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小儿术中知晓的发生率：儿童知晓与回忆评估

麻醉与镇痛 2011年第5期7卷 75-82页

作者： shobha malviya, MD Jeffrey L. Galinkin, MD, FAAP Carolyn F. Bannister, MD, FAAP Constance Burke, BSN, RN Jeannie Zuk, PhD, RN Mark Popenhagen, PsyD Samatha Brown, RN Terri Voepel-Lewis, MSN, RN 胥亮（译） Department of Anesthesiology at University of Michigan Health Systems Ann Arbor Michigan University of Colorado Denver Colorado Emory University Atlanta Georgia 不详

背景小儿麻醉中知晓发生率的报道有很大差异（0．2％-2．7％）。在本次前瞻性观察队列研究中，我们做了以下评估：（D三种情况下小儿全麻知晓发生率；（爹知晓的相关因素；③知晓的短期心理影响。方法纳入标准为：5-15岁、行全身麻醉的... 详细信息

背景小儿麻醉中知晓发生率的报道有很大差异（0．2％-2．7％）。在本次前瞻性观察队列研究中，我们做了以下评估：（D三种情况下小儿全麻知晓发生率；（爹知晓的相关因素；③知晓的短期心理影响。方法纳入标准为：5-15岁、行全身麻醉的儿童，详细记录包括麻醉用药在内的围术期资料。使用半结构化问卷于术后对小儿进行3次随访。所有可能或疑似知晓的病例，均需和小儿的医护人员充分讨论以证实或排除所述记忆。不同中心的研究人员内部需要达成一致，而这些病例及随机选出的其他部分病例再交由3个研究之外人员审核。根据此研究的目的，可能僚似知晓定义为内部研究者一致同意，3个外部审核者至少2个认同。结果1，784例儿童完成了至少一次的随访。有32例被至少1位研究人员（中心内部研究人员或一位外部审核者）评估为可能或疑似知晓。其中14例符合可能／疑似知晓的定义标准，知晓率为0．8％。14例知晓儿童中有6例（43％）回忆起手术中感到恐惧，3例（21％）述感觉疼痛。知晓组中有2例（14％）表示如果再次手术会感觉更差，这与无知晓组小儿的比例（15％）无明显差异。知晓患儿无需进一步心理干预。内镜手术是知晓发生的高风险因素（相对危险度为4．5，可信区间1．5—13．6）。结论尽管本研究中有0．8％的患儿出现了可能／疑似知晓，但没有病例出现短期的心理应激状态。

关键词：知晓发生率小儿麻醉儿童评估术中知晓回忆研究人员心理应激状态

Clonal Characterization of Bone Marrow Derived Stem Cells and Their Application for Bone Regeneration

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International Journal of Oral Science 2010年第3期2卷 127-135页

作者： shobha Mareddy Ross Crawford Institute of Health and Biomedical Innovation Queensland University of Technology

Tissue engineering allows the design of functionally active cells within supportive bio-scaffolds to promote the development of new tissues such as cartilage and bone for the restoration of pathologically altered tissues. However, all bone tissue engineering applications are limited by a shortage of stem cells. The adult bone marrow stroma contains a subset of nonhematopoietic cells referred to as bone marrow mesenchymal stem cells （BMSCs）. BMSCs are of interest because they are easily isolated from a small aspirate of bone marrow and readily generate singlecell-derived colonies. These cells have the capacity to undergo extensive replication in an undifferentiated state ex vivo. In addition, BMSCs have the potential to develop either in vitro or in vivo into distinct mesenchymal tissues,including bone, cartilage, fat, tendon, muscle, and marrow stroma. Thus, BMSCs are an attractive cell source for tissue engineering approaches. However, BMSCs are not homogeneous and the quantity of stem cells decreases in the bone marrow in aged population. A sequential loss of lineage differentiation potential has been found in the mixed culture of bone marrow stromal cells due to a heterogenous popu- lation. Therefore, a number of studies have proposed that homogenous bone marrow stem cells can be generated from clonal culture of bone marrow cells and that BMSC clones have the greatest potential for the application of bone regeneration in vivo.

关键词： bone morrow stem cell meserichymal clonalculture regenerative medicine differentiation

Fault analysis method of integrated high voltage direct current transmission lines for onshore wind farm

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Journal of Modern Power Systems and Clean Energy 2019年第3期7卷 621-632页

作者： shobha AGARWAL Aleena SWETAPADMA Chinmoy PANIGRAHI Abhijit DASGUPTA School of Electrical Engineering KIIT UniversityBhubaneswarIndia School of Computer Engineering KIIT UniversityBhubaneswarIndia

Voltage source converter(VSC) based high voltage direct current(HVDC) transmission is most suited for the wind farm as it allows flexibility for reactive power control in multi-terminal transmission lines and transmits low power over smaller distance. In this work, a new method has been proposed to detect the fault, identify the section of faults and classify the pole of the fault in DC transmission lines fed from onshore wind farm. In the proposed scheme, voltage signal from rectifier end terminal is extracted with sampling frequency of 1 k Hz given as the input to the detection, classification and section discrimi-nation module. In this work, severe AC faults are also considered for section discrimination. Proposed method uses fuzzy inference system(FIS) to carry out all relaying task. The reach setting of the relay is 99.9% of the transmission line. Besides, the protection covers and discriminates the grounding fault with fault resistance up to 300 Ω.Considering the results of the proposed method, it can beused effectively in real power network.

关键词： Voltage source converter based high voltage direct current(VSC-HVDC) transmission lines Wind farm Doubly-fed induction generator(DFIG) Fuzzy inference system(FIS)

Molecular characterization of VP4,VP6,VP7 and NSP4 genes of group B rotavirus strains from outbreaks of gastroenteritis

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Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 846-849页

作者： Anismrita Lahon shobha D Chitambar Enteric Viruses Group National Institute of VirologyPune-411001India

Objective:To characterize VP4,VP6,VP7 and NSP4 genes of representative GBR strains(NIV- ***-04622 and NIV-094456) delected as the major eliolngic agenl in the outbreaks of gastroenteritis in western ***:Fecal specimens collected during the outbreaks of gastroenteritis were processed for RNA ***-PCR using GBR ***7 and NSP4 gene specific primers,nucleotide sequencing of the amplicons and phylogenetic analysis of the ***:Phylogenetic analysis of all of the ***7 and NSP4 gene sequences revealed clustering of GBR strains in Indian-Bangladeshi lineage of genotype G2 with 95.8%- 99.4%nucleotide and 97.3%-100.0%amino acid ***,all three strains showed the presence of unique amino acid substitutions in the VP4 protein suggesting alteration in the antigenicity of outbreak strains of *** VP8* and VP5* regions of VP4 proteins showed respectively 0.5%-6.3%and 0.2%-1.1%amino acid divergence from human GBR strains of Indian-Bangladeshi ***:These data confirm the reported variability of VP8* region and suggest the possible role of this region in the perpetuation of GBR infections in the *** is the first study to document the phylogenetic relationship of VP4,***7 and NSP4 genes of GBR strains detected in the outbreaks of gastroenteritis from India with the CBR strains from other parts of world.

关键词： Acute gastroenteritis Group B rotavirus VP4 VP6 VP7 NSP4

Development of Palmprint Verification System Using Biometrics

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软件学报 2006年第8期17卷 1824-1836页

作者： G. shobha M. Krishna S.C. Sharma R.V. College of Engineering Mysore Road Bangalore 560059 India

Palmprint verification system using Biometrics is one of the emerging technologies, which recognizes a person based on the principle lines, wrinkles and ridges on the surface of the palm. These line structures are stable and remain unchanged throughout the life of an individual. More importantly, no two palmprints from different individuals are the same, and normally people do not feel uneasy to have their palmprint images taken for testing. Therefore palmprint recognition offers a promising future for medium-security access control systems. In this paper, a new approach for personal authentication using hand images is discussed. Gray-Scale palm images are captured using a digital camera at a resolution of 640×480. Each of these gray-scale images is aligned and then used to extract palmprint and hand geometry features. These features are then used for authenticating users. The image acquisition setup used here is inherently simple and it does not employ any special illumination nor does it use any pegs that might cause any inconvenience to users. Experimental results show that the designed system achieves an acceptable level of performance.

关键词：灰色图象边缘追踪顶点检测验证系统

Graphene-Based Coronal Hybrids for Enhanced Energy Storage

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Energy Material Advances 2021年第1期2021卷 218-232页

作者： Karthik Kiran Sarigamala shobha Shukla Alexander Struck Sumit Saxena Centre for Research in Nanotechnology and Science Indian Institute of Technology Bombay400076MumbaiIndia Nanostructures Engineering and Modelling Laboratory Department of Metallurgical Engineering and Materials ScienceIndian Institute of Technology Bombay400076MumbaiIndia Faculty of Technology and Bionics Rhein-Waal University of Applied SciencesKleveGermany 47533

Functional materials with designer morphologies are anticipated to be the next generation materials for energy storage *** this manuscript,we have developed a holistic approach to enhance the surface area and hence the properties of nanostructures by synthesizing coronal nanohybrids of *** nanohybrids provide distinctive advantages in terms of performance and stability over vertically stacked nanocomposites reported in *** double hydroxide materials self-assembled as coronal lamellae on graphene shells have been synthesized and systematically *** coronal nanohybrids result in about a threefold increase in energy storage capacity as compared to their traditionally synthesized nanocomposite *** 3D graphene-based nanofibrils in the synthesized coronal nanohybrids provide mechanical support and connect the nodes of the double hydroxide lattices to inhibit *** morphologies such as coronal nanostructures increase the interaction surface of the nanostructure *** an approach is also expected to bring a paradigm shift in development of functional materials for various applications such as sensors,energy storage,and catalysis.

关键词： hydroxide hence shells

Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults

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Asian Pacific Journal of Tropical Medicine 2020年第8期13卷 358-365页

作者： Raghavendra Rao Snehal Nayak Akhilesh K Pandey shobha U Kamath Department of Medicine Kasturba Medical CollegeManipalIndia Manipal Academy of Higher Education ManipalIndia Department of Biochemistry Kasturba Medical CollegeManipalIndia Department of Community Medicine Kasturba Medical CollegeManipalIndia

Objective: To determine the relationship between C-reactive protein(CRP) level and the severity of dengue and the potential use of CRP in predicting acute dengue ***: A prospective observational study was performed on dengue patients admitted to a tertiary care hospital in southern India. All patients of age above 18 years, diagnosed with dengue were included in the study. The detailed laboratory parameters pertaining to dengue were recorded. CRP levels were estimated and compared between groups i.e. severe and non-severe dengue. CRP cut-off value was detected using the receiver-operator ***: Totally 98 patients with a mean age of 40 years were included. Among them, 11.2% of the patients suffered from severe dengue, 54.1% of the cases had non-severe dengue without warning signs, and 34.7% had non-severe dengue with warning signs. The median CRP was significantly higher in patients with severe dengue compared to patients with non-severe dengue(96.2 mg/d L vs. 5.3 mg/d L). Univariate logistic regression analysis showed that the odd’s ratio(OR) of CRP was 1.053(P≤0.001, 95% CI=1.029-1.078). CRP at a cutoff value of 21.6 mg/L(0.929 AUC) had excellent sensitivity(100%) and specificity(81.6%) in predicting severe dengue infection. Multivariate logistic regression analysis showed that CRP(OR=1.089, P=0.013) and ALT(OR=1.010, P=0.034) were statistically significant independent predictors of dengue ***: CRP level could be used as a potential biomarker to predict severity of dengue in adults.

关键词： Vector-borne Arbovirus Inflammation Biochemical Tropical disease

Identification of SARS-CoV-2 Spike Protein Inhibitors from Urtica dioica to Develop Herbal-Based Therapeutics Against COVID-19

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World Journal of Traditional Chinese Medicine 2023年第1期9卷 61-70页

作者： shobha Upreti Jyoti Sankar Prusty Awanish Kumar Mukesh Samant Cell and Molecular Biology Laboratory Department of ZoologySoban Singh Jeena University CampusAlmoraUttarakhand Department of Zoology Kumaun UniversityNainital Uttarakhand Department of Biotechnology National Institute of TechnologyRaipur(Chhattisgarh)India

Objective: The high transmission rate and mutations of SARS-Co V-2 have made it a global pandemic, and the shortage of any effective clinical treatment has created such a commotion. There are some synthetic antiviral drugs, such as remdesivir and lopinavir that are being repurposed to treat SARS-Co V-2, but all of these demonstrate extreme side effects in humans. Hence, promoting herbal-based drug development has become crucial as they are cost-effective and have lesser or no side effects. Urtica dioica is abundant in the Himalayan region and the compounds present in it have shown significant antiviral and anti-SARS activity. Therefore, molecular docking studies were performed to identify SARS-Co V-2 spike protein inhibitors from U. dioica to combat the COVID-19 disease. Materials and Methods: Compounds from U. dioica were screened using the bioinformatic approach, and subsequently, these compounds were docked with the S1 subunit of the COVID-19 spike protein(PDB ID: 6YOR). Molecular docking was carried out using the Py Rx software(0.8 version) and further examined by employing the Discovery Studio Visualizer. Results: About all the selected compounds showed significant binding energy(e.g., beta-sitosterol:-10.3 kcal/mol) in contrast to the control chloroquine phosphate. This binding was observed with the spike protein residues that were common in the old strain and the more contagious newly modified B.1.1.7 strain of SARS-Co V-2. Conclusions: Thus, our study can be used in effective drug development against SARS-Co V-2 and its mutant strains also.

关键词： Herbal therapeutics molecular docking SARS-CoV-2 spike protein Urtica dioica

Nanobiocomposite Electrochemical Biosensor Utilizing Synergic Action of Neutral Red Functionalized Carbon Nanotubes

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Nano-Micro Letters 2012年第4期4卷 220-227页

作者： D.R.shobha Jeykumari R.Kalaivani S.Sriman Narayanan Department of Chemistry Women’s Christian college Department of Chemistry School of Basic Sciences VELS University Department of Analytical Chemistry School of Chemical Sciences University of Madras Guindy Campus National Centre for Nanoscience and Nanotechnology University of Madras Guindy campus

An amperometric hydrogen peroxide biosensor using a nanobiocomposite based on neutral red modified carbon nanotubes and co-immobilized glucose oxidase and horseradish peroxidase is reported. Modification of the nanobiocomposite electrode with neutral red resulted in a sensitive, low-cost and reliable H_2O_2 sensor. The use of carbon nanotubes, as the conductive part of the composite, facilitated fast electron transfer rates. The biosensor was characterized for the influence of p H, potential and temperature. A remarkable feature of the biosensor is the detection of H_2O_2 at low applied potentials where the noise level and interferences are minimal. The sensor has a fast steady-state measuring time of 10 s with a quick response(2 s). The biosensor showed a linear range from 15 n M to 45 m M of H_2O_2 and a detection limit of 5 n M. Nafion, which is used as a binder, makes the determination free from other electroactive substances. The repeatability, reproducibility,stability and analytical performance of the sensor are very good.

关键词： Multiwalled carbon nanotubes Neutral red Glucose oxidase Horseradish peroxidase Nafion Nanobiocomposite biosensor