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Intracellular calcium ions facilitate dengue virus entry into endothelial cells and compromise endothelial barrier integrity

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Asian Pacific Journal of Tropical Medicine 2021年第11期14卷 505-516页

作者： Meng-Hooi Shu Pooi-Fong Wong Sing-Sin Sam shih-keng loong Boon-Teong Teoh Sazaly AbuBakar Tropical Infectious Diseases Research and Education Centre(TIDREC) Universiti Malaya50603 Kuala LumpurMalaysia Department of Pharmacology Faculty of MedicineUniversiti Malaya50603 Kuala LumpurMalaysia World Health Organization Collaborating Centre for Arbovirus Reference and Research(Dengue and Severe Dengue)MAA-12 Universiti Malaya50603 Kuala LumpurMalaysia

Objective:To investigate the involvement of Ca^(2+)in dengue virus(DENV)-infected human umbilical vein endothelial cells(HUVECs)and the disruption of endothelial ***:HUVECs were infected with DENV-2 in the presence of intracellular Ca^(2+)or endoplasmic reticulum Ca^(2+)*** infectivity was measured by focus-forming assay and quantitative *** Ca^(2+)was measured using Fluo-4-AM ***-cadherin and focal adhesion kinase(FAK)expressions were investigated by immunofluorescence and immunoblotting assays,***:DENV infection increased intracellular cytosolic Ca^(2+)levels and caused disassembly of the adherens junction protein,VEcadherin as evidenced by decreased VE-cadherin expression at the periphery of DENV-2 infected *** of intracellular Ca^(2+)stores,particularly those of the endoplasmic reticulum Ca^(2+),significantly decreased DENV yield in *** virus yield following the depletion of intracellular Ca^(2+)was caused by the inhibition of viral entry into HUVECs and not the inhibition of viral binding or ***-2 infection also resulted in Ca^(2+)-dependent activation of ***:Intracellular Ca^(2+)is required for the early phases of DENV infection in endothelial *** cytosolic Ca^(2+)levels in endothelial cells during DENV infection activated FAK,disrupted adherens junctions and compromised barrier ***,Ca^(2+)plays an important role in DENV infection in endothelial cells.

关键词： Endothelial cells Calcium signalling Dengue virus Endothelium permeability Intracellular calcium

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Misidentification of multidrug resistant Enterococcus faecium using a commercial identification method

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Asian Pacific Journal of Tropical Medicine 2020年第10期13卷 474-476页

作者： shih keng loong Nurul Asma Anati Che-Mat-Seri Nur Hidayana Mahfodz Sazaly AbuBakar Tropical Infectious Diseases Research&Education Centre University of Malaya50603 Kuala LumpurMalaysia Department of Medical Microbiology Faculty of Medicine50603 Kuala LumpurMalaysia

Enterococcus(E.)faecium is recognized as a leading cause of nosocomial infections *** with the organism is often difficult to treat due to its inherent ability to acquire glycopeptide resistance genes and other virule... 详细信息

关键词： identification multidrug resistant

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Isolation of Kytococcus schroeteri from the brown rat Rattus norvegicus

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Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 191-192页

作者： shih keng loong Nurul Asma Anati Che-Mat-Seri Kim-Kee Tan Noor-Syahida Azizan Siti Noraisah Ahmad-Nasrah Siti Nursheena Mohd-Zain Sazaly AbuBakar Tropical Infectious Diseases Research&Education Centre High Impact Research BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Department of Medical Microbiology Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Institute of Biological Sciences Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia

Rodents such as Rattus rattus and Rattus norvegicus have adapted to living close to human settlements[1].This presents a public health challenge as these rodents are considered as pests that can transmit a number of zoonotic diseases to humans[1,2].A rodent surveillance programme was initiated between the years 2014 and 2015,focusing on rodents captured at wet markets where there is abundant food and considerable human *** present study was conducted in several wet markets in Kuala Terengganu,Malaysia(5.3333°N,103.1500°E).

关键词： Rattus initiated abundant

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Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer

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Science China Chemistry 2024年第2期67卷 652-663页

作者： Chong Li Minghao Han Ji Gao Shuxian Wang Song-Bo Lu Yaxi Li Zhao Liu Chen Zhang Zhaojin Wang Fangliang Wang Yuang Sun Chun loong Ho Kai Wang Yun Shen Kai Li Shenzhen Key Laboratory of Smart Healthcare Engineering Guangdong Provincial Key Laboratory of Advanced BiomaterialsDepartment of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen518055China Department of Chemical and Environmental Engineering University of California RiversideRiverside92521USA Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen518055China

The critical factor of spatial constraint,provided by the external confinement(e.g.,matrix),is often overlooked during photodynamic inactivation,despite playing a crucial role in determining the molecular photophysical process and subsequent antipathogen ***,as a proof-of-concept model,we employed two types of polymers with varying interaction energies with dopants to investigate the intrinsic relationship between spatial constraint and the essential excited-state behaviors of doped photosensitizer(4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)ethyl)-1-methylquinolin-1-ium iodine,TPP).Through experimental investigation and theoretical calculations,we found that TPP tends to remain in the excited state for a shorter dwell time under weaker spatial constraints due to less restricted molecular motion in polyurethane(PU) ***,the singlet oxygen(^(1)O_(2)) generated from doped-TPP shows a 9.23-fold enhancement in PU than in the polyvinylchloride(PVC) *** light irradiation,the PU@TPP nanofiber can efficiently eliminate the coronavirus MHV-A59(≥99.9997%) at a 220,000-fold higher concentration than the infected *** antibacterial efficacy has also been demonstrated,with a killing rate of ≥99%.

关键词： photodynamic antibacterial singlet oxygen triphenylamine nanofiber

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Thermal pyrolysis conversion of methane to hydrogen(H_(2)):A review on process parameters,reaction kinetics and techno-economic analysis

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Chinese Chemical Letters 2024年第8期35卷 62-73页

作者： Yi Herng Chan Zhe Phak Chan Serene Sow Mun Lock Chung loong Yiin Shin Ying Foong Mee Kee Wong Muhammad Anwar Ishak Ven Chian Quek Shengbo Ge Su Shiung Lam PETRONAS Research Sdn.Bhd.(PRSB) Kawasan Institusi BangiLot 3288&3289Off Jalan Ayer ItamKajang 43000Malaysia PETRONAS Carbon Capture&Storage(CCS)Enterprise PETRONAS Twin TowersKuala Lumpur City CentreKuala Lumpur 50088Malaysia CO_(2)Research Center(CO2RES) Department of Chemical EngineeringUniversiti Teknologi PETRONASSeri Iskandar 32610Malaysia Department of Chemical Engineering and Energy Sustainability Faculty of EngineeringUniversiti Malaysia Sarawak(UNIMAS)Kota Samarahan 94300Malaysia Institute of Sustainable and Renewable Energy(ISuRE) Universiti Malaysia Sarawak(UNIMAS)Kota Samarahan 94300Malaysia Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti Malaysia TerengganuKuala Nerus 21030Malaysia Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China Center for Global Health Research(CGHR) Saveetha Medical CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennai 602105India

Hydrogen(H_(2))is a promising renewable energy which finds wide applications as the world gears toward low-carbon ***,current H_(2) production via steam methane reforming of natural gas or gasification of coal are laden with high CO_(2) ***,methane(CH_(4))pyrolysis has emerged as a potential technology to generate low-carbon H_(2) and solid *** this review,the current state-of-art and recent progress of H_(2) production from CH_(4) pyrolysis are reviewed in *** such as funda-mental mechanism and chemistry involved,effect of process parameters on the conversion efficiency and reaction kinetics for various reaction media and catalysts are elucidated and critically ***-ature,among other factors,plays the most critical influence on the methane pyrolysis *** metal/salt could lower the operating temperature of methane pyrolysis to1000℃.Based on the reaction kinetics,metal-based cata-lysts were more efficient in lowering the activation energy of the reaction to 29.5-88 kJ/mol from that of uncatalyzed reaction(147-420.7 kJ/mol).Besides,the current techno-economic performance of the pro-cess reveals that the levelized cost of H_(2) is directly influenced by the sales price of carbon(by-product)generated,which could offset the overall ***,the main challenges of reactor design for efficient product separation and retrieval,as well as catalyst deactivation/poisoning need to be debottlenecked.

关键词： Pyrolysis Methane Hydrogen Reaction kinetics Techno-economic analysis

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Treatment of uterine fibroid with triptorelin before hysterectomy

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Chinese Medical Journal 1998年第1期111卷 67-70页

作者： loong EP Lo KW Chinese Univ Hong Kong Prince Wales Hosp Dept Obstet & Gynaecol Shatin NT Peoples R China

OBJECTIVE: To study the effects of pretreatment with triptorelin on uterine fibroid before abdominal hysterectomy. METHODS: Fifteen premenopausal Chinese women with symptomatic uterine fibroids requiring hysterectomy were recruited in the study. All patients received monthly intramuscular injections of 3.75 mg triptorelin for three months prior to abdominal hysterectomy. RESULTS: There was significant reduction in the serum levels of oestradiol (68.6%), progesterone (95.6%) and luteinizing hormone (73.9%) and in uterine (45.0%) and fibroid (68.0%) volumes. The serum level of follicle-stimulating hormone and haemoglobin concentration were not significantly different. CONCLUSIONS: Shrinkage of uterine fibroids can be achieved in women who are rendered hypoestrogenic with monthly injections of triptorelin for three months. This treatment modality may be of value prior to hysterectomy or myomectomy especially when the fibroid is large.

关键词： Adult Chemotherapy, Adjuvant Female Humans Hysterectomy Injections, Intramuscular Leiomyoma Luteolytic Agents Middle Aged Preoperative Care Triptorelin Uterine Neoplasms

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A comparative study of pancreas transplantation between type 1 and 2 diabetes mellitus

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 443-453页

作者： Bor-Shiuan Shyr Bor-Uei Shyr shih-Chin Chen Che-Chuan loong Yi-Ming Shyr Shin-E Wang Division of General Surgery Department of SurgeryTaipei Veterans General Hospitaland National Yang Ming UniversityTaipei Division of Transplant Surgery Department of SurgeryTaipei Veterans General Hospitaland National Yang Ming UniversityTaipei

Background:Pancreas transplantation remains the best long-term treatment option to achieve physiological euglycemia and insulin independence in patients with labile diabetes mellitus(DM).It is widely accepted as an optimal procedure for type 1 DM(T1DM),but its application in type 2 DM(T2DM)is not unanimously ***:In total,146 diabetes patients undergoing pancreas transplantation were included in this *** data and outcomes were compared between the T1DM and T2DM ***:Majority(93%)of the pancreas transplantations in T2DM were for uremic *** occurred in 106(73%)patients,including 70(48%)with early complications before discharge and 79(54%)with late complications during follow-up ***,rejection of pancreas graft occurred in 37(25%)*** rejection rate in T2DM recipients was significantly lower than that in *** short-and long-term outcomes for endocrine function in terms of fasting blood sugar and hemoglobin A1c levels and graft survival rates are comparable between the T2DM and T1DM ***:T2DM is not inferior to T1DM after pancreas transplantation in terms of surgical risks,immunological and endocrine outcomes,and graft survival ***,pancreas transplantation could be an effective option to treat selected uremic T2DM patients without significant insulin resistance.

关键词： Type 2 diabetes mellitus(T2DM) pancreas transplantation

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Performance Analysis of Intelligent Robust Facility Layout Design

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Chinese Journal of Mechanical Engineering 2017年第2期30卷 407-418页

作者： G MOSLEMIPOUR T S LEE Y T loong Department of Industrial Engineering Payame Noor University Faculty of Engineering and Technology Multimedia University

Design of a robust production facility layout with minimum handling cost （MHC） presents an appropriate approach to tackle facility layout problems in a dynamic volatile environment, in which product demands randomly change in each planning period. The objective of the design is to find the robust facility layout with minimum total material handling cost over the entire multiperiod planning horizon. This paper proposes a new mathematical model for designing robust machine layout in the stochastic dynamic environment of manufacturing systems using quadratic assignment problem （QAP） formulation. In this investigation, product demands are assumed to be normally distributed random variables with known expected value, variance, and covariance that randomly change from period to period. The proposed model was verified and validated using randomly generated numerical data and benchmark examples. The effect of dependent product demands and varying interest rate on the total cost function of the proposed model has also been investigated. Sensitivity analysis on the proposed model has been performed. Dynamic programming and simulated annealing optimization algorithms were used in solving the modeled example problems.

关键词： Robust layout Dynamic stochastic environment Manufacturing system Dynamic programming

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Fuzzy-based risk prioritization for a hydrogen refueling facility in Malaysia

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第8期14卷 834-834页

作者： Hue-yee Chong Mahidzal Dahari Hwa-jen Yap Ying-tai loong Department of Mechanical Engineering Faculty of Engineering University Malaya

Hydrogen is starting to be mentioned as an alternative fuel to replace the fossil fuel in future transportation applications due to its characteristics of zero greenhouse gas emission and high energy efficiency. Before hydrogen fuel and its facilities can be introduced to the public, relevant safety issues and its hazards must be assessed in order to avoid any chance of injury or loss. While a traditional risk assessment has difficulty in prioritizing the risk of failure modes, this paper proposes a new fuzzy-based risk evaluation technique which uses fuzzy value to prioritize the risk of various scenarios. In this study, the final risk of each failure modes was prioritized by using the MATLAB fuzzy logic tool box with a combination of two assessments. The first assessment was concerned with the criteria which affected the actual probability of *** assessment considered the availability of the standard that was applied to prevent the likelihood of the scenario occurring. On the other hand, the second assessment was focused on evaluating the consequence of the failure by taking into account the availability of detection and the complexity of the failure rather than only the severity of the scenarios. A total of 87 failure scenarios were identified using failure modes and effect analysis(FMEA) procedures on hydrogen refueling station models. Fuzzy-based assessments were performed through risk prioritizing various failure scenarios with a fuzzy value(0 to 1) and risk level(low, medium, and high)while a traditional risk assessment approach presented the risks only in forms of level(low, medium, and/or high). Availability of the fuzzy value enabled further prioritizing on the risk results that fell in the same level of risk. This study concluded that fuzzy-based risk evaluation is able to further prioritize the decisions when compared with a traditional risk assessment method.

关键词：风险评估方法模糊值加氢站马来西亚设施优先级模糊逻辑工具箱故障模式

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A MATHEMATICAL MODEL OF ENTERPRISE COMPETITIVE ABILITY AND PERFORMANCE THROUGH EMDEN-FOWLER EQUATION (Ⅱ)

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Acta Mathematica Scientia 2013年第4期33卷 1127-1140页

作者： Meng-Rong LI Yue-loong CHANG Yu-Tso LI Department of Mathematical Sciences National Chengchi University Department of Psychology National Chengchi University Department of Aerospace and Systems Engineering Feng Chia University

In this paper we work with the ordinary equation u＇＇ - u2 （u ＋） = 0 and ob- tain some interesting phenomena concerning, blow-up, blow-up rate, life-span of solutions to those equations.

关键词： estimate life-span blow-up blow-up rate performance competitive ability

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