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Establishment of a rat model of severe spontaneous intracerebral hemorrhage

Journal of Intensive Medicine 2024年第1期4卷 108-117页

作者： Shuixiang Deng shengjie feng Yuewen Xin Yu He Yao Wang Mi Tian Ye Gong Department of Critical Care Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiChina

Background:Severe intracerebral hemorrhage(ICH)is the most devastating subtype of stroke resulting in high mortality and *** present,the development of targeted treatments to minimize the high morbidity and mortality is limited partly due to the lack of a severe ICH animal *** this study,we aimed to establish an accurate severe ICH model in rats and examine the pathological and physiological changes associated with ***:A rat model of severe ICH model was established by intrastriatal injection of autologous blood using different blood volumes(ICH 100μL group,ICH 130μL group,ICH 160μL group,ICH 170μL group,and ICH 180μL group).The mortality was assessed during the 28-day post-ICH ***-and long-term neurological deficits were evaluated using the Longa method,foot fault,falling latency,and Morris water maze *** water content,hematoma volume,hemoglobin content,and magnetic resonance imaging were assessed to determine the extent of brain *** staining was conducted to examine microglial activation and neuronal *** and eosin(H&E)staining,lung water content,and western blotting were used to assess lung injury following ***:The mortality of ICH rats increased significantly with an increase in autologous blood *** 28-day mortality in the 100μL,130μL,160μL,170μL,and 180μL ICH groups were 5%,20%,40%,75%,and 100%,respectively.A significantly higher 28-day mortality was observed in the ICH 160μL group compared to the ICH 100μL *** ICH 160μL group exhibited significantly increased neurological deficits,brain edema,hematoma volume,and hemoglobin content compared to the sham *** with the sham operation group,the activation of microglia and neuronal death in ICH 160μL rats *** use of H&E staining and western blotting demonstrated that disruption of the intra-alveolar structure,alveolar edema,and infiltration of inflammatory cells and cytokines into the lung tissu

关键词： Severe spontaneous intracerebral hemorrhage Animal model Autologous blood injection Animal behavior Lung injury

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液滴撞击单丝铺展特性的数值研究

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化工学报 2024年第6期75卷 2233-2242页

作者：黄斌丰生杰傅程张威重庆科技大学石油与天然气工程学院重庆401331 东北石油大学石油工程学院黑龙江大庆163318

液滴撞击单丝现象在石油与天然气处理过程中广泛存在,研究液滴撞击单丝的铺展特性对于提高化工设备的热质传递效率有重要意义。基于VOF方法建立液滴撞击单丝的数值模型,系统研究了初始速度、初始直径、撞击偏心距、撞击角度对液滴铺展... 详细信息

液滴撞击单丝现象在石油与天然气处理过程中广泛存在,研究液滴撞击单丝的铺展特性对于提高化工设备的热质传递效率有重要意义。基于VOF方法建立液滴撞击单丝的数值模型,系统研究了初始速度、初始直径、撞击偏心距、撞击角度对液滴铺展因子的影响。结果表明,增加初始速度能加快铺展因子增长速率并延长其最大铺展因子的保持时间。减小液滴的初始直径显示出更高的铺展因子;缩短撞击偏心距有助于液滴的更充分铺展,控制在0.2R以内时铺展效果最佳;减小撞击角度也可促进液滴更充分地铺展,其中铺展因子曲线在不同撞击角度下存在一个铺展转换点。此外液膜中心与两侧压差驱动液滴快速铺展,直至达到最大铺展长度后停止。研究结果可为含有丝网填料的化工设备的优化设计提供理论参考。

关键词：液滴碰撞铺展因子铺展机制数值模拟

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Ca^(2+) signaling initiated by canonical transient receptor potential channels in dendritic development

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Neuroscience Bulletin 2015年第3期31卷 351-356页

作者： shengjie feng Zhuohao He Hongyu Li Yizheng Wang Laboratory of Neural Signal Transduction Institute of Neuroscience Shanghai Institutes of Biological Sciences State Key Laboratory of Neuroscience The Graduate School Chinese Academy of Sciences

The spatial patterns of dendritic structures diverge in different types of neurons as adaptations to their unique functions. Although different intracellular mechanisms underlying dendritic morphogenesis have been suggested, it is evident that the elevation in intracellular Ca2＋ levels plays a major role in the process. Canonical transient receptor potential （TRPC） channels, known to be non-selective Ca2＋-permeable cation channels, act as environmental detectors to sense and transduce extracellular signals into different intracellular responses, including the regulation of dendritic growth, via Ca2＋ influx. Here, we review recent advances in the understanding of Ca2＋ signaling, especially signals mediated by Ca2＋ influx via TRPC channels, and the underlying molecular events in dendritic development.

关键词： dendrite calcium TRPC neurotrophin

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A High-Contrast Autolysosome Probe for Detecting Interaction between Autophagosomes and Autolysosomes in Mitophagy

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Chinese Journal of Chemistry 2024年第8期42卷 858-866页

作者： Weihua Wang Chu Han shengjie Xie Zisong Cong Zixuan Yang Yuxin feng Limin Xiang Heng Song College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,Autophagy is a multi-step cell metabolism process in which cells remove damaged and unwanted *** autophagy,autophagosomes fuse with lysosomes to form *** membrane components are recycled from autolysosomes through the autophagosomal components recycling(ACR),while lysosomal components circulate on the autolysosomal surface through the autophagic lysosome reformation(ALR)*** contain components from autophagosomes and ***,whether there is a fusion between autolysosome and autophagosome or lysosome at the organelle level remains *** this study,a pH and viscosity dual-controlled mitochondria-targeting fluorescent probe Mito-Q was designed based on an asymmetric norcyanine to achieve the high-contrast imaging of mitochondria-containing ***-Q not only effectively detected mitochondrial viscosity changes and mitophagy with high sensitivity,but more importantly,the fusion of mitochondria-containing autolysosomes and autophagosomes(FMAA)was observed during autophagy by the real-time confocal imaging of HeLa cells.

关键词： Mitophagy Autolysosomes Bioimaging Biosensors Fluorescence imaging

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Prevalence of and risk factors for infections in patients with spontaneous intracerebral hemorrhage at the intensive care unit

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Chinese Medical Journal 2022年第9期135卷 1096-1098页

作者： shengjie Sheng Miaoxian Yang Shuixiang Deng feng Zhao Peng Jin Mi Tian Ye Gong Department of Critical Care Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Emergency Medicine Shanghai Medical College Fudan UniversityShanghai 200032China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200040China

Intracerebral hemorrhage(ICH)is a severe neurological disease with high morbidity and mortality.[1,2]Infection rates of 26%to 58%have been reported in patients with ICH.[3]Infections not only increase the length of hospital stay and healthcare costs but also increase mortality,worsen functional outcomes,and increase hospital readmission *** current study sought to determine the prevalence of and risk factors associated with infections in patients with ICH and to investigate their impact on patient outcome upon discharge from the hospital.

关键词： infections hemorrhage cerebral

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Oxidative stress as a bridge between age and stroke:A narrative review

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Journal of Intensive Medicine 2023年第4期3卷 313-319页

作者： shengjie feng Miaoxian Yang Shengpeng Liu Yu He Shuixiang Deng Ye Gong Department of Critical Care Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Pediatrics Shenzhen People's HospitalThe Second Clinical Medical College of Jinan UniversityShenzhenGuangdong518020China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200040China

Stroke is the third most common cause of death globally and a leading cause of *** cellular and molecular changes following stroke and causes of neuronal death are not fully understood,and there are few effective treatments currently available.A rapid increase in the levels of reactive oxygen species(ROS)post stroke can overwhelm antioxidant defenses and trigger a series of pathophysiologic events including the inflammatory response,blood-brain barrier(BBB)disruption,apoptosis,and autophagy,ultimately leading to neuron degeneration and *** is thought that beyond a certain age,the RoS accumulation resulting from stroke increases the risk of morbidity and *** the present review,we summarize the role of oxidative stress(OS)as a link between aging and stroke *** also discuss how antioxidants can play a beneficial role in the prevention and treatment of stroke by eliminating harmful ROS,delaying aging,and alleviating damage to neurons.

关键词： Stroke Age Oxidative stress Review

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Epidemic intelligence trinity:Detection,risk assessment,and early warning

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Chinese Medical Journal 2024年第11期137卷 1313-1315页

作者： Ting Zhang Luzhao feng shengjie Lai Zhihang Peng Yajia Lan Weizhong Yang Department of Infectious Diseases School of Population Medicine and Public HealthChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China WorldPop School of Geography and Environmental ScienceUniversity of SouthamptonSouthamptonSO171BJUK Department of Epidemiology and Health Statistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Occupational Health and Environmental Health West China School of Public HealthSichuan UniversityChengduSichuan 610041China

Emerging infectious diseases have been frequently *** occurrence of infectious diseases is highly uncertain because of the unpredictability of pathogen,the complexity of occurrence time and site,and the characteristics of *** detection and immediate implementation of effective interventions within a reasonable time are the keys to preventing pandemics.[1]However,due to the insufficiency of the traditional surveillance and early warning,which relied heavily on passive reporting by healthcare institutions,[2]the early warning time lags behind the risk factor identification,syndrome differentiation(pneumonia of unknown cause),and suspected case confirmation of the infectious disease at the gateway of clustered *** paper aimed to face the challenges mentioned above and propose a universal epidemic intelligence model to establish a novel infectious disease surveillance and early warning system based on the trinity of surveillance and detection,risk assessment,and early warning.

关键词： mentioned warning intelligence

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88例细菌性脑膜炎患者的临床及病原学分析

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中国感染与化疗杂志 2019年第2期19卷 151-153页

作者：张静倪洁徐山山沈隽冯圣捷复旦大学附属华山医院普外科上海200040

目的分析复旦大学附属华山医院重症监护室(ICU)2013-2017年收治的急性细菌性脑膜炎患者的临床特征和病原构成,为拟订经验治疗方案提供依据。方法查阅本院ICU 2013-2017年收治的细菌性脑膜炎88例患者的临床资料并进行回顾性分析。结果入... 详细信息

目的分析复旦大学附属华山医院重症监护室(ICU)2013-2017年收治的急性细菌性脑膜炎患者的临床特征和病原构成,为拟订经验治疗方案提供依据。方法查阅本院ICU 2013-2017年收治的细菌性脑膜炎88例患者的临床资料并进行回顾性分析。结果入选病例中,77例(87.5%)发热; 67例(76.1%)诉头痛; 21例(23.9%)表现脑膜刺激征。脑脊液白细胞数在100×10~6/L以上46例(52.3%);脑脊液葡萄糖含量在正常值下限(2.5mmol/L)以下的43例(48.9%)。脑脊液培养共培养出细菌27株,其中主要为凝固酶阴性葡萄球菌(10株)和鲍曼不动杆菌(7株)。结论本院ICU收治的急性细菌性脑膜炎患者最常见的临床症状为发热和头痛。分离到的病原菌以凝固酶阴性葡萄球菌为主。

关键词：细菌性脑膜炎病原菌重症监护室

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调环酸钙对盐胁迫下水稻幼苗生长及抗性生理的影响

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植物生理学报 2021年第10期57卷 1897-1906页

作者：李瑶郑殿峰冯乃杰冯胜杰余明龙黄露张容郡孟枫岩黑龙江八一农垦大学农学院黑龙江大庆163000 广东海洋大学滨海农业学院广东湛江524088

为探讨调环酸钙(prohexadione-calcium,Pro-Ca)对盐胁迫下水稻幼苗的缓解作用,明确Pro-Ca提高水稻耐盐能力的最适浓度,以水稻品种‘黄华占’为试验材料,研究不同浓度(25、50、75、100、125、150mg·L^(-1))Pro-Ca对盐胁迫下水稻幼苗生... 详细信息

为探讨调环酸钙(prohexadione-calcium,Pro-Ca)对盐胁迫下水稻幼苗的缓解作用,明确Pro-Ca提高水稻耐盐能力的最适浓度,以水稻品种‘黄华占’为试验材料,研究不同浓度(25、50、75、100、125、150mg·L^(-1))Pro-Ca对盐胁迫下水稻幼苗生长及抗性生理的影响。结果表明:盐胁迫抑制水稻正常生长,对水稻抗性生理产生不利影响。外源添加Pro-Ca促进盐胁迫下水稻幼苗的地上部生长,提高根系活力,增强超氧化物歧化酶(SOD)、过氧化物酶(POD)、过氧化氢酶(CAT)和抗坏血酸过氧化物酶(APX)活性,提高可溶性蛋白和脯氨酸的含量,降低叶片相对电导率及O_(2)^(-)·的产生速率,增加叶片SPAD,提高净光合速率(Pn)、气孔导度(Gs)、蒸腾速率(Tr)、胞间CO2浓度(Ci)和表观叶肉导度(AMC)。综合分析,100 mg·L^(-1)浓度处理时效果最好,表现为茎基宽、根系总长度、干质量、净光合速率及CAT等出现最大值。初步推断在盐胁迫下,Pro-Ca通过提高植物抗氧化酶活性、叶绿素含量及渗透调节物质含量,降低幼苗O_(2)^(-)·的产生速率及电解质渗透来保护细胞结构的完整,促进幼苗生长及光合速率的上升,从而增强水稻幼苗耐盐能力。

关键词：水稻盐胁迫调环酸钙幼苗生长抗性生理

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基于MR数据的LTE网络规划及结构优化

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邮电设计技术 2019年第3期 52-55页

作者：田桂宾冯胜杰姬刚中国移动通信集团设计院有限公司新疆分公司新疆乌鲁木齐830011 大唐移动通信设备有限公司北京100089 中国移动通信集团新疆有限公司新疆乌鲁木齐830013

介绍了现网TD-LTE无线规划及优化流程,总结了现有的流程优缺点,分析了利用MR数据进行网络规划与优化的优劣势,提出了利用MR数据与路测数据相结合进行网络精细化规划的流程,对网络精细化规划与优化流程应用实现进行了说明;对网络精细化... 详细信息

介绍了现网TD-LTE无线规划及优化流程,总结了现有的流程优缺点,分析了利用MR数据进行网络规划与优化的优劣势,提出了利用MR数据与路测数据相结合进行网络精细化规划的流程,对网络精细化规划与优化流程应用实现进行了说明;对网络精细化规划与优化流程的优点进行了分析。

关键词：网络规划优化精细化规划 MR 路测数据仿真

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