The blood lactate/serum albumin ratio might represent a good prognostic indicator of 28-day mortality in patients with acute respiratory distress syndrome:a retrospective observational study

作     者：Jiahao Chen Chang Gao Ling Yang Lijuan Yang Ying He Shiqi Guo Yuanxiao Sun Siyu He Qiang Guo Jiahao Chen;Chang Gao;Ling Yang;Lijuan Yang;Ying He;Shiqi Guo;Yuanxiao Sun;Siyu He;Qiang Guo

作者机构：Department of Critical Care MedicineThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Emergency and Critical Care MedicineDushu Lake Hospital Affiliated to Soochow University(Suzhou Dushu Lake Hospital)SuzhouJiangsuChina 

出 版 物：《Emergency and Critical Care Medicine》 (急危重症医学（英文）)

年 卷 期：2024年第4卷第2期

页      面：52-59页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from Jiangsu Province’s Key Provincial Talents Program(ZDRCA2016046) Key Health Talents in Gusu(GSWS2019009) 

主　　题：Acute respiratory distress syndrome Albumin Lactate Mortality Predictor 

摘      要：Background:Acute respiratory distress syndrome(ARDS)is an acute inflammatory lung injury with a high mortality ***,previous ARDS prognostic scoring systems or predictors have been limited by complex formulas that are relatively expensive and inconvenient to ***,this study aimed to explore the clinical significance of the blood lactate/serum albumin ratio(LAR)in assessing the prognosis of ARDS patients and compare it with other indicators related to 28-day mortality in ARDS ***:We conducted a single-center retrospective study involving patients who fulfilled the Berlin definition of ARDS between 2016 and *** data were collected from medical records within 24 hours after ARDS *** LAR,neutrophil-to-lymphocyte ratio,and monocyteto-lymphocyte ratio(MLR)were *** primary clinical outcome was 28-day *** risk factors for 28-day mortality were determined using conditional logistic regression *** receiver operating characteristic curve was used to evaluate the area under the curve(AUC).Results:A total of 276 ARDS patients met the inclusion criteria and were divided into surviving and nonsurviving groups according to 28-day *** were significant differences in the Acute Physiologic Assessment and Chronic Health Evaluation II scores,Sequential Organ Failure Assessment scores,MLRs,and LARs between the surviving and nonsurviving *** AUC for the LAR was 0.790(P0.001),whereas the AUCs for the Acute Physiologic Assessment and Chronic Health Evaluation II score,Sequential Organ Failure Assessment score,neutrophil-to-lymphocyte ratio,and MLR were 0.584,0.599,0.524,and 0.587,*** grouping according to an LAR optimal cutoff value of 0.07,28-day mortality was significantly higher in the high-LAR group than in the low-LAR group(47.18 vs.12.69,P0.001).Conclusion:The LAR is an independent risk factor for 28-day mortality in ARDS patients and can be used to assess the severity of