Anti-Lipidemic Effect of Combined Leaf Extracts of <i>Moringa oleifera</i>and <i>Peristrophe bicalyculata</i>in Alloxan-Induced Diabetic Rats

作     者：I. A. Iwara G. O. Igile I. P. Ogar O. E. Mboso U. P. Ujong E. U. Eyong P. E. Ebong 

作者机构：Department of Biochemistry Faculty of Basic Medical Sciences Cross River State University of Technology Calabar Nigeria Department of Biochemistry Faculty of Basic Medical Sciences University of Calabar Calabar Nigeria 

出 版 物：《Pharmacology & Pharmacy》 (药理与制药（英文）)

年 卷 期：2014年第5卷第4期

页      面：340-348页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Diabetes Anti-Lipidemia Cholesterol Moringa oleifera Peristrophe bicalyculata Hypertension 

摘      要：In this study, the anti-lipidemic effects of combined extracts of Moringa oleifera and Peristrophe bicalyculata in allxoan-induced diabetic rats were investigated. Fifty four (54) adult male albino Wistar rats weighing between 140-180 g were shared into 5 parallel groups consisting of diabetic (DC) and non-diabetic (NC) groups. Each group consisted of 6 rats. Groups 2-5 were made diabetic using alloxan (150 mg/kg b.w in distil H2O). Except for groups 1 and 2, animals were gavaged at doses of 500 mg/kg b.w for the single dose of extract and 250 mg/kg for the combine extract treatment. Insulin served as a standard drug and was administered at 5IU/kg b.w. The control animal groups (NC, DC) received 0.2 ml of normal saline (placebo) for fourteen (14) consecutive days. Groups treated with extracts showed a significant (p 0.05) change was observed in HDL-C level in treated groups when compared to the normal control, diabetic control and insulin groups, suggesting a potential protection against cardiovascular diseases (CVDs) by these plants. No reduction in body weight was observed within the experimental period of 14 days. The results obtained in this study are in agreement with several other research results with these plants and claims by ethno-medical practitioners on the use of Moringa oleifera and Peristrophe bicalyculata in the treatment of hypertension and related CVDs.