Novel Hydralazine Schiff Base Derivatives and Their Antimicrobial, Antioxidant and Antiplasmodial Properties

作     者：Angelbert F. Awantu Yannick Stephane F. Fongang Godfred A. Ayimele Edouard A. Nantia Patrick V. T. Fokou Fabrice F. Boyom Celine K. Ngwang Bruno N. Lenta Silvère A. Ngouela 

作者机构：Department of Chemistry The University of Bamenda Bambili Cameroon Department of Chemistry University of Maroua Maroua Cameroon Department of Chemistry University of Buea Buea Cameroon Department of Biochemistry The University of Bamenda Bambili Cameroon Department of Biochemistry University of Yaoundé I Yaoundé Cameroon Department of Chemistry Higher Teachers’ Training College University of Yaoundé I Yaoundé Cameroon Department of Organic Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon 

出 版 物：《International Journal of Organic Chemistry》 (有机化学国际期刊（英文）)

年 卷 期：2020年第10卷第1期

页      面：1-16页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Hydralazine Hydrochloride Schiff Bases Antimicrobial Anti-Oxidant Anti-Plasmodial Activities 

摘      要：Two novel Schiff bases, 3-[1-(2-(phthalazin-1-yl)hydrazono)ethyl)-1,3-oxa- zinane (PHEO) and 2-[(2-(phthalazin-1-yl)hydrazono)methyl]phenol (PHMP), derived from hydralazine hydrochloride, an effective drug against hypertension, were synthesized and characterized by spectroscopic methods, Infrared (IR), Proton Nuclear Magnetic Resonance (1H NMR) and Carbon-13 Nuclear Magnetic Resonance (13C NMR). PHEO showed low antimicrobial activity against one bacterial strain with MIC value of 250 μg/ml while PHMP showed interesting activity against 4 bacterial strains with MIC of 31.25 - 250 μg/ml compared to the standard drug, amoxicillin. PHEO and PHMP showed higher reducing activity on ferric ions compared to Vitamin C. On lipid peroxidation, PHEO showed higher inhibition while PHMP showed lower inhibition compared to Vitamin C. Both compounds presented lower stimulating effect and lower catalase activity compared to the standard Vitamin C. PHEO and PHMP showed less than 80% inhibition in the preliminary antiplasmodial assay and so were not considered for the dose-response studies.