Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm

作     者：Zhi-Yang Yao Yong-Shun Xiao Ji-Zhong Zhao Zhi-Yang Yao;Yong-Shun Xiao;Ji-Zhong Zhao

作者机构：Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Key Laboratory of Particle&Radiation Imaging(Tsinghua University)Ministry of EducationBeijing 100084China 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2023年第34卷第4期

页      面：135-148页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 1001[医学-基础医学(可授医学、理学学位)] 081104[工学-模式识别与智能系统] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 0835[工学-软件工程] 100106[医学-放射医学] 0811[工学-控制科学与工程] 0812[工学-计算机科学与技术（可授工学、理学学位）] 10[医学] 

基　　金：supported by Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation)(No.7191005) 

主　　题：Prompt gamma imaging Dose reconstruction Range verification Origin ensemble Compton camera Evolutionary algorithm 

摘      要：Compton camera-based prompt gamma(PG) imaging has been proposed for range verification during proton therapy. However, a deviation between the PG and dose distributions, as well as the difference between the reconstructed PG and exact values, limit the effectiveness of the approach in accurate range monitoring during clinical applications. The aim of the study was to realize a PG-based dose reconstruction with a Compton camera, thereby further improving the prediction accuracy of in vivo range verification and providing a novel method for beam monitoring during proton therapy. In this paper, we present an approach based on a subset-driven origin ensemble with resolution recovery and a double evolutionary algorithm to reconstruct the dose depth profile(DDP) from the gamma events obtained by a cadmium-zinc-telluride Compton camera with limited position and energy resolution. Simulations of proton pencil beams with clinical particle rate irradiating phantoms made of different materials and the CT-based thoracic phantom were used to evaluate the feasibility of the proposed method. The results show that for the monoenergetic proton pencil beam irradiating homogeneous-material box phantom,the accuracy of the reconstructed DDP was within 0.3 mm for range prediction and within 5.2% for dose prediction. In particular, for 1.6-Gy irradiation in the therapy simulation of thoracic tumors, the range deviation of the reconstructed spreadout Bragg peak was within 0.8 mm, and the relative dose deviation in the peak area was less than 7% compared to the exact values. The results demonstrate the potential and feasibility of the proposed method in future Compton-based accurate dose reconstruction and range verification during proton therapy.