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具有增强一致性和透气性的无基底超薄表皮生物电极用于长期生理监测

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Science China Materials 2024年第5期67卷 1481-1490页

作者：李冠军公彦婷方诗镪游通邵瑞瑞姚兰前刘晨武春锦牛坚赖文勇 State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts&TelecommunicationsNanjing210023China

开发耐用且可靠的生物电极,用以采集高质量的生物电信号,已成为人体生理状态监测和人机交互领域的关键技术.然而,现有的生物电极多基于传统弹性基底,这导致了机械性能不匹配和低渗透性等问题,并且缺乏与生物皮肤类似的多方面属性和必要... 详细信息

开发耐用且可靠的生物电极,用以采集高质量的生物电信号,已成为人体生理状态监测和人机交互领域的关键技术.然而,现有的生物电极多基于传统弹性基底,这导致了机械性能不匹配和低渗透性等问题,并且缺乏与生物皮肤类似的多方面属性和必要的协同特性.本研究中,我们报道了一种新型的基于自支撑导电全聚合物薄膜的超薄表皮生物电极(ASU-EBE).该电极将超一致性、优异的拉伸性和透气性集成于一体,展现了约475 S cm^(-1)的高导电性,约48%的出色拉伸性,与生物组织界面的超一致性以及优异的透气性.该电极的电子和机械性能得到提升,这归功于在PEDOT:PSS中引入水溶性聚氧化乙烯,以调节分子间π-π堆积距离,并促进纳米纤维结构的形成.因此,ASU-EBE在与皮肤接触时的阻抗远低于标准凝胶电极,使其成为复杂日常环境下长期医疗监测的理想选择.

关键词： flexible bioelectronics epidermal bioelectrodes freestanding conductive films conformality breathability

Protein hairy enhancer of split-1 expression during differentiation of muscle-derived stem cells into neuron-like cells

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Neural Regeneration Research 2012年第28期7卷 2182-2187页

作者： Mina Huang Zhanpeng Guo Kun Liu Xifan Mei shiqiang fang Jinhao Zeng Yansong Wang Yajiang Yuan Department of Nursing College Liaoning Medical College Jinzhou 121000 Liaoning Province China Department of Orthopedics FirstAffiliated Hospital of Liaoning Medical College Jinzhou 121000 Liaoning Province China

Muscle-derived stem cells were isolated from the skeletal muscle of Sprague-Dawley neonatal rats aged 3 days old. Cells at passage 5 were incubated in Dulbecco＇s modified Eagle＇s medium supplemented with 10% （v/v） fetal bovine serum, 20 IJg/L nerve growth factor, 20 pg/L basic fibroblast growth factor and 1% （v/v） penicillin for 6 days. Cells presented with long processes, similar to nerve cells. Connections were formed between cell processes. Immunocytochemical staining with neuron specific enolase verified that cells differentiated into neuron-like cells. Immunofluorescence cytochemistry and western blot results revealed that the expression of protein hairy enhancer of split-1 was significantly reduced. These results indicate that low expression of protein hairy enhancer of split-1 participates in the differentiation of muscle-derived stem cells into neuron-like cells.

关键词： muscle-derived stem cells neuron-like cells protein hairy enhancer of split-l proliferation neuronspecific enolase neural regeneration

Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress

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Neural Regeneration Research 2014年第14期9卷 1379-1385页

作者： Jianbo Zhao shiqiang fang Yajiang Yuan Zhanpeng Guo Jinhao Zeng Yue Guo Peifu Tang Xifan Mei Vertebral Column Ward Department of OrthopedicsFirst Affiliated Hospital of Liaoning Medical University Department of Orthopedics General Hospital of People’s Liberation Army

Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations （50-200μg,/mL） of green tea polyphenol to the cell medium for 24 hours. Measurements of superoxide dismutase activity, malondialdehyde content, and expression of apoptosis-related genes and proteins revealed that green tea polyphenol effectively alleviated oxidative stress. Our results indicate that green tea polyphenols play a protective role in spinal cord neurons under oxidative stress.

关键词： nerve regeneration spinal cord injury nerve cells green tea polyphenols spinal cordneurons oxidative stress apoptosis malondialdehyde superoxide dismutase rats NSFC grant neural regeneration

Negative effects of Notch1 on the differentiation of muscle-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2011年第31期6卷 2414-2418页

作者： Xifan Mei Chang Liu Zhanpeng Guo Yajiang Yuan shiqiang fang Yansong Wang Yue Guo Jinhao Zeng Department of Orthopedics First Affiliated Hospital of Liaoning Medical University Jinzhou 121000 Liaoning Province China Department of Endocrinology First Affiliated Hospital of Liaoning Medical University Jinzhou 121000 Liaoning Province China

We cultured rat muscle-derived stem cells in medium containing nerve growth factor and basic fi-broblast growth factor to induce neuronal-like cell *** staining and reverse transcription-PCR showed that the differentiated muscle-derived stem cells exhibited processes similar to those of neuronal-like cells and neuron-specific enolase expression,but Notch1 mRNA and protein expression was ***-regulation of Notch1 expression may facilitate neuronal-like cell differentiation from muscle-derived stem cells.

关键词： muscle-derived stem cells neuronal-like cells Notch signal pathway Notch1 differentiation neural regeneration

Dynamic Resistance and Energy Absorption of Sandwich Beam via a Micro-Topology Optimization

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 146-162页

作者： shiqiang Li Yuwei Li Xiaomin Ma Jianguang fang Zhifang Liu Zhihua Wang Institute of Applied Mechanics Taiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Material Strength and Structural Impact Taiyuan University of TechnologyTaiyuan 030024China School of Civil and Environmental Engineering University of Technology SydneySydneyNSW 2007Australia

The current research of sandwich structures under dynamic loading mainly focus on the response characteristic of *** micro-topology of core layers would sufficiently influence the property of sandwich ***,the micro deformation and topology mechanism of structural deformation and energy absorption are *** this paper,based on the bi-directional evolutionary structural optimization method and periodic base cell(PBC)technology,a topology optimization frame work is proposed to optimize the core layer of sandwich *** objective of the present optimization problem is to maximize shear stiffness of PBC with a volume *** effects of the volume fraction,filter radius,and initial PBC aspect ratio on the micro-topology of the core were *** dynamic response process,core compression,and energy absorption capacity of the sandwich beams under blast impact loading were analyzed by the finite element *** results demonstrated that the overpressure action stage was coupled with the core compression *** the same loading and mass per unit area,the sandwich beam with a 20%volume fraction core layer had the best blast *** filter radius has a slight effect on the shear stiffness and blast resistances of the sandwich *** increasing the filter radius could slightly improve the bending *** changing the initial PBC aspect ratio,there are three ways for PBC evolution:The first is to change the angle between the adjacent bars,the second is to further form holes in the bars,and the third is to combine the first two ***,not all three ways can improve the energy absorption capacity of the *** the aspect ratio of the PBC arbitrarily may lead to worse *** studies are necessary for further detailed *** research proposes a new topology sandwich beam structure by micro-topology optimization,which has sufficient shear *** micro mechanism of structural

关键词： Topology optimization Sandwich beam Impact loading Dynamic resistance Energy absorption Micro mechanism

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中国传统蛋清灰浆的应用历史和科学性

中国科学：技术科学 2015年第6期45卷 635-642页

作者：张坤方世强张秉坚浙江大学文物与博物馆学系杭州310007 浙江大学化学系杭州310027

蛋清灰浆是一种传统有机-无机复合灰浆,在中国古代应用广泛,主要用于三合土建筑、砖石砌筑、泥塑彩绘壁画等方面,与糯米灰浆、桐油灰浆、血料灰浆等共同构成了具有中国特色的古代建筑胶凝材料体系.研究这一人工复合材料的应用历史和科... 详细信息

蛋清灰浆是一种传统有机-无机复合灰浆,在中国古代应用广泛,主要用于三合土建筑、砖石砌筑、泥塑彩绘壁画等方面,与糯米灰浆、桐油灰浆、血料灰浆等共同构成了具有中国特色的古代建筑胶凝材料体系.研究这一人工复合材料的应用历史和科学性无疑可对中国古代建筑史和科技史起到丰富和补充作用.研究发现,将蛋清加入石灰、黏土等无机物浆体中时,会产生一系列物理化学作用,如加气作用、黏接作用、杀菌作用和防水作用等,其作用机理与蛋白质分子及水化产物的界面活性作用有关,也与生物矿化的模板调控作用有关.运用化学检测和酶联免疫检测分析方法,在149处古建筑及遗迹的灰浆样品中发现含有蛋白质成分的有32个以上,充分说明蛋白质类灰浆应用广泛和历史久远的事实,同时也为文物建筑维修保护方案设计提供了参考资料.

关键词：蛋清灰浆历史机理检测

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古代三合土灰浆中蛋清的酶联免疫检测研究

建筑材料学报 2015年第4期18卷 716-720页

作者：张秉坚胡文静张坤方世强浙江大学化学系浙江杭州310027 浙江大学文物与博物馆学系浙江杭州310027

蛋清灰浆三合土(简称蛋清灰浆)是中国古代广泛应用的一种重要建筑灰浆,了解其成分不仅是研究中国建筑科技史的需要,对于濒危文物建筑的维修加固等也具有十分重要的意义.利用抗原-抗体免疫反应的高特异性和灵敏度,采用酶联免疫吸附法(ELI... 详细信息

蛋清灰浆三合土(简称蛋清灰浆)是中国古代广泛应用的一种重要建筑灰浆,了解其成分不仅是研究中国建筑科技史的需要,对于濒危文物建筑的维修加固等也具有十分重要的意义.利用抗原-抗体免疫反应的高特异性和灵敏度,采用酶联免疫吸附法(ELISA),首次实现了蛋清灰浆中微量蛋清成分的准确检测,最低检出浓度(质量分数)可达0.003%,同时解决了灰土本身的颜色干扰问题,为研究古代蛋清类灰浆的成分提供了有效检测技术.

关键词：蛋清灰浆检测分析酶联免疫吸附法

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米浆种类对传统灰浆性能的影响

建筑材料学报 2014年第4期17卷 618-622,665页

作者：魏国锋方世强康予虎张秉坚安徽大学历史系安徽合肥230039 浙江工业大学化学工程与材料学院浙江杭州310014 湖北省文物考古研究所湖北武汉430077 浙江大学文物与博物馆学系浙江杭州310027

在传统灰浆中添加不同种类米浆,然后测试灰浆稠度、表面硬度、抗压强度、收缩率和耐冻融性,观察分析灰浆的微观形貌和结构,探讨米浆种类对灰浆性能的影响及作用机理.结果表明:糯米、糯黄米、血糯米、大米和高粱米米浆的添加,均使灰浆的... 详细信息

在传统灰浆中添加不同种类米浆,然后测试灰浆稠度、表面硬度、抗压强度、收缩率和耐冻融性,观察分析灰浆的微观形貌和结构,探讨米浆种类对灰浆性能的影响及作用机理.结果表明:糯米、糯黄米、血糯米、大米和高粱米米浆的添加,均使灰浆的稠度和收缩率降低,表面硬度、抗压强度和耐冻融性提高;在各种米浆灰浆中,糯黄米灰浆的综合性能最佳,其28d抗压强度和60d抗压强度较纯灰浆分别提高了103.6%和69.4%,耐冻融性提高了150%.建议在砖石质文物保护中使用糯黄米浆作为灰浆的有机添加剂.米浆灰浆良好的力学性能源于米浆灰浆的细密结构,与米浆中的支链淀粉含量相关.

关键词：米浆传统灰浆支链淀粉

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石灰种类对传统糯米灰浆性能的影响

建筑材料学报 2015年第5期18卷 873-878页

作者：魏国锋周虎方世强黄晓娟张秉坚安徽大学历史系安徽合肥230039 浙江工业大学化学工程与材料学院浙江杭州310014 陕西省考古研究院陕西西安710043 浙江大学文物与博物馆学系浙江杭州310027

测试了不同种类石灰制备的(传统)糯米灰浆的表面硬度、抗压强度、耐冻融性等性能,观察了不同种类石灰及其制备的糯米灰浆的微观形貌,探讨了石灰种类对糯米灰浆性能的影响机理.结果表明:采用分析纯氧化钙和工业氧化钙制备的糯米灰浆的抗... 详细信息

测试了不同种类石灰制备的(传统)糯米灰浆的表面硬度、抗压强度、耐冻融性等性能,观察了不同种类石灰及其制备的糯米灰浆的微观形貌,探讨了石灰种类对糯米灰浆性能的影响机理.结果表明:采用分析纯氧化钙和工业氧化钙制备的糯米灰浆的抗压强度、表面硬度和耐冻融性均优于采用分析纯氢氧化钙和工业灰钙粉制备的糯米灰浆,其中,采用分析纯氧化钙制备的糯米灰浆的抗压强度等性能最好.在砖石质不可移动文化遗产保护实践中,建议采用分析纯氧化钙制备糯米灰浆.氧化钙陈化过程中形成的较小氢氧化钙板状晶粒是采用氧化钙制备的糯米灰浆微观结构细密的主要成因.正是由于采用氧化钙制备的糯米灰浆的微观结构细密,因此该类糯米灰浆的抗压强度等性能良好.

关键词：糯米灰浆氧化钙氢氧化钙工业灰钙粉