Human seroreactivity against Bartonella species in the Democratic Republic of Congo

作     者：Anne Laudisoit Jennifer Iverson Simon Neerinckx Jean-Christophe Shako Jean-Marie Mafuko Nsabimana Gilbert Kersh Michael Kosoy Nordin Zeidner 

作者机构：University of LiverpoolLiverpoolUnited Kingdom University of AntwerpenAntwerpenBelgium Centers for Disease Control and PreventionFort CollinsColoradoUSA Katholieke Universiteit LeuvenHeverleeBelgium Medical Reference LaboratoryBuniaDemocratic Republic of Congo UrbanRefugees Health Supervisor Handicap International France/ Burundi Centers for Disease Control and PreventionAtlantaUSA 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2011年第4卷第4期

页      面：320-322页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by a Belgian Funds for Scientific Research(FNRS) grant.the Belgian Funds for research in Agriculture and Industry(FRIA) and Dr. Eric Bertherat(WHO) for financial assistance and logistical support in the field 

主　　题：Bartonella Democratic Republic of Congo Serology Human 

摘      要：Objective:To assess the presence and identity of Bartonella species in a pool of human blood samples from DRC Congo.Methods:Blood(±120μL) was collected anonymously from Congolese patients and placed on calibrated filter papers.Bartonella serology determination was performed using an indirect immun of luorescence assay(IFA) against six specific Bartonella antigens and Coxiella burnetii(C.burnetii) antigen.The end cut- of f value for Bartonella sp.was a titre greater than 1200.Results:None of the patients was positive for Bartonella elizabethae, Bartonella vinsonii subsp.vinsonii or Bartonella vinsonii subsp.arupensis nor for C.burnetti, but 4.5%of the 1SS samples were positive for either Bartonella henselae,Bartonella quintana, or Bartonella clarridgeiae.Conclusions:This preliminary study presents the first report of Bartonella species in the DR Congo and the first report of antibodies to Bartonella clarridgeiae in an African human population.Although few experimental trials have established the link between fleas and Bartonella transmission,the repeated detection of similar Bartonella species in fleas and humans in several countries suggests that Bartonellosis could be another flea-borne disease which specific reservoirs are still unknown.