Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress

作     者：Jianbo Zhao Shiqiang Fang Yajiang Yuan Zhanpeng Guo Jinhao Zeng Yue Guo Peifu Tang Xifan Mei 

作者机构：Vertebral Column WardDepartment of OrthopedicsFirst Affiliated Hospital of Liaoning Medical University Department of OrthopedicsGeneral Hospital of People’s Liberation Army 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第14期

页      面：1379-1385页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China,No.81171799 China Postdoctoral Science Foundation,No.2013T60948 

主　　题：nerve regeneration spinal cord injury nerve cells green tea polyphenols spinal cordneurons oxidative stress apoptosis malondialdehyde superoxide dismutase rats NSFC grant neural regeneration 

摘      要：Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations （50-200μg,/mL） of green tea polyphenol to the cell medium for 24 hours. Measurements of superoxide dismutase activity, malondialdehyde content, and expression of apoptosis-related genes and proteins revealed that green tea polyphenol effectively alleviated oxidative stress. Our results indicate that green tea polyphenols play a protective role in spinal cord neurons under oxidative stress.