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Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro

World Journal of Stem Cells 2024年第2期16卷 163-175页

作者： yan ren yan-Ni Cui Hong-Wei Wang The Second Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology Key Laboratory of Molecular Diagnosis and Treatment of Blood Diseases in Shanxi ProvinceTaiyuan 030001Shanxi ProvinceChina

BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital resource.Nicotinamide(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cells(HSPCs,CD34^(+)CD38)and functional subtypes of HSCs-shortterm repopulating HSCs(ST-HSCs,CD34^(+)CD38CD45RACD49f^(+))and long-term repopulating HSCs(LT-HSCs,CD34^(+)CD38CD45RACD49f^(+)CD90^(+))is not yet known.As a sirtuin 1(SIRT1)inhibitor,NAM participates in regulating cell adhesion,polarity,migration,proliferation,and differentiation.However,SIRT1 exhibits dual effects by promoting or inhibiting differentiation in different tissues or cells.We propose that the concentration of NAM may influence proliferation,differentiation,and SIRT1 signaling of HSCs.AIM To evaluate the effects and underlying mechanisms of action of different concentrations of NAM on HSC proliferation and differentiation.METHODS CD34^(+)cells were purified from umbilical cord blood using MacsCD34 beads,and cultured for 10-12 d in a serum-free medium supplemented with cytokines,with different concentrations of NAM added according to experimental requirements.Flow cytometry was used to detect phenotype,cell cycle distribution,and apoptosis of the cultured cells.Real-time polymerase chain reaction was used to detect the transcription levels of target genes encoding stemness-related factors,che mokines,components of hypoxia pathways,and antioxidant enzymes.Dichloro-dihydro-fluorescein diacetate probes were used to evaluate intracellular production of reactive oxygen species(ROS).Determination of the effect of different culture conditions on the balance of cytokine by cytometric bead array.RESULTS Compared with the control group,the proportion and expansion folds of HSPCs(CD34^(+)CD38)incubated with 5 mmol/L or 10 mmol/L NAM were significantly increased(all P<0.05).The ST-HSCs ratio and fold expansion of the 5 mmol/L NAM group were significantly higher than those of the control and 10 mmol/L N

关键词： Hematopoietic stem cells Nicotinamide Concentration Proliferation Differentiation Sirtuin 1

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Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG Xiao-ying shi Li-ping ZHU Jun-long BAI ren-ren XIE Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

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The risk factors and threshold level of subchronic inhalation exposure of reclaimed water

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Journal of Environmental Sciences 2024年第3期137卷 639-650页

作者： Jiayang Kong Yun Lu Yunru ren Menghao Chen Gang Liu Liangliang shi State Key Joint Laboratory of Environment Simulation and Pollution Control State Environment Protection Key Laboratory of Microorganism Application and Risk ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China

Inhalation of reclaimed water is known to cause lung infammation,and free endotoxins have been shown to be a major risk factor for acute exposure.Subchronic exposure has also been shown to induce infammatory responses with visible tissue damage.However,subchronic risk factors have yet to be identified,and a threshold for the protection of occupational populations during urban reuse is necessary.In this study,potential risk factors in reclaimed water were examined by subchronic exposure with fractionated reclaimed water,and the health risk threshold was tested with a series of diluted reclaimed water.Accordingly,following a 12-week exposure,macromolecules and microorganisms were found to be two major risk factors in reclaimed water that could cause pulmonary infammation,including increased proportion of polymorphonuclear leukocytes in bronchoalveolar fuid,formation of inducible bronchus-associated lymphoid tissue,and elevation of Immunoglobulin A levels.Moreover,infammation persisted after a 4-week recovery period.The calculated threshold of reclaimed water exposure for mice was 31.8 Endotoxin Unit(EU)/(kg·day)under when exposed to 50%additional relative humidity from reclaimed water at 25℃ for 2 hr/day.Meanwhile,the subchronic threshold estimate for humans under the same exposure conditions was found to be 12.2 EU/(kg·day),corresponding to endotoxin levels of 61.7 EU/mL in reclaimed water.The threshold level of endotoxin was lower than that in most non-potable reclaimed water.The findings of this study suggest that occupational exposure of reclaimed water can serve as a potential risk to workers.

关键词： Reclaimed water Inhalation exposure Risk factor Threshold Infammation Endotoxin

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The impact of water quality on the formation of halogenated benzoquinones and the adsorption efficiency by activated carbon

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Journal of Environmental Sciences 2024年第1期135卷 693-702页

作者： Yongjing Wang Song Gao Xinyu yan Songtao Wang Ruolin Zhang yan Zhou Lianhai ren Cheng Li State Environmental Protection Key Laboratory of Food Chain Pollution Control Beijing Technology and Business UniversityBeijing 100048China Institute of Scientific and Technical Information of China Beijing 100038China Institute of Quality Standard and Testing Technology Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China Key Laboratory of Cleaner Production and Integrated Resource Utilization of China National Light Industry Beijing Technology and Business UniversityBeijing 100048China

Halogenated benzoquinones(HBQs)could cause bladder cancer,but there were few related studies on the generation and control.In this study,the impact of different precursors,pH,bromide concentration,and algae-derived organic matters on the formation of HBQs and the removal efficiency by activated carbon were investigated.It was found that the chlorination of bisphenol A produced the most 2,6-dichloro-1,4-benzoquinone(2,6-DCBQ),reaching 14.86μg/L at 1 hr,followed by tyrosine,2-chlorophenol,P-hydroxybenzoic acid,trichlorophenol,and N-methylaniline.The production of 2,6-DCBQ increased first and then decreased from 0 to 36 hr(chlorination doses 0-20 mg/L),indicating that HBQs were unstable in water.Trihalomethanes(THMs)were detected during chlorination,and the concentration increased with prolongation of reaction time.2,6-DCBQ production decreased and 2,6-dibromo-1,4-benzoquinone(2,6-DBBQ)production increased with increment bromide concentration and the bromide promoted the formation of tribromomethane.The production of 2,6-DCBQ decreased with increase of pH,and the maximum production was 141.38μg/L at pH of 5.Microcystis aeruginosa,Chlorella algae cells,and intracellular organic matters(IOM)could be chlorinated as potential precursors for HBQs.The most amount of 2,6-DCBQ was generated from algae cells of Microcystis aeruginosa,followed by Chlorella algae cells,Microcystis aeruginosa IOM,and Chlorella IOM.This study compared the removal efficiency of HBQs by granular activated carbon(GAC)and columnar activated carbon(CAC)under different carbon doses and initial concentrations of HBQs.It was found that the removal efficiency by GAC(80.1%)was higher than that by CAC(51.8%),indicating that GAC has better control for HBQs.

关键词： HBQS DBPS Drinking water Algae derived organic matters Activated carbon

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2022 Monkeypox outbreak:Why is it a public health emergency of international concern?What can we do to control it?

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World Journal of Clinical Cases 2022年第30期10卷 10873-10881页

作者： shi-yan ren Jing Li Rong-Ding Gao Department of Laser and Vascular Surgery Aviation General HospitalChina Medical UniversityBeijing 100012China Department of Infectious Disease Aviation General HospitalChina Medical UniversityBeijing 100012China

The World Health Organization(WHO) called the recent monkeypox(MPX)outbreak a Public Health Emergency of International Concern on July 23,2022.The United States of America(US) alarmed the recent MPX outbreak as the US public health emergency on August 4,2022.Since early May 2022,more than 35000 MPX cases and 12 deaths had been reported to WHO from 92 countries and territories by August 17,2022,and MPX cases continue rising rapidly with improved surveillance,access to diagnosis,and continuous virus spreading globally.Approximately 99% MPX cases are men,of which 95% cases are men who have sex with man.No evidence of MPX being sexually transmitted infections(STIs) is found;however,a high percentage(25%) of concurrent STIs and frequent anogenital symptoms suggest transmission through local inoculation during close intimate contact or sexual activity.Many approaches including a comprehensive international vaccination strategy and adequate supplies are mandatory to prevent MPX pandemic.Education,vaccination,MPX scrutiny and careful monitoring,and crossborder collaborations with international sectors are practical strategy to contain MPX outbreaks.People are educated to reduce the risk of exposure and to reduce the number of sexual partners especially new ones,to avoid contacting travelers from epidemic regions or animals that may carry MPX virus,and avoid traveling to endemic areas.

关键词： Monkeypox Outbreak Public Health Emergency of International Concern vaccination Infectivity Transmission Man who have sex with man

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Establishment of an Iron Deficiency Model by Iron Depletion in Pregnant Rats

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Biomedical and Environmental Sciences 2024年第2期37卷 210-215页

作者： CHEN Xi HAN Chao ZHAO Jin Peng SHEN shi WANG Li Yuan ren Shou WANG Tong Lei MA yan XU Ze Chao HUO Jun Sheng Key Laboratory of Trace Element Nutrition National Health Commission of the People’s Republic of ChinaNational Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China

Anemia,a global public health problem,has significant adverse consequences on the cognitive development of children and the work capacity of adults;affecting social and economic development.Globally,roughly 43%of children under five years of age,38%of pregnant women,and 29%of nonpregnant women had anemia.Anemia during pregnancy significantly increases the risk of low birth weight and preterm birth.A 10 g/L increase in hemoglobin has been estimated to decrease the risk of maternal and perinatal mortality by 29%and 28%.

关键词： mortality pregnancy anemia

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The tangential k-Cauchy-Fueter type operator and Penrose type integral formula on the generalized complex Heisenberg group

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 181-190页

作者： ren Guang-zhen shi Yun KANG Qian-qian Department of Mathematics Zhejiang International Studies UniversityHangzhou 310023China Department of Mathematics Zhejiang University of Science and TechnologyHangzhou 310023China

The tangential k-Cauchy-Fueter operator and k-CF functions are counterparts of the tangential Cauchy–Riemann operator and CR functions on the Heisenberg group in the theory of several complex variables,respectively.In this paper,we introduce a Lie group that the Heisenberg group can be imbedded into and call it generalized complex Heisenberg.We investigate quaternionic analysis on the generalized complex Heisenberg.We also give the Penrose integral formula for k-CF functions and construct the tangential k-Cauchy-Fueter complex.

关键词： the generalized complex Heisenberg group the tangential k-Cauchy-Fueter type operator Penrose-type integral formula

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Numerical Simulation of Rainfall-induced Xianchi Reservoir Landslide in Yunyang,Chongqing,China

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 505-517页

作者： yan Jinkai MA yan LIU Lei WANG Zhihui ren Tianxiang Chinese Academy of Geological Sciences Beijing 100037China Urban Construction School Beijing City UniversityBeijing 100083China

A calamitous landslide happened at 22:00 on September 1,2014 in the Yunyang area of Chongqing City,southwest China,enforcing the evacuation of 508 people and damaging 23 buildings.The landslide volume comprised 1.44 million m^(3) of material in the source area and 0.4 million m^(3) of shoveled material.The debris flow runout extended 400 m vertically and 1600 m horizontally.The Xianchi reservoir landslide event has been investigated as follows:(1)samples collected from the main body of landslide were carried out using GCTS ring shear apparatus;(2)the parameters of shear and pore water pressure have been measured;and(3)the post-failure characteristics of landslide have been analyzed using the numerical simulation method.The excess pore-water pressure and erosion in the motion path are considered to be the key reasons for the long-runout motion and the scale-up of landslides,such as that at Xianchi,were caused by the heavy rainfall.The aim of this paper is to acquired numerical parameters and the basic resistance model,which is beneficial to improve simulation accuracy for hazard assessment for similar to potentially dangerous hillslopes in China and elsewhere.

关键词： geohazards landslide post-failure rapid and long runout ring shear test

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Negative enthalpy alloys and local chemical ordering:a concept and route leading to synergy of strength and ductility

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National Science Review 2024年第4期11卷 172-184页

作者： Zibing An Tao yang Caijuan shi Shengcheng Mao Lihua Wang Ang Li Wei Li Xianmeng Xue Ming Sun Yifan Bai Yapeng He Fuzeng ren Zhouguang Lu Ming yan yang ren Chain-Tsuan Liu Ze Zhang Xiaodong Han Beijing Key Lab of Microstructure and Property of Advanced Materials College of Materials Science &Engineering Beijing University of Technology Department of Materials Science and Engineering City University of Hong Kong Key Laboratory of Partial Acceleration Physics& Technology Institute of High Energy PhysicsChinese Academy of Sciences Department of Materials Science &Engineering Southern University of Science and Technology Department of Physics City University of Hong Kong State Key Laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University

Solid solutions are ubiquitous in metals and alloys. Local chemical ordering(LCO) is a fundamental sub-nano/nanoscale process that occurs in many solid solutions and can be used as a microstructure to optimize strength and ductility. However, the formation of LCO has not been fully elucidated, let alone how to provide efficient routes for designing LCO to achieve synergistic effects on both superb strength and ductility. Herein, we propose the formation and control of LCO in negative enthalpy alloys. With engineering negative enthalpy in solid solutions, genetic LCO components are formed in negative enthalpy refractory high-entropy alloys(RHEAs). In contrast to conventional ‘trial-and-error' approaches, the control of LCO by using engineering negative enthalpy in RHEAs is instructive and results in superior strength(1160 MPa) and uniform ductility(24.5%) under tension at ambient temperature, which are among the best reported so far. LCO can promote dislocation cross-slip, enhancing the interaction between dislocations and their accumulation at large tensile strains; sustainable strain hardening can thereby be attained to ensure high ductility of the alloy. This work paves the way for new research fields on negative enthalpy solid solutions and alloys for the synergy of strength and ductility as well as new functions.

关键词： negative enthalpy alloys local chemical ordering strength ductility dislocation

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A Practical Approach for Missing Wireless Sensor Networks Data Recovery

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China Communications 2024年第5期21卷 202-217页

作者： Song Xiaoxiang Guo yan Li Ning ren Bing The College of Communications Engineering Army Engineering University of PLANanjing 210007China The 63891 Unit of PLA Luoyang 471000China

In wireless sensor networks(WSNs),the performance of related applications is highly dependent on the quality of data collected.Unfortunately,missing data is almost inevitable in the process of data acquisition and transmission.Existing methods often rely on prior information such as low-rank characteristics or spatiotemporal correlation when recovering missing WSNs data.However,in realistic application scenarios,it is very difficult to obtain these prior information from incomplete data sets.Therefore,we aim to recover the missing WSNs data effectively while getting rid of the perplexity of prior information.By designing the corresponding measurement matrix that can capture the position of missing data and sparse representation matrix,a compressive sensing(CS)based missing data recovery model is established.Then,we design a comparison standard to select the best sparse representation basis and introduce average cross-correlation to examine the rationality of the established model.Furthermore,an improved fast matching pursuit algorithm is proposed to solve the model.Simulation results show that the proposed method can effectively recover the missing WSNs data.

关键词： average cross correlation matching pursuit missing data wireless sensor networks

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