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Implantable Thermal Therapeutic Device with Precise Temperature Control Enabled by Foldable Electronics and Heat-Insulating Pads

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Research 2022年第3期2022卷 297-307页

作者： Min Cai Huang Yang Liyin Shen shuang nie Zhengwei Mao Changyou Gao Yang Zhu Jizhou Song Department of Rehabilitation Medicine the First Affiliated Hospital College of MedicineZhejiang UniversityHangzhou 310003China Department of Engineering Mechanics Soft Matter Research Centerand Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou 310027China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Thermal therapy has continued to attract the attention of researchers and clinicians due to its important applications in tumor ablation,wound management,and drug *** lack of precise temperature control capability in traditional thermal treatment may cause the decrease of therapeutic effect and thermal damage to normal ***,we report an implantable thermal therapeutic device(ITTD),which offers precise closed loop heating,in situ temperature monitoring,and thermal *** ITTD features a multifunctional foldable electronics device wrapped on a heat-insulating composite *** and numerical studies reveal the fundamental aspects of the design,fabrication,and operation of the *** vivo experiments of the ITTD in thermal ablation for antitumor demonstrate that the proposed ITTD is capable of controlling the ablation temperature precisely in real time with a precision of at least 0.7℃ and providing effective thermal protection to normal *** proof-of-concept research creates a promising route to develop ITTD with precise temperature control capability,which is highly desired in thermal therapy and other disease diagnosis and treatments.

关键词： composite precise treatment

Adult-onset idiopathic hypogonadotropic hypogonadism： possible aetiology, clinical manifestations and management

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Asian Journal of Andrology 2010年第4期12卷 611-614页

作者： Jiang-Feng Mao Min nie shuang-Yu Lu Xue-Yan Wu Department of Endocrinology Peking Union Medical College Hospital Beijing 100730 China

We are doctors from Peking Union Medical College Hospital, Beijing, China. Male idiopathic hypogonadotropic hypogonadism （IHH） is a congenital disease that manifests as small testes, a short penis and no pubertal development. Some patients exhibit cryptorchism and ambiguous genitalia [1]. IHH has been reported being caused by gene mutations in KAL-1, FGFR1, GnRHR, GPR54, and several other ligands and receptors [2]. For these patients, gonadotropins or testosterone is the primary choice of therapy. However, adult-onset IHH,

关键词： possible aetiology clinical manifestations management

Switchable dry adhesive based on shape memory polymer with hemispherical indenters for transfer printing

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Theoretical & Applied Mechanics Letters 2021年第6期11卷 375-379页

作者： Hongyu Luo Chenglong Li Chuanqian Shi shuang nie Jizhou Song Department of Engineering Mechanics Soft Matter Research Centerand Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Transfer printing based on switchable adhesive is essential for developing unconventional systems,including flexible electronics,stretchable electronics,and micro light-emitting diode(LED)*** we report a design of switchable dry adhesive based on shape memory polymer(SMP)with hemispherical indenters,which offers a continuously tunable and reversible adhesion through the combination of the preloading effect and the thermal actuation of *** and numerical studies reveal the fundamental aspects of design,fabrication,and operation of the switchable dry *** of this adhesive concept in transfer printing of flat objects(e.g.,silicon wafers),three-dimensional(3D)objects(e.g.,stainless steel balls),and rough objects(e.g.,frosted glasses)in two-dimensional(2D)or 3D layouts illustrate its unusual manipulation capabilities in heterogeneous material integration applications.

关键词： Switchable dry adhesive Shape memory polymer Transfer printing

Soft,stretchable thermal protective substrates for wearable electronics

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npj Flexible Electronics 2022年第1期6卷 401-409页

作者： shuang nie Min Cai Huang Yang Liyin Shen Suhao Wang Yang Zhu Jizhou Song Department of Rehabilitation Medicine The First Affiliated Hospital College of MedicineZhejiang UniversityHangzhou 310027China Department of Engineering Mechanics Soft Matter Research Centerand Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou 310027China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310003China

Wearable electronics have continued to attract the attention of researchers and clinicians due to their great potential in medical *** their operations,the undesired heating may cause thermal discomfort or damage to *** materials and structures for advanced thermal protection has become an urgent ***,we report a soft,stretchable thermal protective substrate for wearable electronics with remarkable thermal insulating performance,mechanical compliance and *** thermal protective substrate features a composite design of the widely used polymeric material polydimethylsiloxane with embedded heat absorbing microspheres,consisting of phase change materials encapsulated inside the resin *** and numerical studies show that the thermal protective substrate could be subjected to complex deformations over 150% and could reduce the peak skin temperature increase by 82% or higher under *** vivo demonstration of this concept on the mouse skin illustrates its unusual thermal protection capability for wearable thermal management.

关键词： wear protective thermal

Risk factors of gastroparesis syndrome after abdominal nongastroduodenal operation and its prevention

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Asian Pacific Journal of Tropical Medicine 2013年第6期6卷 497-499页

作者： Dong-Dong Yang Kun He Xue-Liang Wu Li-Kun Yang shuang-Fa nie First Affiliated Hospital Hebei North University

Objective:To investigate risk factors of gastroparesis syndrome(PGS) after abdominal nongastroduodenal operation and its ***:Clinical data of 22 patients with PGS after abdominal non-gastroduodenal operation was analyzed retrospectively,and compared with the patients of non-PGS after abdominal non-gastroduodenal operation during the same *** possible influencing factors of PCS were analyzed by single factor analysis and logistic regression ***:All t3 selected factors related with PGS,including age,disease category (benign and malignant),operation time,intraoperative blood loss,postoperative analgesic pump, postoperative enteral nutrition time,postoperative parenteral nutrition time,perioperative blood glucose level,perioperative nutrition status(anaemia or lower proleinemia),pylorus obstruction before surgery,intra-abdominal infection after surgery,and spiritual factor were related with *** statistical analysis showed that the difference was statistical significant(P0.05);non-conditional multivariate analysis showed that malignant tumor,perioperative nutrition status,pylorus obstruction,operation time,blood loss, intra-abdominal infection after surgery,and mental factor were significant related with PGS as dependent variable and related risk factors in single factor analysis as independent variables (P <0.05).Conclusions:PGS is a result of multiple factors,and among these factors,malignant tumor,poor nutrition status,pylorus obstruction before surgery,longer operation—time,more blood loss,intra-abdominal infection after surgery,and mental factor are major risk factors of PGS.

关键词： Abdominal non-gastroduodenal operation Postsurgical gastroparesis syndrome Risk factors Comparative analysis

Dragon Boat Racing in Zigui,Qu Yuan's Hometown

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China News Release 2022年第6期 68-71页

作者： nie shuang 不详

In Zigui County,Hubei Province,the Dragon Boat Festival has long been seen as having equal importance to the Spring *** more than 1,000 years,it is a tradition in Zigui that the Dragon Boat Festival is celebrated thre... 详细信息

关键词： Dragon fifth celebrated

Tumor recurrence and survival prognosis in patients with advanced gastric cancer after radical resection with radiotherapy and chemotherapy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1660-1669页

作者： shuang-Fa nie Chen-Yang Wang Lei Li Cheng Yang Zi-Ming Zhu Jian-Dong Fei Department of General Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 75000Hebei ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China

BACKGROUND Advanced gastric cancer is a common malignancy that is often diagnosed at an advanced stage and is still at risk of recurrence after radical surgical ***,as one of the important treatment methods for gastric cancer,is of great significance for improving the survival rate of ***,the tumor recurrence and survival prognosis of gastric cancer patients after radio-therapy and chemotherapy are still *** To analyze the tumor recurrence after radical radiotherapy and chemotherapy for advanced gastric cancer and provide more in-depth guidance for *** A retrospective analysis was performed on 171 patients with gastric cancer who received postoperative adjuvant radiotherapy and chemotherapy in our hospital from 2021 to *** Kaplan-Meier method was used to calculate the recurrence rate and survival rate;the log-rank method was used to analyze the single-factor prognosis;and the Cox model was used to analyze the prognosis associated with multiple *** The median follow-up time of the whole group was 63 months,and the follow-up rate was 93.6%.Stage Ⅱ and Ⅲ patients accounted for 31.0%and 66.7%,*** incidences of Grade 3 and above acute gastrointestinal reactions and hematological adverse reactions were 8.8%and 9.9%,respectively.A total of 166 patients completed the entire chemoradiotherapy regimen,during which no adverse reaction-related deaths *** terms of the recurrence pattern,17 patients had local recurrence,29 patients had distant metastasis,and 12 patients had peritoneal implantation *** 1-year,3-year,and 5-year overall survival(OS)rates were 83.7%,66.3%,and 60.0%,*** 1-year,3-year,and 5-year disease-free survival rates were 75.5%,62.7%,and 56.5%,*** analysis revealed that T stage,peripheral nerve invasion,and the lymph node metastasis rate(LNR)were independent prognostic factors for *** Postoperative intensity-

关键词： Tumor recurrence Survival prognosis Advanced gastric cancer Radical resection Retrospective study

数字空间政府的应急协同治理——基于“结构—机制—效能”框架的阐析

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行政论坛 2023年第6期30卷 109-116页

作者：樊博聂爽上海交通大学国际与公共事务学院上海200030

第四次工业革命推动了数字空间政府形态的重塑,蕴含应急治理结构的深刻变革。新兴数字技术的发展迭代作为驱动应急协同治理实现引领性跃迁的重要支撑和工具,为加速我国应急治理体系和治理能力现代化的进程扩充了边界空间。置于新时代中... 详细信息

第四次工业革命推动了数字空间政府形态的重塑,蕴含应急治理结构的深刻变革。新兴数字技术的发展迭代作为驱动应急协同治理实现引领性跃迁的重要支撑和工具,为加速我国应急治理体系和治理能力现代化的进程扩充了边界空间。置于新时代中国应急治理的特色场域,从新安全格局保障新发展格局的战略需求出发,通过构建“结构—机制—效能”分析框架,对我国应急协同治理的数字化嬗变进路进行全链条的机理阐析,研究认为:面向中国未来应急治理的“治道”,应从体制、体系、技术赋能等三个维度为建立大应急大安全框架提供理论启示与借鉴,以期提升我国应急治理的韧性和实质效能。

关键词：数字空间政府数字技术应急协同治理治理效能

城市应急恢复中非政府组织的自主性研究——整体性治理视域下的解读

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上海行政学院学报 2016年第2期17卷 23-33页

作者：樊博聂爽上海交通大学上海200040

城市迈向全面现代化的行进中,不可避免地遭遇突发公共事件的冲击,应急管理由此纳入城市治理体系并成为其关注的重要领域。应急恢复阶段作为一项复杂性与可持续性并存的系统工程,可视为连接当下与面向未来的关键结点,对灾后城市的发展具... 详细信息

城市迈向全面现代化的行进中,不可避免地遭遇突发公共事件的冲击,应急管理由此纳入城市治理体系并成为其关注的重要领域。应急恢复阶段作为一项复杂性与可持续性并存的系统工程,可视为连接当下与面向未来的关键结点,对灾后城市的发展具有重要意义。但当前聚焦于恢复阶段的研究尚不够深入,尤其是对非政府组织参与灾后恢复工作中的自主性探析更少有涉猎。因此,本文面向应急恢复阶段,基于整体性治理这一自反性认同视角对自主性进行解读,从多节点交互维度对理论框架进行扩展并提出研究假设,进而结合我国湖南冰灾实践的展现形态进行深入分析,为城市应急治理的重构与完善提供新思路。

关键词：城市应急恢复非政府组织自主性整体性治理