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Open Journal of Radiology 2014年第1期4卷 123-129页

作者： Yoshiyuki ozawa Masaki Hara Maho Kato Shigeki Shimizu Yuta Shibamoto Departments of Clinical Pathology Nagoya City University Graduate School of Medical Sciences Nagoya Japan Departments of Radiology Nagoya City University Graduate School of Medical Sciences Nagoya Japan

Purpose: Relationship between CT or MR images and histological findings, especially vascularity, has not been adequately evaluated. The purpose of this study was to investigate correlation between contrast enhancement on CT and MRI and histological findings in posterior mediastinal ganglioneuromas. Materials and Methods: Contrast-enhanced (CE) CT (n = 11) and CE MRI (n = 5) of 12 patients with ganglioneuroma were reviewed. The attenuation, signal intensity, and dynamic enhancement pattern of the tumors were evaluated. The vascularity was histologically evaluated by the numbers of vessels. Results: Enhancement on CE-CT was none, mild, moderate, and high enhancement in 5 (45%), 2 (18%), 3 (27%), and 1 (9%) of the 11 lesions, respectively. Dynamic MRI showed mild, moderate and high enhancement in 3 (60%), 1 (20%) and 1 (20%) cases, respectively. The level of contrast enhancement correlated well only with the number of capillary vessels (r = 0.79, P = 0.0037). Conclusion: The posterior mediastinal ganglioneuromas sometimes show insufficient enhancement particularly on CE-CT. The level of enhancement might correlate with the amount of capillary vessels.

关键词： Ganglioneuroma Enhancement CT MRI Mediastinum

Postoperative Complications and Medium-term Follw-up of Laparoscopic-assisted Colectomy for Colorectal Cancer in a Personal Series

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Postoperative Complications and Medium-term Follw-up of Lapa...

Synthesis and Fluorescence Quantum Yield of Gd<sub>1-x</sub>Eu<sub>x</sub>OOH Crystals

第六次全国大肠癌会议暨中日韩大肠癌会议

作者： Fumio Konishi Hideo Nagai Akihito ozawa

＜正＞The intraoperative and postoperative complications of laparoscopic colectomy were analyzed in a consecutive personal series of 90 cases. The final histological diagnosis of these patients was adenoma of the colon in 8, carcinoma of the colon and rectum in 80, leiomyoma of the colon in 1 and Crohn’s disease in 1. The TNM staging of the carcinomas in our series was Tis in 7, T1 in 21, T2 in 12 and T3 in 30, T4 in 10 cases. Six of the 90 cases had to be converted to open surgery. The reasons for conversion were

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Journal of Materials Science and Chemical Engineering 2014年第3期2卷 23-29页

作者： Hiroaki Samata Daisuke Itakura shungo Imanaka Tadashi C. ozawa Graduate School of Maritime Sciences Kobe University Kobe Japan International Center for Materials Nanoarchitectonics National Institute for Materials Science Tsukuba Japan

Eu3+-doped gadolinium oxyhydroxide Gd1-xEuxOOH crystals were synthesized by the flux method. The X-ray diffraction data for the crystals were well refined assuming a monoclinic structure with the P21/m space group. Gd1-xEuxOOH (x ≤ 0.2) crystals showed strong red emission, and the highest fluorescence quantum yield (Φf) was 0.27, obtained for x = 0.10. Φf decreased rapidly as the Eu3+ content x increased above 0.2, owing to concentration quenching. Analysis with a percolation model indicated three-dimensional energy transfer between the Eu3+ ions.

关键词： Gadolinium Oxyhydroxide Fluorescence Quantum Yield Percolation Model

Occupational stress and its related factors among university teachers in Japan

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Health 2014年第5期6卷 299-305页

作者： Mika Kataoka Kazuhiro ozawa Masahito Tomotake Tetsuya Tanioka Beth King Christine E. Lynn College of Nursing Florida Atlantic University Boca Raton USA Department of Nursing Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan Gifu College of Nursing Gifu Japan

The purpose of this research was to investigate occupational stress and its related factors among university teachers in Japan. Questionnaire surveys were mailed to 924 university teachers in Japan with a response rate of 43.8%, N = 405. The General Health Questionnaire 28 (GHQ-28), Multidimensional Scale of Perceived Social Support (MSPSS), short Japanese version of brief Coping Orientation to Problems Experienced (COPE) and the Work Situation Questionnaires (WSQ) developed by the authors were administered to participants. Results indicated that university teachers had some mental health problems in relation to gender, professional position, conditions of taking paid leave, job satisfaction, job control, social support, and coping skills. These findings provide evidence that in order to improve the mental health of university, teachers need to take their paid leave freely. It is important to keep high their job satisfaction levels, job control levels, and social support. The results also indicated that the ineffective coping styles lead to poor mental health. In addition, the findings identified the necessity for support of female teachers and younger lecturers, who had a greater tendency toward poor mental health.

关键词： Occupational Stress Mental Health Japan University Teachers

A Case of Exfoliation of Oral Mucosal Epithelium in a Patient with Anti-Desmoglein 1 Antibody-Positive and Anti-Desmoglein 3 Equivocal Antibody

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Open Journal of Stomatology 2017年第6期7卷 299-304页

作者： Michiko ozawa Yoshinori Jinbu Hiromi Hayashi Tadahide Noguchi Yoshiyuki Mori Department of Dentistry Oral and Maxillofacial Surgery Jichi Medical University Tochigi Japan

Pemphigus is an autoimmune bullous disease observed with lesions in the skin and mucosa. Pemphigus is classified by antibodies against desmogleins, which is cadherin type intercellular adhesion factors involved in adhesion between epidermal cells. In this case, because erosion of the oral mucosa was the primary symptom, a relationship with membrane-dominant pemphigus vulgaris was strongly suspected. And in terms of histopathology, findings not conflicted with pemphigus vulgaris were observed, but given all these different findings, the results did not correspond with bullous pemphigoid in clinical findings, and with pemphigus foliaceus and pemphigus vulgaris in various testing results, leading us to believe this represented a very rare case. We started oral health care, and when application of steroid ointment to the entire surface of the mucosa was continued, symptoms disappeared within approximately 2 months. In this case, relapse has not yet occurred and periodic follow-up was continued.

关键词： Anti-Desmoglein 3 Antibodies Anti-Desmoglein 1 Antibodies Autoimmune Bullous Disease Oral Mucosa

woLiver Regeneration Effect of Oncostatin M Following Hepatectomy for the Rat Cirrhotic Liver Model

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Surgical Science 2012年第11期3卷 530-536页

作者： Naoki Togo Masaki Ueno Kazuhisa Uchiyama Satoru ozawa Hiroki Yamaue Second Department of Surgery School of Medicine Wakayama Medical University Wakayama Japan

Background/Aims: Liver resection represents the treatment of choice for hepatocellular carcinoma (HCC) arising in well-compensated cirrhosis. Gene expression of the multifunctional cytokine, Oncostatin M (OSM), stimulates liver regeneration and adenoviral vector expressing OSM (AdOSM) allows a persistent expression of the gene. The aim of this study is to evaluate the benefits of the preoperative injection of AdOSM to the remnant lobes to regenerate the liver. Methods: A 70% partial hepatectomy was performed in dimethylnitrosamine-administrated cirrhotic rats with a preoperative injection of AdOSM, adenoviral vector carrying β-galactosidase (AdLacZ), or phosphate-buffered saline (PBS). The morphologic, histologic, and biochemical changes in the remnant liver and survival rates were then assessed. Results: Portal injection with clamping the portal branches of the resected lobes for 5 min made it possible to effectively transduce the adenoviral vector into the remnant lobes. The ratio of the remnant liver weight/body weight (%) was 2.3 ± 0.5 in the AdOSM group, 1.1 ± 0.3 in the AdLacZ group (p < 0.001), and 1.6 ± 0.4 in the PBS group (p = 0.02). The fibrous ratio (%) was 21.3 ± 4.6 in the AdOSM group and 35.2 ± 4.5 in the AdLacZ group on day 4 after hepatectomy and fibrous status was significantly decreased in the AdOSM group (p = 0.02). Serum hyaluronic acid which is the indicator of liver fibrosis was 215 ± 141 ng/mL in the AdOSM group and 1963 ± 1225 ng/mL in the AdLacZ group (p = 0.03). Conclusions: The OSM gene therapy may increase the possibility of hepatectomy in a cirrhotic liver by improving fibrosis, hepatic function, and hepatocyte regeneration.

关键词： Oncostatin M Liver Regeneration Cirrhosis Anti-Fibrosis

^(17)C反应截面的测量及其密度分布分析

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原子核物理评论 2005年第1期22卷 17-19页

作者：吴翠娥 Yamaguchi Y ozawa A Tanihata I 叶沿林北京大学物理学院技术物理系 The Institute of Physical and Chemical Research(RIKEN) Saitama3510198Japan

在日本理化学研究所的放射性束流线上用透射法测量了能量为 79MeV/u的17C在 12C反应靶上的反应截面; 利用有限力程Glauber模型对17C的密度分布进行了分析. 同时拟合本实验结果及高能区的实验数据发现, 17C的中子密度分布中存在一个尾巴.... 详细信息

在日本理化学研究所的放射性束流线上用透射法测量了能量为 79MeV/u的17C在 12C反应靶上的反应截面; 利用有限力程Glauber模型对17C的密度分布进行了分析. 同时拟合本实验结果及高能区的实验数据发现, 17C的中子密度分布中存在一个尾巴. 基于芯核加单粒子密度分布的假设, 认为17C的价中子主要处于 1d5 /2轨道.

关键词：反应截面密度分布 Glauber模型单粒子放射性束流高能透射法中子密度实验结果拟合

Protein intake and risk of stroke

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中华物理医学与康复杂志 2017年第8期39卷 576-576页

作者： ozawa M Yoshida D Hata J

BACKGROUND AND OBJECTIVE As several epidemiological studies have demonstrated that higher protein intake may reduce the risk of stroke,this prospective,cohort study was designed to further explore this *** In 1988,a s... 详细信息

关键词：流行病医学研究发展现状蛋白质

Dataset for Beam Commissioning of the Vero4DRT System

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第1期5卷 70-77页

作者： Hideharu Miura Shuichi ozawa Shintaro Tsuda Masahiro Hayata Kiyoshi Yamada Yasushi Nagata Hiroshima High-Precision Radiotherapy Cancer Center Hiroshima Japan Department of Radiation Oncology Institute of Biomedical & Health Science Hiroshima University Hiroshima Japan

We present the results of measurements made using the Vero4DRT radiation therapy system, which is not yet widely used, to assist technicians in achieving reliable and safe radiotherapy to the patient. We measured percent depth dose, beam profile, and relative scatter factor under water and air conditions. The Vero4DRT system has a 150 × 150-mm fixed secondary collimator. Its multileaf collimator (MLC) design is a single-focus type, with 30 pairs of 5 mm thick leaves at the isocenter, and produces a maximum field size of 150 × 150 mm. Profile measurements were performed using a 0.016-cm3 ionization chamber (PTW31016 pinpoint chamber;PTW, Freiburg GmbH Germany). A brass build-up cap was used for measurements obtained in air conditions. We present a useful measurement dataset for users of the Vero4DRT system.

关键词： Vero4DRT Beam Characteristic Commissioning

Development of highly sensitive and rapid antigen detection assay for diagnosis of COVID-19 utilizing optical waveguide immunosensor

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Journal of Molecular Cell Biology 2021年第10期13卷 763-766页

作者： Rikako Funabashi Kei Miyakawa Yutaro Yamaoka Seiko Yoshimura Satoshi Yamane Sundararaj Stanleyraj Jeremiah Kohei Shimizu Hiroki ozawa Chiharu Kawakami Shuzo Usuku Nobuko Tanaka Etsuko Yamazaki Hirokazu Kimura Hideki Hasegawa Akihide Ryo Department of Microbiology Yokohama City University Graduate School of MedicineKanagawajapan Life Science Laboratory Technology and Development DivisionKanto Chemical Co.Inc.KanagawaJapan Primary Care Testing Solution Development Department Canon Medical Systems CorporationTochigiJapan Yokohama City Institute of Public Health KanagawaJapan Clinical Laboratory Department Yokohama City University HospitalKanagawaJapan Department of Health Science Gunma Paz University Graduate SchoolGunmajapan Center for Influenza and Respiratory Virus Research National Institute of Infectious DiseasesMusashimurayamaTokyoJapan

Ever since its outbreak,the COVID-19 pandemic caused by SARS-CoV-2 has been spreading rapidly causing a global health *** diagnosis and instituting appropriate intervention to relevant individuals are essential not only to slow down the spread of this pandemic but also to manage our resources *** date,testing for SARS-CoV-2 infection mostly relies on reverse transcription-quantitative polymerase chain reaction(RT-qPCR)on a nasopharyngeal or saliva specimen and remains the gold standard for diagnosis as it exhibits high sensitivity and specificity.

关键词： diagnosis specificity nasopharyngeal