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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih hung lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

Defective lysosomal acidification:a new prognostic marker and therapeutic target for neurodegenerative diseases

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Translational Neurodegeneration 2023年第1期12卷 500-510页

作者： Chih hung lo Jialiu Zeng Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s *** genetic factors have been linked to lysosomal de-acidification through impairing the vacuolar-type ATPase and ion channels on the organelle *** lysosomal abnormalities are also present in sporadic forms of neurodegeneration,although the underlying pathogenic mechanisms are unclear and remain to be ***,recent studies have revealed early occurrence of lysosomal acidification impairment before the onset of neurodegeneration and late-stage ***,there is a lack of methods for organelle pH monitoring in vivo and a dearth of lysosome-acidifying therapeutic ***,we summarize and present evidence for the notion of defective lysosomal acidification as an early indicator of neurodegeneration and urge the critical need for technological advancement in developing tools for lysosomal pH monitoring and detection both in vivo and for clinical *** further discuss current preclinical pharmacological agents that modulate lysosomal acidification,including small molecules and nanomedicine,and their potential clinical translation into lysosome-targeting *** timely detection of lysosomal dysfunction and development of therapeutics that restore lysosomal function represent paradigm shifts in targeting neurodegenerative diseases.

关键词： Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Lysosomal de-acidification Autophagy dysfunction Early detection Prognostic marker Small molecules Nanomedicine Nanoparticles

Study on the Tin Oxide Sol-Gel Membrane as a pH Sensing Electrode

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稀有金属材料与工程 2006年第A03期35卷 238-239页

作者： Chin-shuen hung Jung-Chuan Chou Tai-Ping Sun Shen-Kan Hsiung Institute of Electronic Engineering Chung Yuan Christian University Chung-Li Taiwan 320China Graduate School of Electronic Engineering National Yunlin University of Science and Technology Douliou Taiwan 640China Department of Electrical Engineering National Chi Nan University Nantou Taiwan 545 China

In this study,tin oxide sensing membrane was derived by sol-gel method and was coated onto indium tin oxide (ITO) glass substrate by spin-coating technique to fabricate a pH sensing ***,the morphology of the tin oxide membrane has been discussed through the instrumental ***,the sensing characteristics of the pH electrode was measured by commercial instrumental amplifier as the readout *** to the sol-gel method has many advantages such as easy fabrication of gel solution,ability to dope other materials without any expensive fabricating ***,it is suitable for the mass production of a disposable sensor.

关键词： tin oxide sensing membrane sol-gel method spin-coating technology pH sensing electrode

Ileocolonic mucormycosis in adult immunocompromised patients:A surgeon's perspective

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World Journal of Gastroenterology 2010年第9期16卷 1165-1170页

作者： Oswens Siu-hung lo Wai-Lun Law Division of Colorectal Surgery Department of SurgeryUniversity of Hong Kong Medical CentreQueen Mary Hospital

We report three cases of ileocolic mucormycosis in adult immunocompromised patients presenting as acute *** patients underwent laparotomy but two of them died from multiorgan failure before the diagnoses were *** diagnosis of gastrointestinal mucormycosis is rarely suspected,and antemortem diagnosis is made in only 25%-50% of *** cases illustrate the difficulty encountered by surgeons in managing acute abdomen in neutropenic patients with hematological *** management of colonic mucormycosis in the published literature is also reviewed.

关键词： Gastrointestinal mucormycosis Colon Immunocompromised Surgery

Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management:A case report

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World Journal of Clinical Cases 2021年第16期9卷 4081-4089页

作者： Frederick Chi-Wai Lui Oswens Siu-hung lo Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Glycogen storage disease(GSD)is an autosomal recessive inborn metabolic *** with GSD are prone to hypoglycaemia,hyperlactacidemia and *** type 1b(GSD-1b)patients specifically can develop neutropenia,recurrent bacterial infection and inflammatory bowel disease(IBD).Documentation of the long-term outcomes of surgical management of GSD-1b has been scarce,especially for Asian *** herein describe a case of GSD-1b complicated by IBD-like colitis and coloduodenal *** patient was managed successfully with surgical *** SUMMARY A 20-year-old Chinese lady confirmed by genetic testing to have GSD-1b was initially managed with uncooked cornstarch and granulocyte-colony stimulating *** recurrent abdominal symptoms,her condition was treated as clinical“Crohn’s disease”with mesalazine,prednisolone and azathioprine *** showed a tight stricture at the hepatic *** computerized tomographic colonography revealed a phlegmon at the ileocaecal region with a suspected coloduodenal *** an exploratory laparotomy was performed and severe colitis at the ascending colon with coloduodenal fistula was *** hemicolectomy with primary anastomosis and repair of the duodenum were *** management of complications from GSD-1b associated IBD-like colitis has rarely been ***-line treatment would usually be *** intervention like hemicolectomy is mainly reserved for refractory *** Surgical management of coloduodenal fistula in GSD-1b patients is a feasible and safe option when failed conservative management.

关键词： Glycogen storage disease Coloduodenal fistula Inflammatory bowel diseaselike colitis Case report Perioperative management

Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease

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Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asimakidou Richard Reynolds Anna M.Barron Chih hung lo Department of Clinical Neurosciences University of CambridgeCambridgeUK Department of Brain Sciences Faculty of MedicineImperial College LondonLondonUK Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression.

关键词： Alzheimer death tau Aβ

Integrative multi-omics and systems bioinformatics in translational neuroscience:A data mining perspective

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Journal of Pharmaceutical Analysis 2023年第8期13卷 836-850页

作者： Lance M.O'Connor Blake A.O'Connor Su Bin Lim Jialiu Zeng Chih hung lo College of Biological Sciences University of MinnesotaMinneapolisMN55455USA School of Pharmacy University of WisconsinMadisonWI53705USA Department of Biochemistry and Molecular Biology Ajou University School of MedicineSuwon16499South Korea Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore308232Singapore

Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed *** mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative ***,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain *** this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple *** then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics *** further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain ***,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease *** conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personaliz

关键词： Multi-omics integration Systems bioinformatics Data mining Human brain profile reconstruction Translational neuroscience

Cross-Frequency Coupling and Intelligent Neuromodulation

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Cyborg and Bionic Systems 2023年第1期4卷 284-297页

作者： Chien-hung Yeh Chuting Zhang Wenbin Shi Men-Tzung lo Gerd Tinkhauser Ashwini Oswal School of Information and Electronics Beijing Institute of TechnologyBeijingChina Department of Biomedical Sciences and Engineering National Central UniversityTaoyuanTaiwan Department of Neurology Bern University Hospital and University of BernBernSwitzerland MRC Brain Network Dynamics Unit University of OxfordOxfordUK

Cross-frequency coupling(CFC)reflects(nonlinear)interactions between signals of different *** from both patient and healthy participant studies suggests that CFC plays an essential role in neuronal computation,interregional interaction,and disease *** present review discusses methodological advances and challenges in the computation of CFC with particular emphasis on potential solutions to spurious coupling,inferring intrinsic rhythms in a targeted frequency band,and causal *** specifically focus on the literature exploring CFC in the context of cognition/memory tasks,sleep,and neurological disorders,such as Alzheimer's disease,epilepsy,and Parkinson's ***,we highlight the implication of CFC in the context and for the optimization of invasive and noninvasive neuromodulation and ***,CFC could support advancing the understanding of the neurophysiology of cognition and motor control,serve as a biomarker for disease symptoms,and leverage the optimization of therapeutic interventions,e.g.,closed-loop brain *** the evident advantages of CFC as an investigative and translational tool in neuroscience,further methodological improvements are required to facilitate practical and correct use in cyborg and bionic systems in the field.

关键词： epilepsy spite evident

Smart Dynamic Resource Allocation Model for Patient-Driven Mobile Medical Information System Using C4.5 Algorithm

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Journal of Electronic Science and Technology 2019年第3期17卷 231-241页

作者： Ching-Kan lo Hsing-Chung Chen Pei-Yuan Lee Ming-Chou Ku Lidia Ogiela Cheng-hung Chuang the Department of Orthopedics and the Department of Information Show-Chwan Health Care SystemChanghua 50008 the Department of Computer Science and Information Engineering and the Department of Bioinformatics and Medical Engineering Asia UniversityTaichung 41354 the Department of Orthopedics Show-Chwan Health Care SystemChanghua 50008 the Department of Applied Informatics Akademia Gorniczo-Hutnicza University of Science and TechnologyKrakow 30-059

A mobile medical information system (MMIS) is an integrated application (app) of traditional hospital information systems (HIS) which comprise a picture archiving and communications system (PACS), laboratory information system (LIS), pharmaceutical management information system (PMIS), radiology information system (RIS), and nursing information system (NIS). A dynamic resource allocation table is critical for optimizing the performance to the mobile system, including the doctors, nurses, or other relevant health workers. We have designed a smart dynamic resource allocation model by using the C4.5 algorithm and cumulative distribution for optimizing the weight of resource allocated for the five major attributes in a cooperation communications system. Weka is used in this study. The class of concept is the performance of the app, optimal or suboptimal. Three generations of optimization of the weight in accordance with the optimizing rate are shown.

关键词： Dynamic resource allocation electronic health record hospital information system mobile medical information system