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High multiple mutations of Plasmodium falciparum-resistant genotypes to sulphadoxine-pyrimethamine in Lagos, Nigeria

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Infectious Diseases of Poverty 2020年第4期9卷 152-153页

作者： Hong Quan Uche Igbasi Wellington Oyibo Sunday Omilabu shen-bo chen Hai-Mo shen Chukwuma Okolie Jun-Hu chen Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Center for Tropical DiseasesNational Centre for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai200025People’s Republic of China National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention-Shenzhen Center for Disease Control and Prevention Joint Laboratory for Imported Tropical Disease ControlShanghai200025People’s Republic of China Center for Infectious Diseases Research Microbiology DepartmentNigerian Institute of Medical Research6 Edmund CrescentYabaLagosNigeria ANDI Center of Excellence for Malaria Diagnosis Department of Medical Microbiology and ParasitologyCollege of MedicineUniversity of LagosLagosNigeria Department of Medical Microbiology and Parasitology College of MedicineUniversity of LagosLagosNigeria Department of Surveying and Geoinformatics Faculty of EngineeringUniversity of LagosLagosNigeria

Background Plasmodium falciparum-resistance to sulphadoxine-pyrimethamine(SP)has been largely reported among pregnant ***,the profile of resistance markers to SP dihydrofolate reductase(dhfr)and dihydropteroate synthase(dhps)in the general population are varied and not frequently ***,SP is used as partner drug for artemisinin combination therapy(SP-artesunate)in some sub-Saharan African countries or as a prophylactic drug in intermittent preventive treatment of malaria during pregnancy and infants and in seasonal malaria chemoprevention(SMC).Profiling of ***-resistant genotypes to SP is dynamic and critical in providing data that would be useful for malaria control *** study assessed the profile of dhfr and dhps genes genotypes among individuals with malaria in Lagos,*** Molecular markers of SP resistance were identified by nested PCR and sequenced among malaria positive dried blood spots(DBS)that were collected from individuals attending health facilities from January 2013 to February 2014 and during community surveys from October 2010 to September 2011 across different Local Government Areas of Lagos State,*** A total of 242 and 167 samples were sequenced for dhfr and dhps,*** analysis of dhfr showed that 95.5%(231/242),96.3%(233/242)and 96.7%(234/242)of the samples had N51I,C59R and S108N mutant alleles,*** prevalence of dhps mutation at codons A437G,A613S,S436A,A581G,I431V and K540E were 95.8%(160/167),41.9%(70/167),41.3%(69/167),31.1%(52/167),25.1%(42/167),and 1.2%(2/167)*** prevalence of triple mutations(CIRNI)in dhfr was 93.8%and 44.3%for the single dhps haplotype mutation(SGKAA).Partial SP-resistance due to quadruple dhfr-dhps haplotype mutations(CIRNI-SGKAA)and octuple haplotype mutations(CIRNI-VAGKGS)with rate of 42.6%and 22.0%,respectively has been *** There was increased prevalence in dhfr triple haplotype mutations when com

关键词： Plasmodium falciparum Antimalarial drug resistance Sulphadoxine-pyrimethamine Dihydrofolate reductase Dihydropteroate synthase

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Co-infections with Babesia microti and Plasmodium parasites along the China-Myanmar border

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Infectious Diseases of Poverty 2013年第1期2卷 188-194页

作者： Xia Zhou sheng-Guo Li shen-bo chen Jia-Zhi Wang Bin Xu He-Jun Zhou Hong-Xiang Zhu Ge Jun-Hu chen Wei Hu National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborating Centre for MalariaSchistosomiasis and FilariasisKey Laboratory of Parasite&Vector Biology Ministry of HealthShanghai 200025China Department of Parasitology Medical College of Soochow UniversityNo.199 Renai RoadSuzhou 215123China Tengchong Center for Disease Control and prevention Yunnan province 679100China Department of Microbiology and Microbial Engineering School of Life ScienceFudan UniversityShanghai 200433China

Background:Babesiosis is an emerging health risk in several parts of the ***,little is known about the prevalence of Babesia in malaria-endemic *** area along the China-Myanmar border in Yunnan is a main endemic area of malaria in ***,however,human infection with Babesia microti(***)is not recognized in this region,and its profile of co-infection is not yet ***:To understand its profile of co-infections with ***,our investigation was undertaken in the malaria-endemic area along the China-Myanmar border in Yunnan between April 2012 and June *** parasite species,including ***,Plasmodium falciparum(***),***,and ***,were identified among 449 suspected febrile persons detected by nested polymerase chain reaction(PCR)assay based on small subunit ribosomal ribonucleic acid(RNA)genes of *** and Plasmodium ***:Of all the collected samples from febrile patients,mono-infection with ***,***,***,and *** accounted for 1.8%(8/449),9.8%(44/449),2.9%(13/449),and 0.2%(1/449),*** rate of mixed infections of *** with *** or *** are both 0.2%(1/449),and mixed infections of *** and *** accounted for 1.1%(5/449).Conclusions:This report supports the hypothesis that babesiosis caused by *** is emerging along the China-Myanmar border in the Yunnan province,***,but it was ignored because of low parasitemia or mixed infection with Plasmodium *** sensitive and specific diagnosis methods are needed to find the rapid response mechanism of emergency for babesiosis and malaria co-prevalence areas.

关键词： Babesia Plasmodium Co-infection China-Myanmar border

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Study roadmap for high-throughput development of easy to use and affordable biomarkers as diagnostics for tropical diseases:a focus on malaria and schistosomiasis

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Infectious Diseases of Poverty 2017年第1期6卷 1149-1156页

作者： Kokouvi Kassegne Ting Zhang shen-bo chen Bin Xu Zhi-sheng Dang Wang-Ping Deng Eniola Michael Abe Hai-Mo shen Wei Hu Takele Geressu Guyo Solomon Nwaka Jun-Hu chen Xiao-Nong Zhou National Institute of Parasitic Diseases(NIPD) Chinese Centre for Disease Control and PreventionShanghai 200025People’s Republic of China WHO Collaborating Centre for Tropical Diseases National Centre for International Research on Tropical DiseasesKey Laboratory of Parasite and Vector Biology of the Chinese Ministry of HealthShanghai 200025People’s Republic of China Department of Microbiology and Microbial Engineering School of Life ScienceFudan UniversityShanghai 200433People’s Republic of China African Network for Drugs&Diagnostics Innovation(ANDI) Addis AbabaEthiopia

Background:Interventions are currently being used against‘infectious diseases of poverty’,which remain highly debilitating and deadly in most endemic countries,especially malaria,schistosomiasis,echinococcosis and African sleeping ***,major limitations of current‘traditional’methods for diagnosis are neither simple nor convenient for population surveillance,and showed low sensitivity and *** to novel technologies for the development of adequate and reliable tools are expressly needed.A collaborative project between African Network for Drugs and Diagnostics Innovation and partner institutions in Africa and China aims to screen suitable serological biomarkers for diagnostic pipelines against these‘diseases of the poor’.Methods:Parasite-specific exposed versus unexposed individuals were screened and sera or urine/stools were collected through case-control studies in China and African *** genes/open reading frames were selected,then will be cloned and cell-free expressed,quantified and *** antigens/epitopes will be probed and screened with sera from exposed or unexposed individuals using a high-throughput antigen screening platform as the study *** specificity and sensitivity of highly immunoreactive biomarkers will be evaluated as well,using enzyme-linked immunosorbent assays or ***:This roadmap explicitly unfolds the integrated operating procedures with focus on malaria and schistosomiasis,for the identification of suitable biomarkers that will aid the prioritization of diagnostics for population ***,there is need to further validate any new diagnostic through comparison with standard methods in field deployable tests for each *** expectations for the future are to seek regulatory approval and promote the use of diagnostics in endemic areas.

关键词： Malaria Schistosomiasis Neglected tropical diseases Immunoproteomics Protein microarray Serological biomarker Diagnosis

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油气管道运输中的工艺设备与自动化控制

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制造业自动化 2021年第8期43卷 69-73页

作者：陈浩沈博臣钱泓超杭州安全生产科学技术有限公司杭州310007

由于油气存储要求较高,为运输环节带来了较大阻碍。油气运输过程若发生事故,不但会对财产、人员造成损失,也会对社会安定造成一定的威胁,为了在根源上阻止油气管道运输事故的发生,对油气管道运输自动化控制方法进行研究。为了弥补现有... 详细信息

由于油气存储要求较高,为运输环节带来了较大阻碍。油气运输过程若发生事故,不但会对财产、人员造成损失,也会对社会安定造成一定的威胁,为了在根源上阻止油气管道运输事故的发生,对油气管道运输自动化控制方法进行研究。为了弥补现有方法的不足,深入探究油气运输工艺设备特征与分类情况,以此为基础,结合管道事故类型构造油气管道运输事故成因关系链,基于油气管道运输事故成因关系链,选择适当的自动化监测硬件,并对其进行合理部署,基于PID控制原理制定油气管道运输自动化控制程序,依照既定规则执行自动化控制程序,即可实现油气管道运输工艺设备的自动化控制。通过实验数据对比可知,与现有方法相比较,提出方法调节时间较短,超调量较小,充分证实了提出方法的应用性能更好,对油气管道运输提供更加有效的保障。

关键词：油气管道油气运输工艺设备自动化控制

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Effects of Global Warming on the Production Patterns of Agriculture and Animal Husbandry in Qinghai

Effects of Global Warming on the Production Patterns of Agri...

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作者： Li Yingnian,shen Zhenxi,chen bo,Wang Wenying and Jiang WenboNorthwest Plateau Institute of Biology,Chinese Academy of Sciences,Xining 810008,P.R. China

The production patterns of agriculture and animal husbandry in different areas underpresent conditions were analyzed in this paper.A regression equation was established based on thedemarcation temperature and its duration(days) and the present environmental condition in *** correlatiqn is distinctive among the distributive patterns of agricultural and animalhusbandry production,local heat quantity and duration(days) of differnt *** the equation,the possible change of the production pattrns of agriculture,animal husbandryand forestry in Qinghai was estimated under future climatic ***,future thermalresources of Qinghai were also *** results showed that the accumulative temperaturesof demarcation temperature would be increased by about 380℃d. The days of duration will alsobe increased by 20 days under the condition of air temperature raising by 2℃ and precipitationincreasing by 10%.It will lead to expansion of Qinghai plantation area(especially economicalcrops in forest-line) and in the level of *** in different areas will become moreseriously because of the increase of the evaporahon of soil surface.

关键词： global warming,production pattern,demarcation temperature,accumulative temperature

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Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin Xiao Liang Shu-Peng Liu Rui-Lan Wang Qing-Wei Zhang Yu-Feng shen Xiao-bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,Pbody(PCA)antibody was higher in these patients than in those without GPs(88.6%vs 73.6%,P<0.001).Multivariate and univariate analyses revealed that PCA positivity[odds ratio(OR)=2.003,P=0.017],pepsinogen II(OR=1.053,P=0.015),and enterochromaffin like cells hyperplasia(OR=3.116,P<0.001)were significant risk factors for GPs,while pepsinogen I was identified as a protective *** PCA positivity and enterochromaffin like cells hyperplasia are significant risk factor for the development of GPs in patients with *** gastrin-17 levels may also play a role in this *** findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram

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Effects of Global Warming on the Production Patterns of Agriculture and Animal Husbandry in Qinghai

Effects of Global Warming on the Production Patterns of Agri...

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作者： Li Yingnian, shen Zhenxi, chen bo, Wang Wenying and Jiang Wenbo Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810008, P.R. China

＜正＞The production patterns of agriculture and animal husbandry in different areas under present conditions were analyzed in this paper. A regression equation was established based on the demarcation temperature and its duration （days） and the present environmental condition in every area. The correlation is distinctive among the distributive patterns of agricultural and animal husbandry production, local heat quantity and duration （days） of different temperatures. According to the equation, the possible change of the production patterns of agriculture, animal husbandry and forestry in Qinghai was estimated under future climatic changes. Meanwhile, future thermal resources of Qinghai were also analyzed. The results showed that the accumulative temperatures of demarcation temperature would be increased by about 380℃-d. The days of duration will also be increased by 20 days under the condition of air temperature raising by 2℃and precipitation increasing by 10%. It will lead to expansion of Qinghai plantation area （especially economical crops in forest-line） and in the level of latitude. Drought in different areas will become more seriously because of the increase of the evaporation of soil surface.

关键词： global wanning production pattern demarcation temperature accumulative temperature

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油气储运设施在线监测预警系统设计

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粘接 2020年第8期43卷 32-36页

作者：陈浩刘珊沈博臣杭州安全生产科学技术有限公司浙江杭州310007

随着人们对油气储运设施安全性能的不断提高,使用在线监测预警系统将能够降低安全事故的发生,防患于未然。于是文章将设计一种油气储运设施在线监测预警系统。首先对系统设计之前的准备工作进行分析,然后再研究系统的设计过程。通过对... 详细信息

随着人们对油气储运设施安全性能的不断提高,使用在线监测预警系统将能够降低安全事故的发生,防患于未然。于是文章将设计一种油气储运设施在线监测预警系统。首先对系统设计之前的准备工作进行分析,然后再研究系统的设计过程。通过对油气储运设施的相关指标进行监测,从而存储相关数据,并对数据进行筛选和分析,可以及时发现油气储运设施的问题,及时发出预警,有利于油气储运设施的安全运行。

关键词：油气储运监测预警系统设计

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Effects of Salvia miltiorrhiza on intestinal microflora in rats with ischemia/reperfusion liver injury

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 274-280页

作者： Hui-Chun Xing, Lan-Juan Li, Kai-Jin Xu, Tian shen, Yun-bo chen, Yu chen, Su-Zhen Fu, Ji-Fang sheng, Chun-Lei chen, Jian-Guo Wang, Dong Yan, Fang-Wei Dai and Xiao-Ying Sha Hangzhou, China Key Laboratory of Infectious Diseases, Ministry of Public Health of China, and Institute of Infectious Diseases, Department of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Zhejiang Academy of Medical Sciences, Hangzhou 310012, China Department of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China.

BACKGROUND: Hepatic ischemia/reperfusion injury may induce intestinal microflora imbalance. Salvia miltiorrhiza is effective in promoting blood circulation and counteracting peroxidation in tissues. The aim of the present study was to determine the effects of Salvia miltiorrhiza on intestinal mi- croflora, endotoxemia, and bacterial translocation in rats with hepatic I/R injury. METHODS: Sprague-Dawley rats in specific pathogen free grade were divided into 3 groups: group I(n =6) for sham operation: groups ( n = 7) for liver ische- mia for 20 minutes and reperfusion for 22 hours. Group was also pretreated with 4 ml/day of Salvia miltiorrhiza solu- tion (250 mg/kg) by daily gavage for 7 days. The levels of serum alanine aminotransferase (ALT), aspartate amino- transferase (AST), malondialdehyde ( MDA) and supero- xide dismutase ( SOD ) in liver tissues, serum endotoxin, intestinal bacterial counts, intestinal mucosal histology and bacterial translocation were studied. RESULTS: The levels of ALT, AST, plasma endotoxin and MDA in liver tissues were decreased more markedly in group (57.57 ± 18.08 U/L, 147.57 ±40.84 U/L, 0.42 ± 0.144 EU/ml and 0. 52 ±0.19 nmol/mg-prot respectively) in group 295.9±216.92 U/L, 0.80± 0.262 EU/ml and 0.72±0.12 nmol/mg-prot; P <0.05-0.01 respectively). Liver SOD activity was increased more sig- nificantly in group (318.47±64.62 U/mg-prot) than in group U/mg-prot, P<0.05). The counts of Bifidobacteria and Bacteroides increased more significantly in group than in group but were similar to those in group I. Bacterial translocation to the kidney in group was 50% (5/10), whereas no bacterial translocation to the kidney occurred in the other two groups (P <0. 01). Ileal mucosal structure was markedly ameliorated in group as compared with group CONCLUSIONS: Salviae miltiorrhiza could partially restore intestinal microflora balance, improve intestinal mucosal integrity, and reduce bacterial translocation and plasma en- dotoxin in rats with hepatic is

关键词： Salviae miltiorrhiza hepatic ischemia/reperfusion microflora endotoxin bacterial translocation

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炎症性肠病肠道微生物整合代谢网络的构建与分析

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军事医学 2019年第7期43卷 522-527页

作者：周贤斌沈玲燕沈陈波季新荣曹洋温州医科大学附属台州医院浙江台州317000 台州恩泽医疗中心(集团)恩泽医院浙江台州318050 军事科学院军事医学研究院环境医学与作业医学研究所天津300050

目的构建炎症性肠病(IBD)肠道微生物整合代谢网络,比较分析IBD整合代谢网络的拓扑变化。方法参考KEGG数据库,根据肠道微生物参与的代谢反应构建整合代谢网络,用KO丰度差异abs(log2OR)评估KO与机体状态的关联,丰度差异>1的KO即为IBD相关... 详细信息

目的构建炎症性肠病(IBD)肠道微生物整合代谢网络,比较分析IBD整合代谢网络的拓扑变化。方法参考KEGG数据库,根据肠道微生物参与的代谢反应构建整合代谢网络,用KO丰度差异abs(log2OR)评估KO与机体状态的关联,丰度差异>1的KO即为IBD相关KO,分析IBD相关KO与网络节点的介数中心度、聚类系数和度的关联,并比较IBD和健康整合代谢网络的模块化程度、稳定性和密度。结果构建了含1300个节点(KO)的整合代谢网络;发现366个KO与IBD相关(254个高表达,112个低表达);IBD相关的KO介数中心度和度显著小于IBD无关的KO,聚类系数显著大于IBD无关KO;IBD减少网络的模块化程度、稳定性和密度。结论IBD引起整合代谢网络拓扑属性的变化,IBD相关的KO倾向于在网络的边缘,整合代谢网络方法可从整体上解释肠道微生物变化与IBD的本质关联。

关键词：炎症性肠病整合代谢网络拓扑属性肠道微生物

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