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A Unified Shared-Private Network with Denoising for Dialogue State Tracking

Journal of Computer Science & Technology 2021年第6期36卷 1407-1419页

作者： Qing-Bin liu Shi-Zhu He Kang liu sheng-ping liu Jun Zhao National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Beijing Unisound Information Technology Co. LtdBeijing 100096China

Dialogue state tracking(DST)leverages dialogue information to predict dialogues states which are generally represented as slot-value ***,previous work usually has limitations to efficiently predict values due to the lack of a powerful strategy for generating values from both the dialogue history and the predefined *** predicting values from the predefined value set,previous discriminative DST methods are difficult to handle unknown *** generative DST methods determine values based on mentions in the dialogue history,which makes it difficult for them to handle uncovered and non-pointable ***,existing generative DST methods usually ignore the unlabeled instances and suffer from the label noise problem,which limits the generation of mentions and eventually hurts *** this paper,we propose a unified shared-private network(USPN)to generate values from both the dialogue history and the predefined values through a unified ***,USPN uses an encoder to construct a complete generative space for each slot and to discern shared information between slots through a shared-private ***,our model predicts values from the generative space through a shared-private *** further utilize reinforcement learning to alleviate the label noise problem by learning indirect supervision from semantic relations between conversational words and predefined slot-value *** results on three public datasets show the effectiveness of USPN by outperforming state-of-the-art baselines in both supervised and unsupervised DST tasks.

关键词： dialogue state tracking unified strategy shared-private network reinforcement learning

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Zwitterionic-phosphonate block polymer as anti-fouling coating for biomedical metals

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Rare Metals 2022年第2期41卷 700-712页

作者： Ya-Hui Gu Hong-Wei liu Xiao-Han Dong Zhuang-Zhuang Ma You-Xin Li Li Li Dong-Lin Gan ping-sheng liu Jian Shen Jiangsu Key Laboratory of Bio-Functional Materials Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Engineering Research Center of Interfacial Chemistry Nanjing UniversityNanjing 210093China

Antifouling ability and blood compatibility are critically important in the development of medical metallic implants for clinical ***,we report the zwitterionic-phosphonate block polymer as a new type of high-efficiency antifouling coating for metallic *** block polymers(pSBMA-b-pDEMMP)with different segment lengths(nSBMA:nDEMMP=10:25,40:25,100:25,75:5,75:40,75:100)were prepared and anchored on titanium alloy(TC4)substrates.1H nuclear magnetic resonance(NMR)results clearly showed the precise preparation of the block *** analysis and water contact angle measurement indicated the successful construction of the block polymer on TC4 *** relationship between the antifouling performance of the polymer coating and the length of pDEMMP and pSBMA segments in the block polymer was *** showed that the polymer containing the pSBMA segment above 40 repeat units could significantly inhibit protein adsorption,platelet adhesion,bacterial adhesion and cell adhesion,while the pDEMMP segment above 5 repeat units is able to generate stable zwitterionic polymer coating on TC4 *** ease of production and high-efficiency antifouling modification strategy elucidated here may find broad application for biomedical implants and devices in clinical applications.

关键词： Zwitterionic Phosphonate Anti-fouling coating Biomedical metals

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Crystal and molecular structure of 2,3-benzo-1,4,7,13-tetraoxa-10-selenacyclopentadeca-2-ene

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Chinese Journal of Chemistry 1993年第5期11卷 401-405页

作者： XU,Han-sheng LI,Wei-ping liu,Xiu-Fang Department of Chemistry,Wuhan University,Wuhan 430072HUANG,You-Qing HU,sheng-Zhi Department of Chemistry,Xiamen University,Xiamen 361005 Department of Chemistry Wuhan University Wuhan 430072 Department of Chemistry Xiamen University Xiamen 361005

The crystal structure of 2,3-benzo-1,4,7,13-tetraoxa-10-selenacyclopentadeca-2-ene was de- termined,C_(14)H_(20)O_4Se,M_r:331.27,orthorhombic,Pbca,a=18.445(3),b=16.334(4),c9.232(2) ,V=2781.3 ~3,Z=8,Dx=1.582 Mg m^(-3),λ(Mo K_α)=0.71073 ,μ=26.77 cm^(-1),F(000)=1360, T=297 K,R=0.0329,R_w=0.0438 for 2192 reflections with I>3 σ(I).The crystal structure is closely related to that of benzo-15-crown-5(at 123 K),whereas the molecular geometry of the two coronands is different according to their torsion angles calculated and the shapes exhibited.

关键词： Crystal and molecular structure of 2 3-benzo-1 4 7 13-tetraoxa-10-selenacyclopentadeca-2-ene

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Construction, expression and characterization of the engineered antibody against tumor surface antigen, p185c-erbB-2

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Cell Research 2003年第1期13卷 35-48页

作者： LIAN sheng CHENG, AI ping liu, JIA HONG YANG, YAN QIU DONG, LIANG WEI LI, JING WANG, CHAO CHEN WANG, JING liuSchool of Life Science, University of Science and Technology of China, Hefei 230027, China School of Life Science University of Science and Technology of China Hefei China

The c-erbB-2 proto-oncogene encodes a 185kDa protein p!85, which belongs to epidermal growth factor receptor family. Amplification of this gene has been shown to correlate with poor clinical prognosis for certain cancer patients. The monoclonal antibody A21 which directed against p185 specifically inhibits proliferation of tumor cells overexpressing p185, hence allows it to be a candidate for targeted therapy. In order to overcome several drawbacks of murine MAb, we cloned its VH and VL genes and constructed the single-chain Fv (scFv) through a peptide linker. The recombinant scFvA21 was expressed in Escherichia coli and purified by the affinity column. Subsequently it was characterized by ELISA, Western blot, cell immunohistochemistry and FACS. All these assays showed the binding activity to extracellular domain (ECD) of p!85. Based on those properties of scFvA21, we further constructed the scFv-Fc fusion molecule with a homodimer form and the recombinant product was expressed in mammalian cells. In a

关键词： p185 c-erbB-2 scFv scFv-Fc.

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High-intensity focused ultrasound treatment for patients with unresectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 655-660页

作者： Peng-Zhou Li, Shai-Hong Zhu, Wei He, Li-Yong Zhu, sheng-ping liu, Yan liu, Guo-Hui Wang, Fei Ye Department of General Surgery ,Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013, China Department of General Surgery Third Xiangya Hospital Central South University Changsha 410013 China Department of Radiology Third Xiangya Hospital Central South University Changsha 410013 China

BACKGROUND: High-intensity focused ultrasound (HIFU) is a non-invasive method of solid tissue ablation therapy. However, only a few studies have reported the effect of HIFU for unresectable pancreatic cancer. This study aimed to evaluate the clinical benefits, survival time and complications associated with the use of HIFU ablation in patients with unresectable pancreatic cancer. METHODS: Twenty-five patients with unresectable pancreatic cancer were enrolled in our study. All patients received HIFU therapy for tumors at least once. The therapeutic effects of HIFU was evaluated in terms of Karnofsky performance status (KPS) scores, pain relief, serum CA19-9, and imaging by B-US and CT before and after the therapy. We also recorded median overall survival time and complications caused by the treatment. RESULTS: In the 25 patients, KPS scores were above 60, and increased KPS was observed in 23 patients after treatment. Pain relief occurred in 23 patients. Serum CA19-9 levels were significantly reduced one month after HIFU treatment and became negative in 5 patients. B-US revealed enhanced tumor echogenicity in 13 patients and decreased tumor blood supply in 9. Tumor necrosis was confirmed by CT in 8 patients one month after HIFU treatment. The median overall survival time was 10 months, and the 1-year survival rate was 42%. No severe complications were observed after HIFU treatment. CONCLUSION: HIFU can effectively relieve pain, increase KPS, decrease tumor growth and prolong the survival time of patients with unresectable pancreatic cancer.

关键词： pancreatic cancer high-intensity focused ultrasound therapy

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Racl＋ cells distributed in accordance with CD 133＋ cells in glioblastomas and the elevated invasiveness of CD 133＋ glioma cells with higher Racl activity

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Chinese Medical Journal 2012年第24期125卷 4344-4348页

作者： ZHANG Bin SUN Jian YU sheng-ping CHEN Cong liu Bin liu Zhi-feng REN Bing-cheng MING Hao-lang YANG Xue-jun Department of Neurosurgery Tianjin Medical University General Hospital Tianjin 300052 China

Background Recent studies have suggested that cancer stem cells are one of the major causes for tumor recurrence due to their resistance to radiotherapy and chemotherapy. Although the highly invasive nature of glioblastoma （GBM） cells is also implicated in the failure of current therapies, it is not clear how glioma stem cells （GSCs） are involved in invasiveness. Racl activity is necessary for inducing reorganization of actin cytoskeleton and cell movement. In this study, we aimed to investigate the distribution characteristics of CD133＋ cells and Racl＋ cells in GBM as well as Racl activity in CD133＋ GBM cells, and analyze the migration and invasion potential of these cells. Methods A series of 21 patients with GBM were admitted consecutively and received tumor resection in Tianjin Medical University General Hospital during the first half of the year 2011. Tissue specimens were collected both from the peripheral and the central parts for each tumor under magnetic resonance imaging （MRI） navigation guidance. Immunohistochemical staining was used to detect the CD133＋ cells and Racl＋ cells distribution in GBM specimens. Double-labeling immunofluorescence was further used to analyze CD133 and Racl co-expression and the relationship between CD133＋ cells distribution and Racl expression. Serum-free medium culture and magnetic sorting were used to isolate CD133＋ cells from U87 cell line. Racl activation assay was conducted to assess the activation of Racl in CD133＋ and CD133- U87 cells. The migration and invasive ability of CD133＋ and CD133- U87 cells were determined by cell migration and invasion assays in vitro. Student＇s t-test and one-way analysis of variance （ANOVA） test were used to determine statistical significance in this study. Results In the central parts of GBMs, CD133＋ cells were found to cluster around necrosis and occasionally cluster around the vessels under the microscope by immunohistological staining. In the peripheral parts of the tumors, CD133＋ cells w

关键词： glioblastoma stem cells invasion migration Racl

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Real-time Digital Simulation of Control System with LabVIEW Simulation Interface Toolkit

Real-time Digital Simulation of Control System with LabVIEW ...

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第二十六届中国控制会议

作者： Xiang Xuejun,Xia ping,Yang sheng,liu ping China Three Gorges University,Yichang 443002,P.R.China

In this paper,the virtual instruments software LabVIEW and its Simulation Interface Toolkit are introduced at *** visualization technology,LabVIEW can simulate an industry plant with better *** LabVIEW Simulation Interface Toolkit（SIT）provides a seamless integration between MATLAB/Simulink software and LabVIEW.A method is presented to implement real-time digital simulation with no hardware-in-the-loop and a pure software real-time digital simulation example of a lever process control system using LabVIEW Simulation Interface Toolkit is *** can get better effect in teaching or training of industry process control system with minimal cost.

关键词： LabVIEW Simulation Interface Toolkit Real-time Digital Simulation MATLAB

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan ping Wang Bin liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Insights from untargeted metabolomics: revealing potential marker compounds into the maturation of fermented chili

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Food Science and Human Wellness 2025年

作者： Shiyu liu Mingyuan Yang Jianhua Zhao Meijuan Lei Jinlin Han Min Xu ping liu Jie Tang Hongbin Lin School of Food and Bio-engineering， Xihua University China Agricultural University-Sichuan Advanced Agricultural & Industrial Institute Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing Food Microbiology Key Laboratory of Sichuan Province

Chili fermentation is one of the most important processes in the production of Pixian Douban (PXDB)， which determines the flavor and product quality of PXDB. However， the maturity of fermented chili mainly depends on empirical judgment， which can not satisfy the need for standardized production of PXDB. Therefore， this study aimed to investigate volatile and non-volatile substances during the maturation process and to find markers related to the maturity of fermented chili. GC×GC-MS combined with multivariate statistical analysis revealed that 2-methoxy-3-isobutyl pyrazine， linalool， 3-(methylthio)propionaldehyde， myrcene， and decanal (ROAV ≥ 1， VIP > 1， P < 0.05) were regarded as potentially active aromatic markers for differentiating fermentation time. Additionally， UPLC-QTOF-MS combined with multivariate statistical analysis resulted that 14 compounds can serve as differentiated non-volatile compounds. The correlation of maturity-related physico-chemical indicators with volatile and non-volatile compounds revealed that three volatile compounds (2-methoxy-3-isobutylpyrazine， linalool， and decanal) along with fructose and adenosine could serve as markers for evaluating the maturity of chili. This study is expected to establish a standard for the determination of maturity the fermented chili and lay the foundation for intelligent production of PXDB.

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