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An emerging role of vitamin D_(3) in amino acid absorption in different intestinal segments of on-growing grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2022年第3期10卷 305-318页

作者： yao Zhang Chao-Nan Li Wei-Dan Jiang Pei Wu Yang Liu sheng-yao kuang Ling Tang Shu-Wei Li Xiao-Wan Jin Hong-Mei Ren Xiao-Qiu Zhou Lin Feng Animal Nutrition Institute Sichuan Agricultural UniversityChengduChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengduChina Key Laboratory for Animal Disease-resistant Nutrition of China Ministry of Education Sichuan Agricultural UniversityChengduChina Sichuan Animal Science Academy Sichuan Animtech Feed Co.LtdChengduChina Animal Breeding and Genetics Key Laboratory of Sichuan Province Animal Nutrition InstituteSichuan Academy of Animal ScienceChengduChina

Vitamin D_(3)(VD_(3)),an essential nutrient for animals,has been demonstrated to stimulate the uptake of certain amino ***,the role of VD_(3) in the intestine,the primary site for digestion and absorption of nutrients,remains poorly ***,the grass carp(Ctenopharyngodon idella)was studied to assess the influence of different doses of VD_(3)(15.2,364.3,782.5,1,167.9,1,573.8,and 1,980.1 IU/kg)on growth performance,intestinal morphology,digestive absorption,amino acid transport,and potential signaling molecule levels in a feeding *** a result,dietary VD_(3) improved growth performance,intestinal structure,and digestive and brush border enzyme ***,most intestinal free amino acids and their transporters were upregulated after VD_(3) intake,except for Ala,Lys,Asp,Leu,solute carrier(SLC)7A7,SLC1A5,and SLC1A3 mRNA in different segments,Leu and SLC6A14 mRNA in the proximal intestine,and SLC7A5 mRNA in the mid and distal *** the crucial target of rapamycin(TOR)signal pathway of amino acid transport,the gene and protein expression of TOR,S6 kinase 1,and activating transcription factor 4 were elevated,whereas 4E-binding protein 1 was decreased,further suggesting an advanced amino acid absorption capacity in the fish due to VD_(3) *** on percentage weight gain,feed efficiency,and trypsin activity,the VD_(3) requirements of on-growing grass carp were estimated to be 968.33,1,005.00,and 1,166.67 IU/kg,*** findings provide novel recommendations for VD_(3) supplementation to promote digestion and absorption capacities of fish,contributing to the overall productivity of aquaculture.

关键词： Vitamin D_(3) Intestinal segment Intestinal absorption Amino acid transporter Peptide transporter TOR signaling

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Vitamin D,selenium,and antidiabetic drugs in the treatment of type 2 diabetes mellitus with Hashimoto's thyroiditis

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World Journal of Diabetes 2024年第2期15卷 209-219页

作者： Fen Feng Bin Zhou Ci-La Zhou Ping Huang Gang Wang kuang yao School of Pharmacy Shaoyang UniversityShaoyang 422099Hunan ProvinceChina Department of Endocrinology The Central Hospital of ShaoyangShaoyang 422099Hunan ProvinceChina

BACKGROUND Diabetes and thyroiditis are closely *** occur in combination and cause significant damage to the *** is no clear treatment for type-2 diabetes mellitus(T2DM)with Hashimoto's thyroiditis(HT).While single symptomatic drug treatment of the two diseases is less effective,combined drug treatment may improve *** To investigate the effect of a combination of vitamin D,selenium,and hypoglycemic agents in T2DM with *** This retrospective study included 150 patients with T2DM and HT treated at The Central Hospital of Shaoyang from March 2020 to February *** patients were assigned to the control group,test group A,and test group B according to different treatment *** control group received low-iodine diet guidance and hypoglycemic drug *** group A received the control treatment plus vitamin D *** group B received the group A treatment plus *** levels of markers of thyroid function[free T3(FT3),thyroid stimulating hormone(TSH),free T4(FT4)],autoantibodies[thyroid peroxidase antibody(TPOAB)and thyroid globulin antibody(TGAB)],blood lipid index[low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triacylglycerol(TG)],blood glucose index[fasting blood glucose(FBG),and hemoglobin A1c(HbA1c)]were measured pre-treatment and 3 and 6 months after *** relationships between serum 25-hydroxyvitamin D3[25(OH)D3]level and each of these indices were *** The levels of 25(OH)D3,FT3,FT4,and LDL-C increased in the order of the control group,test group A,and test group B(all P

关键词： Type-2 diabetes mellitus Hashimoto's thyroiditis Vitamin D Selenium agent Hypoglycemic drugs Curative effect

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Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

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National Science Review 2024年第4期11卷 24-27页

作者： Xingyue Wu yao Chen Kangli Cao yao Shen Xueling Wu Yilin Yang Zhongshu kuang Qingrun Li Zhenzhen Lu Yichen Jia Mian Shao Guorong Gu Xiangwei Wang Ye yao Ying Wang Shaodie Chen Zhigao Yu Wei Wei Longfei Ding Lulu Lan Tianwen Gu Xiangyu Long Jian Sun Lingyu Xing Jiayuan Shen Yi Han Yue Luo Sucheng Mu Mengna Lin Xiaoyan Zhang Rong Zeng Jianqing Xu Guoping Zhao Lihong Huang Zhenju Song Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of Pulmonology Renji Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai Public Health Clinical Center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key Laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data Center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

The emergence of SARS-Co V-2 variant of concern omicron BA.2 led to high infection incidence rates as well as reduced severity of COVID-19 during the Shanghai Spring epidemic of 2022 [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 258 confirmed COVID-19cases identified between April and June of 2022, from four COVID-19 designated hospitals located in two areas of Shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).

关键词： REPLICATION

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Integrated network pharmacology and metabolomics to explore the mechanisms of Shenzao dripping pill against chronic myocardial ischemia

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Traditional Medicine Research 2024年第11期9卷 12-26页

作者： Jie-Hui kuang Tao Hu Lu-Yong Zhang Yu-Feng yao Ming-Hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical UniversityGuangzhou 510006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527500China.

Background:Shenzao dripping pill(SZDP)is empirically prescribed for treating cardiac ***,there is a lack of comprehensive knowledge regarding the underlying mechanisms contributing to its therapeutic *** objective of this study is to investigate the underlying mechanism of SZDP against chronic myocardial ischemia(CMI)in a rat ***:In this study,we utilized electrocardiographic and echocardiographic detection along with pathological tissue analysis to evaluate the efficacy of *** integration of network pharmacology and metabolomics was conducted to investigate the *** docking and molecular dynamics simulations were used to validate the binding energy between the compounds of SZDP and the associated ***:The results showed that SZDP was able to improve T wave voltage,reverse CMI abnormalities in ejection fraction and fractional shortening,and restore histopathological heart *** results indicated that disturbances of metabolic profile in CMI rats were partly corrected after SZDP administration,mainly affecting purine metabolism.13-Docosenamide may be the potential metabolic biomarker of the therapeutic application of SZDP for *** network pharmacology and metabolomics,thiopurine S-methyltransferase(TPMT),xanthine dehydrogenase/oxidase(XDH),bifunctional purine biosynthesis protein ATIC(ATIC),and cytochrome p4501A1(CYP1A1)were identified as possible targets of SZDP to exert therapeutic effects by enhancing the metabolic levels of L-Tryptophan,Deoxyribose 1-phosphate and Phosphoribosyl ***:SZDP has a therapeutic effect on CMI by regulating metabolite levels,acting on the targets of TMPT,XDH,ATIC,and CYP1A1,and reducing cardiomyocyte injury and myocardial fibrosis.

关键词： chronic myocardial ischemia metabolomics network pharmacology serum metabolites Shenzao dripping pill

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潮流作用下环礁断面的流动特征研究

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海洋通报 2024年第3期43卷 312-320页

作者：旷敏姚宇彭尔曼长沙理工大学水利与环境工程学院湖南长沙410114 水沙科学与水灾害防治湖南省重点实验室湖南长沙410114

本文首先通过循环水槽试验测量分析了正向和反向潮流影响下概化环礁断面的流动特性,试验结果表明:在正向流和反向流作用时,礁坪上仅存在亚临界流,并可观察到经典的壁面有界流动流速剖面特征;沿礁的平均水位与各个测线上的流速随潮流幅... 详细信息

本文首先通过循环水槽试验测量分析了正向和反向潮流影响下概化环礁断面的流动特性,试验结果表明:在正向流和反向流作用时,礁坪上仅存在亚临界流,并可观察到经典的壁面有界流动流速剖面特征;沿礁的平均水位与各个测线上的流速随潮流幅值的增大而增大。本文随后采用雷诺平均的Navier-Stokes方程并结合标准的k-ωSST湍流模型建立数值水槽,进一步研究了多种水动力与礁型因素影响下前后礁外礁缘处的流速变化规律。数值模拟结果表明:后礁外礁缘处的平均流速均大于前礁外礁缘处;平均流速随潮流幅值的增大而增大,随礁坪水深、礁坪宽度、潟湖宽度和礁前斜坡坡度的增大而减小;最后基于数值模拟结果提出了预测各种因素影响下前后礁外礁缘处流速的幂函数型经验公式。

关键词：珊瑚环礁潮流流动特性基于雷诺平均的Navier-Stokes方程

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以纺织微带单元及阵列天线为接收天线的射频能量收集系统输出电压比较研究

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Journal of Donghua University(English Edition) 2024年第3期41卷 275-281页

作者：王楠李梦蝶邝野李瑶姚澜东华大学纺织学院上海201620 浙江理工大学服装学院浙江杭州310018

近些年,纺织天线作为可穿戴产品射频能量收集系统中的重要电子设备,越来越受到青睐。为研究基于纺织天线的射频能量收集系统的收集性能,该研究设计并制备了以涤纶毡为基底的纺织微带单元天线和纺织微带阵列天线。为了建立一个完整的射... 详细信息

近些年,纺织天线作为可穿戴产品射频能量收集系统中的重要电子设备,越来越受到青睐。为研究基于纺织天线的射频能量收集系统的收集性能,该研究设计并制备了以涤纶毡为基底的纺织微带单元天线和纺织微带阵列天线。为了建立一个完整的射频能量收集系统,将信号发生器、功率放大器、发射天线和所设计的纺织微带天线(作为接收天线)与整流电路连接。研究结果表明,阵列天线的最大增益比单元天线高5.35 dB。最终的输出电压显示了射频能量收集系统的有效性。随着输入功率的增加、接收距离的减小,输出电压增加。通过单元天线的最高输出电压为39.2 mV,通过阵列天线的最高输出电压为72.7 mV,这是由于阵列天线的增益较高。这项研究将为该领域带来更多的研究思路。

关键词：射频能量收集纺织品微带单元天线微带阵列天线整流电路

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Physical and Flavor Characteristics, Fatty Acid Profile, Antioxidant Status and Nrf2-Dependent Antioxidant Enzyme Gene Expression Changes in Young Grass Carp(Ctenopharyngodon idella) Fillets Fed Dietary Valine

Physical and Flavor Characteristics, Fatty Acid Profile, Ant...

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第十三届中国实验动物科学年会

作者： Jian-Bo Luo Lin Feng Wei-Dan Jiang Yang Liu Pei Wu Jun Jiang sheng-yao kuang Ling Tang Wu-Neng Tang Yong-An Zhang Xiao-Qiu Zhou Animal Nutrition Institute Sichuan Agricultural University Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural University Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education Sichuan Agricultural University Animal Nutrition Institute Sichuan Academy of Animal Science Institute of Hydrobiology Chinese Academy of Sciences

This study was conducted to examine the effects of dietary valine on the physical and flavor characteristics, fatty acid(FA) profile, antioxidant status and Nrf2-dependent antioxidant enzyme gene expression in the muscle of young grass carp(Ctenopharyngodon idella) fed increasing levels of valine(4.3, 8.0, 10.6, 13.1, 16.9 and 19.1 g/kg) for 8 weeks. Compared with the control group, the group fed valine showed improved physical characteristics of fish fillets(increased relative shear force, hydroxyproline, protein and lipid levels and decreased cathepsin B and L activities, as well as cooking loss, were observed). Moreover, valine improved the flavor of young grass carp fillets by increasing the amino acid(AA) concentration in fish muscle(increased aspartic acid, threonine, glutamine, cystine, methionine, leucine, tyrosine, phenylalanine, lysine, histidine, arginine and valine concentrations were observed). Additionally, optimal valine supplementation increased the potential health benefits to humans by decreasing the saturated FA(C15:0 and C16:0) concentration and increasing the unsaturated FA(monounsaturated FAs(MUFAs), such as C16:1, C18:1 c+t and C20:1, and polyunsaturated FAs(PUFAs), such as C18:3 n-3, C20:2 and C22:6) concentration. In addition, the reduced glutathione(GSH) content and the activities of Cu/Zn superoxide dismutase(SOD1), catalase(CAT) and Selenium-dependent glutathione peroxydase(Se-GPx) increased under valine supplementation(P < 0.05). Furthermore, the SOD1, CAT and Se-GPx mRNA levels increased with dietary valine levels, possibly due to the up-regulation of NF-E2-related factor 2(Nrf2), target of rapamycin(TOR) and ribosomal protein S6 kinase 1(S6K1) and the down-regulation of Kelch-like-ECH-associated protein 1(Keap1) in muscle(P < 0.05). In conclusion, valine improved the physical and flavor characteristics, FA profile, and antioxidant status and regulated the expression of the antioxidant enzyme genes Nrf2, Keap1, TOR and S6K1 in fish fill

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穿越走滑断层隧道错动影响分区及隧道节段式衬砌抗错断性能控制

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科学技术与工程 2024年第18期24卷 7534-7541页

作者：粟威陶伟明易鹏豪申玉生匡亮王耀达中铁二院工程集团有限公司成都610031 西南交通大学土木工程学院成都610031 西南交通大学交通隧道工程教育部重点实验室成都610031

为了揭示中国西部地区穿越活动断裂公路隧道工程的变形及力学特性,通过数值模拟分析了断层左旋走滑运动对隧道结构产生的错动响应,建立隧道受断层错动影响分区,并提出隧道节段衬砌铰接设计这一抗错断措施。通过对比在影响区内设置不同... 详细信息

为了揭示中国西部地区穿越活动断裂公路隧道工程的变形及力学特性,通过数值模拟分析了断层左旋走滑运动对隧道结构产生的错动响应,建立隧道受断层错动影响分区,并提出隧道节段衬砌铰接设计这一抗错断措施。通过对比在影响区内设置不同长度节段衬砌时隧道结构的应力、位移响应规律,得出最优衬砌节段布置形式。研究结果表明:断层走滑错动2.5 m时,隧道结构受错影响范围为断层与活动盘交界面附近2.7 d(d为隧道跨径)内,定义1 d~2.7 d范围内为次要影响区,1 d范围内为主要影响区;通过对比分析发现3 m节段对衬砌结构水平位移和最大剪应力的控制效果最好,峰值最大降低率分别达到了3.38%和43.34%;隧道结构在断层交界面附近水平位移达到最大,随后向两侧较远位置变形不断减小至平稳;可见隧道结构沿纵向所受的最大剪应力值集中在错动影响区内,且在此范围内变化相较此范围外更加剧烈,错动影响区是抗断层错动设防重点关注对象。研究结果可为隧道抗错断设计提供参考。

关键词：公路隧道走滑断层节段衬砌影响分区数值计算

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Mirrorless MEMS imaging:a nonlinear vibrational approach utilizing aerosol-jetted PZT-actuated fiber MEMS scanner for microscale illumination

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Microsystems & Nanoengineering 2024年第1期10卷 175-192页

作者： Wei-Chih Wang Ming-yao Li Kuan-Chang Peng Yi-Feng Hsu Benjamin Estroff Pao-Yun Yen David Schipf Wen-Jong Wu Department of Power Mechanical Engineering National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchuTaiwan 30013China Institute of NanoEngineering and Microsystems National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchuTaiwan 30013China Department of Mechanical Engineering University of WashingtonSeattleWA 98195USA Department of Electrical Engineering University of WashingtonSeattleWA 98195USA Department of Engineering Science and Ocean Engineering National Taiwan UniversityTaiwanChina

This study introduces a novel image capture and lighting techniques using a cutting-edge hybrid MEMS scanner system designed for compact microscopic *** scanner comprises a tapered optical fiber waveguide and innovative aerosol-jet printed PZT(lead zirconate titanate)bimorph push-pull actuators on a stainless-steel substrate,effectively addressing issues that are commonly associated with PZT on silicon substrates such as fracture and layer *** leveraging nonlinear vibration,the scanner achieves a spiral scan pattern from a single signal input,in addition to the expected two-dimensional scanning and target illumination from two phase-shifted *** capability is further enhanced by a novel process to taper the optical fiber,which reduces illumination scattering and tunes the fiber to the resonant frequencies of the *** precisely tapered tip enables large fields of view while maintaining independent 2-axis scanning through one-degree-of-freedom *** validation showcases the successful generation of a spiral scan pattern with a 60μm diameter scan area and a 10 Hz frame rate,effectively reconstructing scanned images of 5μm lines,cross patterns(15μm in length with a 5μm gap),and structures of a Psychodidae wing.

关键词： steel fiber scanner

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数字化背景下羌绣文创产品设计及美育价值建构

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包装工程 2024年第4期45卷 478-484页

作者：王雪丹李淑媛邝良锋姚欢西南民族大学成都610041

目的中华优秀传统文化需要将艺术价值与时代价值统一起来。针对羌绣文创产品,当前人们大多关注其艺术价值、数字化设计与市场开发方面,忽视了羌绣文创产品的审美教育价值(以下简称美育价值),因此要将产品设计和美育价值建构融合在一起... 详细信息

目的中华优秀传统文化需要将艺术价值与时代价值统一起来。针对羌绣文创产品,当前人们大多关注其艺术价值、数字化设计与市场开发方面,忽视了羌绣文创产品的审美教育价值(以下简称美育价值),因此要将产品设计和美育价值建构融合在一起研究。首先,为羌绣文创产品提炼美育价值内容;其次,以数字技术助推羌绣文创产品美育元素的跨界设计;然后,挖掘并满足羌绣文创产品潜在消费群体的美育元素;最后,要对羌绣中的文化内容进行转译以适合文创产品的数据化应用。此外,为广泛推进其美育价值,需要建设羌绣美育文创产品数据库。方法通过文献研究法与图像分析整理出羌绣美育价值符号,使用田野调查法及人物访谈方式了解羌绣文创产品类型及羌绣美育价值的数字化设计情况,以及数据库的建立情况。结论在数字化背景下,羌绣文创产品设计需要在空间设计、交互体验和文化转译上将羌绣文创产品的美育价值融入其中,从而为促进中华民族共同体意识的建设贡献力量。

关键词：数字化羌绣文创产品设计美育价值

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