Implantable Thermal Therapeutic Device with Precise Temperature Control Enabled by Foldable Electronics and Heat-Insulating Pads

作     者：Min Cai Huang Yang Liyin Shen Shuang Nie Zhengwei Mao Changyou Gao Yang Zhu Jizhou Song 

作者机构：Department of Rehabilitation Medicinethe First Affiliated Hospital College of MedicineZhejiang UniversityHangzhou 310003China Department of Engineering MechanicsSoft Matter Research Centerand Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou 310027China MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou 310027China 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2022年第2022卷第3期

页      面：297-307页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：the National Natural Science Foundation of China(grant numbers U20A6001 and 11872331) National Key Research and Development Program of China(grant number 2019YFE0117400) Zhejiang University K.P.Chao’s High Technology Development Foundation 

主　　题：composite precise treatment 

摘      要：Thermal therapy has continued to attract the attention of researchers and clinicians due to its important applications in tumor ablation,wound management,and drug *** lack of precise temperature control capability in traditional thermal treatment may cause the decrease of therapeutic effect and thermal damage to normal ***,we report an implantable thermal therapeutic device(ITTD),which offers precise closed loop heating,in situ temperature monitoring,and thermal *** ITTD features a multifunctional foldable electronics device wrapped on a heat-insulating composite *** and numerical studies reveal the fundamental aspects of the design,fabrication,and operation of the *** vivo experiments of the ITTD in thermal ablation for antitumor demonstrate that the proposed ITTD is capable of controlling the ablation temperature precisely in real time with a precision of at least 0.7℃ and providing effective thermal protection to normal *** proof-of-concept research creates a promising route to develop ITTD with precise temperature control capability,which is highly desired in thermal therapy and other disease diagnosis and treatments.