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堰塞坝溃决及防范

水利水电技术 2008年第7期39卷 97-99页

作者： Takahisa Mizuyama shigekiyo tabata Toshio Mori Fumito Watanabe Kimio Inoue4 宋守度 Professor Division of Forest ScienceGraduate School of AgricultureKyoto University Kyoto 606-8502Japan Sabo Frontier Foundation Sabo-kaikanHirakawa-cho 2-7-4Chiyoda-kuTokyo 102-0093Japan Tateyama Sabo Office Ministry of LandInfrastructure and TransportJapan(at presentstays in Indonesia as a JICA expert) Nippon Koei Corp.Ltd.Koji-machi 5-4 ChiyodaTokyo 102-8539Japan

由暴雨、地震等引起的山体滑坡或泥石流堵塞山区河道形成堰塞湖和堰塞坝.所壅起的水量会淹没上游地区,且堰塞坝一旦溃决,所产生的洪峰将淹没下游地区.尽管阻止滑坡和堰塞坝的形成十分困难,但若有必要的信息资料可资利用的话,即可对溃坝... 详细信息

由暴雨、地震等引起的山体滑坡或泥石流堵塞山区河道形成堰塞湖和堰塞坝.所壅起的水量会淹没上游地区,且堰塞坝一旦溃决,所产生的洪峰将淹没下游地区.尽管阻止滑坡和堰塞坝的形成十分困难,但若有必要的信息资料可资利用的话,即可对溃坝及由此引发的洪水危害做出预测.

关键词：堰塞坝坝溃决水槽实验计算机模拟应对措施日本

Molecular typing guiding treatment and prognosis of endometrial cancer

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 7-17页

作者： Junya tabata Masataka Takenaka Aikou Okamoto Department of Obstetrics and Gynecology The Jikei University School of MedicineJapan

Genetic abnormalities,such as PTEN,PIK3CA,CTNNB1,ARID1A,and ERBB2,which frequently occur in endometrial cancer(EC),are potential therapeutic *** 2013,integrated genomic analysis conducted by The Cancer Genome Atlas identified four molecular subtypes,including POLE ultra-mutated,microsatellite instability hypermutated,copy-number low,and copy-number high,which strongly correlate with *** markers-based molecular classification methods have been developed to make these molecular classifications accessible and affordable,achieving classification into POLEmut,mismatch repair deficient(MMRd),p53abn,and no specific molecular profile(NSMP)with normal p53 *** POLEmut EC has aggressive pathologic features,there are few cases of advanced and/or ***,the possibility of de-escalating adjuvant therapy can be ***,immune checkpoint inhibitors(ICI)may be a candidate for treating advanced and recurrent POLEmut EC because of their high *** EC shows an intermediate prognosis between those of POLEmut and p53abn *** EC is generally characterized by high immunogenicity similar to POLEmut EC,suggesting that ICI can also be a potential therapeutic *** the four molecular subtypes,p53abn EC has the worst ***,some p53abn tumors have the molecular hallmark of homologous recombination deficiency and could be treated with poly(ADP-ribose)polymerase *** addition,some p53abn tumors overexpress the human epidermal growth factor receptor 2,which can also be a potential therapeutic *** EC are a heterogeneous population because they lack characteristic molecular biological *** half of the NSMP EC show high expression of estrogen receptor/progesterone receptor,suggesting the possibility of hormonal *** addition,the PI3K/AKT/mTOR pathway frequently altered in EC may be a therapeutic *** review summarizes the molecular biological character

关键词： Endometrial cancer Molecular classification Molecular typing Surrogate markers Targeted therapy Precision medicine

ARSlice:Head-Mounted Display Augmented with Dynamic Tracking and Projection

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Journal of Computer Science & Technology 2022年第3期37卷 666-679页

作者：王瑀屏解森炜王立辉徐鸿金 Satoshi tabata Masatoshi Ishikawa Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China Institute of Semiconductors Guangdong Academy of SciencesGuangzhou 510651China Data Science Research Division Information Technology CenterThe University of TokyoTokyo 113-8656Japan Core Network Department Advanced Operations Development DivisionKDDI CooperationTokyo 206-0034Japan Tokyo University of Science Tokyo 113-8601Japan

Computed tomography(CT)generates cross-sectional images of the *** CT images has been a challenging *** emergence of the augmented and virtual reality technology has provided promising ***,existing solutions suffer from tethered display or wireless transmission *** this paper,we present ARSlice,a proof-of-concept prototype that can visualize CT images in an untethered manner without wireless transmission *** ARSlice prototype consists of two parts,the user end and the projector *** employing dynamic tracking and projection,the projector end can track the user-end equipment and project CT images onto it in real *** user-end equipment is responsible for displaying these CT images into the 3D *** main feature is that the user-end equipment is a pure optical device with light weight,low cost,and no energy *** experiments demonstrate that our ARSlice prototype provides part of six degrees of freedom for the user,and a high frame *** interactively visualizing CT images into the 3D space,our ARSlice prototype can help untrained users better understand that CT images are slices of a body.

关键词： augmented and virtual reality computed tomography(CT)image visualization interactive visualization

Nicotiana benthamiana XYLEM CYSTEINE PROTEASE genes facilitate tracheary element formation in interfamily grafting

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Horticulture Research 2023年第6期10卷 70-81页

作者： Chaokun Huang Ken-ichi Kurotani Ryo tabata Nobutaka Mitsuda Ryohei Sugita Keitaro Tanoi Michitaka Notaguchi Graduate School of Bioagricultural Sciences Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Bioscience and Biotechnology Center Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Bioproduction Research Institute National Institute of Advanced Industrial Science and Technology(AIST)TsukubaIbaraki 305-8566Japan Isotope Facility for Agricultural Education and Research Graduate School of Agricultural and Life SciencesThe University of TokyoYayoiBunkyo-kuTokyo 113-8657Japan Radioisotope Research Center Nagoya UniversityFuro-choChikusa-kuNagoya 464-8602Japan Institute of Transformative Bio-Molecules Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

Grafting is a plant propagation technique widely used in agriculture.A recent discovery of the capability of interfamily grafting in Nicotiana has expanded the potential combinations of *** this study,we showed that xylem connection is essential for the achievement of interfamily grafting and investigated the molecular basis of xylem formation at the graft *** and gene network analyses revealed gene modules for tracheary element(TE)formation during grafting that include genes associated with xylem cell differentiation and immune *** reliability of the drawn network was validated by examining the role of the Nicotiana benthamiana XYLEM CYSTEINE PROTEASE(NbXCP)genes in TE formation during interfamily *** activities of NbXCP1 and NbXCP2 genes were found in differentiating TE cells in the stem and callus tissues at the graft *** of a Nbxcp1;Nbxcp2 loss-of-function mutant indicated that NbXCPs control the timing of de novo TE formation at the graft ***,grafts of the NbXCP1 overexpressor increased the scion growth rate as well as the fruit ***,we identified gene modules for TE formation at the graft boundary and demonstrated potential ways to enhance Nicotiana interfamily grafting.

关键词： grafting element graft

Clinical implications of accessory pancreatic duct

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World Journal of Gastroenterology 2010年第36期16卷 4499-4503页

作者： Terumi Kamisawa Kensuke Takuma Taku tabata Naoto Egawa Department of Internal Medicine Tokyo Metropolitan Komagome Hospital3-18-22 HonkomagomeBunkyo-kuTokyo 113-8677Japan

The accessory pancreatic duct (APD) is the main drainage duct of the dorsal pancreatic bud in the embryo,entering the duodenum at the minor duodenal papilla (MIP).With the growth,the duct of the dorsal bud undergoes varying degrees of atrophy at the duodenal *** of the APD in 291 control cases was 43% as determined by dye-injection endoscopic retrograde *** of the APD in 46 patients with acute pancreatitis was only 17%,which was significantly lower than in control cases (P < 0.01).The terminal shape of the APD was correlated with APD *** on the data about correlation between the terminal shape of the APD and its patency,the estimated APD patency in 167 patients with acute pancreatitis was 21%,which was signif icantly lower than in control cases (P < 0.01).A patent APD may function as a second drainage system for the main pancreatic duct to reduce the pressure in the main pancreatic duct and prevent acute *** f indings of 91 patients with pancreaticobiliary maljunction (PBM) were divided into a normal duct group (80 patients) and a dorsal pancreatic duct (DPD) dominant group (11 patients).While 48 patients (60%) with biliary carcinoma (gallbladder carcinoma,n=42;bile duct carcinoma,n=6) were identified in PBM with a normal pancreatic duct system,only two cases of gallbladder carcinoma (18%) occurred in DPD-dominant patients (P < 0.05).Concentration of amylase in the bile of DPD dominance was signifi cantly lower than that of normal pancreatic duct system (75 403.5 ± 82 015.4 IU/L vs 278 157.0 ± 207 395.0 IU/L,P < 0.05).In PBM with DPD dominance,most pancreatic juice in the upper DPD is drained into the duodenum via the MIP,and reflux of pancreatic juice to the biliary tract might be reduced,resulting in less frequency of associated biliary carcinoma.

关键词： Accessory pancreatic duct Minor duodenal papilla Pancreas divisum Main pancreatic duct Acute pancreatitis Pancreaticobiliary maljunction

The transcriptional regulator JAZ8 interacts with the C2 protein from geminiviruses and limits the geminiviral infection in Arabidopsis

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Journal of Integrative Plant Biology 2023年第7期65卷 1826-1840页

作者： tabata Rosas-Diaz Pepe Cana-Quijada Mengshi Wu Du Hui Gemma Fernandez-Barbero Alberto PMacho Roberto Solano Araceli GCastillo Xiao-Wei Wang Rosa Lozano-Duran Eduardo R.Bejarano Departamento de Biología Celular Genética y FisiologíaFacultad de CienciasInstituto de Hortofruticultura Subtropical y Mediterránea“La Mayora”(IHSM‐UMA‐CSIC)Universidad de MálagaMálagaSpain Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Institute of Insect Sciences Zhejiang UniversityHangzhou 310058China Departamento de Genética Molecular de Plantas Centro Nacional de Biotecnología‐Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Plant Biochemistry Centre for Plant Molecular BiologyEberhard Karls UniversityTübingen D‐72076Germany

Jasmonates(JAs) are phytohormones that finely regulate critical biological processes, including plant development and defense. JASMONATE ZIM-DOMAIN(JAZ) proteins are crucial transcriptional regulators that keep JA-responsive genes in a repressed state. In the presence of JA-Ile, JAZ repressors are ubiquitinated and targeted for degradation by the ubiquitin/proteasome system,allowing the activation of downstream transcription factors and, consequently, the induction of JA-responsive genes. A growing body of evidence has shown that JA signaling is crucial in defending against plant viruses and their insect vectors. Here, we describe the interaction of C2proteins from two tomato-infecting geminiviruses from the genus Begomovirus, tomato yellow leaf curl virus(TYLCV) and tomato yellow curl Sardinia virus(TYLCSaV), with the transcriptional repressor JAZ8 from Arabidopsis thaliana and its closest orthologue in tomato, SlJAZ9. Both JAZ and C2proteins colocalize in the nucleus, forming discrete nuclear speckles. Overexpression of JAZ8did not lead to altered responses to TYLCV infection in Arabidopsis;however, knock-down of JAZ8 favors geminiviral infection. Low levels of JAZ8 likely affect the viral infection specifically,since JAZ8-silenced plants neither display obvious developmental phenotypes nor present differences in their interaction with the viral insect vector. In summary, our results show that the geminivirus-encoded C2 interacts with JAZ8 in the nucleus, and suggest that this plant protein exerts an anti-geminiviral effect.

关键词： C2 protein geminivirus jasmonates JAZ8 transcriptional repressor TYLCV

Biological nano agent produced by hypoxic preconditioning stem cell for stroke treatment

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Nano Research 2023年第5期16卷 7413-7421页

作者： Xin-Chi Jiang Hong-Hui Wu Tianyuan Zhang Yun-Fei Dong Yao-Sheng Li Ting Huang An-Hao Tian Peng-Xiang Chen Xian-Ming Lin Ying-Zhi Huang Chong Liu Xiang-Nan Zhang Zhong Chen Yasuhiko tabata Jian-Qing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China Department of Pathology and Pathophysiology and Department of Neurosurgery of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China The Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310058China SinoCell Biotechnology Ltd. Ningbo 315000China Key Laboratory of Medical Neurobiology of the Ministry of Health of China Institute of Pharmacology&ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Laboratory of Biomaterials Department of Regeneration Science and EngineeringInstitute for Frontier Life and Medical SciencesKyoto UniversityKyoto 606-8501Japan

Exosomes make a significant contribution during stem cell-based therapy due to the abundant *** evidence implies exosomes can act as potential biological nano *** herein propose hypoxic preconditioning for neural stem cells(NSCs)that could produce hypoxic exosomes for efficient treatment of ischemic *** preconditioning on NSCs significantly altered the miRNAs encapsulated in ***,hypoxic exosomes could target the injured brain to regulate the microenvironment to inhibit neuroinflammation and promote blood–brain barrier permeability ***,the autologous NSCs in Nestin-CreER mice could be activated by hypoxic exosomes to facilitate nerve *** hypoxic preconditioning,exosomes further exerted therapeutic effects on both survival(25%)and behavioral outcomes in ischemic stroke ***,hypoxic preconditioning NSCs can produce effective nano agent and may represent a promising strategy for clinical neurorestorative therapy.

关键词： exosomes hypoxia-preconditioning stem cells ischemic stroke microenvironment

Differences between diffuse and focal autoimmune pancreatitis

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World Journal of Gastroenterology 2012年第17期18卷 2099-2104页

作者： Taku tabata Terumi Kamisawa Kensuke Takuma Seiichi Hara Sawako Kuruma Yoshihiko Inaba Department of Internal Medicine Tokyo Metropolitan Komagome Hospital3-18-22 HonkomagomeBunkyo-kuTokyo 113-8677Japan

AIM:To investigate differences in clinical features between diffuse-and focal-type autoimmune pancreatitis(AIP).METHODS:Based on radiological findings by computed tomography and/or magnetic resonance imaging,we divided 67 AIP patients into diffuse type(D type) and focal type(F type).We further divided F type into head type(H type) and body and/or tail type(B/T type) according to the location of ***,we classified the 67 AIP patients into three groups:D type,H type and B/T *** compared the three types of AIP in terms of clinical,laboratory,radiological,functional and histological findings and clinical ***:There were 34 patients with D-type,19 with H-type and 14 with B/T-type *** obstructive jaundice was frequently detected in D-typepatients(88%) and H-type patients(68%),no B/T-type patients showed jaundice as an initial symptom(P < 0.001).There were no differences in frequency of abdominal pain,but acute pancreatitis was associated more frequently in B/T-type patients(36%) than in D-type patients(3%)(P = 0.017).Serum immunoglobulin G(IgG)4 levels were significantly higher in D-type patients(median 309 mg/dL) than in B/T-type patients(133.5 mg/dL)(P = 0.042).Serum amylase levels in B/T-type patients(median:114 IU/L) were significantly greater than in H-type patients(72 IU/L)(P = 0.049).Lymphoplasmacytic sclerosing pancreatitis(LPSP) was histologically confirmed in 6 D-type,7 H-type and 4 B/T-type patients;idiopathic duct-centric pancreatitis was observed in no *** fibrosis and abundant infiltration of CD20-positive B lymphocytes with few IgG4-positive plasma cells were detected in 2 B/T-type *** therapy was effective in all 50 patients(31 D type,13 H type and 6 B/T type).Although AIP relapsed during tapering or after stopping steroids in 3 D-type and 3 H-type patients,no patients relapsed in B/T *** follow-up,radiological features of 6 B/T-type patients were not changed and 1 B/T-type patient impr

关键词：急性胰腺炎自身免疫性弥漫性计算机断层扫描血清免疫球蛋白临床特点检查结果 AIP

Utility of pancreatography for diagnosing autoimmune pancreatitis

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World Journal of Gastroenterology 2011年第18期17卷 2332-2337页

作者： Kensuke Takuma Terumi Kamisawa Taku tabata Yoshihiko Inaba Naoto Egawa Yoshinori Igarashi Department of Internal Medicine Tokyo Metropolitan Komagome Hospital Department of Gastroenterology and Hepatology Omori Medical Center Toho University School of Medicine

AIM: To identify pancreatographic findings that facilitate differentiating between autoimmune pancreatitis (AIP) and pancreatic cancer (PC) on endoscopic retrograde cholangiopancreatography (ERCP) and magnetic resonance cholangiopancreatography (MRCP). METHODS: ERCP findings of 48 AIP and 143 PC patients were compared. Diagnostic accuracies for AIP by ERCP and MRCP were compared in 30 AIP patients. RESULTS: The following ERCP findings suggested a diagnosis of AIP rather than PC. Obstruction of the main pancreatic duct (MPD) was more frequently detected in PC (P < 0.001). Skipped MPD lesions were detected only in AIP (P < 0.001). Side branch derivation from the narrowed MPD was more frequent in AIP (P < 0.001). The narrowed MPD was longer in AIP (P < 0.001), and a narrowed MPD longer than 3 cm was more frequent in AIP (P < 0.001). Maximal diameter of the upstream MPD was smaller in AIP (P < 0.001), and upstream dilatation of the MPD less than 5 mm was more frequent in AIP (P < 0.001). Stenosis of the lower bile duct was smooth in 87% of AIP and irregular in 65% of PC patients (P < 0.001). Stenosis of the intrahepatic or hilar bile duct was detected only in AIP (P = 0.001). On MRCP, diffuse narrowing of the MPD on ERCP was shown as a skipped non-visualized lesion in 50% and faint visualization in 19%, but segmental narrowing of the MPD was visualized faintly in only 14%. CONCLUSION: Several ERCP findings are useful for differentiating AIP from PC. Although MRCP cannot replace ERCP for the diagnostic evaluation of AIP, some MRCP findings support the diagnosis of AIP.

关键词：自身免疫性胰腺炎诊断实用工具检查结果 AIP MPD 可视化