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Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression

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Signal Transduction and Targeted Therapy 2024年第1期9卷 279-294页

作者： Liping Chen shihao zhu Tianyuan Liu Xuan Zhao Tao Xiang Xiao Hu Chen Wu Dongxin Lin Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Cancer Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China CAMS Oxford Institute Chinese Academy of Medical SciencesBeijing 100006China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

Epithelial-mesenchymal transition(EMT)and proliferation play important roles in epithelial cancer formation and progression,but what molecules and how they trigger EMT is largely *** we performed spatial transcriptomic and functional analyses on samples of multistage esophageal squamous-cell carcinoma(ESCC)from mice and humans to decipher these critical *** investigating spatiotemporal gene expression patterns and cell–cell interactions,we demonstrated that the aberrant epithelial cell interaction via EFNB1-EPHB4 triggers EMT and cell cycle mediated by downstream SRC/ERK/AKT *** aberrant epithelial cell interaction occurs within the basal layer at early precancerous lesions,which expands to the whole epithelial layer and strengthens along the cancer development and *** analysis revealed that the aberrant EFNB1-EPHB4 interaction is caused by overexpressedΔNP63 due to TP53 mutation,the culprit in human ESCC *** results shed new light on the role of TP53-TP63/ΔNP63-EFNB1-EPHB4 axis in EMT and cell proliferation in epithelial cancer formation.

关键词： esophageal TP53 squamous

Effects of pressure and doping on Ruddlesden-Popper phases La_(n+1)Ni_(n)O_(3 n+1)

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Journal of Materials Science & Technology 2024年第18期185卷 147-154页

作者： Mingxin Zhang Cuiying Pei Qi Wang Yi Zhao Changhua Li Weizheng Cao shihao zhu Juefei Wu Yanpeng Qi School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210China

Recently,the discovery of superconductivity with a critical temperature Tc up to 80 K in Ruddlesden-Popper phases La_(n+1)Ni_(n)O_(3 n+1)(n=2)under pressure has garnered considerable *** to now,the superconductivity was only observed in La_(3)Ni_(2)O_(7)single crystal grown with the optical-image float-ing zone furnace under oxygen *** remains to be understood the effect of chemical doping on superconducting La_(3)Ni_(2)O_(7)as well as other Ruddlesden-Popper ***,we systematically investi-gate the effect of external pressure and chemical doping on polycrystalline Ruddlesden-Popper *** results demonstrate that the application of pressure and doping effectively tunes the transport prop-erties of Ruddlesden-Popper *** find pressure-induced superconductivity up to 86 K in La_(3)Ni_(2)O_(7)polycrystalline sample,while no signatures of superconductivity are observed in La_(2)NiO_(4)and La_(4)Ni_(3)O_(10)polycrystalline samples under high pressure up to 50 *** study sheds light on the exploration of high-Tc superconductivity in nickelates.

关键词： Unconventional superconductivity High pressure Nickelates Ruddlesden-Popper phases

Principle and application of three-band gradient difference vegetation index

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Science China Earth Sciences 2005年第2期48卷 241-249页

作者： TANG shihao, zhu Qijiang, WANG Jindi, ZHOU Yuyu & ZHAO Feng Research Center for Remote Sensing and GIS, Department of Geography, Beijing Normal University, Beijing 100875, China National Satellite Meteorological Center, China Meteorological Administration, Beijing 100081, China 1. Research Center for Remote Sensing and GIS Department of Geography Beijing Normal University 100875 Beijing China 2. National Satellite Meteorological Center China Meteorological Administration 100081 Beijing China

Vegetation index is a simple, effective and experiential measurement of terrestrial vegetation activity, and plays a very important role in qualitative and quantitative remote sensing. Aiming at shortages of current vegetation indices, and starting from the analysis of vegetation spectral characteristics, we put forward a new vegetation index, the three-band gradient difference vegetation index (TGDVI), and established algorithms to inverse crown cover fraction and leaf area index (LAI) from it. Theoretical analysis and model simulation show that TGDVI has high saturation point and the ability to remove the influence of background to some degree, and the explicit functional relation with crown cover fraction and LAI can be established. Moreover, study shows that TGDVI also has the ability to partly remove the influence of thin cloud. Experiment in the Shunyi District, Beijing, China shows that reasonable result can be reached using the vegetation index to retrieve LAI. We also theoretically analyzed the reason why the normalized difference vegetation index (NDVI) owns the low saturation point, and show that it is determined by the definition of NDVI and the characteristic of vegetation spectra, and is unavoidable to some degree. Meanwhile, through model simulation, we also indicate that the relationship between simple ratio vegetation index (SR) and LAI closes to a piecewise linear one instead of a linear one, which is mainly caused by the influence of background and different change rates of reflectance in red and infrared bands with LAI increasing.

关键词： vegetation index, remote sensing, LAI, crown cover fraction, remote sensing inversion.

基于TCT结构采用变异系数法光伏阵列重构策略

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电源技术 2022年第7期46卷 807-810页

作者：朱世豪朱武上海电力大学电子与信息工程学院上海200090

为了提高光照不均或局部遮荫条件下光伏阵列的输出功率,将网状连接TCT(total-cross-tied)型的光伏阵列结构划分为活动补偿部分和固定输出部分,提出一种基于变异系数的方法来控制连接两部分的矩阵开关,该方法不仅可以反映重构前后光伏阵... 详细信息

为了提高光照不均或局部遮荫条件下光伏阵列的输出功率,将网状连接TCT(total-cross-tied)型的光伏阵列结构划分为活动补偿部分和固定输出部分,提出一种基于变异系数的方法来控制连接两部分的矩阵开关,该方法不仅可以反映重构前后光伏阵列的变异情况,还能避免重构过程中矩阵开关的非必要动作,使得光伏阵列可以根据不同的阴影情况快速完成开关切换,调整两部分光伏组件的连接结构。仿真结果表明,重构后的光伏阵列不但较重构前明显提高了输出功率,而且使得功率曲线更趋向于单峰值特征,在重构实施过程中还大幅降低了矩阵开关的尝试次数,节约了功耗和时间。

关键词：光伏阵列局部阴影局部重构变异系数开关策略

VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2906-2919页

作者： Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang shihao zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cancer Institute Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqiChina Key Laboratory of Oncology of Xinjiang Uygur Autonomous Region UrumqiChina Department of pharmacy Qilu HospitalCheeloo College of MedicineShandong UniversityJinanChina Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhouChina Jiangsu Key Laboratory of Cancer Biomarkers Prevention and TreatmentCollaborative Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingChina CAMS Key Laboratory of Genetics and Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely ***,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary *** have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation.

关键词： cancer clinical resistance

赣南马尾松林地表细小死可燃物含水率动态及模型

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林业科学 2024年第5期60卷 158-168页

作者：朱诗豪吴志伟李政杰李顺江西师范大学地理与环境学院、江西师范大学鄱阳湖湿地与流域研究教育部重点实验室、江西省自然灾害监测预警与评估重点实验室南昌330022

[目的]建立森林地表细小死可燃物(枯落叶、细枯枝、枯草等)含水率预测模型,预警区域森林火灾引燃的可能性及其潜在火行为。[方法]基于野外长期定位观测的赣南地区典型植被类型马尾松林地表细小死可燃物含水率数据,在不同地形条件和时间... 详细信息

[目的]建立森林地表细小死可燃物(枯落叶、细枯枝、枯草等)含水率预测模型,预警区域森林火灾引燃的可能性及其潜在火行为。[方法]基于野外长期定位观测的赣南地区典型植被类型马尾松林地表细小死可燃物含水率数据,在不同地形条件和时间段进行气象因子随机森林相对重要性排序和皮尔逊相关性分析,建立地表细小死可燃物含水率随机森林模型和气象要素回归模型,比较不同模型精度指标,筛选适合赣南地区的森林火灾预测模型。[结果]赣南地区马尾松林地表细小死可燃物含水率具有明显变异性,阴坡含水率显著高于阳坡,在防火期初期最明显。地表细小死可燃物含水率与各气象要素(温度、相对湿度、风速、光照强度)具有极显著相关性(P<0.001);随机森林模型预测精度高于气象要素回归模型,阴坡2种模型精度均高于阳坡;具有滞后效应的光照强度因子对地表细小死可燃物含水率影响最大,影响地表细小死可燃物含水率的关键因素在阳坡是相对湿度、阴坡是风速。[结论]具有滞后效应的气象因子对赣南地区马尾松林地表细小死可燃物含水率有显著影响,考虑增加这些因素能更好预测地表细小死可燃物含水率变化,为火险预警提供可靠依据。

关键词：地表细小死可燃物含水率预测模型气象要素回归模型随机森林赣南地区

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实际气体效应对碳氢燃料点火延迟时间的影响

西安交通大学学报 2022年第1期56卷 1-11页

作者：梁兴雨廖寄语朱仕皓沈位王昆天津大学内燃机燃烧学国家重点实验室天津300072

当前商业软件或数值计算方法基于理想气体假设对点火延迟时间等碳氢燃料基础燃烧数据进行仿真模拟,在高压或超临界压力条件下可能导致较大误差。本研究依托开源化学反应动力学计算平台Cantera,构建了考虑实际气体效应的模拟仿真框架,进... 详细信息

当前商业软件或数值计算方法基于理想气体假设对点火延迟时间等碳氢燃料基础燃烧数据进行仿真模拟,在高压或超临界压力条件下可能导致较大误差。本研究依托开源化学反应动力学计算平台Cantera,构建了考虑实际气体效应的模拟仿真框架,进行了平台可靠性的验证,计算了丙烷、正庚烷和正十二烷等典型燃料体系在不同压力条件下的点火延迟时间,分析了实际气体效应对碳氢燃料点火延迟时间的影响。结果表明:高压条件下实际气体效应对点火延迟时间的影响较为显著,仿真计算中须考虑该效应以获得准确结果;燃料物化性质的非理想性随压力升高而增加,采用实际气体状态方程可以恰当地描述该变化特征;点火延迟时间的非理想性偏差与压力、温度存在较明显关联,且随着压力升高而单调增大,与温度的关联则呈现非单调性,在负温度系数区域出现峰值。本研究可为碳氢燃料在热力设备高压或超临界压力条件下燃烧反应过程的高精度模拟提供理论支持。

关键词：气体状态方程碳氢燃料点火延迟时间燃烧反应动力学

长三角都市圈小城镇住宅价格空间分布特征研究--以湖州市为例

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小城镇建设 2020年第3期38卷 12-18页

作者：朱世豪黄大全北京师范大学地理科学学部地理学院北京师范大学地理科学学部地理学院、环境遥感与数字城市北京市重点实验室

城市住宅价格一直是城市地理学、城市规划学和经济地理学研究的重点内容。都市圈内部房地产市场发展迥异,体现了一个地区不同尺度之间资源配置能力和作用。本文采用克里金插值方法对长三角都市圈房价空间分布格局进行空间估计,并重点讨... 详细信息

城市住宅价格一直是城市地理学、城市规划学和经济地理学研究的重点内容。都市圈内部房地产市场发展迥异,体现了一个地区不同尺度之间资源配置能力和作用。本文采用克里金插值方法对长三角都市圈房价空间分布格局进行空间估计,并重点讨论浙江省湖州市小城镇房价的影响因素。研究结果表明:(1)长三角都市圈房价分布呈现出多中心的分布特征,但省间的共通性不强。(2)湖州市房价分布受杭州房价溢出效应影响,呈现出轴线状的双中心特征,垂直于轴向东西两侧衰减。(3)都市圈核心城市房价溢出效应远大于小城镇自身核心区的集聚效应,小城市的房价水平受邻近的大城市影响显著。

关键词：小城镇住宅价格克里金插值溢出效应长三角都市圈湖州市

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地理信息系统在国防工程选址中的应用

防护工程 2019年第2期38卷 67-72页

作者：朱世豪王昱蘅 65129部队吉林通化134102 陆军工程大学徐州训练基地江苏徐州221004

由于计算机网络技术的迅速发展,地理信息系统(GIS)从一门技术系统不断地发展成为一门由地理学、测绘学、遥感、计算机科学、数学和管理学等交叉形成的新兴边缘学科,广泛地应用于社会各个领域。立足于GIS在国防工程选址中的应用,论述了... 详细信息

由于计算机网络技术的迅速发展,地理信息系统(GIS)从一门技术系统不断地发展成为一门由地理学、测绘学、遥感、计算机科学、数学和管理学等交叉形成的新兴边缘学科,广泛地应用于社会各个领域。立足于GIS在国防工程选址中的应用,论述了选址空间模型的建立和GIS的空间分析及空间建模能力,研究探讨了运用模型编辑器将选址理论模型转化为数据模型解决选址问题,将花费大量人力物力的人工选址转变为借助GIS的强大空间数据处理能力的计算机辅助决策,提出将GIS运用于国防工程建设管理提高国防工程信息化水平的初步设想。

关键词：地理信息系统国防工程空间分析空间建模