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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei Jin Liu Tao Zhu cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Single-wall carbon nanotube fiber non-woven fabrics with a high electrothermal heating response

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Nano Research 2024年第6期17卷 5621-5628页

作者： Xinyu Jiao Lele Xu Xinyang Sun Chao shi Peng-xiang Hou Chang Liu Hui-Ming cheng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China Faculty of Materials Science and Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Carbon nanotube(CNT)fibers have great promise for constructing multifunctional fabrics with high electrical conductivity,good electro-heating ability,excellent flexibility,and a low ***,the inter-fiber contacts in the fabric greatly reduce these advantages and limit their ***,a simple pressure-fusing method to fabricate single-wall CNT(SWCNT)fiber non-woven fabrics(NWFs)that are composed of interconnected SWCNT fibers with fused joints is reported,which have good flexibility,a low density of 0.46 g/cm^(3),a high electrical conductivity of 3.7×10^(5)S/m,and a record high specific electrical conductivity of 803(S·m^(2))/*** also showed excellent electrical heating ability,so that a temperature of~160℃was rapidly reached at a low voltage of 2 *** with their low density,the SWCNT fiber NWFs are promising for use as a heating unit for low temperature battery protection and de-icing applications.

关键词： carbon nanotube fiber nonwoven fabrics fusing electrothermal heating

Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第3期7卷 245-250页

作者： ZHANG Ye-jing xiang Mei-xiang SAN Jiang cheng Gang WANG shi-sheng Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective： To explore the effect and mechanism of matrine （Mt.） on myocardial interstitial fibrosis induced by pressure overload. Methods： Pressure overloaded myocardial hypertrophy was produced by banding of aorta abdominalis in 67 male Sprague-Dawley rats weighing （200±15） g. The rats were assigned into one of the following groups： sham-operation control, operation control, operation group treated with matrine （15 mg/（kg·d）） and treated with carvedilol （Car.）（3.6 mg/（kg·d）） group. The rats were given drugs one day after operation. Five weeks after treatment, the left ventricular weight （LVW） was measured and the volume of myocardial cells was detected with Hematoxylin-Eosin （H-E） stain and Masson stain was used to assess the level of fibrosis of the myocardial matrix. Myocardial metalloproteinase activity was quantified with zymography, and survival rate was calculated. Results： Survival rate significantly decreased （P〈0.05）, LVW/BW （body weight）, MMP-2 （matrix metalloproteinase-2） activity （P〈0.05）, size of cardiomyocytes and interstitial fibrosis obviously increased in the operation group compared with sham control group. Mr. and Car. treatment can significantly increase survival rate （P〈0.05）, decrease LVW/BW （P〈0.05） and MMP-2 activity （P〈0.05）, decrease size of cardiomyocytes and interstitial fibrosis compared with operation group. But there was difference compared with sham group. Conclusion： Matrine was shown to be able to prevent cardiac remodelling of bypertrophy cardium induced by pressure overload including myocardial hypertrophy and fibrosis which may be associated with the decrease in MMP-2 activity of heart.

关键词： Matrine Carvedilol Myocardial Hypertrophy fibrosis MMP-2

Direct Reduction Experiment on Iron-Bearing Waste Slag

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Journal of Iron and Steel Research International 2013年第3期20卷 24-29,35页

作者： cheng xiang-li ZHAO Kai QI Yuan-hong shi Xue-feng ZHEN Chang-liang State Key Laboratory of Advanced Steel Process and Products Central Iron and Steel Research Institute

A lot of iron-bearing slags were produced,and whose grade is much more than that of industrial iron ore *** analysis and phase identification shows that the iron-bearing slag is amorphous,has fayalite main phase,iron grade is 36.10%,and is difficult to recover iron from the *** calculation indicates that CO cannot reduce fayalite at high temperature and carbon direct reduction can be ***,the reaction begins at 770 ℃ and the temperature can be reduced down to 500℃ when CaO is *** this basis,a method is put forward to making direct enrichment of iron by taking carbon contained pellets to realize the rapid reduction of fayalite,and the direct reduction process were studied in this *** show that xC/xO should be less than 1.5 for the need of reduction and carburization,and CaO and Al2O3 can spur the reduction of *** conditions that xC/xO is 1.2,metallization rate can be 77% when temperature is 1 250 ℃ and only carbon is added,and metallization rate can be 74% when temperature is 1 200 ℃ and only CaO is *** the addition of Al2O3 can get a higher metallization rate（10% or so） than usual as R is between 0.4 and *** the optimized condition of R equals to 0.6,temperature of 1 250 ℃,slag melting point of 1 320 ℃,and time of 30 min,the metallization rate can reach 88.43%.

关键词： iron-bearing slag fayalite metallization rate basicity

Synthesis of 3＇,4＇-Diaryl-4＇H-spiro[indoline-3,5＇-[1＇,2＇,4＇]- oxadiazol]-2-ones via DMAP-catalyzed Domino Reactions and Their Antibacterial Activity

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Chinese Journal of Chemistry 2016年第9期34卷 901-909页

作者： Guanghao shi Xinwei He Yongjia Shang Liwei xiang cheng Yang Guang Han Bing Du Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Key Laboratory of Molecule-Based Materials College of Chemistry and Materials Science Anhui Normal University Wuhu Anhui 241000 China Institute of Biomedical Sciences School of Life Sciences East China Normal University Shanghai 200241 China

A convenient and metal-flee DMAP-catalyzed domino reaction of isatins, arylamines and hydroximoyl chlorides has been developed to achieve 1,3-dipolar cycloaddition of imines into aryl nitrile oxides at ambient tempera- ture. In this one-pot transformation, a 1,2,4-oxadiazole skeleton was efficiently formed. This methodology needs no extra additives and features wide substrate scope, good functional group tolerance and mild reaction conditions. A plausible mechanism for this process was proposed. Moreover, the antibacterial activities of the products were evaluated towards Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae using the Broth microdilution method.

关键词： 4-dimethylaminopyridine antimicrobial activity isatins domino reactions oxadiazoles

Cloud-Verhulst hybrid prediction model for dam deformation under uncertain conditions

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Water Science and Engineering 2018年第1期11卷 61-67页

作者： Jin-ping He Zhen-xiang Jiang cheng Zhao Zheng-quan Peng Yu-qun shi School of Water Resources and Hydropower Engineering Wuhan UniversityWuhan 430072China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China Large Dam Safety Supervision Center National Energy AdministrationHangzhou 311122China

Uncertainties existing in the process of dam deformation negatively influence deformation prediction. However, existing deformation pre- diction models seldom consider uncertainties. In this study, a cloud-Verhulst hybrid prediction model was established by combing a cloud model with the Verhulst model. The expectation, one of the cloud characteristic parameters, was obtained using the Verhulst model, and the other two cloud characteristic parameters, entropy and hyper-entropy, were calculated by introducing inertia weight. The hybrid prediction model was used to predict the dam deformation in a hydroelectric project. Comparison of the prediction results of the hybrid prediction model with those of a traditional statistical model and the monitoring values shows that the proposed model has higher prediction accuracy than the traditional sta- tistical model. It provides a new approach to predicting dam deformation under uncertain conditions.

关键词： Dam deformation prediction Cloud model Verhulst model Uncertainty Inertia weight

Characterization of thermal-shock cracks in ceramic bars

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Science China(Physics,Mechanics & Astronomy) 2014年第12期57卷 2205-2208页

作者： XU xiang Hong TIAN cheng SHENG shi Long LIN Zhong Kang SONG Fan State Key Laboratory of Nonlinear Mechanics (LNM) Institute of Mechanics Chinese Academy of Sciences

Experimental analysis of the cracking in the ceramics subsequent to water quenching have been conducted to clarify the uncertainties of cracking in the ceramics when subjected to thermal *** results here indicate that at the critical point of quench temperature,the crack density and the depth reached the minimum and the maximum limits,*** increase of the quench temperature,the crack density increased rapidly before reaching its saturation point,while the crack depth initially decreased rapidly and then increased gradually before reaching its saturation point.

关键词： thermal-shock crack ceramics

Effects of Buyang Huanwu Decoction on antioxidant and drug-metabolizing enzymes in rat liver

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Chinese Journal of Natural Medicines 2014年第6期12卷 449-454页

作者： FAN Xing-Hua shi Wei-Zhou cheng Yun-xiang YANG Xiu-Fen Department of Pharmacology College of Pharmacy Guangxi University of Chinese Medicine Department of pharmacy Liuzhou Worker's Hospital

AIM: To study the effect of Buyang Huanwu Decoction(BYHWD) on the antioxidant enzymes and drug-metabolizing enzymes in rat liver. METHOD: Following treatment of rats with BYHWD at 6.42, 12.83, or 25.66 g·kg–1 per day for 15 days, microsomes and cytosols isolated from the liver tissues were prepared by differential centrifugation according to standard procedures. The activities of the antioxidant enzymes and cytochrome b5, NADPH-cytochrome P450 reductase, CYP3 A, CYP2E1, UGT, and GST of the rat livers were determined by UV-Vis spectrophotometer. RESULTS: The activities of ALT, AST, antioxidant enzymes, and the Hepatosomatic Index in serum were not significantly affected. In cytosols, the activity of CAT was significantly increased at the dosage of 12.83 g·kg–1, and all the other antioxidant activities and MDA levels were not affected by this treatment. BYHWD had no effect on cytochrome b5, NADPH-cytochrome P450 reductase, CYP3 A, and UGT. At the highest dose(25.66 g·kg–1), the activity of CYP2E1 was significantly inhibited, and the activities of GST and the level of GSH were increased. CONCLUSION: BYHWD is safe for the liver, and has the functions of detoxification and antioxidant. Patients should be cautioned about the herb-drug interaction of BYHWD and CYP2E1 substrates.

关键词： Buyang Huanwu Decoction Antioxidant Drug-metabolizing enzymes

Solution of ODE u″+p(u)(u′)2+q(u)=0 and Applications to Classifications of All Single Travelling Wave Solutions to Some Nonlinear Mathematical Physics Equations

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Communications in Theoretical Physics 2008年第2期49卷 291-296页

作者： LIU cheng-shi Department of Mathematics Daqing Petroleum Institute Daqing 163318 China

Under the travelling wave transformation, some nonlinear partial differential equations such as Camassa-Holm equation, High-order KdV equation, etc., are reduced to an integrable ODE expressed by u＂＋p（u）（u＇）^2 ＋ q（u） = 0 whose generai solution can be given. Furthermore, combining complete discrimination system for polynomiai, the classifications of all single travelling wave solutions to these equations are obtained. The equation u＂＋p（u）（u＇）^2＋q（u） = 0 includes the equation （u＇）^2 = f（u） as a special case, so the proposed method can be also applied to a large number of nonlinear equations. These complete results cannot be obtained by any indirect method.

关键词： classification of travelling wave solution symmetry group nonlinear partial differential equation