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干扰素治疗前后慢性乙型肝炎患者外周血单核细胞Toll样受体4水平的变化

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临床肝胆病杂志 2012年第11期28卷 828-830页

作者：阎双缓曹志宸石家庄市第五医院感染五科石家庄050021 河北医科大学第三医院中西医结合肝病科石家庄050051

目的探讨慢性乙型肝炎(CHB)患者干扰素治疗前后外周血单核细胞Toll样受体(TLR)4水平的变化及其意义。方法用流式细胞仪检测30例健康人、65例CHB患者外周血单核细胞表面TLR4的表达,ELISA法检测上述患者血清白细胞介素(IL)-6的水平,鲎试... 详细信息

目的探讨慢性乙型肝炎(CHB)患者干扰素治疗前后外周血单核细胞Toll样受体(TLR)4水平的变化及其意义。方法用流式细胞仪检测30例健康人、65例CHB患者外周血单核细胞表面TLR4的表达,ELISA法检测上述患者血清白细胞介素(IL)-6的水平,鲎试验检测血清内毒素。结果 CHB患者组与正常对照组比较,外周血单核细胞TLR4表达水平、血清IL-6及内毒素水平均升高,具有显著性差异(P0.05),内毒素水平下降较明显(P<0.05);治疗24周时,患者TLR4水平、血清IL-6水平及内毒素水平均明显下降,与治疗前比较有显著性差异(P<0.05,P<0.01,P<0.01)。结论外周血单核细胞TLR4表达水平与CHB的发病及治疗转归有关,且TLR4水平与IL-6及内毒素水平密切相关。

关键词：肝炎,乙型,慢性 Toll样受体4 白细胞介素6 内毒素类干扰素α-2b

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慢性乙型肝炎免疫功能缺陷与抗病毒治疗现状

国际内科学杂志 2007年第8期34卷 460-463页

作者：阎双缓曹治宸河北医科大学第三医院中西医结合肝病科河北石家庄050051

乙型肝炎病毒(HBV)感染人体后,特异性细胞免疫是发病的关键环节,细胞免疫应答低下是HBV持续感染的关键因素。目前抗病毒治疗存在持续应答率低、疗程长、病毒变异等一系列问题,主要原因是抗病毒药物只能抑制HBV复制,都不能彻底清除共价... 详细信息

乙型肝炎病毒(HBV)感染人体后,特异性细胞免疫是发病的关键环节,细胞免疫应答低下是HBV持续感染的关键因素。目前抗病毒治疗存在持续应答率低、疗程长、病毒变异等一系列问题,主要原因是抗病毒药物只能抑制HBV复制,都不能彻底清除共价闭合环状DNA(cccDNA),也与患者免疫缺陷不能得到充分恢复有一定的关系。因此,抗病毒治疗过程中,如何发挥现有药物各自优点,同时提高患者的特异性细胞免疫功能,加强免疫介导的病毒清除,从而达到彻底清除HBVcccDNA的目的,应成为关注的重点。

关键词：慢性乙型肝炎免疫缺陷 cccDNA 抗病毒治疗

Pleural effusion in an immunocompetent host with cryptococcal pneumonia:A case report

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World Journal of Clinical Cases 2020年第7期8卷 1295-1300页

作者： huan-huan Wu yan-Xiao Chen shuang-yan Fang Department of Respiratory Medicine Dongyang Hospital Affiliated to Wenzhou Medical UniversityDongyang 322100Zhejiang ProvinceChina Department of Evidence-base Medicine Dongyang Hospital Affiliated to Wenzhou Medical UniversityDongyang 322100Zhejiang ProvinceChina

BACKGROUND Pulmonary cryptococcosis is an opportunistic infection that mainly occurs among immunocompromised patients although it can sometimes occur in immunocompetent ***,the imaging findings of pulmonary cryptococcosis in immunocompetent hosts differ from those in immunosuppressed *** addition,the most common imaging findings of isolated pulmonary cryptococcosis are single or multiple *** and the halo sign are,however,prevalent in immunosuppressed *** immunocompetent patients,lung consolidation,pleural effusion or cavities are *** SUMMARY A 29-year-old Asian male was admitted to our hospital with complaints of cough and fever that had persisted for a *** a chest computed tomography scan showed consolidation in his left lower lobe,he was initially diagnosed with pneumonia and received antibiotic treatment.A second review of the chest computed tomography image revealed multiple cavities and pleural *** fiberoptic bronchoscopy was subsequently performed,bronchoalveolar lavage fluid and serum cryptococcal antigen tests were *** capsules were observed in bronchoalveolar lavage fluid ink *** examination of a percutaneous lung biopsy from the left lower lobe further revealed granulomatous inflammation,and periodic acid-Schiff staining showed red-colored yeast walls,signifying pulmonary *** patient was then treated with a daily dose of fluconazole(0.4 g),but the cough and fever still *** therefore changed treatment to voriconazole(0.2 g,twice a day),and the patient’s clinical outcome was *** Although rare,clinicians should not disregard the possibility of cavities and pleural effusion occurring in immunocompetent hosts without underlying diseases.

关键词： Pulmonary cryptococcosis Immunocompetent Computed tomography Pleural effusion Imaging findings Case report

拉米夫定治疗对慢性乙型肝炎患者干扰素-γ和白细胞介素-4的影响

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中华传染病杂志 2009年第1期27卷 27-30页

作者：阎双缓曹治宸孔丽南月敏张庆山封会茹马英河北医科大学第三医院中西医结合肝病科石家庄050051 北京市丰台区疾病预防控制中心微生物检验科

目的观察拉米夫定治疗慢性乙型肝炎患者血清IFN-7和IL-4水平的动态变化。方法ELISA法分别检测66例慢性乙型肝炎患者在拉米夫定治疗前，治疗后第3、6、9、12个月时的血清IFN-7和IL-4水平。选取20名健康献血员作为健康对照。治疗前后比较... 详细信息

目的观察拉米夫定治疗慢性乙型肝炎患者血清IFN-7和IL-4水平的动态变化。方法ELISA法分别检测66例慢性乙型肝炎患者在拉米夫定治疗前，治疗后第3、6、9、12个月时的血清IFN-7和IL-4水平。选取20名健康献血员作为健康对照。治疗前后比较用t检验，计数资料采用非参数秩和检验。结果HBeAg阳性患者拉米夫定治疗前，完全应答组IFN-γ水平为（21．03±4．44）ng／L，明显高于部分应答组的（13．85±3．92）ng／L及无应答组的（10．63±3．11）ng／L（t=7．56，t=11．87，均P〈0．01）；以IFN-7为15.66ng／L为界，治疗前IFN-γ高水平患者完全应答率明显高于低水平患者（31．0％比8．7％，χ^2=8．391，P〈0．01），无应答率明显低于低水平患者（13．8％比52．2％，）χ^2=4．256，P〈0．01）。治疗后完全应答组患者IFN-γ／IL-4接近或高于对照组，部分应答组和无应答组低于对照组；HBeAg阴性患者拉米夫定治疗后IFN-γ／IL-4缓慢上升，但未达对照组水平。结论拉米夫定治疗慢性乙型肝炎可增加IFN-γ释放，抑制IL-4释放，治疗应答程度与治疗后辅助性T淋巴细胞（Th）1／Th2平衡的恢复及治疗前IFN-γ水平有关。

关键词：肝炎乙型慢性拉米夫定干扰素Ⅱ型白细胞介素4

Two paths, one goal: mechanism of calcium homeostasis to balance plant growth and immunity

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Science China Life Sciences 2025年第1期 306-308页

作者： Aziz Ul Ikram yanping Jing huan Chen Jian Chen International Genome Center Jiangsu University Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong University

Calcium(Ca2+) is an essential nutrient and a cellular signal in plants. The level of free Ca2+in the apoplast is ～10,000-fold higher than that in the cytoplasm at the resting state. This large Ca2+level gradient across the membrane between the interior and exterior can cause Ca2+overload and toxicity. Plants have evolved mechanisms to export Ca2+out of the cytoplasm or store it in intracellular organelles, such as endoplasmic reticulum（ER）, mitochondria, and vacuole.

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Treatment of Pneumocystis jirovecii pneumonia in non-human immunodeficiency virus-infected patients using a combination of trimethoprim-sulfamethoxazole and caspofungin

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World Journal of Clinical Cases 2022年第9期10卷 2743-2750页

作者： huan-huan Wu shuang-yan Fang yan-Xiao Chen Lan-Fang Feng Department of Respiratory Medicine Dongyang Hospital Affiliated to Wenzhou Medical UniversityDongyang 322100Zhejiang ProvinceChina

BACKGROUND Pneumocystis jirovecii pneumonia(PJP)is an infectious disease common in immunocompromised ***,the currently,the clinical characteristics of non-HIV patients with PJP infection have not been fully *** To explore efficacy of trimethoprim–sulfamethoxazole(TMP-SMX)and caspofungin for treatment of non-human immunodeficiency virus(HIV)-infected PJP *** A retrospective study enrolled 22 patients with non-HIV-infected PJP treated with TMP-SMX and caspofungin from 2019 to *** manifestations,treatment and prognosis of the patients were *** Five patients presented with comorbidity of autoimmune diseases,seven with lung cancer,four with lymphoma,two with organ transplantation and four with membranous nephropathy associated with use of immunosuppressive *** main clinical manifestations of patients were fever,dry cough,and progressive *** patients presented with acute onset and respiratory *** most common imaging manifestation was ground glass opacity around the hilar,mainly in the upper *** patients were diagnosed using next-generation sequencing,and were treated with a combination of TMP-SMX and *** them,17 patients received short-term adjuvant glucocorticoid *** patients recovered well and were discharged from *** Non-HIV-infected PJP have rapid disease progression,high risk of respiratory failure,and high *** of TMP-SMX and caspofungin can effectively treat severe non-HIVinfected PJP patients with respiratory failure.

关键词： Acquired immunodeficiency syndrome Non-human immunodeficiency virus-infected patients Immunosuppression caspofungin Mortality Pneumocystis jirovecii pneumonia

Dual modulation of homogeneous nanomaterialization and electrochemical activation enhancing zinc ion storage

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Science China Chemistry 2025年第01期 385-393页

作者： Jianwei Wang huan Wang Kangning Wang Wenhui Wang Wenlin Zhang yanzhong Zhen School of Chemistry & Chemical Engineering Yan'an University

Vanadium-based electrode materials are widely investigated,but the low specific capacity and slow electrochemical kinetics in aqueous zinc-ion batteries still limit their commercial ***,the VS2/Ca V4O9material with the morphology of nanoflower was synthesized by a one-step hydrothermal *** to the blocky structure of pure VS2material,the VS2/Ca V4O9material is composed of thinner homogeneous *** open structures could provide abundant electrochemical active sites and ion transport channels,and then promote the electrochemical reaction *** addition,they can also buffer the bulk strain during the reaction *** improve the utilization of vanadium elements,an in-situ electrochemical activation strategy is used to explore the storage performance of the VS2/Ca V4O9material,the different activation voltage range of 0.4–1.6 and 0.4–1.4 V are selected,*** with the longer activation plateau of activated-VS2,the VS2/Ca V4O9cathode could quickly reach the activation state in the range of 1.4–1.6 V and cause the release of additional Zn storage sites *** VS2/Ca V4O9cathode delivers a higher power density of 37,000 W kg-1and a significant energy density of 423 Wh *** the high current density of 15 A g-1,the VS2/Ca V4O9cathode still has a discharge capacity of 183.9m Ah g-1after 5,000 cycles,and the capacity decay rate per cycle is only 0.0042%.Continuous cyclic voltammetry （CV） curves,electrochemical impedance spectroscopy （EIS） measurements,density functional theory （DFT） calculation and galvanostatic intermittent titration technique （GITT） measurements demonstrate that the VS2/Ca V4O9cathode has a faster ion diffusion/charge transfer ***,the assembled flexible device has an excellent mechanical stability.

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内科综合治疗HBV-ACLF患者的临床特点及转归

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肝脏 2020年第4期25卷 375-378页

作者：高朋彬郑欢伟赵晓彦王德华秦浩孟明辉张建集闫双缓石家庄市第五医院感染科 050000 石家庄市第五医院肿瘤内科 050000 石家庄市第五医院重症医学科 050000 河北医科大学附属第一医院儿科

目的了解HBV-ACLF内科治疗患者的临床特点及预后。方法回顾性分析140例接受内科综合治疗的HBV-ACLF患者临床资料,根据治疗效果分为有效组和无效组。比较两组患者临床特点。结果内科综合治疗有效98例,无效42例,死亡23例。有效组肝硬化病... 详细信息

目的了解HBV-ACLF内科治疗患者的临床特点及预后。方法回顾性分析140例接受内科综合治疗的HBV-ACLF患者临床资料,根据治疗效果分为有效组和无效组。比较两组患者临床特点。结果内科综合治疗有效98例,无效42例,死亡23例。有效组肝硬化病史、肝性脑病、消化道出血及肝肾综合征发生率均低于无效组(P<0.05)。Logistic多因素分析显示,肝性脑病(OR=1.869,95%CI=1.073~3.256)、消化道出血(OR=3.478,95%CI=1.621~7.462)、肝肾综合征(OR=4.141,95%CI=1.031~5.091)、INR(OR=3.081,95%CI=1.497~6.341)、Scr(OR=2.817,95%CI=1.629~4.871)和MELD评分(OR=1.305,95%CI=1.194~1.426)是影响其疗效的独立因素(P<0.05)。结论HBV-ACLF内科综合疗效肯定,恩替卡韦联合糖皮质激素有助于提高疗效,而对于合并并发症、肝功能下降及MELD评分升高者,内科治疗效果较差。

关键词： HBV-ACLF 临床特点预后转归

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Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： Tongyue Li Ziliang Xie Wenjiao Zhou huan Tong Dawen yang Anjia Zhang Yuan Wu Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&Tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics