Zwitterionic-phosphonate block polymer as anti-fouling coating for biomedical metals

作     者：Ya-Hui Gu Hong-Wei Liu Xiao-Han Dong Zhuang-Zhuang Ma You-Xin Li Li Li Dong-Lin Gan Ping-Sheng Liu Jian Shen Ya-Hui Gu;Hong-Wei Liu;Xiao-Han Dong;Zhuang-Zhuang Ma;You-Xin Li;Li Li;Dong-Lin Gan;Ping-Sheng Liu;Jian Shen

作者机构：Jiangsu Key Laboratory of Bio-Functional MaterialsJiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Engineering Research Center of Interfacial ChemistryNanjing UniversityNanjing 210093China 

出 版 物：《Rare Metals》 (稀有金属（英文版）)

年 卷 期：2022年第41卷第2期

页      面：700-712页

核心收录：

学科分类：080503[工学-材料加工工程] 0806[工学-冶金工程] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：This work was financially supported by the Six Talent Peaks Project in Jiangsu Province(No.SWYY-060) the National Natural Science Foundation of China(No.21504046) the Projects of Nanjing Normal University(Nos.184080H20192,184080H10386 and 184080H202B283) 

主　　题：Zwitterionic Phosphonate Anti-fouling coating Biomedical metals 

摘      要：Antifouling ability and blood compatibility are critically important in the development of medical metallic implants for clinical ***,we report the zwitterionic-phosphonate block polymer as a new type of high-efficiency antifouling coating for metallic *** block polymers(pSBMA-b-pDEMMP)with different segment lengths(nSBMA:nDEMMP=10:25,40:25,100:25,75:5,75:40,75:100)were prepared and anchored on titanium alloy(TC4)substrates.1H nuclear magnetic resonance(NMR)results clearly showed the precise preparation of the block *** analysis and water contact angle measurement indicated the successful construction of the block polymer on TC4 *** relationship between the antifouling performance of the polymer coating and the length of pDEMMP and pSBMA segments in the block polymer was *** showed that the polymer containing the pSBMA segment above 40 repeat units could significantly inhibit protein adsorption,platelet adhesion,bacterial adhesion and cell adhesion,while the pDEMMP segment above 5 repeat units is able to generate stable zwitterionic polymer coating on TC4 *** ease of production and high-efficiency antifouling modification strategy elucidated here may find broad application for biomedical implants and devices in clinical applications.