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The blood lactate/serum albumin ratio might represent a good prognostic indicator of 28-day mortality in patients with acute respiratory distress syndrome:a retrospective observational study

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Emergency and Critical Care Medicine 2024年第2期4卷 52-59页

作者： Jiahao Chen Chang Gao Ling Yang Lijuan Yang Ying He shiqi guo Yuanxiao Sun Siyu He Qiang guo Department of Critical Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Emergency and Critical Care Medicine Dushu Lake Hospital Affiliated to Soochow University(Suzhou Dushu Lake Hospital)SuzhouJiangsuChina

Background:Acute respiratory distress syndrome(ARDS)is an acute inflammatory lung injury with a high mortality ***,previous ARDS prognostic scoring systems or predictors have been limited by complex formulas that are relatively expensive and inconvenient to ***,this study aimed to explore the clinical significance of the blood lactate/serum albumin ratio(LAR)in assessing the prognosis of ARDS patients and compare it with other indicators related to 28-day mortality in ARDS ***:We conducted a single-center retrospective study involving patients who fulfilled the Berlin definition of ARDS between 2016 and *** data were collected from medical records within 24 hours after ARDS *** LAR,neutrophil-to-lymphocyte ratio,and monocyteto-lymphocyte ratio(MLR)were *** primary clinical outcome was 28-day *** risk factors for 28-day mortality were determined using conditional logistic regression *** receiver operating characteristic curve was used to evaluate the area under the curve(AUC).Results:A total of 276 ARDS patients met the inclusion criteria and were divided into surviving and nonsurviving groups according to 28-day *** were significant differences in the Acute Physiologic Assessment and Chronic Health Evaluation II scores,Sequential Organ Failure Assessment scores,MLRs,and LARs between the surviving and nonsurviving *** AUC for the LAR was 0.790(P<0.001),whereas the AUCs for the Acute Physiologic Assessment and Chronic Health Evaluation II score,Sequential Organ Failure Assessment score,neutrophil-to-lymphocyte ratio,and MLR were 0.584,0.599,0.524,and 0.587,*** grouping according to an LAR optimal cutoff value of 0.07,28-day mortality was significantly higher in the high-LAR group than in the low-LAR group(47.18 vs.12.69,P<0.001).Conclusion:The LAR is an independent risk factor for 28-day mortality in ARDS patients and can be used to assess the severity of

关键词： Acute respiratory distress syndrome Albumin Lactate Mortality Predictor

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中国职业技能结构转型:任务内容的视角

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经济研究 2024年第1期59卷 188-207页

作者：胡涟漪盖庆恩朱喜郭士祺上海交通大学安泰经济与管理学院 200030 上海财经大学财经研究所 200433

本文基于《中华人民共和国职业分类大典》和《现代汉语分类词典》,使用自然语言处理法分析职业技能属性,构建中国职业的抽象、常规和社交技能指数,并从时间、人口特征和空间层面描述劳动力市场的职业技能变化趋势,总结其结构转型的规律... 详细信息

本文基于《中华人民共和国职业分类大典》和《现代汉语分类词典》,使用自然语言处理法分析职业技能属性,构建中国职业的抽象、常规和社交技能指数,并从时间、人口特征和空间层面描述劳动力市场的职业技能变化趋势,总结其结构转型的规律。本文研究发现:首先,1990年至2015年期间,高抽象、低常规、高社交职业的就业份额呈上升趋势,尤其是同时具备抽象和社交技能的复合型职业的增长幅度最大;其次,职业技能属性在不同教育水平、年龄、出生年代和户口类型劳动力之间存在显著差异;最后,经济发展水平与抽象、社交就业比例呈“U”型关系,与常规就业比例呈倒“U”型关系。本文研究结果意味着,落实就业优先战略,需要重视职业技能结构转型的趋势和特征,从而有效促进高质量充分就业。

关键词：职业技能任务内容就业结构经济发展

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万全的小儿体质观

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中医药导报 2024年第7期30卷 193-196页

作者：郭仕琪赵艳北京中医药大学中医学院北京102488

基于明代著名儿科医家万全的《片玉心书》《育婴家秘》《幼科发挥》等儿科著作进行文献研究,分析总结万全临证中的小儿体质理论及思想。从万全对小儿体质的共性观和个性观展开探讨。万全指出小儿在形体结构、生理机能、心理状态三方面... 详细信息

基于明代著名儿科医家万全的《片玉心书》《育婴家秘》《幼科发挥》等儿科著作进行文献研究,分析总结万全临证中的小儿体质理论及思想。从万全对小儿体质的共性观和个性观展开探讨。万全指出小儿在形体结构、生理机能、心理状态三方面存在体质共性特点:形具而微,其用随长;机能欠匀,感传有势;稚神萌发,易塑易动。小儿体质同样存在个体差异,自然环境、父母体质、调护、社会环境等因素均会造成小儿体质个体差异,并初步指出了服药物、重养护的体质干预手段。以期对儿科临床充分把握小儿体质特点、实现治未病有所助益。

关键词：小儿体质万全中医儿科

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改性黄曲霉A5P1对染料酸性蓝25的吸附效果与机理研究

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工业水处理 2024年第2期44卷 95-104页

作者：郭世琦覃雯李青云唐爱星刘幽燕广西大学化学化工学院广西南宁530004 广西生物炼制重点实验室广西南宁530004

以黄曲霉A5P1为原料,利用盐酸改性法制成生物吸附剂A5P1_(acid),用于吸附酸性蓝25(AB25)染料。对A5P1_(acid)吸附的影响因素进行分析,结果表明:染料吸附的最佳吸附剂用量为0.5 g/L,最适pH为2,60 min达到吸附平衡。吸附剂经盐酸改性后,... 详细信息

以黄曲霉A5P1为原料,利用盐酸改性法制成生物吸附剂A5P1_(acid),用于吸附酸性蓝25(AB25)染料。对A5P1_(acid)吸附的影响因素进行分析,结果表明:染料吸附的最佳吸附剂用量为0.5 g/L,最适pH为2,60 min达到吸附平衡。吸附剂经盐酸改性后,吸附量从137 mg/g提高到182 mg/g,染料去除率提高了32%。通过分析A5P1_(acid)吸附去除AB25的机理,发现吸附过程符合准二级动力学模型,是由化学吸附控制吸附速率;符合Freundlich吸附等温线,吸附属于多层非均相吸附。热力学结果表明吸附过程是一个吸热自发的过程。Zeta电位和FTIR结果表明,吸附是由多种官能团的静电吸附和氢键作用的。吸附剂经过循环吸附-解吸7次仍保留初始吸附量的50.6%。实验研究证明,A5P1_(acid)是一种绿色有效可用于去除阴离子染料的生物吸附质材料。

关键词：黄曲霉吸附酸改性染料脱色

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护士处方权在糖尿病管理中应用的研究进展

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护理研究 2024年第12期38卷 2173-2177页

作者：程娜周秀玲郭士琪薛静雅长春中医药大学吉林130117

对国内外护士处方权的研究现状进行综述,分析护士处方权对糖尿病管理的作用及意义,并提出相关建议,为我国糖尿病护士处方权的管理提供参考。

关键词：护士处方权糖尿病糖尿病管理糖尿病专科护士综述

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Rational design of Aspergillus flavus A5p1-immobilized cell system to enhance the decolorization of reactive blue 4(RB4)

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Chinese Journal of Chemical Engineering 2022年第12期52卷 37-44页

作者： Wenbo Yang Qingyun Li shiqi guo Shijie Sun Aixing Tang Haibo Liu Youyan Liu School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China Guangxi Key Laboratory of Biorefining Nanning 530003China

Anthraquinone dyes are a class of typical carcinogenic and hard-biodegradable organic *** study aimed to enhance the decolorization of anthraquinone dye by rationally designing an expected immobilized *** blue 4(RB4) was used as a substrate model and a previous isolated dyedegrading strain Aspergillus flavus A5pl was purposefully *** the effects of cell attachment and mass transfer,the polyurethane foam(PUF) with open pore structure was selected as the immobilization *** showed that the RB4 decolorization efficiency was significant enhanced after *** to the free mycelium system,the decolorization time of200 mg·L^(-1)RB4 was shortened from 48 h to 28 h by the PUF-immobilized cell ***,the PUF-immobilized system could tolerate RB4 up to 2000 mg-L^(-1).In the packed bed bioreactor(PBBR),an average decolorization efficiency of 93.3% could be maintained by the PUF-immobilized system for26 *** decolorization process of RB4 was well described by the logistic equation and the degradation pathway was *** was found that the higher specific growth rate of the PUF-immobilized cells was one of reasons for the enhanced *** good performance of the PUFimmobilized cell system would make it have potential application value for RB4 bioremediation.

关键词： Aspergillus flavus A5p1 Reactive blue 4(RB4) Polyurethane foam(PUF) Immobilized cell Decolorization

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Room temperature compressive properties and strengthening mechanism of Mg96.17Zn3.15Y0.50Zr0.18 alloy solidified under high pressure

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Journal of Rare Earths 2020年第6期38卷 657-664页

作者： Xiaoping Lin Zhibin Fan Chang Xu Kunyu guo Chang Xu shiqi guo School of Materials and Engineering Northeast UniversityShenyang 110819China School of Resources and Materials Northeast University at QinhuangdaoQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Qinhuangdao 066004China

The microstructures of Mg96.17Zn3.15Y0.50Zr0.18 alloys solidified under 2-6 GPa high pressure were investigated by employing SEM(EDS) and *** strengthening mechanism of experimental alloy solidified under high pressure is also discussed by analyzing the compressive properties and compression fracture *** results show that the microstructure of experimental alloy becomes significantly fine-grained with increasing GPa level high pressure during solidification process,and the secondary dendrite arm spacing reduces from 40 μm at atmospheric pressure to 10 μm at 6 GPa *** morphology of the second phases changes from the net structure by the lamellar-type eutectic structure at atmospheric pressure to discontinuous thin rods or particles at 6 GPa ***,the solid solubility of Zn in the Mg matrix is improved with the increase of the solidification *** with atmospheric-pressure solidification,high-pressure solidification can improve the strength of the experimental *** compressive stre ngth is improved from 263 to 437 MPa at 6 *** fracture mechanism of the experimental alloy changes from cleavage fracture at atmospheric pressure to quasi-cleavage fracture at high *** main mechanism of the strength improvement of the experimental alloy includes the grain refinement strengthening caused by the refinement of the solidification microstructure,the second phase strengthening caused by the improvement of the morphology and distribution of the second phases,and solid solution strengthening caused by the increase of the solid solubility of Zn in the Mg matrix.

关键词： High-pressure solidification Mg96.17Zn3.15Y0.50Zr0.18 alloys Secondary dendrite arm spacing Solid solubility Rare earths

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Manipulation of low-refractive-index particles using customized dark traps

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Photonics Research 2024年第6期12卷 1334-1343页

作者： MINRU HE YANSHENG LIANG XUE YUN SHAOWEI WANG TIANYU ZHAO LINQUAN guo XINYU ZHANG shiqi KUANG JINXIAO CHEN MING LEI MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter School of PhysicsXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

Low-refractive-index particles play significant roles in physics,drug delivery,biomedical science,and other ***,they have not attained sufficient utilization in active manipulation due to the repulsive effect of *** this work,the establishment of customized dark traps is demonstrated to fulfill the demands of versatile manipulation of low-refractive-index *** customized dark traps are generated by assembling generalized perfect optical vortices based on the free lens modulation method,by which the beams’shape,intensity,and position can be elaborately designed with size independent of topological *** the customized dark traps with high quality and high efficiency,rotation along arbitrary trajectories with controllable speed,parallel manipulation,and sorting of low-refractive-index particles by size can be *** unprecedented flexibility and quality,the customized dark traps provide tremendous potential in optical trapping,lithography,and biomedicine.

关键词： refractive rotation versatile

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Silkworm pupa peptide ameliorates dextrose sodium sulfate-induced colitis by enhancing gut barriers and modifying gut flora

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Food Science and Human Wellness 2024年

作者： Yaxi Zhou Diandian Wang Hao Duan shiqi Zhou Jinhong guo Yu guo Jian Zhao Wenjie Yan Beijing Key Laboratory of Bioactive Substances and Functional Food College of Biochemical Engineering Beijing Union University

The anti-inflammatory properties of silkworm pupa peptide (SPP) have been recognized for their potential benefits in colitis treatment. However， the underlying mechanism of SPP in colitis animal models remains unclear. The objective of our work was to investigate the improving effect and the mechanism of action of SPP on a mouse model of dextrose sodium sulfate (DSS)-induced colitis. The findings suggested that SPP effectively eased ulcerative colitis (UC) symptoms in mice by decreasing disease activity index， ameliorating histopathological injury， and decreasing serum and colonic markers of inflammation. In addition， our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1 (ZO-1)， claudin-1， claudin-3， occludin， and adherens junction protein E-cadherin1. Further， SPP supplementation enhanced the concentration of short-chain fatty acids and positively altered the makeup of the gut bacteria in the mice’s gut. These findings underscore SPP’s ability to slow the progression of colitis and point to its possible use as a functional component in dietary supplements for the prevention of early-stage colitis.

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Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility:What can we learn from the literature

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Asian Journal of Pharmaceutical Sciences 2021年第5期16卷 551-576页

作者： shiqi guo Yanan Shi Yanzi Liang Lanze Liu Kaoxiang Sun Youxin Li College of Life Science Yantai UniversityYantai 264005China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China State Key Laboratory of Long-acting and Targeting Drug Delivery System Luye Pharmaceutical Co.Ltd.Yantai 264003China

This article discusses the various blood interactions that may occur with various types of nano drug-loading systems. Nanoparticles enter the blood circulation as foreign objects. On the one hand, they may cause a series of inflammatory reactions and immune reactions, resulting in the rapid elimination of immune cells and the reticuloendothelial system, affecting their durability in the blood circulation. On the other hand, the premise of the drug-carrying system to play a therapeutic role depends on whether they cause coagulation and platelet activation, the absence of hemolysis and the elimination of immune cells. For different forms of nano drug-carrying systems, we can find the characteristics, elements and coping strategies of adverse blood reactions that we can find in previous researches. These adverse reactions may include destruction of blood cells, abnormal coagulation system, abnormal effects of plasma proteins, abnormal blood cell behavior, adverse immune and inflammatory reactions, and excessive vascular stimulation. In order to provide help for future research and formulation work on the blood compatibility of nano drug carriers.

关键词： Nano-drug delivery system Hemocompatibility Adverse interaction Improvement strategy

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