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Anti-trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei-infected rats

Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 523-531页

作者： Abdulazeez Mansurah Abimbola Ibrahim Abdulrazak Baba Edibo Zakari Yenusa Sidali Joseph Omanibe Idris Habeeb Oladimeji Department of Biochemistry Faculty of Sciences Ahmadu Bello UniversityZaria Kaduna State Nigeria Embrapa Recursos Genética e Biotecnologia Laboratório de Transferência e Expresso de GenesPqEB W5 Asa Norte Brasilia-DF Brazil

Objective:To investigate thein vitroandin vivoeffect of whole plant extracts ofPeristrophe bicalyculataonTrypanosoma brucei brucei-infected ***:The experiment wasdivided into two phases:In the first phase,the anti-trypanosomal activity of the hot water,cold water,methanol and butanol extracts of the whole plant were determined by incubatingwithTrypanosoma brucei *** cold water extract was partially-purified and the anti-trypanosomal activity of the fractions *** the second phase,Trypanosoma brucei brucei-infected rats were treated with fraction 2c for nine *** cell volume(PCV),highdensity lipoprotein(HDL),low density lipoprotein(LDL),total cholesterol(TC),triacylglycerol(TAG),aspartate aminotransferase,alanine aminotransferases(ALT),alkaline phosphatase(ALP),total and direct bilirubin levels were determined at the end of the ***:Cold water extract immobilized 90%of the parasites after 60 min of incubation,and fraction 2ccompletely immobilized the parasites after 35 *** significantly increased PCV inTrypanosoma brucei brucei-infected *** TC,TAG,HDL and LDL levels of infected rats increasedsignificantly when rats were treated with the fraction,while elevated levels of total bilirubinand ALT also *** difference in urea,direct bilirubin and ALP was not significantwhen infected rats were compared to rats in other ***:The ability of the plantto ameliorate the infection-induced biochemical changes calls for detailed investigation of thepotentials of the plant for antitrypanosomiasis drug delivery.

关键词： Anti-trypanosomal activity Trypanosoma brucei brucei Peristrophe bicalyculata Lipoproteins

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Anti-Lipidemic Effect of Combined Leaf Extracts of <i>Moringa oleifera</i>and <i>Peristrophe bicalyculata</i>in Alloxan-Induced Diabetic Rats

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Pharmacology & Pharmacy 2014年第4期5卷 340-348页

作者： I. A. Iwara G. O. Igile I. P. Ogar O. E. Mboso U. P. Ujong E. U. Eyong P. E. Ebong Department of Biochemistry Faculty of Basic Medical Sciences Cross River State University of Technology Calabar Nigeria Department of Biochemistry Faculty of Basic Medical Sciences University of Calabar Calabar Nigeria

In this study, the anti-lipidemic effects of combined extracts of Moringa oleifera and Peristrophe bicalyculata in allxoan-induced diabetic rats were investigated. Fifty four (54) adult male albino Wistar rats weighing between 140-180 g were shared into 5 parallel groups consisting of diabetic (DC) and non-diabetic (NC) groups. Each group consisted of 6 rats. Groups 2-5 were made diabetic using alloxan (150 mg/kg b.w in distil H2O). Except for groups 1 and 2, animals were gavaged at doses of 500 mg/kg b.w for the single dose of extract and 250 mg/kg for the combine extract treatment. Insulin served as a standard drug and was administered at 5IU/kg b.w. The control animal groups (NC, DC) received 0.2 ml of normal saline (placebo) for fourteen (14) consecutive days. Groups treated with extracts showed a significant (p 0.05) change was observed in HDL-C level in treated groups when compared to the normal control, diabetic control and insulin groups, suggesting a potential protection against cardiovascular diseases (CVDs) by these plants. No reduction in body weight was observed within the experimental period of 14 days. The results obtained in this study are in agreement with several other research results with these plants and claims by ethno-medical practitioners on the use of Moringa oleifera and Peristrophe bicalyculata in the treatment of hypertension and related CVDs.

关键词： Diabetes Anti-Lipidemia Cholesterol Moringa oleifera Peristrophe bicalyculata Hypertension

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