniversity of Yaounde IYaoundeCameroon

Pyrite deposit of pK27, Douala sub-basin (Cameroon, Central Africa) was studied in a tropical forest setting physically and using X-ray diffraction and X-ray fluorescence spectrometry (XRF) in order to characterize the mineralization for his industrial utilization. The sedimentary materials from the pyrite deposit were grouped into five (05) main lithofacies, including four claystone facies and one conglomeratic facies. The mineralization occurs along the low slopes of valleys in?light grey claystone facies situated on the bottom of outcrops with 80 to 200 cm thickness. The?particle size distribution of clayey materials host rocks shows that they are essentially constituted of clay and silts fractions. However, their Sorting index (So) more than 4.5 corresponds to poorly sorted sediments and the torrential type;whereas their Coefficient of asymmetry (A) more than 1?indicates that the sorting is carried out towards fine particles. Macroscopically, pyrite in these?materials is in crumbly and consolidated piles with aggregate pyrites in oolithic concretions, and?globular, cubic, octaedric, massive and fossiliferous forms. The mineralogical compositions of?these clayey materials indicate that they are essentially kaolinitic and illitic, followed by goethite, quartz, pyrite, halloysite, anatase and rutile with hematite as accessory minerals. Pyrite in sand fractions is associated with kyanite, grenat, rutile, diopside, muscovite and tourmaline the minerals which?recognize the regional metamorphism. However, the specific chemical signature of SO3content?high in clayey materials and abundant (50.86% - 57.64% SO3) in pyrite is characteristic of the pK27 pyritic formations in the eastern part of Douala sub-basin. Moreover, the Co:Ni ratios of pyrites approximately 0.25 to 0.8 are characteristic of sedimentary pyrites and also suggest an anoxic environment.

关键词： Douala Sub-Basin Geochemical Geological Mineralogical Pyrite Deposits

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Gastric Adenocarcinoma Treatment in Africa: Surgery Alone or Perioperative Chemotherapy?

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Journal of Cancer Therapy 2017年第7期8卷 653-662页

作者： Nayi Zongo Bagué Abdoul Halim Ouangré Edgar Bagré Sidpawalmde Carine Zida Maurice Boukoungou gilbert Sanou Adama Lompo Olga Mélanie Traoré Si simon Ahmadou Dem General and Digestive Surgery Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Oncology Institute Joliot Curie of Dakar Dakar Senegal General and Digestive Surgery Department University Hospital Center Blaise COMPAORE Ouagadougou Burkina Faso Pathological Anatomy and Forensic Unit Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso

Aim: Evaluate the impact of MAGIC trial on gastric adenocarcinoma’s management in Africa. Method and methodology: It was about a review of literature on therapeutic aspects of gastric adenocarcinoma in the African area. We have taken a census of 21 articles including 2792 patients published between 1980 and 2013. We have distinguished articles published before 2006 (group 1) from those published after 2006 (group 2) to better understand therapeutic changes after that perioperative chemotherapy has become a standard in gastric adenocarcinoma’s management. Results: Surgery remains in Africa the first and practically the only treatment weapon in gastric adenocarcinoma: 46% to 92% people in the 1st group and 65% to 100% people in the 2nd group underwent surgical procedures. Perioperative chemotherapy takes longer to be part of therapeutic habits (0.18%). Factors related to patients such alteration of general state with a WHO performance status superior to 2 in 72% of cases, the lack of financial accessibility to anticancerous drugs explains partly the non-use of perioperative chemotherapy. This is also due to factors peculiar to our sanitation structures which don’t have enough cancer specialists. So we noticed that MAGIC trial is simply ignored in certain studies. The lack of adoption of perioperative chemotherapy explains with delayed diagnosis the low survival of patients in the African area. Conclusion: MAGIC trial practically has no effect on therapeutic behavior yet comparatively to gastric adenocarcinoma in Africa. The insurance particularly relies on surgery only until now. However, it might enable us to improve gastric adenocarcinoma’s survival rates.

关键词： Adenocarcinoma Stomach Surgery Perioperative Chemotherapy Africa

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Transanal Evisceration of Small Bowel about One Case at the University Hospital Yalgado Ouédraogo of Ouagadougou

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Surgical Science 2016年第7期7卷 291-294页

作者： Adama Sanou Moussa Bazongo Edgar Ouangré Maurice Zida gilbert Patindé Bonkoungou Rodrique Namékinsba Doamba Sylvain Wendmi Karfo Elie Yamba Sawadogo Nayi Zongo Si simon Traoré Division of General and Digestive Surgery University Hospital Blaise Compaoré Ouagadougou Burkina Faso Division of General and Digestive Surgery University Hospital Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: Transanal evisceration of small bowel is an extremely rare condition that can occur spontaneously or after trauma. Objective: To report a case of Transanal evisceration of small bowel to describe the circumstances of occurrence and our therapeutic attitude. Observation: An 80-year-old female patient was received at the visceral Emergency of University Hospital Yalgado Ouédraogo for the outcome of the small intestine by the anus with the waning of a defecation effort. The physical examination of the patient accustomed to evacuation purgation noted, eviscerated the small bowel through the anus, edematous but viable. The preoperative laboratory tests were normal. In emergency, under general anesthesia, a laparotomy was possible to objectify the incarceration of intestinal loops through linear perforation of 5 cenimeter from the anterior surface of the rectosigmoid hinge. We conducted an ileo-ileal resection anastomosis, a suture rectosigmoid breach and anal extraction of small bowel incarcerated measuring 200 centimeter. The evolution was simple. Conclusion: The weakening of the rectal mucosa by repeated purges has certainly been the contributory factor. The surgical treatment must be precocious to avoid extensive intestinal resection.

关键词： Evisceration Transanal Small Bowel Rectum Sigmoid

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