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A new horizon for neuroscience:terahertz biotechnology in brain research

Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao Shi Ying zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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Consensus of multi-vehicle cooperative attack with stochastic multi-hop time-varying delay and actuator fault

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Journal of Systems Engineering and Electronics 2021年第1期32卷 228-242页

作者： cai Guangbin zhao Yushan zhao Yang HU Changhua College of Missile Engineering Rocket Force University of EngineeringXi’an 710025China School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China

A consensus-distributed fault-tolerant(CDFT)control law is proposed for a class of leader-following multi-vehicle cooperative attack(MVCA)systems in this *** particular,the switching communication topologies,stochastic multi-hop timevarying delays,and actuator faults are considered,which may lead to system performance degradation or on certain occasions even cause system ***,the estimator of actuator faults for the following vehicle is designed to identify the actuator faults under a fixed *** the CDFT control protocol and trajectory following error are derived by the relevant content of Lyapunov stability theory,the graph theory,and the matrix *** CDFT control protocol is proposed in the same manner,where a more realistic scenario is considered,in which the maximum trajectory following error and information on the switching topologies during the cooperative attack are ***,numerical simulation are carried out to indicate that the proposed distributed fault-tolerant(DFT)control law is effective.

关键词： leader-following multi-vehicle cooperative attack(MVCA) switching topology fault-tolerant control stochastic multi-hop time-varying delay stochastic actuator fault

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PI3K/AKT/mTOR signaling pathway inhibitors in proliferation of retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 675-680页

作者： Na cai shun-Dong Dai Ning-Ning Liu Li-Min Liu Ning zhao Lei Chen Department of Ophthalmology the First Affiliated Hospital of China Medical University Department of Pathology the First Affiliated Hospital and College of Basic Medical Sciences China Medical University Institutes of Pathology and Pathophysiology China Medical University

AIM: To determine whether the PI3K/AKT/mTOR pathway is activated in proliferative vitreoretinopathy (PVR) in homo-sapiens. METHODS: The retina of controls and patients with PVR were collected and their levels of PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP-1 were determined by Western blot. The cultured human retinal pigment epithelial cell line D407 was treated with a specific mTOR inhibitor, rapamycin (RAPA) or a PI3K inhibitor, LY294002, of various concentrations and durations. Cell morphology was observed by phase contrast microscopy and the proliferation and apoptosis of treated cells were determined by MTT assay and flow cytometry. RESULTS: Levels of PI3K, phospho-AKT, phospho-mTOR, phospho-P70S6K and phospho-4EBP1 was increased in the retina in PVR (P <0.05). In D407 cells, both RAPA and LY294002 significantly inhibited cell proliferation and cell cycle progression, and promoted apoptosis (P <0.05); morphologically, the cells became smaller. Both RAPA and LY294002 reduced levels of phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP1 expression (P <0.05). RAPA, but not LY294002, had no significant effect on PI3K expression. CONCLUSION: PI3K/AKT/mTOR signaling pathway is highly activated in the retinal pigment epithelial cells of PVR. The inhibitors of PI3K/AKT/mTOR signaling pathway, RAPA and LY294002, could inhibited the PI3K/AKT/mTOR signaling pathway by reducing the levels of phosphorylation of mTOR pathway components.

关键词： human retinal pigment epithelial cell proliferative vitreoretinopathy PI3K/AKT/mTOR signal pathway

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功能性胆汁酸生物合成及应用研究进展

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食品科学 2025年第1期46卷 255-265页

作者：郑苗常超苏琪蔡成岗逯与运赵敏洁蔡海莺浙江科技学院生物与化学工程学院浙江杭州310023 新加坡国立大学食品科学与工程系新加坡117542 浙江大学生物系统工程与食品科学学院浙江杭州310058 美欣达集团有限公司浙江湖州313002

胆汁酸(bile acid,BA)作为胆汁重要的两性固醇类物质,可通过与受体、肠道菌群的相互作用调节糖脂代谢及稳态、肠道微生态、肠道屏障、炎症、免疫系统和神经系统等生理功能,影响机体代谢和营养健康。本文综述主要新型功能性BA的合成通路... 详细信息

胆汁酸(bile acid,BA)作为胆汁重要的两性固醇类物质,可通过与受体、肠道菌群的相互作用调节糖脂代谢及稳态、肠道微生态、肠道屏障、炎症、免疫系统和神经系统等生理功能,影响机体代谢和营养健康。本文综述主要新型功能性BA的合成通路,系统总结主要功能性BA的功能活性、化学合成和生物转化研究进展。此外,归纳新型BA(异脱氧胆酸、异石胆酸、异别脱氧胆酸、异别石胆酸)功能性研究,以及新型BA生物转化酶的微生物来源、催化性质及其应用于BA合成的潜力。展望功能性BA在食品和医药等领域的应用潜力,为新型功能性BA的合成转化及综合应用提供一定参考。

关键词：胆汁酸功能性生物转化羟基类固醇脱氢酶应用

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Preparation and reaction mechanism of novel Ce_(x)Co_(y)Cuz oxide composite catalysts towards oxidation of o-xylene

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Journal of Rare Earths 2022年第10期40卷 1573-1583页

作者： Mengge zhao Weijian cai Jiwu Li School of Environmental Science and Engineering Zhejiang Gongshang UniversityHangzhou 310018China Department of Chemistry School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Ce_(x)Co_(y)Cuzoxide composite catalysts were prepared by using polyethylene glycol, citrate sol-gel method combined with PMMA template for the oxidation of o-xylene. The catalysts were characterized by the Xray diffraction(XRD), H2-temperature programmed reduction(H2-TPR), X-ray photoelectron spectroscopy(XPS) and Fourier transform infrared spectroscopy(FT-IR), etc. The catalytic activity for o-xylene was investigated. The catalytic degradation pathway and mechanism of o-xylene were inferred. The results show that Ce O_(2)is mainly present on the surface of all catalysts. The surface area of Ce_(2)Co1Cu1is up to 77.2 m^(2)/g, and the average pore size is 10.62 nm. It exhibits redox and sufficient Ce^(4+)and Ce^(^(3+)), and reactive oxygen species, and has maximum O-H and C=O in the five catalyst samples. The catalytic activity of Ce2Co1Cu1is the best at low temperature, with the T50and T90values of 235 and 258°C at a space velocity of 32000 h-1, respectively. The o-xylene is oxidized to o-methyl benzaldehyde, and then further oxidized to o-methylbenzoic acid, and finally CO_(2)and H2O are formed.

关键词： Ce_(x)Co_(y)Cuz composite oxide catalyst Polyethylene glycol Citrate sol-gel method Catalytic activity o-xylene Rare earths

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Energy Control of Plug-In Hybrid Electric Vehicles Using Model Predictive Control With Route Preview

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IEEE/CAA Journal of Automatica Sinica 2021年第12期8卷 1948-1955页

作者： Yang zhao Yanguang cai Qiwen Song Department of Mechanical and Electrical Engineering Guangdong University of Science and TechnologyDongguan 523083China School of Automation Guangdong University of TechnologyGuangzhou 510006China Transport Infrastructure Investment Company Guangzhou 510620China

The paper proposes an adoption of slope,elevation,speed and route distance preview to achieve optimal energymanagement of plug-in hybrid electric vehicles(PHEVs).Theapproach is to identify route features from historical and real-time traffic data,in which information fusion model and trafficprediction model are used to improve the information ***,dynamic programming combined with equivalent con-sumption minimization strategy is used to compute an optimalsolution for real-time energy *** solution is thereference for PHEV energy management control along the *** improve the system's ability of handling changing situation,the study further explores predictive control model in the real-time control of the energy.A simulation is performed to modelPHEV under above energy control strategy with route *** results show that the average fuel consumption of PHEValong the previewed route with model predictive control(MPC)strategy can be reduced compared with optimal strategy andbase control strategy.

关键词： Energy management model predictive control(MPC) optimal control plug-in hybrid electric vehicle(PHEV)

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Effect of Intake Air Humidification and EGR on Combustion and Emission Characteristics of Marine Diesel Engine at Advanced Injection Timing

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Journal of Thermal Science 2021年第4期30卷 1174-1186页

作者： WANG Ke zhao Changpu cai Yujie 300072

The trade-off between NO_(x)-soot and ISFC(Indicated Specific Fuel Consumption)brings new challenges for the development and application of innovative techniques that could reduce the NO_(x)-soot emissions of diesel engine simultaneously with the lowest possible fuel *** this study,the two coupling measures,advanced SOI(start of injection)respectively coupled with intake air humidification(IAH)and EGR,were used to achieve lower NO_(x)-soot emissions than the original engine while minimizing the increase in *** studies were conducted on a four-stroke supercharged intercooled marine diesel engine under 75%loads at 1350 r/min by using AVL Fire *** advanced SOI varied from 14.5°CA BTDC to 20°CA BTDC;humidity ratio ranged from 0 to 100%in increments of 20%,and EGR rate ranged from 0 to 25%in increments of 5%.The technical route to achieve Tier III emission standards was also analyzed in this *** result indicates that lower in-cylinder pressure,temperature and NO_(x)emissions,higher ISFC and soot emissions are observed when only IAH or EGR technology is applied,while opposite trends are found when only using advanced *** proper combination of different SOI respectively with humidity ratio and EGR rate can improve the trade-off relationship between NO_(x)and ***,the increase in ISFC is improved by using advanced SOI under high EGR rate or humidity *** with the advanced SOI coupled with EGR,advanced SOI coupled with IAH results in less loss of *** results reveal that both above-mentioned coupling measures can achieve low NO_(x)-soot emissions while ensuring that ISFC does not *** expected,there are nine combinations of advanced SOI coupled EGR that can achieve NO emissions to meet the Tier III standard,while advanced SOI coupled IAH has only one combination to meet this regulation.

关键词： intake air humidification EGR advanced SOI NO_(x)-soot emissions ISFC TierⅢ

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SSO Risk Evaluation for a Grid-connected PMSG-based Wind Farm Based on Sequential Monte Carlo Simulation

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CSEE Journal of Power and Energy Systems 2023年第4期9卷 1348-1358页

作者： shun Tao Yunbo Liu Yanan Yan Lei zhao the State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing102206China.

In a grid-connected wind farm based on permanent magnet synchronous generators(PMSGs),the wind speed and the number of operating PMSGs are the two most important influencing factors along with the stochastic nature of sub-synchronous oscillation(SSO)from the point view of the *** paper proposes a method of unstable SSO risk evaluation for grid-connected PMSG-based wind farms based on the sequential Monte Carlo simulation(SMCS).The determination of critical wind speed(CWS)of SSO and the sequential simulation strategy of wind speed states and PMSG states in a wind farm at the same wind speed(S-WF),as well as in a wind farm at different wind speeds(D-WF),are *** indices evaluating the expectation,duration,frequency and energy loss of SsO risk are ***,a strategy to reduce SsO risk by adjusting the cut-in wind speed is *** effectiveness of the discussed issues in this paper are proved by the case studies of a 750-PMSG wind farm based on the actual wind speed data collected.

关键词： PMSG-based wind farm subsynchronous oscillation(SSO) Sequential Monte Carlo simulation(SMCS) risk evaluation

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Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm

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Nuclear Science and Techniques 2023年第4期34卷 135-148页

作者： Zhi-Yang Yao Yong-shun Xiao Ji-Zhong zhao Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle&Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

Compton camera-based prompt gamma(PG) imaging has been proposed for range verification during proton therapy. However, a deviation between the PG and dose distributions, as well as the difference between the reconstructed PG and exact values, limit the effectiveness of the approach in accurate range monitoring during clinical applications. The aim of the study was to realize a PG-based dose reconstruction with a Compton camera, thereby further improving the prediction accuracy of in vivo range verification and providing a novel method for beam monitoring during proton therapy. In this paper, we present an approach based on a subset-driven origin ensemble with resolution recovery and a double evolutionary algorithm to reconstruct the dose depth profile(DDP) from the gamma events obtained by a cadmium-zinc-telluride Compton camera with limited position and energy resolution. Simulations of proton pencil beams with clinical particle rate irradiating phantoms made of different materials and the CT-based thoracic phantom were used to evaluate the feasibility of the proposed method. The results show that for the monoenergetic proton pencil beam irradiating homogeneous-material box phantom,the accuracy of the reconstructed DDP was within 0.3 mm for range prediction and within 5.2% for dose prediction. In particular, for 1.6-Gy irradiation in the therapy simulation of thoracic tumors, the range deviation of the reconstructed spreadout Bragg peak was within 0.8 mm, and the relative dose deviation in the peak area was less than 7% compared to the exact values. The results demonstrate the potential and feasibility of the proposed method in future Compton-based accurate dose reconstruction and range verification during proton therapy.

关键词： Prompt gamma imaging Dose reconstruction Range verification Origin ensemble Compton camera Evolutionary algorithm

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