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Virologica Sinica 2022年第5期37卷 769-773页

作者： Kaw Bing Chua Qimei ng tao Meng Qiang Jia Temasek Life Sciences Laboratory 1 Research LinkNational University of Singapore117604Singapore

Dear Editor,Coxsackievirus A16(CA16)and enterovirus A71(EV-A71)are the main causative agents of hand foot and mouth disease(HFMD)(Alexander et al.,1994).Besides HFMD,EV-A71 infection in young children can lead to a spectrum of other clinical diseases and associated neurological complications and mortality(Melnick JL.,1996).In recent decades,EV-A71 infections have become a major public health concern throughout the world,following the frequent occurrence of epidemics and outbreaks of HFMD associated with neurological complications and high mortality in young children(Ishimaru et al.,1980;Tagaya et al.,1981;Chomnaitree et al.,1982;Samuda et al.,1987;Gilbert et al.,1988;Hayward et al.,1989;Lum et al.,1998;Chang et al.,1998;Liu et al.,2000;Yang et al.,2011;Zeng et al.,2012).

关键词： mortality enterovirus

Genome Alignment Spanning Major Poaceae Lineages Reveals Heterogeneous Evolutionary Rates and Alters Inferred Dates for KeyEvolutionary Events

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Molecular Plant 2015年第6期8卷 885-898页

作者： Xiyin Wa ng Jingpeng Wang Dianchuan Jin Hui Guo Tae-Ho Lee tao Liu Andrew H. Paterson Plant Genome Mapping Laboratory University of Athens GA 30602 USA Center for Genomics and Computational Biology North China University of Science and Technology Tangshan Hebei 063000 China College of Life Sciences North China University of Science and Technology Tangshan Hebei 063000 China College of Sciences North China University of Science and Technology Tangshan Hebei 063000 China Department of Plant Biology University of Georgia Athens GA 30602 USA Department of Crop and Soil Science University of Georgia Athens GA 30602 USA Department of Genetics University of Georgia Athens GA 30602 USA

Multiple comparisons among genomes can clarify their evolution, speciation, and functional innova- tions. To date, the genome sequences of eight grasses representing the most economically important Poaceae （grass） clades have been published, and their genomic-level comparison is an essential foundation for evolutionary, functional, and translational research. Using a formal and conservative approach, we aligned these genomes. Direct comparison of paralogous gene pairs all duplicated simultaneously reveal striking variation in evolutionary rates among whole genomes, with nucleotide substitution slowest in rice and up to 48% faster in other grasses, adding a new dimension to the value of rice as a grass model. We reconstructed ancestral genome contents for major evolutionary nodes, potentially contributing to understanding the divergence and speciation of grasses. Recent fossil evidence suggests revisions of the estimated dates of key evolutionary events, implying that the pan-grass polyploidization occurred ~96 million years ago and could not be related to the Creta- ceous-Tertiary mass extinction as previously inferred. Adjusted dating to reflect both updated fossil evidence and lineage-specific evolutionary rates suggested that maize subgenome divergence and maize-sorghum divergence were virtually simultaneous, a coincidence that would be explained if poly- ploidization directly contributed to speciation. This work lays a solid foundation for Poaceae transla- tional genomics.

关键词： grasses polyploidy genome alignment evolutionary rates whole-genome duplication

Long-term clinical outcomes of lipiodol marking using standard gastroscopy for image-guided radiotherapy of upper gastrointestinal cancers

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World Journal of Gastroenterology 2021年第42期27卷 7387-7401页

作者： Kim Hay Be Richard Khor Daryl Lim Joon Ben Starvaggi Michael Chao Sweet Ping ng Michael ng Leonardo Zorron Cheng tao Pu Marios Efthymiou Rhys Vaughan Sujievvan Chandran Department of Gastroenterology and Hepatology Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiation Oncology Austin HealthHeidelberg 3084VictoriaAustralia School of Cancer Medicine La Trobe UniversityMelbourne 3086VictoriaAustralia Medicine Dentistry and Health SciencesUniversity of MelbourneParkville 3010VictoriaAustralia Genesis Care East Melbourne 3002VictoriaAustralia

BACKGROUND Image-guided radiotherapy(IGRT)has significantly improved the precision in which radiotherapy is delivered in cancer ***,IGRT uses bony landmarks and key anatomical structures to locate the *** studies have demonstrated the feasibility of peri-tumor fiducials in enabling even more accurate delineation of target and normal *** use of gold coils as fiducials in gastrointestinal tumors has been extensively ***,placement requires expertise and specialized endoscopic ultrasound *** article reports the long-term outcomes of using a standard gastroscopy to inject liquid fiducials for the treatment of oesophageal and gastric tumors with *** To assess the long-term outcomes of liquid fiducial-guided IGRT in a cohort of oesophageal and gastric cancer *** A retrospective cohort study of consecutive adults with Oesophagogastric cancers referred for liquid fiducial placement before definitive/neo-adjuvant or palliative IGRT between 2013 and 2021 at a tertiary hospital in Melbourne,Australia was *** to four liquid fiducials were inserted per patient,each injection consisting of 0.2-0.5mL of a 1:1 mixture of iodized oil(Lipiodol;Aspen Pharmacare)and n-butyl 2-cyanoacrylate(Histoacryl®;***).A 23-gauge injector(Cook Medical)was used for the *** procedures were performed by or under the supervision of a *** fiducial-based IGRT(LF-IGRT)consisted of computer-assisted direct matching of the fiducial region on cone-beam computerised tomography at the time of *** received standard-IGRT(S-IGRT)if fiducial visibility was insufficient,consisting of bone match as a surrogate for tumor *** was delivered to 54Gy in 30 fractions for curative patients and up to 45Gy in 15 fractions for palliative *** 52 patients were referred for liquid fiducial placement within the study period.A total of 51 patients underwent liquid f

关键词： Image-guided radiotherapy Lipiodol Gastroscopy Gastric cancer Oesophageal cancer Fiducial

An Overview of the Expert Consensus on the Prevention and Treatment of Gaming Disorder in China(2019 Edition)

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Neuroscience Bulletin 2020年第7期36卷 825-828页

作者： Yu-tao Xiang Yu Jin Ling Zhang Lu Li Gabor S.Ungvari Chee H.ng Min Zhao Wei Hao Unit of Psychiatry Institute of Translational MedicineFaculty of Health SciencesUniversity of MacaoMacao 999078China Center for Cognition and Brain Sciences University of MacaoMacao 999078China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital&the Advanced Innovation Center for Human Brain ProtectionCapital Medical UniversitySchool of Mental HealthBeijing 100088China The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital) Guangzhou 510370China 不详

Gaming disorder has gained considerable attention worldwide,including in China[1],where epidemiological surveys have found that its prevalence is as high as 17%[2].The Bureau of Disease Control and Prevention run by the National Health and Health Commission in China recently released an expert consensus[2]that systematically describes the definition,clinical presentation,assess-assessment,diagnosis,treatment,rehabilitation,and related areas of gaming disorder.

关键词： gained Expert diagnosis

Flexible multifunctional platform based on piezoelectric acoustics for human–machine interaction and environmental perception

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Microsystems & Nanoengineering 2022年第5期8卷 91-103页

作者： Qian Zhang Yong Wang Dongsheng Li Jin Xie Ran tao Jingting Luo Xuewu Dai Hamdi Torun Qiang Wu Wai Pang ng Richard Binns YongQing Fu The State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University310027 HangzhouChina Faculty of Engineering and Environment University of NorthumbriaNewcastle upon Tyne NE18STUK Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake University310024 HangzhouChina Key Laboratory of Optoelectronic Devices and Systems of Education Ministry and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen University518060 ShenzhenChina

Flexible human–machine interfaces show broad prospects for next-generation flexible or wearable electronics compared with their currently available bulky and rigid ***,compared to their rigid counterparts,most reported flexible devices(e.g.,flexible loudspeakers and microphones)show inferior performance,mainly due to the nature of their ***,it is of great significance to improve their performance by developing and optimizing new materials,structures and design *** this paper,a flexible acoustic platform based on a zinc oxide(ZnO)thin film on an aluminum foil substrate is developed and optimized;this platform can be applied as a loudspeaker,a microphone,or an ambient sensor depending on the selection of its excitation *** used as a speaker,the proposed structure shows a high sound pressure level(SPL)of~90 dB(with a standard deviation of~3.6 dB),a low total harmonic distortion of~1.41%,and a uniform directivity(with a standard deviation of~4 dB).Its normalized SPL is higher than those of similar devices reported in the recent *** used as a microphone,the proposed device shows a precision of 98%for speech recognition,and the measured audio signals show a strong similarity to the original audio signals,demonstrating its equivalent performance compared to a rigid commercial *** a flexible sensor,this device shows a high temperature coefficient of frequency of−289 ppm/K and good performance for respiratory monitoring.

关键词： acoustics piezoelectric speakers

Misperceptions among patients with chronic hepatitis B in Singapore

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World Journal of Gastroenterology 2005年第32期11卷 5002-5005页

作者： Chun-tao Wai Belinda Mak Winnie Chua Mei-Hua Tan Seline ng Amelia Cheok Mee-Lian Wong Seng-Gee Lira Division of GastroenterologyNational University Hospital Singapore Department of Community Occupational andFamily Medicine National University of Singapore Singapore

AIM： To identify the misperceptions among CHB patients,as well as to determine the factors associated with ***： A telephone interview was conducted on 292 adult CHB patients, who earlier responded to an advertisement for free screening. The questionnaire included items about socio-demographic factors and a24-item quiz on knowledge of general aspects,transmission, and management of HBV ***： The mean knowledge score on HBV was 10.4/14. Common misperceptions included availability of treatment for HBV infection and early liver cancer, as well as on transmission. Having completed tertiary education was the only independent factor associated with a high knowledge score, after controlling other demographic ***： More educational efforts should be focused on patients＇ misperceptions and target the less educated HBV carriers.

关键词： Knowledge Hepatitis B virus Public health Education

Lifespan Risk Exposure Measurement Instrument： a Feasible and Effective Tool for Life Course Epidemiology Research

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Biomedical and Environmental Sciences 2017年第1期30卷 59-63页

作者： D1ng Li Jie LIU Rui Hong JI Xiao Kang YUAN Zhong Shang ZHAng tao XUE Fu Zhong Department of Biostatistics School of Public Health Shandong University Jinan 250012 Shandong China

Life course epidemiology should practically illustrate how risk exposures and their dynamic changes influence the occurrence,development and prognosis of chronic diseases from early life to the *** paper develops the ... 详细信息

关键词： practically illustrate instrument exposure intake prognosis epidemiology match retrospective cohort

Safety and efficacy of Kaffes intraductal self-expanding metal stents in the management of post-liver transplant anastomotic strictures

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World Journal of Transplantation 2024年第2期14卷 88-98页

作者： Chee Lim Jonathan ng Babak Sarraf Rhys Vaughan Marios Efthymiou Leonardo Zorron Cheng tao Pu Sujievvan Chandran Department of Gastroenterology and Hepatology Austin HealthMelbourne HeidelbergVIC 3084Australia Melbourne Medical School The University of MelbourneMelbourne ParkvilleVIC 3052Australia

BACKGROUND Endoscopic management is the first-line therapy for post-liver-transplant anas-tomotic *** the optimal duration of treatment with plastic stents has been reported to be 8-12 months,data on safety and duration for metal stents in this setting is *** to limited access to endoscopic retrograde cholan-giopancreatography(ERCP)during the coronavirus disease 2019 pandemic in our centre,there was a change in practice towards increased usage and length-of-stay of the Kaffes biliary intraductal self-expanding stent in patients with suitable *** was mainly due to the theoretical benefit of Kaffes stents allowing for longer indwelling periods compared to the traditional plastic *** Adult liver transplant recipients aged 18 years and above who underwent ERCP were retrospectively identified during a 10-year period through a database *** admissions post-Kaffes stent insertion were identified manually through electronic and scanned medical *** main outcome was the incidence of complications when stents were left indwelling for 3 months vs 6 *** efficacy was calculated via rates of stricture recurrence between patients that had stenting courses for≤120 d or>120 *** During the study period,a total of 66 ERCPs with Kaffes insertion were performed in 54 patients throughout their stenting *** 33 ERCPs,the stent was removed or exchanged on a 3-month *** pancreatitis,perfor-ations or deaths *** post-ERCP complications were similar between the 3-month(abdominal pain and intraductal migration)and 6-month(abdominal pain,septic shower and embedded stent)groups-6.1%vs 9.1%respectively,P=*** strictures resolved at the end of the stenting course,but the stenting course was variable from 3 to 22 *** recurrence rate for stenting courses lasting for up to 120 d was 71.4%and 21.4%for stenting courses of 121 d or over(P=0.03).There were 28 patients that were treated with a sin

关键词： Liver transplantation Cholangiopancreatography Endoscopic retrograde Constriction Pathologic Self expandable metallic stents Bile duct diseases Cholestasis

Chemical constituents and pharmacological effects of durian shells in ASEAN countries:A review

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Chinese Herbal Medicines 2021年第4期13卷 461-471页

作者： Yuan-fei Zhan Xiao-tao Hou Li-li Fan Zheng-cai Du Soo Ee Ch'ng Siok Meng ng Khamphanh Thepkaysone Er-wei Hao Jia-gang Deng Faculty of Pharmacy Guangxi University of Chinese MedicineNanning 530200China Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Guangxi University of Chinese MedicineNanning 530001China Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues Guangxi University of Chinese MedicineNanning 530200China China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research Guangxi University of Chinese MedicineNanning 530200China Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases Guangxi University of Chinese MedicineNanning530001China CAIQ Test Innovation(Malaysia)Service Center Selangor 40150Malaysia Bio-Axis Healthcare Limited Hong Kong 999077China Institute of Traditional Medicine VientianeLao PDR

Durio zibethnus is mainly distributed in Southeast *** Chinese medicine believes that durian shells have the effects of clearing heat and purging fire,nourishing yin and moisturizing ***,it is often used as a pharmaceutic food in the Chinese folk to assist treating *** present,the chemical constituents isolated from durian shell include phenolic acids,phenolic glycosides,flavonoids,coumarins,triterpenes,simple glycosides and other *** pharmacological studies show that durian shell has many pharmacological activities,such as antioxidant,antiinflammatory,regulation of glucose and lipid *** chemical composition and pharmacological effects of durian shells are summarized in order to provide references for the further research and application of durian shell.

关键词： agricultural residues chemical constituents durian shell Durio zibethnus Murr. pharmacological effects

Microbleeds in fronto-subcortical circuits are predictive of dementia conversion in patients with vascular cognitive impairment but no dementia

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Neural Regeneration Research 2018年第11期13卷 1913-1918页

作者： Yang-Kun Chen Wei-Min Xiao Wei Li Zhuo-Xin Ni Yong-Lin Liu Li Xu Jian-Feng Qu Chee H.ng Yu-tao Xiang Department of Neurology Dongguan People’s Hospital(Affiliated Dongguan HospitalSouth Medical University) Faculty of Neurology Guangdong Medical University Department of Psychiatry University of Melbourne Faculty of Health Sciences University of Macao

Cerebral small vessel disease（CSVD） is a common etiology of vascular cognitive impairment with no dementia（V-CIND）. Studies have revealed that cerebral microbleeds（CMBs）, a feature of CSVD, contribute to cognitive impairment. However, the association between CMBs and dementia conversion in individuals with V-CIND is still unclear. Here, we analyzed the predictive role of CMBs in the conversion from V-CIND to dementia in CSVD patients. We recruited and prospectively assessed 85 patients with CSVD and V-CIND. V-CIND was evaluated using a series of comprehensive neuropsychological scales, including the Chinese version of the Montreal Cognitive Assessment and the Clinical Dementia Rating. MRI assessments were used to quantify lacunar infarcts, white matter hyperintensities, CMBs, and medial temporal lobe atrophy. Eighty-two of the 85 patients completed the assessment for dementia conversion at a 1-year follow-up assessment. Multivariate logistic regression analyses were conducted to examine independent clinical and MRI variables associated with dementia conversion. Twenty-four patients（29.3%） had converted to dementia at the 1-year follow-up, and these individuals had significantly more CMBs in the fronto-subcortical circuits. Multivariate logistic regression analyses revealed that the patients with CMBs in the fronto-subcortical circuits（odds ratio = 4.4; 95% confidence interval： 1.602-12.081, P = 0.004） and 5 or more CMBs overall（odds ratio = 17.6, 95% confidence interval： 3.23-95.84, P = 0.001） had a significantly increased risk of dementia at the 1-year follow-up. These findings indicate that CMBs in the fronto-subcortical circuits may be predictive of dementia conversion in CSVD patients with V-CIND, and thus extend the clinical significance of CMBs.

关键词： cerebrovascular disease stroke cerebral microbleeds cognitive impairment fronto-subcortical circuits small vessel disease whitematter hyperintensities lacunar infarct magnetic resonance imaging subcortical ischemic vascular disease