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Effects of extracts from Hibiscus macranthus and Basella alba mixture on testosterone production in vitro in adult rat testes slices

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Asian Journal of Andrology 2006年第1期8卷 111-114页

作者： Paul E Moundipa silvère ngouela Pierre Kamtchouing Etienne Tsamo Félicité M.Tchouanguep Serge Carreau Laboratory of Nutrition and Biochemical Toxicology Laboratory of Organic Chemistry Department of Animal Biology and Physiology University of Yaoundé IP.O.Box 812YaoundéCameroon Faculty of Science University of DschangP.O.Box 67DschangCameroon USC INRA-EA 2608.Laboratoire de Biochimie Esplanade de la paixUniversité de Caen14032 Caen-cedexFrance

Aim： To find an in vitro system for the measurement of the androgenic effects of different extracts of Hibiscus macranthus （Malvaceae） and Basella alba （Basellaceae）. Methods： The production of testosterone from testes slices incubated in two media, either Krebs-Henseleit buffer containing 0.5% Bovine serum albumin （BSA） or Dubecco＇s Modified Eagle＇s medium-F12 Ham nutrient mixture （DME/Ham F12）, under a mixture of 5% CO2 in 95% air was determined either in the presence or absence of cofactors and Hibiscus macranthus plus Basella alba （HMBA） extracts. results： The testosterone production was increased in testes slices incubated in DME/Ham F12 medium in response to the cofactors （49%） and aqueous extracts （34%-60% according to dilutions）. Under the same atmospheric conditions, there was no positive response of the testes slices to either cofactor or HMBA extract stimulation in Krebs-Henseleit buffer containing 0.5% BSA, In further investigations related to the effect of HMBA, the DME/ Ham F12 medium was used. The results obtained from the in vitro test showed that the activity was present mainly in methylene chloride and methanol, since these extracts induced an increase in testosterone production by testes slices. Conclusion： The testes slice system is suitable to be used for further in vitro investigations of the isolation of androgenic bioactive components of plants. （Asian J Androl 2006 Jan; 8： 111-114）

关键词： testis testosterone plant extracts Hibiscus macranthus Basella alba

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Effects of Basella alba and Hibiscus macranthus extracts on testosterone production of adult rat and bull Leydig cells

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Asian Journal of Andrology 2005年第4期7卷 411-417,页

作者： Paul F.Moundipa Nathalie Sara E.Beboy Fabien Zelefack silvère ngouela Etienne Tsamo Wolf-Bernhard Schill Thomas K.Monsees Departments of Biochemistry Organic Chemistry University of Yaounde IP.O.Box 812 YaoundeCameroon Centre for Dermatology and Andrology Justus Liebig UniversityGaffkystr.1435385 GiessenGermany Centre for Dermatology and Andrology Justus Liebig UniversityGaffkystr.1435385 GiessenGermany Department of AnatomyUniversity of TechnologyFetscherstr.7401307 DresdenGermany

Aim： To determine the androgenic effects of Basella alba and Hibiscus macranthus extracts in the rat and the bull, and to develop a novel in vitro test system using Leydig cells from bull testes. Methods： The effect of methanol extracts from both plants on testosterone production in isolated Leydig cells from the rat and the bull was analyzed using ^125I-radioimmunoassay （^125I-RIA）. Rat Leydig cells were obtained by common methods, whereas a novel technique was used to purify Leydig cells from bull testes. results： Bull testes from the slaughter house were a cheap source of pure Leydig cells. In culture, these cells produced testosterone for 5-6 days, which can be stimulated by human chorionic gonadotrophin （hCG）. Basella alba extracts significantly enhanced testosterone production in bull and rat Leydig cells in a concentration-dependent manner. Hibiscus macranthus showed no androgenic effect but was shown to inhibit testosterone production at higher concentrations. Conclusion： Leydig cells purified from bull testes can be used as an alternative tool in experimental animal research. Certain fractions of Basella alba extract demonstrated androgenic potential whereas Hibiscus macranthus extracts did not.

关键词： bull rats Leydig cells testosterone Basella alba Hibiscus macranthus plant extract

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Synthesis, Molecular Structure, Anti-Plasmodial, Antimicrobial and Anti-Oxidant Screening of (E)-1-(Phthalazin-1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine and 1-[2-(1-(pyridine-3- yl)ethylidene)hydrazinyl]phthalazine

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International Journal of Organic Chemistry 2021年第3期11卷 91-105页

作者： Angelbert F. Awantu Godfred A. Ayimele Jean Jules K. Bankeu Edouard A. Nantia Patrick V. T. Fokou Fabrice F. Boyom Emmanuel N. Nfor Bruno N. Lenta silvère A. ngouela Department of Chemistry The University of Bamenda Bambili Cameroon Department of Chemistry University of Buea Buea Cameroon Department of Biochemistry The University of Bamenda Bambili Cameroon Department of Biochemistry University of Yaoundé I Yaoundé Cameroon Department of Chemistry Higher Teachers’ Training College University of Yaoundé I Yaoundé Cameroon Department of Organic Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon

Two new hydralazine hydrochloride-derived Schiff bases: (E)-1-(Phthalazin- 1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine (PPEH), and 1-[2-(1-(pyridine- 3-yl)ethylidene)hydrazinyl]phthalazine (PEHP), were synthesized and partially characterized by spectroscopic and crystallographic methods including IR and X-ray. The single-crystal X-ray diffraction (SCXRD) analysis of PEHP indicates that the hydralazine moiety of both ligands possesses the exocyclic C=N bond. Both, PPEH and PEHP were tested as antimicrobials and antiparasites. Just PEHP could be considered as slightly antiplasmodial and antibacterial agent. In effect, PPEH showed low antimicrobial activity against one bacterial strain with Minimum Inhibitory Concentration (MIC) value of 250 μg/ml while PEHP showed very interesting activity against 18 out of 19 bacterial strains with MIC of 31.25 - 250 μg/ml compared to the standard drug, amoxicillin. PPEH and PEHP showed higher reducing activity on ferric ions compared to Vitamin C. On the other hand, both hidrazaline synthetized derivatives showed as better reducing agents than Vitamin C on ferric io

关键词： Schiff Base Hydralazine Hydrochloride Anti-Plasmodial Activity Antimicrobial Activity Anti-Oxidant Activity

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Novel Hydralazine Schiff Base Derivatives and Their Antimicrobial, Antioxidant and Antiplasmodial Properties

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International Journal of Organic Chemistry 2020年第1期10卷 1-16页

作者： Angelbert F. Awantu Yannick Stephane F. Fongang Godfred A. Ayimele Edouard A. Nantia Patrick V. T. Fokou Fabrice F. Boyom Celine K. Ngwang Bruno N. Lenta silvère A. ngouela Department of Chemistry The University of Bamenda Bambili Cameroon Department of Chemistry University of Maroua Maroua Cameroon Department of Chemistry University of Buea Buea Cameroon Department of Biochemistry The University of Bamenda Bambili Cameroon Department of Biochemistry University of Yaoundé I Yaoundé Cameroon Department of Chemistry Higher Teachers’ Training College University of Yaoundé I Yaoundé Cameroon Department of Organic Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon

Two novel Schiff bases, 3-[1-(2-(phthalazin-1-yl)hydrazono)ethyl)-1,3-oxa- zinane (PHEO) and 2-[(2-(phthalazin-1-yl)hydrazono)methyl]phenol (PHMP), derived from hydralazine hydrochloride, an effective drug against hypertension, were synthesized and characterized by spectroscopic methods, Infrared (IR), Proton Nuclear Magnetic resonance (1H NMR) and Carbon-13 Nuclear Magnetic resonance (13C NMR). PHEO showed low antimicrobial activity against one bacterial strain with MIC value of 250 μg/ml while PHMP showed interesting activity against 4 bacterial strains with MIC of 31.25 - 250 μg/ml compared to the standard drug, amoxicillin. PHEO and PHMP showed higher reducing activity on ferric ions compared to Vitamin C. On lipid peroxidation, PHEO showed higher inhibition while PHMP showed lower inhibition compared to Vitamin C. Both compounds presented lower stimulating effect and lower catalase activity compared to the standard Vitamin C. PHEO and PHMP showed less than 80% inhibition in the preliminary antiplasmodial assay and so were not considered for the dose-response studies.

关键词： Hydralazine Hydrochloride Schiff Bases Antimicrobial Anti-Oxidant Anti-Plasmodial Activities

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Synthesis,Urease Inhibition and Molecular Modelling Studies of Novel Derivatives of the Naturally Occurring b-Amyrenone

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Natural Products and Bioprospecting 2019年第1期9卷 49-59页

作者： Jean J.K.Bankeu Hira Sattar Yannick S.F.Fongang Syeda W.Muhammadi Conrad V.Simoben Fidele Ntie-Kang Guy R.T.Feuya Marthe A.T.Tchuenmogne Mehreen Lateef Bruno N.Lenta Muhammad S.Ali Augustin S.ngouela Department of Chemistry Faculty of ScienceThe University of BamendaP.O.Box 39BambiliCameroon International Center for Chemical and Biological Sciences University of KarachiKarachi 75270Pakistan Department of Chemistry Higher Teacher Training CollegeUniversity of MarouaP.O.Box 55MarouaCameroon Department of Pharmaceutical Chemistry Martin-Luther University of Halle-WittenbergWolfgang-Langenbeck-Str.406120 Halle(Saale)Germany Department of Chemistry Faculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon Department of Chemistry Faculty of ScienceScientific and Technical University of MasukuBox 943FrancevilleGabon Department of Chemistry Faculty of ScienceUniversity of Yaounde´IP.O.Box 812Yaounde´Cameroon Multi-Disciplinary research Laboratory(MDRL) Bahria University Medical and Dental CollegeBahria UniversityKarachiPakistan Department of Chemistry Higher Teacher Training CollegeUniversity of Yaounde´IP.O.Box 47Yaounde´Cameroon

Urease enzyme(UE)has been reported to be a potent virulence factor for Helicobacter pylori(HP)bacteria indicated to be responsible for various gastrointestinal ***,the spread of HP,currently regarded by the World Health Organization as a class 1 carcinogen,could be better controlled by targeting *** is in this line that we have synthesized three new derivatives(2–4)of the naturally occurring olean-12-en-3-one(1),which was previously isolated from the figs of Ficus vallis-choudae Delile(Moraceae).Among the synthesized compounds,3 and 4 contain an indole *** structures were unambiguously assigned by spectroscopic and spectrometric techniques(1D-NMR,2D-NMR and MS).The starting material and the synthesized compounds were screened for UE inhibition activity,and showed significant activities with IC50 values ranging from 14.5 to 24.6 lM,with compound(1)being the most potent as compared to the positive control thiourea(IC50=21.6 lM).Amongst the synthetic derivatives,compound 4 was the most potent(IC50-=17.9 lM),while the others showed activities close to that of the *** addition,molecular docking study of target compounds 2–4 was performed in an attempt to explore their binding mode for the design of more potent UE inhibitors.

关键词： Helicobacter pylori Urease inhibition Docking Olean-12-en-3-one derivatives

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