Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16

作     者：Kaw Bing Chua Qimei Ng Tao Meng Qiang Jia Kaw Bing Chua;Qimei Ng;Tao Meng;Qiang Jia

作者机构：Temasek Life Sciences Laboratory1 Research LinkNational University of Singapore117604Singapore 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2022年第37卷第5期

页      面：769-773页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：funded by the Temasek Lifesciences Laboratory core funding 

主　　题：mortality enterovirus 

摘      要：Dear Editor,Coxsackievirus A16(CA16)and enterovirus A71(EV-A71)are the main causative agents of hand foot and mouth disease(HFMD)(Alexander et al.,1994).Besides HFMD,EV-A71 infection in young children can lead to a spectrum of other clinical diseases and associated neurological complications and mortality(Melnick JL.,1996).In recent decades,EV-A71 infections have become a major public health concern throughout the world,following the frequent occurrence of epidemics and outbreaks of HFMD associated with neurological complications and high mortality in young children(Ishimaru et al.,1980;Tagaya et al.,1981;Chomnaitree et al.,1982;Samuda et al.,1987;Gilbert et al.,1988;Hayward et al.,1989;Lum et al.,1998;Chang et al.,1998;Liu et al.,2000;Yang et al.,2011;Zeng et al.,2012).