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Genetic determination of osteoporosis in Chinese

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Chinese Medical Journal 2005年第24期118卷 2077-2088页

作者： XIAO Su-mei lei shu-feng DENG Hong-wen Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education College of Life Sciences Hunan Normal University Changsha 410081 China Department of Orthopedic Surgery School of Medicine University of Missouri-Kansas City 2411 Holmes Street Kansas City MO 64108 USA

Osteoporosis, one of the major and growing health problems around the world, is defined asa systemic SKeletal olsease cnaracterized by ,uw bone mass and microarchitectural deterioration of bone tissue, with high bone fragility and susceptibility to fractures. In China, 6.97% of the population （ 13 billion ） suffered from osteoporosis in 2000. As far as Hongkong was concerned,

关键词： Chinese osteoprosis candidate gene approach

Intermittency of Wind Wave Group Breaking

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China Ocean Engineering 2013年第5期27卷 605-614页

作者：类淑河薛川田文婧管长龙 Department of Mathematics Ocean University of China Physical Oceanography Laboratory Ocean University of China

Knowledge on intermittency of wave breaking is so far limited to a few summary statistics, while the probability distribution of time interval between breaking events can provide a full view of intermittency. Based on a series of experiments on wind wave breaking, such probability distributions are investigated. Breaking waves within a wave group were taken as a single breaking event according to recent studies. Interval between successive wave groups with breaker is the focus of this paper. For intervals in our experiments with different fetch and wind conditions, their distributions are all skewed and weighted on small intervals. Results of Kolmogorov-Smirnov tests on time series of these intervals indicate that they all follow gamma distribution, and some are even exponential type. Average breaking-group-interval decreases with friction velocity and significant steepness until the wind is strong enough;most of them are more than 10 times the dominant wave period. Group breaking probability proposed by Babanin recently and the average number of breaking waves in wave groups are also discussed, and they are seemingly more reasonable and sensitive than traditional breaking probability defined in terms of single wave.

关键词： wave breaking wave group group breaking probability breaking group interval gamma distribution

Recent progress of efficient flexible solar cells based on nanostructures

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Journal of Semiconductors 2021年第10期42卷 93-102页

作者： Yiyi Zhu Qianpeng Zhang lei shu Daquan Zhang Zhiyong Fan Department of Electronic&Computer Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China HKUST-Shenzhen Research Institute Shenzhen 518057China Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology HKUSTHong Kong 999077China

Flexible solar cells are important photovoltaics(PV)technologies due to the reduced processing temperature,less material consumption and mechanical flexibility,thus they have promising applications for portable devices and building-integrated ***,the efficient harvesting of photons is the core hindrance towards efficient,flexible *** management by nanostructures and nanomaterials has opened new pathways for sufficient solar energy *** on top surfaces provide an efficient pathway for the propagation of *** from suppressing incident light reflection,micro-structured back-reflectors reduce transmission via multiple *** themselves can be the absorber *** based on high-crystallinity nanostructured light absorbers demonstrate enhanced power conversion efficiency(PCE)and excellent mechanical *** acquire a deep understanding of the impacts of nanostructures,herein,a concise overview of the recent development in the design and application of nanostructures and nanomaterials for photovoltaics is summarized.

关键词： solar cells nanotechnology antireflection bendability PCE

The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch

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Neuroscience Bulletin 2023年第12期39卷 1807-1822页

作者： Juan Yao Xuan Li Guang-Yan Wu Bing Wu Jun-Hui Long Pu-Jun Wang shu-lei Liu Jie Gao Jian-Feng Sui Experimental Center of Basic Medicine Army Medical UniversityChongqing400038China Department of Physiology College of Basic Medical SciencesArmy Medical UniversityChongqing400038China Department of Dermatology The 958th Army Hospital of the People’s Liberation ArmyChongqing400020China State Key Laboratory of Trauma Burns and Combined InjuryArmy Medical Centre of the PLAInstitute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing400042China

Itch is an unpleasant sensation that urges people and animals to *** studies on itch have yielded extensive correlations with diverse cortical and subcortical regions,including the insular ***,the role and functional specificity of the insular cortex(IC)and its subdivisions in itch mediation remains ***,we demonstrated by immunohistochemistry and fiber photometry tests,that neurons in both the anterior insular cortex(AIC)and the posterior insular cortex(PIC)are activated during acute itch *** experiments revealed that nonselective inhibition of global AIC neurons,or selective inhibition of the activity of glutaminergic neurons in the AIC,reduced the scratching behaviors induced by intradermal injection of 5-hydroxytryptamine(5-HT),but not those induced by compound 48/***,both nonselective inhibition of global PIC neurons and selective inhibition of glutaminergic neurons in the PIC failed to affect the itching-scratching behaviors induced by either 5-HT or compound 48/*** addition,pharmacogenetic inhibition of AIC glutaminergic neurons effectively blocked itch-associated conditioned place aversion behavior,and inhibition of AIC glutaminergic neurons projecting to the prelimbic cortex significantly suppressed 5-HT-evoked *** findings provide preliminary evidence that the AIC is involved,at least partially via aversive emotion mediation,in the regulation of 5-HT-,but not compound 48/80-induced itch.

关键词： Itch-Insular cortex Prelimbic cortex Conditioned place aversion Pharmacogenetic inhibition

Magnolol protects against acute gastrointestinal injury in sepsis by down-regulating regulated on activation,normal T-cell expressed and secreted

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World Journal of Clinical Cases 2021年第34期9卷 10451-10463页

作者： Shi-Hao Mao Dan-Dan Feng Xi Wang Yi-Hui Zhi shu lei Xi Xing Rong-Lin Jiang Jian-Nong Wu Department of Intensive Care Unit The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Key Laboratory of Digestive Pathophysiology of Zhejiang Province The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Sepsis is a major medical *** is an active constituent of Houpu that improves tissue function and exerts strong anti-endotoxin and anti-inflammatory effects,but the mechanism by which it reduces intestinal inflammation in sepsis is yet *** To assess the protective effect of magnolol on intestinal mucosal epithelial cells in sepsis and elucidate the underlying *** Enzyme-linked immunosorbent assay was used to measure tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6,and regulated on activation,normal T-cell expressed and secreted(RANTES)levels in serum and ileal tissue in animal *** histopathological changes of the ileal mucosa in different groups were observed under a *** Counting Kit-8 and cell permeability assays were used to determine the concentration of drug-containing serum that did not affect the activity of Caco2 cells but inhibited lipopolysaccharide(LPS)-induced decrease in *** and Western blot assays were used to detect the levels of RANTES,inhibitor of nuclear factor kappa-B kinaseβ(IKKβ),phosphorylated IKKβ(p-IKKβ),inhibitor of nuclear factor kappa-B kinaseα(IκBα),p65,and p-p65 proteins in different groups in *** In rats treated with LPS by intravenous tail injection in the presence or absence of magnolol,magnolol inhibited the expression of proinflammatory cytokines,IL-1β,IL-6,and TNF-αin a dose-dependent *** addition,magnolol suppressed the production of RANTES in LPS-stimulated sepsis ***,in vitro studies suggested that magnolol inhibited the increase of p65 nucleation,thereby markedly downregulating the production of the phosphorylated form of IKKβin LPS-treated Caco2 ***,magnolol inhibited the translocation of the transcription factor nuclear factor-kappa B(NF-κB)from the cytosol into the nucleus and down-regulated the expression level of the chemokine RANTES in LPS-stimulated Caco2 *** Magno

关键词： Sepsis Magnolol Regulated on activation,normal T-cell expressed and secreted Anti-inflammation Lipopolysaccharide Nuclear factor-kappa B

The modulation of the discharge plateau of benzoquinone for sodium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2021年第10期28卷 1675-1683页

作者： Feng-hua Chen Yi-wen Wu Huan-hong Zhang Zhan-tu Long Xiao-xin Lin Ming-zhe Chen Qing Chen Yi-fan Luo shu-lei Chou Rong-hua Zeng Key Laboratory of Theoretical Chemistry of the Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongInnovation CampusSquires WayNorth WollongongNSW 2522Australia Department of Mechanical and Aerospace Engineering and Department of ChemistryThe Hong Kong University of Science and TechnologyHong KongChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

p-Benzoquinone(BQ)is a promising candidate for next-generation sodium-ion batteries(SIBs)because of its high theoretical specific capacity,good reaction reversibility,and high resource ***,practical application of BQ faces many challenges,such as a low discharge plateau(~2.7 V)as cathode material or a high discharge plateau as anode material compared with inorganic materials for SIBs and high solubility in organic electrolytes,resulting in low power and energy ***,tetrahydroxybenzoquinone tetrasodium salt(Na_(4)C_(6)O_(6))is synthesized through a simple neutralization reaction at low *** four-ONa electron-donating groups introduced on the structure of BQ greatly lower the discharge plateau by over 1.4 V from ~2.70 V to ~1.26 V,which can change BQ from cathode to anode material for *** the same time,the addition of four-ONa hydrophilic groups inhibits the dissolution of BQ in the organic electrolyte to a certain *** a result,Na_(4)C_(6)O_(6) as the anode displays a moderate discharge capacity and cycling performance at an average work voltage of ~1.26 V versus Na/Na^(+).When evaluated as a Na-ion full cell(NIFC),a Na_(3)V_(2)(PO_(4))_(3)||Na_(4)C_(6)O_(6) NIFC reveals a moderate discharge capacity and an average discharge plateau of ~1.4 *** research offers a new molecular structure design strategy for reducing the discharge plateau and simultaneously restraining the dissolution of organic electrode materials.

关键词： discharge plateau electron-donating groups dissolution sodium-ion batteries

Prognostic Value of Feature-Tracking Circumferential Strain in Dilated Cardiomyopathy Patients with Severely Reduced Ejection Fraction Incremental to Late Gadolinium Enhancement

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Current Medical Science 2021年第1期41卷 158-166页

作者： Shcng-lei shu Jing WANG Cheng WANG Feng ZHU Yu-xi JIA Lan ZHANG Xiao-yue ZHOU Tian-jing ZHANG Chuan-sheng ZHENG Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Province Key Laboratory of Molecular Imaging Wuhan430022China Department of Cardiology Institute of CardiologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China MR Collaboration Siemens HealthineersShanghai201318China Philips Healthcare Guangzhou510055China

Myocardial fiber deformation measurements have been reported to be associated with adverse outcomes in patients with acute heart failure and those with myocardial ***,few studies have addressed the prognostic value of global circumferential strain(GCS)in dilated cardiomyopathy(DCM)patients with severely impaired systolic *** study aimed to evaluate the prognostic value of cardiac magnetic resonance(CMR)-derived GCS in DCM patients with severely reduced *** DCM patients with severely reduced ejection fraction(EF<35%)who underwent CMR were *** was calculated from CMR cine *** clinical endpoint was a composite of all-cause mortality,heart transplantation,implantable cardioverter defibrillator(ICD)implantation and aborted sudden cardiac death(SCD).A total of 129 patients with a mean EF of 15.33%(11.36%–22.27%)were *** a median follow-up of 518 days,endpoint events occurred in 50 *** with GCS≥the median(−5.17%)had significantly reduced event-free survival as compared with those with GCS

关键词： cardiac magnetic resonance imaging circumferential strain prognosis late gadolinium enhancement dilated cardiomyopathy

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半导体硫化物纳米微粒的制备

无机化学学报 1999年第1期15卷 1-7页

作者：舒磊俞书宏钱逸泰中国科学技术大学化学系

总结了硫化物半导体纳米微粒的各种合成途径，并就水热技术及在此基础上发展起来的溶剂热合成技术在一系列硫化物纳米微粒的制备与尺寸、形状控制中的应用进行了阐述。

关键词：硫化物纳米微粒合成半导体

Protective effects and mechanisms of Lizhong decoction(理中汤) against non-alcoholic fatty liver disease in a rat model

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Journal of Traditional Chinese Medicine 2022年第5期42卷 773-780页

作者： YANG Jiayao TAO Dongqing MA Wei LIU Song LIAO Yan shu lei ZHANG shu LI Chenyu DU Nianlong Department of Gastroenterology Wuhan Integrated TCM and Western Medicine HospitalWuhan 430022China Department of Endocrinology The Third People's Hospital of Hubei ProvinceWuhan 430033China Department of Center Laboratory Wuhan Integrated TCM and Western Medicine HospitalWuhan 430022China Hubei University of Traditional Chinese Medicine Wuhan 430065China

OBJECTIVE: To investigate the protective effects and molecular mechanisms of Lizhong decoction( 理中汤, LZD) against non-alcoholic fatty liver disease(NAFLD). METHODS: Male Wistar rats were fed a high-fat diet for four weeks to induce NAFLD, and were administered LZD by gavage for four weeks. Potential therapeutic targets for NAFLD were analyzed using network pharmacology. Liver pathology was evaluated using Oil Red O and hematoxylin-eosin staining. Furthermore, mitochondrial function, lipid metabolism, oxidative stress, and inflammatory response were examined. RESULTS: Rats with NAFLD exhibited high levels of hepatic damage and cholesterol deposition. Moreover, apoptosis was increased, superoxide dismutase and glutathione content were reduced, malondialdehyde content was increased, and the protein expression of inflammatory cytokines and p-c-Jun N-terminal kinase was increased. The LZD treatment ameliorated mitochondrial dysfunction, reduced liver damage,inhibited oxidative stress and inflammatory response, upregulated peroxisome proliferator-activated receptor(PPAR)-γ expression, and suppressed dipeptidyl peptidase 4(DPP4) expression in the liver. CONCLUSION: It was found that LZD alleviates NAFLD by activating PPAR-γ and inhibiting DPP4.

关键词： non-alcoholic fatty liver disease PPAR gamma dipeptidyl peptidase 4 Lizhong decoction