Oxidative stress as a bridge between age and stroke:A narrative review
Oxidative stress as a bridge between age and stroke: A narrative review作者机构：Department of Critical Care MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of PediatricsShenzhen People's HospitalThe Second Clinical Medical College of Jinan UniversityShenzhenGuangdong518020China Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai 200040China
出 版 物：《Journal of Intensive Medicine》 (重症医学（英文）)
年 卷 期：2023年第3卷第4期
页 面：313-319页
学科分类：1002[医学-临床医学] 1011[医学-护理学（可授医学、理学学位）] 10[医学]
基 金：supported by a grant from the Shanghai Hospital Development Centre (grant number:SHDC2020CR3021A,to YG) Science and Technology Commission of Shanghai Municipal (grant number:21ZR1410700,to SD)
主 题：Stroke Age Oxidative stress Review
摘 要：Stroke is the third most common cause of death globally and a leading cause of *** cellular and molecular changes following stroke and causes of neuronal death are not fully understood,and there are few effective treatments currently available.A rapid increase in the levels of reactive oxygen species(ROS)post stroke can overwhelm antioxidant defenses and trigger a series of pathophysiologic events including the inflammatory response,blood-brain barrier(BBB)disruption,apoptosis,and autophagy,ultimately leading to neuron degeneration and *** is thought that beyond a certain age,the RoS accumulation resulting from stroke increases the risk of morbidity and *** the present review,we summarize the role of oxidative stress(OS)as a link between aging and stroke *** also discuss how antioxidants can play a beneficial role in the prevention and treatment of stroke by eliminating harmful ROS,delaying aging,and alleviating damage to neurons.
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