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Novel multiplex stool-based assay for the detection of early-stage colon cancer in a Chinese population

World Journal of Gastroenterology 2022年第24期28卷 2705-2720页

作者： Hui-Hong Jiang si-wei xing Xuan Tang Ying Chen Kang Lin Lu-wei He Mou-Bin Lin Er-Jiang Tang Department of General Surgery Yangpu HospitalTongji UniversityShanghai 200090China Institute of Gastrointestinal Surgery and Translational Medicine Tongji University School of MedicineShanghai 200090China Department of Urology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Center for Clinical Research and Translational Medicine Yangpu HospitalTongji UniversityShanghai 200090China

BACKGROUND Stool DNA(sDNA)methylation analysis is a promising,noninvasive approach for colorectal cancer screening;however,reliable biomarkers for detecting early-stage colon cancer(ECC)are lacking,particularly in the Chinese *** To identify a novel stool-based assay that can improve the effectiveness of ECC *** A blinded case-control study was performed using archived stool samples from 125 ECC patients,and 125 control subjects with normal *** cohort was randomly divided into training and test sets at a 1.5:1 *** bisulfite sequencing(TBSeq)was conducted on five pairs of preoperative and postoperative sDNA samples from ECC patients to identify DNA methylation biomarkers,which were validated using *** logistic regression analysis,a multiplex stool-based assay was developed in the training set,and the detection performance was further assessed in the test set and combined ***χ^(2)test was used to investigate the association of detection sensitivity with clinico-pathological *** Following TBSeq,three hypermethylated cytosine-guanine sites were selected as biomarkers,including paired box 8,Ras-association domain family 1 and secreted frizzled-related protein 2,which differed between the groups and were involved in important cancer *** sDNA panel containing the three biomarkers was constructed with a logistic *** operating characteristic(ROC)analysis revealed that this panel was superior to the fecal immunochemical test(FIT)or serum carcinoembryonic antigen for the detection of *** further found that the combination of the sDNA panel with FIT could improve the screening *** the combined set,the sensitivity,specificity and area under the ROC curve for this multiplex assay were 80.0%,93.6%and 0.918,respectively,and the performance remained excellent in the subgroup analysis by tumor *** addition,the detection sensitivity did not differ with tumor site,tumo

关键词： Colon cancer Early screening Stool biomarker DNA methylation Fecal immunochemical test

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需求侧视角下我国体育社会组织发展特征及改革路径研究

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南京体育学院学报（社会科学版） 2017年第5期31卷 40-44页

作者：司幸伟冯霞河南师范大学体育学院河南新乡453007

以社会体育组织的发展和改革为主要研究对象,以需求侧为视角,从政府、民众以及社会体育组织三个方面分析了体育社会组织的发展特征,提出了相应的改革对策。社会体育组织面临的发展困境,从政府需求看,体育社会组织承接公共体育服务能力... 详细信息

以社会体育组织的发展和改革为主要研究对象,以需求侧为视角,从政府、民众以及社会体育组织三个方面分析了体育社会组织的发展特征,提出了相应的改革对策。社会体育组织面临的发展困境,从政府需求看,体育社会组织承接公共体育服务能力亟待提升;从群众需求看,体育社会组织服务能力难以满足多元化需求;从体育社会组织发展需求视角看,自身发展的动力机制尚不完善。提出以下建议:强化体育社会组织的建设和培育;持续提升体育社会组织服务与发展能力;优化体育社会组织健康发展的环境。

关键词：体育社会组织发展现状改革路径需求侧视角研究

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Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： xing Wang wei Pi Sheng Hu Haifeng Bao Na Yao wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

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Controllable synthesis of biomimetic wood stem nanoporous high entropy oxides catalysts for oxygen evolution reaction

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Nano Research 2025年第1期18卷 107-117页

作者： wei Wang weiqi Wang Huihui Wang xing Lu Jinwen Zhang Yunzhuo Lu School of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028China School of Intelligence and Electronic Engineering Dalian Neusoft University of InformationDalian 116023China Guangdong Key Laboratory of Materials and Equipment in Harsh Marine Environment Guangzhou Maritime UniversityGuangzhou 510725China

Bubbles generated during the oxygen evolution reaction(OER)in water splitting readily adhere to the electrode surface,thereby impeding contact between the electrolyte and the active sites,thereby increasing the ***,it is imperative to elucidate the bubble release behavior and engineer electrodes that facilitate faster bubble *** this study,inspired by the wood stem of the Norway spruce,we synthesized a gradient nanoporous high-entropy oxide(GNP-HEO)electrode with a controllable pore *** GNP-HEO,featuring a well-controlled gradient in pore size,is achieved through a straightforward strategy combining selective laser melting with selective phase *** unique gradient nanoporous structure not only facilitates bubble release but also diminishes the bubble shielding effect in OER,thereby enhancing electrocatalytic *** affect interaction of Al,Co,Cr,Fe,and Ni,coupled with the gradient nanoporous structure,yields exceptional OER performance,evidenced by an overpotential of 250 mV at a current density of 50 mA/cm^(2) and a Tafel slope of 38.0 mV/dec in 1 M *** functional theory calculations confirm that the GNPHEO adheres to the adsorbate evolution mechanism reaction pathway and exhibits significant *** work highlights a promising approach for the design and synthesis of high-performance OER electrocatalysts.

关键词： oxygen evolution reaction high-entropy oxides selective phase dis-solution selective laser melting gradient nanoporous

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang wei Kang Zhou Xin Huang xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （siBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for siBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for siBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan wei Yaru Qiao Jiming Xie Xianchao Pan Juan xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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体育学理中的运动技能学习分析

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新乡学院学报 2009年第5期26卷 80-81页

作者：司幸伟乔平均河南师范大学体育学院河南新乡453002

分析了体育学理的内涵与运动技能学习规律及影响因素,并基于"会能度"分类的运动技能对中小学生在学习动作技能时可能产生的影响提出了自己的见解,对体育学理方面的研究提出了一些建议。

关键词：体育学理运动技能会能度

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Molecular Structure Tailoring of Organic Spacers for High‑Performance Ruddlesden–Popper Perovskite Solar Cells

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Nano-Micro Letters 2025年第2期17卷 314-357页

作者： Pengyun Liu Xuejin Li Tonghui Cai wei xing Naitao Yang Hamidreza Arandiyan Zongping Shao Shaobin Wang Shaomin Liu School of Materials Science and Engineering State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum(East China)Qingdao 266580People’s Republic of China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255049People’s Republic of China Centre for Applied Materials and Industrial Chemistry(CAMIC) School of ScienceRMIT UniversityMelbourneVic 3000Australia WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia School of Engineering Great Bay UniversityDongguan 523000People’s Republic of China

Layer-structured Ruddlesden–Popper(RP)perovskites(RPPs)with decent stability have captured the imagination of the photovoltaic research community and bring hope for boosting the development of perovskite solar cell(PSC)***,two-dimensional(2D)or quasi-2D RP PSCs are encountered with some challenges of the large exciton binding energy,blocked charge transport and poor film quality,which restrict their photovoltaic ***,these issues can be readily resolved by rationally designing spacer cations of *** review mainly focuses on how to design the molecular structures of organic spacers and aims to endow RPPs with outstanding photovoltaic *** firstly elucidated the important roles of organic spacers in impacting crystallization kinetics,charge transporting ability and stability of *** we brought three aspects to attention for designing organic ***,we presented the specific molecular structure design strategies for organic spacers of RPPs aiming to improve photovoltaic performance of RP *** proposed strategies in this review will provide new avenues to develop novel organic spacers for RPPs and advance the development of RPP photovoltaic technology for future applications.

关键词： Ruddlesden-Popper perovskites Low-dimensional perovskite solar cells Organic spacers Molecular structure Design strategies

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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巴戟天多糖对炎性微环境牙周膜成纤维细胞FN及FN-EDA表达的影响

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上海口腔医学 2024年第2期33卷 123-129页

作者：张赞戴晶怡蔡红宣司为幸杨静文田亚光海南医学院口腔医学院海南海口570100 北京大学口腔医院修复科北京100080 海南医学院附属海南医院口腔科海南海口570100 海南省人民医院口腔科海南海口570100

目的:探讨巴戟天多糖(morinda officinalis polysaccharides,MOP)对炎性微环境牙周膜成纤维细胞纤连蛋白(fibronectin,FN)及含额外结构域A的纤连蛋白(fibronectin containing extra domain A,FN-EDA)表达的影响。方法:将36只大鼠随机分为对照组(n=12)和模型组(n=24),模型组采用正畸丝结扎法建立牙周炎,3周后每组各取6只大鼠通过Micro-CT确认建模完成;剩余模型组大鼠随机分为牙周炎组、生理盐水组(NS组)和MOP组。MOP组于大鼠左侧上颌第一磨牙腭侧注射MOP(200 mg/kg、3 d,50μL、4周),NS组注射等体积NS,牙周炎组不做任何处理。取大鼠左侧上颌骨组织,采用H-E染色观察牙周组织病理改变,免疫组织化学染色检测FN、FN-EDA的表达。体外培养牙周膜成纤维细胞,CCK-8法检测MOP对细胞活性的影响。将第4代细胞分为对照组、炎症组(10 mg/mL脂多糖)及实验组(12.5μg/mL MOP,12.5μg/mL MOP+10 mg/mL脂多糖)。利用qRT-PCR及Western印迹法检测FN和FN-EDA的表达变化。采用Prism 8.0软件包对数据进行统计学分析。结果:体内实验中,MOP组较牙周炎组和NS组FN-EDA表达显著下降(P<0.05),炎细胞浸润减少;但各组FN表达量未见统计学差异。体外实验中,与对照组相比,炎症组FN-EDA mRNA和蛋白表达量显著增高(P<0.0001);MOP显著降低炎症细胞FN-EDA表达,但对FN表达无明显影响。结论:FN-EDA在炎症牙周膜组织和细胞中表达升高,MOP可能通过下调FN-EDA而发挥炎症抑制作用。

关键词：牙周炎巴戟天多糖纤连蛋白 FN-EDA

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