TEMPERATURE RESPONSIVE METHACRYLAMIDE POLYMERS WITH ANTIBACTERIAL ACTIVITY

作     者：陈伯宽 Shuen-Hung Lo Shu-Feng Lee 

作者机构：Department of Polymer MaterialsKun Shan University 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2010年第28卷第4期

页      面：607-613页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：supported by the National Science Council of Taiwan(Grant NSC 96-2815-C-168-002-E) 

主　　题：Methacrvlamide: NIPAAm: Antibacterial: Temperature rest)onsive 

摘      要：A new methacrylamide monomer, hexylamine methacrylamide （MAHA）, was synthesized and used in polymerizations. The homopolymer of MAHA and its copolymers were synthesized by free radical polymerization techniques with N-isopropyl acrylamide （NIPAAm） in two different compositions. The quatemization of the homopolymer and copolymers were carried out using 1-bromopropane. The copolymers with NIPAAm and a low MAHA content showed temperature-responsive behavior in an aqueous environment. The lower critical solution temperatures （LCSTs） of these polymers varied between 32℃ and 44℃. The LCSTs of quatemized copolymers were higher than those of neutral copolymers because they were more hydrophilic. The obtained homopolymers and copolymers were tested for antibacterial activities against S. aureus and E. coli. The quatemized water-soluble copolymers showed antibacterial activities against S. aureus. The quaternization resulted in the synthesis of both antibacterial and temperature-responsive copolymers.