VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance

作     者：Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu Weiling Liu;Chuanwang Miao;Shaosen Zhang;Yachen Liu;Xiangjie Niu;Yiyi Xi;Wenjia Guo;Jiahui Chu;Ai Lin;Hongjin Liu;Xinyu Yang;Xinjie Chen;Ce Zhong;Yuling Ma;Yuqian Wang;Shihao Zhu;Shuning Liu;Wen Tan;Dongxin Lin;Chen Wu

作者机构：Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cancer InstituteAffiliated Cancer Hospital of Xinjiang Medical UniversityUrumqiChina Key Laboratory of Oncology of Xinjiang Uygur Autonomous RegionUrumqiChina Department of pharmacyQilu HospitalCheeloo College of MedicineShandong UniversityJinanChina Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangzhouChina Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingChina CAMS Key Laboratory of Genetics and Genomic BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第9期

页      面：2906-2919页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 10[医学] 

基　　金：This project was supported by National Science Fund for Distinguished Young Scholars(81725015 to C.W.) Medical and Health Technology Innovation Project of Chinese Academy of Medical Sciences(2016-I2M-3-019 to D.L.,2016-I2M-4-002 to C.W.,2019-I2M-2-001 to D.L.and C.W.,2016-I2M-1-001 and 2019-12M-1-003 to W.T.) Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023027 to C.W.) National Natural Science Foundation of China(81988101 to D.L and C.W.) 

主　　题：cancer clinical resistance 

摘      要：Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely ***,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary *** have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation.