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美国货币政策对中国金融市场的动态传导效应研究

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区域金融研究 2023年第10期 37-46页

作者：司颖华文清兰州财经大学统计学院甘肃兰州730020

文章构建中国动态金融状况指数(FCI),并建立MS-AR模型分析中国动态金融状况指数的区制特征,采用包含随机波动的时变参数的向量自回归(TVP-SV-VAR)模型,实证研究美国货币政策对中国金融市场的动态传导效应。研究结果表明,美国货币政策调... 详细信息

文章构建中国动态金融状况指数(FCI),并建立MS-AR模型分析中国动态金融状况指数的区制特征,采用包含随机波动的时变参数的向量自回归(TVP-SV-VAR)模型,实证研究美国货币政策对中国金融市场的动态传导效应。研究结果表明,美国货币政策调整对中国金融市场短期内存在显著影响,在不同金融区制和不同政策类型下,美国货币政策对中国金融市场产生的影响存在异质性。在此基础上,文章提出加强相关信息披露、积极参与国际贸易合作等对策建议,以维护中国金融市场的稳定和可持续发展。

关键词：金融状况指数美国货币政策溢出效应 TVP-SV-VAR模型 MS-AR模型

PHENOTYPIC CHARACTERISTICS OF HuMAN bLOOD MONOCYTE SubPOPuLATIONS IN PSORIAsiS AND ATOPIC DERMATITIS: EVIDENCE FOR DIFFERENTIAL EXPRESsiON OF SuRFACE MOLECuLES

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Chinese Medical Journal 1995年第3期 80-80页

作者： M Zheng u Mrowietz E Christophers Department oj' Dermatology University of Kiel D-24105 KielDepartment oj' Dermatology University of Kiel D-24105 KielDepartment oj' Dermatology University of Kiel D-24105 Kiel

Peripheral blood monocytes seem to be of importance for the initiation and maintenance of the psoriatic tissue reaction. Hyperproliferation of monocytopoiesis as well as functional abnormalities of monocytes in psotiasis have previously been described. We sought to determine whether peripheral blood monocyte subpopulations from patients with psoriasis show altered phentypes. and how the altered

关键词： HLA DR ICAM EVIDENCE FOR DIFFERENTIAL EXPRESsiON OF SuRFACE MOLECuLES PHENOTYPIC CHARACTERISTICS OF HuMAN bLOOD MONOCYTE SubPOPuLATIONS IN PSORIAsiS AND ATOPIC DERMATITIS INF ZR

Identification and Characterization of Hepatitis b Virus Immune Escape Mutants in Kenya

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American Journal of Molecular biology 2023年第1期13卷 1-17页

作者： Rhoda Elizabeth King James Kimotho Rosaline Macharia Faith Njoki Ndung’u Samson Muuo Nzou Robinson Mugasiali Irekwa Department of Molecular biology and biotechnology Institute for Basic Sciences Technology and Innovation Pan African University Nairobi Kenya Department of Innovation Technology and Transfer Kenya Medical Research Institute Nairobi Kenya Department of biochemistry University of Nairobi Nairobi Kenya Department for Microbiology Research Kenya Medical Research Institute Nairobi Kenya

Hepatitis b Virus (HbV) infections affect ab.ut 400 million people globally and cause ab.ut 1.4 million deaths annually. The virus displays high levels of genetic variations/mutations, some of which are immune escape mutants. The prevalence of HbV infection in Kenya is high at ab.ut 8%. This study aimed at identifying and characterizing HbV immune escape mutants in Kenya. From 547 HbV sequences available in Kenya in NCbI, and HbVdb databases in July 2021, 120 full sequences were retrieved. The S gene sequences at position 1-225, which included the “a” determinant region of the gene were analyzed using various bioinformatics tools such as bioedit software, and Emboss Cons. The clinical significance was flagged from the search of peer-reviewed journals. Forty-six HbV-positive blood donor samples were obtained from the Kenya National blood Transfusion Services without personal identifiers, DNA extracted, and sequenced targeting positions 1 to 520 of S genes. Mutations were similarly identified from seventeen sequences after cleaning and analysis. Out of 120 sequences that were extracted from databases and analyzed, 79 different mutations were identified. Fifteen of them were of clinical importance with an occurrence frequency of at least 5% were obtained. The majority (64.6%, n = 51), with S207N and A194V being most dominant, could result in immune escape and reduced HbsAg detection signals while 24.1% (n = 19) could result in immune escape/reduced HbsAg detection signals and high probability of hepatocellular carcinoma. Most likely to occur on the amino acids Alanine, Lysine, Serine, Asparagine, and Valine in decreasing order. The most dominant genotype was found to be Genotype A (N = 10), while four sequences were Genotype D. In contrast to the in-silico studies, the sequences from HbV samples from blood donors did not demonstrate the presence of S207N and A194V mutations and all the genotypes were type A1. Only two (13.3%) samples showed the same mutations of sK122R

关键词： Hepatitis b Virus Mutations Hepatitis b Surface Antigen Gene Genotype

Anti-Lipidemic Effect of Combined Leaf Extracts of <i>Moringa oleifera</i>and <i>Peristrophe bicalyculata</i>in Alloxan-Induced Diabetic Rats

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Pharmacology & Pharmacy 2014年第4期5卷 340-348页

作者： I. A. Iwara G. O. Igile I. P. Ogar O. E. Mboso u. P. ujong E. u. Eyong P. E. Ebong Department of biochemistry Faculty of Basic Medical Sciences Cross River State University of Technology Calabar Nigeria Department of biochemistry Faculty of Basic Medical Sciences University of Calabar Calabar Nigeria

In this study, the anti-lipidemic effects of combined extracts of Moringa oleifera and Peristrophe bicalyculata in allxoan-induced diabetic rats were investigated. Fifty four (54) adult male albino Wistar rats weighing between 140-180 g were shared into 5 parallel groups consisting of diabetic (DC) and non-diabetic (NC) groups. Each group consisted of 6 rats. Groups 2-5 were made diabetic using alloxan (150 mg/kg b.w in distil H2O). Except for groups 1 and 2, animals were gavaged at doses of 500 mg/kg b.w for the single dose of extract and 250 mg/kg for the combine extract treatment. Insulin served as a standard drug and was administered at 5Iu/kg b.w. The control animal groups (NC, DC) received 0.2 ml of normal saline (placebo) for fourteen (14) consecutive days. Groups treated with extracts showed a significant (p sity lipoprotein (VLDL) and low density lipoprotein (LDL mg/dl) concentrations in all treated groups compared to the diabetic control group. No significant (p > 0.05) change was observed in HDL-C level in treated groups when compared to the normal control, diabetic control and insulin groups, suggesting a potential protection against cardiovascular diseases (CVDs) by these plants. No reduction in body weight was observed within the experimental period of 14 days. The results obtained in this study are in agreement with several other research results with these plants and claims by ethno-medical practitioners on the use of Moringa oleifera and Peristrophe bicalyculata in the treatment of hypertension and related CVDs.

关键词： Diabetes Anti-Lipidemia Cholesterol Moringa oleifera Peristrophe bicalyculata Hypertension

一种新型硅胶固载季鏻盐杀菌剂的制备和性能研究

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高校化学工程学报 2010年第4期24卷 657-662页

作者：金栋王璐吕效平林陵沈旋南京工业大学化学化工学院江苏南京210009

用γ-胺丙基-三乙氧基硅烷(KH550)和卤代烷基三苯基膦溴化物反应,制得硅胶固载季鏻盐杀菌剂。此反应是伯胺的双分子亲核取代反应(SN2反应),研究表明:KH550与溴代烷基三苯基膦溴化物摩尔比为2:1,无水乙醇为溶剂,在此条件下,首先用无水乙... 详细信息

用γ-胺丙基-三乙氧基硅烷(KH550)和卤代烷基三苯基膦溴化物反应,制得硅胶固载季鏻盐杀菌剂。此反应是伯胺的双分子亲核取代反应(SN2反应),研究表明:KH550与溴代烷基三苯基膦溴化物摩尔比为2:1,无水乙醇为溶剂,在此条件下,首先用无水乙醇溶解溴代烷基三苯基膦溴化物,再逐滴加入,产物的产率较高。生产的季鏻化硅烷偶联剂的结构组成通过红外光谱和核磁共振手段进行表征,验证了各步反应的进行并确认其结构。杀菌性测试表明杀菌剂用量为10mg·mL-1时,40min后对异养菌的杀菌率可达100%,重复杀菌4次后杀菌性能减到75%左右,再生后杀菌性能可恢复到96%以上。

关键词：季鏻盐杀菌剂硅胶固载杀菌性能

环保型水切割胶粉对天然橡胶力学性能和动态性能的影响

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复合材料学报 2018年第3期35卷 706-713页

作者：卢娜王洪振辛振祥青岛科技大学高分子科学与工程学院橡塑材料与工程教育部重点实验室青岛266042

采用环保型水切割胶粉及力化学改性胶粉(MRP)与天然橡胶(NR)复合制备胶粉-NR复合胶,并探讨了胶粉用量对复合胶力学性能和动态性能的影响。通过红外和热失重分析确定了胶粉的主要成分为NR和丁苯橡胶(SbR),且改性后胶粉大分子链结构未发... 详细信息

采用环保型水切割胶粉及力化学改性胶粉(MRP)与天然橡胶(NR)复合制备胶粉-NR复合胶,并探讨了胶粉用量对复合胶力学性能和动态性能的影响。通过红外和热失重分析确定了胶粉的主要成分为NR和丁苯橡胶(SbR),且改性后胶粉大分子链结构未发生明显变化。通过橡胶加工分析仪研究了胶粉用量及改性对复合胶加工性能的影响。采用炭黑分散仪研究并观察了胶粉在NR中的分散情况。结果表明,胶粉改性后与NR的相容性提高,二者界面结合力增大,MRP-NR复合胶加工性能改善。炭黑分散结果表明,胶粉用量越多,其分散性越差,改性后胶粉的分散性提高,MRP-NR复合胶的力学性能最优,拉伸强度为27.9 MPa。

关键词：环保型水切割胶粉天然橡胶橡胶加工性能分散性拉伸强度

体外扩增小鼠造血干/祖细胞及重建造血功能的研究

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中华血液学杂志 2003年第11期24卷 584-588页

作者：王金福邱丽燕 Jenny Harrintong Ian K McNiece 浙江大学生命科学学院 310012 bMT Lab University of Colorado Health Science Center

目的　探讨体内中性粒细胞的快速植入及长期重建造血的能力。方法　分离经氟尿嘧啶处理的雄性bDF1小鼠骨髓单个核细胞 ,以MoFlo细胞分选系统分离纯化CD3 4 + /c kit+ 造血干 /祖细胞 ,体外应用骨髓间充质干细胞共培养和阶段扩增结合的... 详细信息

目的　探讨体内中性粒细胞的快速植入及长期重建造血的能力。方法　分离经氟尿嘧啶处理的雄性bDF1小鼠骨髓单个核细胞 ,以MoFlo细胞分选系统分离纯化CD3 4 + /c kit+ 造血干 /祖细胞 ,体外应用骨髓间充质干细胞共培养和阶段扩增结合的方法分别对分离的单个核细胞和CD3 4 + /c kit+ 细胞进行体外扩增 ,并将扩增的有核细胞移植给经亚致死剂量照射的雌性小鼠。结果　以骨髓间充质干细胞为培养基质细胞 ,结合分阶段扩增方法 ,有效提高了各种细胞的扩增倍数 ,其中单个核细胞扩增的总有核细胞、CD3 4 + 细胞、GM CFC和HPP CFC扩增倍数分别为 10 .8,4 .8,6 5 .9和 38 8,CD3 4 + /c kit+ 细胞扩增的以上 4种细胞扩增倍数分别为 76 .1,2 .9,71.7和 5 1.8;扩增细胞移植后可快速产生体内中性粒细胞的植入 ,并在 2个月后的移植小鼠中仍可检测到移植的造血细胞。结论　与骨髓间充质干细胞的共培养 ,为造血干 /祖细胞的有效扩增提供了良好的环境 ,分阶段扩增法加快了体外造血干 /祖细胞的扩增和成熟 ,为移植后体内中性粒细胞的快速植入创造了条件。

关键词：体外扩增小鼠造血干细胞造血功能研究造血祖细胞造血干细胞移植

SEDIMENT TRANSPORT AND STREAM POWER

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International Journal of Sediment Research 2002年第1期17卷 31-38页

作者： Chih Ted YANG1 1 Manager, Sedimentation and River Hydraulics Group. Technical Service Center, u.S. bureau of Reclamation. P.O. box 25007, D-8540, Denver, CO 80225, u.S.A. Manager Sedimentation and River Hydraulics Group. Technical Service Center U.S. Bureau of Reclamation.P.O. Box 25007 D-8540 Denver CO 80225 U.S.A.

This paper provides a step-by-step derivation of the sediment transport functions by Engelund and Hansen (1967) and by Ackers and White (1973). The theoretical derivations demonstrate that these two functions are clos... 详细信息

关键词： Sediment transport Stream power unit stream power

诱导扩增脐血单个核细胞为T/NK细胞的实验研究

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中华血液学杂志 2003年第11期24卷 576-579页

作者：陈戈煜黄绍良周敦华吴燕峰魏菁陈琴中山大学附属第二医院

目的　探索体外诱导脐血单个核细胞 (MNC)扩增分化为T/NK细胞的最佳培养体系。方法　脐血MNC在 6种培养体系中培养 4周 ,于各时间点用流式细胞仪测定细胞表面T/NK标志抗原的表达 ;测定有核细胞 (NC)数 ;并行细胞形态学鉴定及细胞毒功能... 详细信息

目的　探索体外诱导脐血单个核细胞 (MNC)扩增分化为T/NK细胞的最佳培养体系。方法　脐血MNC在 6种培养体系中培养 4周 ,于各时间点用流式细胞仪测定细胞表面T/NK标志抗原的表达 ;测定有核细胞 (NC)数 ;并行细胞形态学鉴定及细胞毒功能实验。结果　脐血MNC在SCF +FLT 3L +IL 7+IL 15 +TNF α +IL 2体系中培养 ,第 2 2天NC数达 (2 0～ 2 6 )× 10 6/ml;淋巴细胞占NC的比例和CD3 + T细胞占淋巴细胞的比例均达到 90 %以上 ,以CD8+ T细胞亚群为主 ,CD4+ T细胞亚群比例下降 ;CD56+ CD3 + NKT细胞和TCRγδ+ 细胞的比例分别由不足 2 %升高到 30 %～ 4 0 %和 10 %～ 15 %。CD3 -CD56+ NK细胞无扩增。培养后细胞在效靶比为 5 0∶1时对K5 6 2细胞和Raji细胞的杀伤率分别达75 %以上和 32 %～ 6 5 %。结论　本实验中体外诱导脐血MNC扩增分化为T/NK细胞的最佳培养体系为SCF +FLT 3L +IL 7+IL 15 +TNF α+IL 2 ,最佳扩增时间是培养后第 2 2天。

关键词：诱导扩增脐血单个核细胞实验研究天然杀伤细胞